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Search results 301 to 312 out of 312 for Cdk8

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0.017s

Type

Details

Score

Publication

7877695 | -

First Author:	Liao SM
Year:	1995
Journal:	Nature
Title:	A kinase-cyclin pair in the RNA polymerase II holoenzyme.
Volume:	374
Issue:	6518
Pages:	193-6

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Publication

9702190 | -

First Author:	Hengartner CJ
Year:	1998
Journal:	Mol Cell
Title:	Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases.
Volume:	2
Issue:	1
Pages:	43-53

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Protein Domain

IPR038089 | Med31_sf

Type:

Homologous_superfamily

Description:

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. On recruitment the Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. The Mediator complex is composed of at least 31 subunits. They form at least three structurally distinct submodules. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation.Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.This entry includes subunit Med31 of the Mediator complex and the Saccharomyces cerevisiae homologue, Soh1. Soh1 is responsible for the repression of temperature sensitive growth of the Hpr1 mutant []and has been found to be a component of the RNA polymerase II transcription complex. Soh1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the Soh1 protein may serve to couple these two processes [].Med31 is organised as a four helix bundle and with the N-terminal part of subunit Med7 forms a submodule of the middle module of the mediator core which is unique in structure and function. In vivo, Med7N/31 has a predominantly positive function on the expression of a specific subset of genes, including genes involved in methionine metabolism and iron transport [].

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Protein

Q62447

Organism:	Mus musculus/domesticus
Length:	283
Fragment?:	false

•

Protein

Q3U6Q7

Organism:	Mus musculus/domesticus
Length:	253
Fragment?:	false

•

Protein

Q497T2

Organism:	Mus musculus/domesticus
Length:	335
Fragment?:	true

•

Protein

Q5PPR1

Organism:	Mus musculus/domesticus
Length:	320
Fragment?:	true

•

Protein

Q05BN1

Organism:	Mus musculus/domesticus
Length:	311
Fragment?:	true

•

Protein

Q6P6A2

Organism:	Mus musculus/domesticus
Length:	314
Fragment?:	true

•

Protein

Q8CAS3

Organism:	Mus musculus/domesticus
Length:	282
Fragment?:	false

•

Protein

Q3UXL9

Organism:	Mus musculus/domesticus
Length:	266
Fragment?:	false

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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