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Search results 301 to 400 out of 447 for Cdk9

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Type Details Score
Publication
20434984 | J:165999
First Author: Rahl PB
Year: 2010
Journal: Cell
Title: c-Myc regulates transcriptional pause release.
Volume: 141
Issue: 3
Pages: 432-45
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Publication
23663783 | J:206891
First Author: Ji X
Year: 2013
Journal: Cell
Title: SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase.
Volume: 153
Issue: 4
Pages: 855-68
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Publication
19914168 | J:157018
First Author: Alarcón C
Year: 2009
Journal: Cell
Title: Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways.
Volume: 139
Issue: 4
Pages: 757-69
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Publication
23921639 | J:210726
First Author: Salem T
Year: 2013
Journal: Nucleic Acids Res
Title: Chromatin loop organization of the junb locus in mouse dendritic cells.
Volume: 41
Issue: 19
Pages: 8908-25
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Publication
22767893 | J:185950
First Author: Padmanabhan K
Year: 2012
Journal: Science
Title: Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex.
Volume: 337
Issue: 6094
Pages: 599-602
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Publication
16245309 | J:230626
First Author: Giacinti C
Year: 2006
Journal: J Cell Physiol
Title: MyoD recruits the cdk9/cyclin T2 complex on myogenic-genes regulatory regions.
Volume: 206
Issue: 3
Pages: 807-13
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Publication
20940258 | J:182924
First Author: Galatioto J
Year: 2010
Journal: J Cell Sci
Title: CLP-1 associates with MyoD and HDAC to restore skeletal muscle cell regeneration.
Volume: 123
Issue: Pt 21
Pages: 3789-95
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Publication
23752591 | J:199171
First Author: Proserpio V
Year: 2013
Journal: Genes Dev
Title: The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy.
Volume: 27
Issue: 11
Pages: 1299-312
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Publication
17108004 | J:119649
First Author: Meier N
Year: 2006
Journal: Development
Title: Novel binding partners of Ldb1 are required for haematopoietic development.
Volume: 133
Issue: 24
Pages: 4913-23
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Publication
26974661 | J:236647
First Author: Di Stefano B
Year: 2016
Journal: Nat Cell Biol
Title: C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4.
Volume: 18
Issue: 4
Pages: 371-81
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Publication
23154982 | J:191206
First Author: Okamura D
Year: 2012
Journal: Genes Dev
Title: Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells.
Volume: 26
Issue: 22
Pages: 2477-82
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Publication
32731332 | J:307678
 
First Author: Campbell GJ
Year: 2020
Journal: Int J Mol Sci
Title: The Role of CDKs and CDKIs in Murine Development.
Volume: 21
Issue: 15
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Publication
25209997 | J:228779
 
