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Search results 301 to 390 out of 390 for Cgas

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Type Details Score
Allele
Cgas<tm1d(EUCOMM)Hmgu> | MGI:5578170
Name: cyclic GMP-AMP synthase; targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
33968056 | J:320987
 
First Author: Chu L
Year: 2021
Journal: Front Immunol
Title: Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response.
Volume: 12
Pages: 655637
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Publication
38200309 | J:349030
First Author: Cho MG
Year: 2024
Journal: Nature
Title: MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.
Volume: 625
Issue: 7995
Pages: 585-592
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Publication
31808743 | J:300652
   
First Author: Volkman HE
Year: 2019
Journal: Elife
Title: Tight nuclear tethering of cGAS is essential for preventing autoreactivity.
Volume: 8
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Publication
37848037 | J:342980
First Author: Zhao C
Year: 2023
Journal: Immunity
Title: Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity.
Volume: 56
Issue: 11
Pages: 2508-2522.e6
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Publication
39080411 | J:361512
First Author: Lv G
Year: 2024
Journal: Nat Cell Biol
Title: mTORC2-driven chromatin cGAS mediates chemoresistance through epigenetic reprogramming in colorectal cancer.
Volume: 26
Issue: 9
Pages: 1585-1596
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Interaction Experiment
Seo GJ (2018)
Description: TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing.
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Publication
32817552 | J:295963
First Author: Song ZM
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: KAT5 acetylates cGAS to promote innate immune response to DNA virus.
Volume: 117
Issue: 35
Pages: 21568-21575
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Publication
26506431 | J:248342
First Author: Watkinson RE
Year: 2015
Journal: PLoS Pathog
Title: TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus.
Volume: 11
Issue: 10
Pages: e1005253
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Publication
37267951 | J:336927
First Author: Fang L
Year: 2023
Journal: Cancer Cell
Title: Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity.
Volume: 41
Issue: 6
Pages: 1118-1133.e12
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Publication
32457395 | J:310174
First Author: Zhang Q
Year: 2020
Journal: Cell Res
Title: USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity.
Volume: 30
Issue: 10
Pages: 914-927
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Publication
34875339 | J:326314
 
First Author: Zou M
Year: 2022
Journal: Free Radic Biol Med
Title: Heterochromatin inhibits cGAS and STING during oxidative stress-induced retinal pigment epithelium and retina degeneration.
Volume: 178
Pages: 147-160
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Publication
30635239 | J:282450
First Author: Ghosh A
Year: 2019
Journal: Immunity
Title: Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production.
Volume: 50
Issue: 1
Pages: 51-63.e5
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Publication
26343537 | J:233645
First Author: Herzner AM
Year: 2015
Journal: Nat Immunol
Title: Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.
Volume: 16
Issue: 10
Pages: 1025-33
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Publication
28314590 | J:243901
First Author: Wang Y
Year: 2017
Journal: Immunity
Title: Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection.
Volume: 46
Issue: 3
Pages: 393-404
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Publication
35712074 | J:327508
First Author: Tan HY
Year: 2022
Journal: iScience
Title: cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model.
Volume: 25
Issue: 6
Pages: 104404
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Publication
30065070 | J:317771
 
First Author: Zheng Y
Year: 2018
Journal: EMBO J
Title: Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis.
Volume: 37
Issue: 18
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Publication
29937271 | -
First Author: Huang ZF
Year: 2018
Journal: Cell Host Microbe
Title: Human Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to Mediate Immune Evasion.
Volume: 24
Issue: 1
Pages: 69-80.e4
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Protein
Q8C6L5
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Publication
26440888 | -
First Author: Seo GJ
Year: 2015
Journal: Cell Rep
Title: Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway.
Volume: 13
Issue: 2
Pages: 440-9
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Publication
29976794 | -
First Author: Du M
Year: 2018
Journal: Science
Title: DNA-induced liquid phase condensation of cGAS activates innate immune signaling.
Volume: 361
Issue: 6403
Pages: 704-709
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Publication
32351706 | -
 
