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Search results 301 to 400 out of 427 for Cd74

0.045s
Type Details Score
Allele
Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Allele
Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); endonuclease-mediated mutation 4, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); endonuclease-mediated mutation 3, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Allele
Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); endonuclease-mediated mutation 4, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Genotype
Symbol: Cd74/Cd74
Background: C57BL/6N-Cd74/H
Zygosity: hm
Has Mutant Allele: true
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Ari Waisman
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
Allele
Name: transgene insertion, Christophe Benoist and Diane Mathis
Allele Type: Transgenic
Attribute String: Transactivator
Allele
Name: transgene insertion, Toshiyuki Fukada
Allele Type: Transgenic
Attribute String: Recombinase
Strain
Attribute String: targeted mutation, mutant strain, congenic
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: mutant strain, congenic, targeted mutation
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: congenic, major histocompatibility congenic, mutant strain, targeted mutation
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Genotype
Symbol: Cd74/Cd74
Background: either: (involves: 129/Sv * B10.BR) or (involves: 129/Sv * C57BL/6)
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74
Background: involves: 129S/SvEv * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74
Background: B6.129S-Cd74
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74
Background: involves: 129S/SvEv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74
Background: involves: 129S/SvEv * BALB/cAn
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74
Background: involves: 129S/SvEv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74
Background: involves: 129S/SvEv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74
Background: involves: 129S/SvEv * BALB/c * C57BL
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74
Background: involves: 129S/SvEv * C57BL * C57BL/10 * C57BR
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74
Background: involves: 129S/SvEv
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74
Background: involves: 129S2/SvPas
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74
Background: involves: 129S2/SvPas
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74
Background: B6.129S2-Cd74
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74
Background: B6.129S-Cd74/J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Stumptner-Cuvelette P
Year: 2002
Journal: Biochim Biophys Acta
Title: Multiple roles of the invariant chain in MHC class II function.
Volume: 1542
Issue: 1-3
Pages: 1-13
Publication
First Author: Schröder B
Year: 2016
Journal: Biochim Biophys Acta
Title: The multifaceted roles of the invariant chain CD74--More than just a chaperone.
Volume: 1863
Issue: 6 Pt A
Pages: 1269-81
Protein Domain
Type: Family
Description: CD74 is expressed on antigen-presenting cells and was initially demonstrated to function as an MHC class II chaperone []. It was originally described as the MHC class II-associated invariant chain and its binding to MHC II alpha and beta chains is crucial for the MHCII antigen presentation pathway. Besides chaperone function, it is also involved in the regulation of endosomal trafficking, cell migration and cellular signalling as surface receptor of the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) []. Macrophage migration inhibitory factor binding to CD74 induces its intramembrane cleavage and the release of its cytosolic intracellular domain (CD74-ICD), which interacts with the transcription factors RUNX (Runt related transcription factor) and NF-kappaB and binds to proximal and distal regulatory sites enriched for genes involved in apoptosis, immune response, and cell migration. Recently, CD74 has been associated with tumor progression and metastasis [].
Strain
Attribute String: mutant strain, congenic, transgenic
Allele
Name: transgene insertion 10G, Naoko Nakano
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 29, Naoko Nakano
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion #, Christophe Benoist and Diane Mathis
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
Allele
Name: transgene insertion 125, Tetsuo Noda
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Johannes Herkel
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
Strain
Attribute String: congenic, mutant strain, targeted mutation, major histocompatibility congenic
Strain
Attribute String: targeted mutation, congenic, mutant strain
Strain
Attribute String: targeted mutation, mutant strain, major histocompatibility congenic, congenic
Genotype
Symbol: Cd1d1/Cd1d1 Cd74/Cd74
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74 Sppl2a/Sppl2a
Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74 Sppl2a/Sppl2a
Background: B6.129-Sppl2a Cd74
Zygosity: cx
Has Mutant Allele: true
Strain
Attribute String: mutant strain, congenic, transgenic
Strain
Attribute String: transgenic, mutant strain, coisogenic
Genotype
Symbol: Tg(SFTPC-CD74/ROS1)125Tno/?
Background: C57BL/6J-Tg(SFTPC-CD74/ROS1)125Tno
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: H2-DMa/H2-DMa Cd74/Cd74
Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74 H2-DMa/H2-DMa
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74
Background: involves: 129S/SvEv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74 H2-DMa/H2-DMa
Background: involves: 129S/SvEv * BALB/c
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74 H2-DMa/H2-DMa Tg(CD74)AR194Ayr/?
Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74 Tap1/Tap1
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74 H2-DMa/H2-DMa Tg(CD74*)1Ayr/?
Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74<+>
Background: involves: 129S/SvEv
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Cd19/Cd19<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Strain
Attribute String: transgenic, targeted mutation, mutant stock
Genotype
Symbol: Smim3/Smim3<+> Cd74/Cd74<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Protein Domain
Type: Family
Description: The CD74 antigen (also known as H-2 class II histocompatibility antigen gamma chain, MHC class II-associated invariant chain, Ia antigen-associated invariant chain, or Ii) plays a key role in MHC class II antigen processing: it stabilises peptide-free class II alpha/beta heterodimers in a nonameric (α-β-gamma)3 complex after their synthesis, and directs transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place []. CD74/Ii is a single-pass type II membrane protein containing a thyroglobulin type-1 domain. The structure of the trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii has been determined by NMR []. The molecule is cylindrical in shape and reveals conserved molecular surfaces that may mediate interactions between Ii and class II molecules [].