First Author: Alpern D
Year: 2014
Journal: Elife
Title: TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.
Volume: 3
Pages: e03613
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Interaction Experiment
MacLachlan TK (1998)
Description: Binding of CDK9 to TRAF2.
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Publication
31827241 | J:288815
First Author: Phillips DC
Year: 2020
Journal: Leukemia
Title: A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies.
Volume: 34
Issue: 6
Pages: 1646-1657
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UniProt Feature
UniProt Feature
Begin: 357
Description: Phosphoserine; by CDK9
Type: modified residue
End: 357
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UniProt Feature
UniProt Feature
Begin: 353
Description: Phosphoserine; by CDK9
Type: modified residue
End: 353
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UniProt Feature
UniProt Feature
Begin: 363
Description: Phosphothreonine; by CDK9
Type: modified residue
End: 363
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UniProt Feature
UniProt Feature
Begin: 350
Description: Phosphothreonine; by CDK9
Type: modified residue
End: 350
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UniProt Feature
UniProt Feature
Begin: 362
Description: Phosphothreonine; by CDK9
Type: modified residue
End: 362
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UniProt Feature
UniProt Feature
Begin: 354
Description: Phosphothreonine; by CDK9
Type: modified residue
End: 354
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UniProt Feature
UniProt Feature
Begin: 61
Description: Phosphoserine; by CDK9
Type: modified residue
End: 61
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UniProt Feature
UniProt Feature
Begin: 120
Description: Phosphoserine; by CDK9
Type: modified residue
End: 120
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UniProt Feature
UniProt Feature
Begin: 778
Description: Phosphothreonine; by CDK9
Type: modified residue
End: 778
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UniProt Feature
UniProt Feature
Begin: 769
Description: Phosphothreonine; by CDK9
Type: modified residue
End: 769
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Publication
32747552 | J:294185
First Author: Liu H
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: JMJD5 couples with CDK9 to release the paused RNA polymerase II.
Volume: 117
Issue: 33
Pages: 19888-19895
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Publication
9827693 | -
First Author: MacLachlan TK
Year: 1998
Journal: J Cell Biochem
Title: Binding of CDK9 to TRAF2.
Volume: 71
Issue: 4
Pages: 467-78
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UniProt Feature
UniProt Feature
Begin: 347
Description: Phosphoserine; by CDK9 and PKA
Type: modified residue
End: 347
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UniProt Feature
UniProt Feature
Begin: 90
Description: Phosphoserine; by CDK1 and CDK9
Type: modified residue
End: 90
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Publication
10574912 | -
First Author: Fu TJ
Year: 1999
Journal: J Biol Chem
Title: Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription.
Volume: 274
Issue: 49
Pages: 34527-30
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Allele
Cdk9<em1Smoc> | MGI:7288900
Name: cyclin dependent kinase 9; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
23110726 | -
 
First Author: Ramakrishnan R
Year: 2012
Journal: Retrovirology
Title: Identification of novel CDK9 and Cyclin T1-associated protein complexes (CCAPs) whose siRNA depletion enhances HIV-1 Tat function.
Volume: 9
Pages: 90
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Strain
MGI:6354671 | C57BL/6JSmoc-Cdk9<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Protein
Q8BNZ8
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
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Protein
Q8BS78
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: false
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Protein Domain
IPR031354 | BRD4_CDT
Type: Domain
Description: This entry represents the short highly conserved C-terminal domain of certain bromodomain proteins, notably Brd4. The Brd4 CTD interacts with the cyclin T1 and Cdk9 subunits of positive transcription elongation factor b (pTEFb) complex. Brd4 displaces negative regulators, the HEXIM1 and 7SKsnRNA complex, from pTEFb, thereby transforming it into an active form that can phosphorylate RNA pol II [, ].
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Publication
26799765 | J:233037
First Author: Schüller R
Year: 2016
Journal: Mol Cell
Title: Heptad-Specific Phosphorylation of RNA Polymerase II CTD.
Volume: 61
Issue: 2
Pages: 305-14
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Publication
21555454 | -
First Author: Rahman S
Year: 2011
Journal: Mol Cell Biol
Title: The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.
Volume: 31
Issue: 13
Pages: 2641-52
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Publication
23060074 | J:228410
First Author: Marchesi I
Year: 2013
Journal: J Cell Biochem
Title: Activation and function of murine Cyclin T2A and Cyclin T2B during skeletal muscle differentiation.
Volume: 114
Issue: 3
Pages: 728-34
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Publication
26439301 | J:270579
First Author: Galli GG
Year: 2015
Journal: Mol Cell
Title: YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers.
Volume: 60
Issue: 2
Pages: 328-37
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Publication
28262505 | J:251939
First Author: Cheung KL
Year: 2017
Journal: Mol Cell
Title: Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.
Volume: 65
Issue: 6
Pages: 1068-1080.e5
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Publication
19103749 | J:145726
First Author: Huang B
Year: 2009
Journal: Mol Cell Biol
Title: Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA.
Volume: 29
Issue: 5
Pages: 1375-87
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Publication
16314494 | J:103778
First Author: Jiang H
Year: 2005
Journal: Mol Cell Biol
Title: Runx1 binds positive transcription elongation factor b and represses transcriptional elongation by RNA polymerase II: possible mechanism of CD4 silencing.
Volume: 25
Issue: 24
Pages: 10675-83
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Publication
22609543 | J:192057
First Author: Song SH
Year: 2012
Journal: Biochim Biophys Acta
Title: Ldb1 regulates carbonic anhydrase 1 during erythroid differentiation.
Volume: 1819
Issue: 8
Pages: 885-91
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Publication
36577375 | J:332374
First Author: Abe K
Year: 2022
Journal: Cell Rep
Title: Distinct patterns of RNA polymerase II and transcriptional elongation characterize mammalian genome activation.
Volume: 41
Issue: 13
Pages: 111865
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Publication
38889007 | J:352992
First Author: Kim J
Year: 2024
Journal: Cell Rep
Title: An enhancer RNA recruits KMT2A to regulate transcription of Myb.
Volume: 43
Issue: 7
Pages: 114378
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Publication
16109377 | -
First Author: Yang Z
Year: 2005
Journal: Mol Cell
Title: Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.
Volume: 19
Issue: 4
Pages: 535-45
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Publication
18655042 | -
First Author: Michels AA
Year: 2008
Journal: Biotechnol J
Title: RNA-driven cyclin-dependent kinase regulation: when CDK9/cyclin T subunits of P-TEFb meet their ribonucleoprotein partners.
Volume: 3
Issue: 8
Pages: 1022-32
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Publication
15276198 | -
 