First Author: Zhong L
Year: 2020
Journal: Cell Discov
Title: Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis.
Volume: 6
Pages: 26
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Publication
33688080 | -
 
First Author: Apel F
Year: 2021
Journal: Sci Signal
Title: The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps.
Volume: 14
Issue: 673
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HT Experiment
GSE226381 | Cyclic GMP-AMP synthase and interferon activation diminish MEF2C-mediated cognitive resilience II
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
31534008 | -
First Author: Guo Y
Year: 2019
Journal: J Immunol
Title: Cutting Edge: USP27X Deubiquitinates and Stabilizes the DNA Sensor cGAS to Regulate Cytosolic DNA-Mediated Signaling.
Volume: 203
Issue: 8
Pages: 2049-2054
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Publication
28902841 | -
First Author: Andreeva L
Year: 2017
Journal: Nature
Title: cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
Volume: 549
Issue: 7672
Pages: 394-398
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Publication
32814054 | -
First Author: Zhao Z
Year: 2020
Journal: Cell Rep
Title: Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2'3'-cGAMP.
Volume: 32
Issue: 7
Pages: 108053
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Publication
33606975 | -
First Author: Zhou W
Year: 2021
Journal: Mol Cell
Title: cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing.
Volume: 81
Issue: 4
Pages: 739-755.e7
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Publication
30193849 | J:268028
First Author: Lian H
Year: 2018
Journal: Immunity
Title: The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors.
Volume: 49
Issue: 3
Pages: 438-448.e5
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Protein Domain
IPR042509 | ZCCHC3
Type: Family
Description: Zinc finger CCHC domain-containing protein 3 (ZCCHC3) is a zinc-finger protein that acts as a co-sensor of cGAS in innate immune response to cytosolic dsDNA and DNA virus []. It has been shown to bind DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS [, ].
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Publication
24462292 | -
First Author: Zhang X
Year: 2014
Journal: Cell Rep
Title: The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop.
Volume: 6
Issue: 3
Pages: 421-30
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Protein Domain
IPR007578 | Herpes_U10
Type: Family
Description: This proteins in this entry belong to the herpesvirus U10 family.Family member Protein UL31 is involved in the inhibition of the host innate immune system. It targets host CGAS, promoting dissociation of DNA from CGAS, thus inhibiting the enzymatic activity of CGAS [].
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Protein Domain
IPR006853 | Poxin_vir
Type: Family
Description: This entry represents Poxin (poxvirus immune nucleases) from Baculovirus and Vaccinia virus. Poxin is a nuclease that cleaves host 2',3'-cGAMP []. In human hosts, enzyme cGAS recognizes cytosolic DNA and synthesizes 2'3' cGAMP to activate STING-dependent interferon and NF-kappaB immune responses. Poxin is the viral factor responsible for 2'3' cGAMP degradation []. Interestingly, in some poxviruses the poxin is expressed as a poxin-schlafen fusion protein.
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Publication
30728498 | -
First Author: Eaglesham JB
Year: 2019
Journal: Nature
Title: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.
Volume: 566
Issue: 7743
Pages: 259-263
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HT Experiment
GSE247546 | RIG-I sensing of self-RNA in aged endothelial cells links cellular senescence with an interferon gene signature I
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
23870141 | J:202706
First Author: Xiao TS
Year: 2013
Journal: Mol Cell
Title: The cGAS-STING pathway for DNA sensing.
Volume: 51
Issue: 2
Pages: 135-9
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Publication
29625897 | J:305320
First Author: Xia P
Year: 2018
Journal: Immunity
Title: A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Volume: 48
Issue: 4
Pages: 688-701.e7
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Publication
30510222 | J:282636
First Author: Liu ZS
Year: 2019
Journal: Nat Immunol
Title: G3BP1 promotes DNA binding and activation of cGAS.
Volume: 20
Issue: 1
Pages: 18-28
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Publication
26300263 | J:227350
First Author: Kranzusch PJ
Year: 2015
Journal: Mol Cell
Title: Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Volume: 59
Issue: 6
Pages: 891-903
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Publication
25774715 | J:231714
First Author: Man SM
Year: 2015
Journal: Nat Immunol
Title: The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.
Volume: 16
Issue: 5
Pages: 467-75
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Publication
33338425 | J:300351
First Author: Lu C
Year: 2021
Journal: Cancer Cell
Title: DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity.
Volume: 39
Issue: 1
Pages: 96-108.e6
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Publication
29268096 | J:256108
First Author: Mathur V
Year: 2017
Journal: Neuron
Title: Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation.
Volume: 96
Issue: 6
Pages: 1290-1302.e6
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Publication
28598415 | J:251687
 