Strain
Attribute String: mutant stock, transgenic, variant allele
Publication
First Author: Obst R
Year: 2005
Journal: J Exp Med
Title: Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response.
Volume: 201
Issue: 10
Pages: 1555-65
Publication
First Author: Inoue M
Year: 2016
Journal: Carcinogenesis
Title: Mouse models for ROS1-fusion-positive lung cancers and their application to the analysis of multikinase inhibitor efficiency.
Volume: 37
Issue: 5
Pages: 452-60
Genotype
Symbol: Cd19/Cd19<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Il10/Il10
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Smim3/Smim3<+> Cd74/Cd74<+> Lmo2/Lmo2<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cd74/Cd74<+> Lmo2/Lmo2<+> Smim3/Smim3<+>
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Smim3/Smim3<+> Cd74/Cd74<+> Lmo2/Lmo2<+> Trp53/Trp53<+>
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Smim3/Smim3<+> Cd74/Cd74<+> Lmo2/Lmo2<+> Trp53/Trp53
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tg(CAG-cat,-EGFP)39Miya/? Tg(Cd74-cre)#Tfk/?
Background: involves: C57BL/6 * DBA/2NJcl
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Qiu Z
Year: 2024
Journal: Sci Adv
Title: IRF8-mutant B cell lymphoma evades immunity through a CD74-dependent deregulation of antigen processing and presentation in MHCII complexes.
Volume: 10
Issue: 28
Pages: eadk2091
Publication
First Author: Kong XF
Year: 2018
Journal: Nat Immunol
Title: Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency.
Volume: 19
Issue: 9
Pages: 973-985
Publication
First Author: Merk M
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF).
Volume: 108
Issue: 34
Pages: E577-85
Protein
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
Publication
First Author: Yamashiro H
Year: 2002
Journal: Int Immunol
Title: Development of CD25(+) T cells secreting transforming growth factor-beta1 by altered peptide ligands expressed as self-antigens.
Volume: 14
Issue: 8
Pages: 857-65
Publication
First Author: Han S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery.
Volume: 107
Issue: 47
Pages: 20453-8
Publication
First Author: Leng L
Year: 2011
Journal: J Immunol
Title: A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice.
Volume: 186
Issue: 1
Pages: 527-38
Publication
First Author: Bernhagen J
Year: 2007
Journal: Nat Med
Title: MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment.
Volume: 13
Issue: 5
Pages: 587-96
Publication  
First Author: Tilstam PV
Year: 2021
Journal: J Clin Invest
Title: MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model.
Volume: 131
Issue: 23
Publication
First Author: Cortés M
Year: 2017
Journal: EMBO J
Title: Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles.
Volume: 36
Issue: 22
Pages: 3336-3355
Publication
First Author: Zhou B
Year: 2023
Journal: Eur J Immunol
Title: Prmt5 deficient mouse B cells display RNA processing complexity and slower colorectal tumor progression.
Volume: 53
Issue: 10
Pages: e2250226
Publication
First Author: Vieira-de-Abreu A
Year: 2011
Journal: Am J Respir Cell Mol Biol
Title: Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene Câ‚„-synthesizing lipid bodies.
Volume: 44
Issue: 4
Pages: 509-16
Publication
First Author: Chatterjee M
Year: 2014
Journal: Circ Res
Title: Macrophage migration inhibitory factor limits activation-induced apoptosis of platelets via CXCR7-dependent Akt signaling.
Volume: 115
Issue: 11
Pages: 939-49
Publication
First Author: Kobayashi M
Year: 2007
Journal: J Histochem Cytochem
Title: A distinctive set of genes is upregulated during the inflammation-carcinoma sequence in mouse stomach infected by Helicobacter felis.
Volume: 55
Issue: 3
Pages: 263-74
Publication
First Author: Nagata Y
Year: 2015
Journal: PLoS One
Title: Role of macrophage migration inhibitory factor (MIF) in pollen-induced allergic conjunctivitis and pollen dermatitis in mice.
Volume: 10
Issue: 2
Pages: e0115593
Publication
First Author: Moon HY
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise.
Volume: 109
Issue: 32
Pages: 13094-9
Publication
First Author: Wong BL
Year: 2009
Journal: Am J Pathol
Title: Essential role for macrophage migration inhibitory factor in gastritis induced by Helicobacter pylori.
Volume: 174
Issue: 4
Pages: 1319-28
Publication  
First Author: Vandenbark AA
Year: 2022
Journal: Cell Immunol
Title: "Near Cure" treatment of severe acute EAE in MIF-1-deficient female and male mice with a bifunctional MHCII-derived molecular construct.
Volume: 378
Pages: 104561
Publication
First Author: Nakamura A
Year: 2021
Journal: Sci Transl Med
Title: Macrophage migration inhibitory factor drives pathology in a mouse model of spondyloarthritis and is associated with human disease.
Volume: 13
Issue: 616
Pages: eabg1210
Publication
First Author: Pellowe AS
Year: 2019
Journal: FASEB J
Title: Endothelial cell-secreted MIF reduces pericyte contractility and enhances neutrophil extravasation.
Volume: 33
Issue: 2
Pages: 2171-2186
Publication
First Author: Schneppenheim J
Year: 2014
Journal: Mol Cell Biol
Title: The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo.
Volume: 34
Issue: 8
Pages: 1398-411