First Author: Garriga J
Year: 2004
Journal: Gene
Title: Cellular control of gene expression by T-type cyclin/CDK9 complexes.
Volume: 337
Pages: 15-23
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Protein Domain
IPR028863 | CCNT1
Type: Family
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). This entry represents cyclin-T1 and cyclin-T.Cyclin-T associates with CDK9. Both cyclin-T and CDK9 are subunits of the positive-transcription elongation factor (P-TEFb), which facilitates transcription elongation by phosphorylating the carboxy-terminal domain (CTD) of the largest subunit of pol II []. In humans, there are three T-type cyclins: cyclins T1, T2a and T2b. Cyclins T2a and T2b are splice variants of a primary transcript []. Each of the T-type cyclin/CDK9 complexes can phosphorylate the C-terminal domain of the large subunit of RNA polymerase II. However, only human cyclin T1/CDK9 complexes can bind HIV Tat and promote RNA Pol II activation, allowing transcription of viral genes [, , , ].
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Publication
9832504 | J:51312
First Author: Garber ME
Year: 1998
Journal: Genes Dev
Title: The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein.
Volume: 12
Issue: 22
Pages: 3512-27
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Publication
31594641 | J:291392
First Author: Song H
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Targeting cyclin-dependent kinase 9 sensitizes medulloblastoma cells to chemotherapy.
Volume: 520
Issue: 2
Pages: 250-256
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Publication
19443839 | J:164763
First Author: Espinoza-Derout J
Year: 2009
Journal: Circ Res
Title: Positive transcription elongation factor b activity in compensatory myocardial hypertrophy is regulated by cardiac lineage protein-1.
Volume: 104
Issue: 12
Pages: 1347-54
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Publication
18624753 | J:156227
First Author: Mascareno E
Year: 2009
Journal: J Cell Mol Med
Title: Down-regulation of cardiac lineage protein (CLP-1) expression in CLP-1 +/- mice affords.
Volume: 13
Issue: 8B
Pages: 2744-53
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Publication
22308025 | J:184573
First Author: Mascareno E
Year: 2012
Journal: J Biol Chem
Title: Cardiac lineage protein-1 (CLP-1) regulates cardiac remodeling via transcriptional modulation of diverse hypertrophic and fibrotic responses and angiotensin II-transforming growth factor β (TGF-β1) signaling axis.
Volume: 287
Issue: 16
Pages: 13084-93
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Publication
25233930 | J:216985
First Author: Smerdová L
Year: 2014
Journal: Carcinogenesis
Title: Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway.
Volume: 35
Issue: 11
Pages: 2534-43
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Publication
16723356 | J:178277
First Author: Flajollet S
Year: 2006
Journal: J Biol Chem
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