First Author: Vanpouille-Box C
Year: 2017
Journal: Nat Commun
Title: DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity.
Volume: 8
Pages: 15618
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Publication
36070769 | J:329937
First Author: Maltbaek JH
Year: 2022
Journal: Immunity
Title: ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP.
Volume: 55
Issue: 10
Pages: 1799-1812.e4
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Publication
38421872 | J:346158
First Author: Chu L
Year: 2024
Journal: Cell Rep
Title: HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity.
Volume: 43
Issue: 3
Pages: 113870
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Publication
37237031 | J:339387
First Author: Chen YH
Year: 2023
Journal: Nat Commun
Title: TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation.
Volume: 14
Issue: 1
Pages: 3050
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Publication
37549268 | J:360348
First Author: Humphries F
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Targeting STING oligomerization with small-molecule inhibitors.
Volume: 120
Issue: 33
Pages: e2305420120
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Publication
34142428 | J:319426
First Author: Chauveau L
Year: 2021
Journal: EMBO Rep
Title: Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity.
Volume: 22
Issue: 8
Pages: e52447
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Publication
39195969 | J:341798
First Author: Lin M
Year: 2023
Journal: Nat Cardiovasc Res
Title: MCM8-mediated mitophagy protects vascular health in response to nitric oxide signaling in a mouse model of Kawasaki disease.
Volume: 2
Issue: 8
Pages: 778-792
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Publication
35675783 | J:326054
First Author: Cai X
Year: 2022
Journal: Cell Rep
Title: Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses.
Volume: 39
Issue: 10
Pages: 110920
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Publication
27264171 | J:238160
First Author: Andrade WA
Year: 2016
Journal: Cell Rep
Title: Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.
Volume: 15
Issue: 11
Pages: 2438-48
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Publication
29472455 | J:260491
 
First Author: McArthur K
Year: 2018
Journal: Science
Title: BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.
Volume: 359
Issue: 6378
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Publication
29653696 | J:272659
First Author: Wang C
Year: 2018
Journal: Immunity
Title: Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses.
Volume: 48
Issue: 4
Pages: 675-687.e7
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Publication
32182222 | J:300625
First Author: Jauhari A
Year: 2020
Journal: J Clin Invest
Title: Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
Volume: 130
Issue: 6
Pages: 3124-3136
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Publication
34901991 | J:320021
 
First Author: Li T
Year: 2022
Journal: J Exp Med
Title: TBK1 recruitment to STING mediates autoinflammatory arthritis caused by defective DNA clearance.
Volume: 219
Issue: 1
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Publication
36346347 | J:335563
 
First Author: Schumann T
Year: 2023
Journal: J Exp Med
Title: Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner.
Volume: 220
Issue: 1
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Protein
Q8BPK2
Organism: Mus musculus/domesticus
Length: 400  
Fragment?: false
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Publication
31511694 | J:279972
First Author: Luteijn RD
Year: 2019
Journal: Nature
Title: SLC19A1 transports immunoreactive cyclic dinucleotides.
Volume: 573
Issue: 7774
Pages: 434-438
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Publication
32404352 | J:303177
First Author: Hoffpauir CT
Year: 2020
Journal: J Immunol
Title: TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection.
Volume: 205
Issue: 1
Pages: 153-167
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Publication
30944173 | J:280417
First Author: Dewi Pamungkas Putri D
Year: 2019
Journal: J Biol Chem
Title: PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking.
Volume: 294
Issue: 21
Pages: 8412-8423
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Publication
25642965 | J:220373
First Author: West AP
Year: 2015
Journal: Nature
Title: Mitochondrial DNA stress primes the antiviral innate immune response.
Volume: 520
Issue: 7548
Pages: 553-7
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Publication
30777870 | J:274248
First Author: Sen T
Year: 2019
Journal: Cancer Discov
Title: Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer.
Volume: 9
Issue: 5
Pages: 646-661
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Publication
36217001 | J:330879
First Author: Xiong TC
Year: 2022
Journal: Nat Commun
Title: The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS.
Volume: 13
Issue: 1
Pages: 5973
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Publication
32512189 | J:299849
First Author: Gong Y
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Double knockout of Akt2 and AMPK accentuates high fat diet-induced cardiac anomalies through a cGAS-STING-mediated mechanism.
Volume: 1866
Issue: 10
Pages: 165855
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Publication
32891637 | J:298086
 
First Author: Liu F
Year: 2020
Journal: J Mol Cell Cardiol
Title: Beclin1 Haploinsufficiency accentuates second-hand smoke exposure -induced myocardial Remodeling and contractile dysfunction through a STING-mediated mechanism.
Volume: 148
Pages: 78-88
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Publication
32715615 | J:298776
First Author: Jena KK
Year: 2020
Journal: EMBO Rep
Title: Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response.
Volume: 21
Issue: 9
Pages: e50051
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Publication
35634291 | J:326465
 
First Author: Schubert N
Year: 2022
Journal: Front Immunol
Title: Genome Replication Is Associated With Release of Immunogenic DNA Waste.
Volume: 13
Pages: 880413
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Publication
38918759 | J:352321
First Author: Ni B
Year: 2024
Journal: J Neuroinflammation
Title: Therapeutic intervention in neuroinflammation for neovascular ocular diseases through targeting the cGAS-STING-necroptosis pathway.
Volume: 21
Issue: 1
Pages: 164
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Publication
28302626 | J:263664
First Author: Mao Y
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity.
Volume: 37
Issue: 5
Pages: 920-929
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Publication
32153571 | J:331747
 
First Author: Walker MM
Year: 2020
Journal: Front Immunol
Title: Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H.
Volume: 11
Pages: 238
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Publication
37259103 | J:354031
First Author: Shin Y
Year: 2023
Journal: Arthritis Res Ther
Title: STING mediates experimental osteoarthritis and mechanical allodynia in mouse.
Volume: 25
Issue: 1
Pages: 90
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Publication
32581130 | J:291551
First Author: Sharma M
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease.
Volume: 117
Issue: 27
Pages: 15989-15999
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Publication
36256824 | J:335124
First Author: Shi X
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: FLASH X-ray spares intestinal crypts from pyroptosis initiated by cGAS-STING activation upon radioimmunotherapy.
Volume: 119
Issue: 43
Pages: e2208506119
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Publication
25730264 | J:227932
First Author: Dey B
Year: 2015
Journal: Nat Med
Title: A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis.
Volume: 21
Issue: 4
Pages: 401-6
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Publication
32571920 | J:291517
First Author: Ku JWK
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Bacterial-induced cell fusion is a danger signal triggering cGAS-STING pathway via micronuclei formation.
Volume: 117
Issue: 27
Pages: 15923-15934
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Publication
33243993 | J:299848
First Author: Zhang Y
Year: 2020
Journal: Nat Commun
Title: β-arrestin 2 as an activator of cGAS-STING signaling and target of viral immune evasion.
Volume: 11
Issue: 1
Pages: 6000
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Publication
32826280 | J:303582
First Author: Jing T
Year: 2020
Journal: J Immunol
Title: The Structural Basis of IRF-3 Activation upon Phosphorylation.
Volume: 205
Issue: 7
Pages: 1886-1896
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Publication
35705809 | J:330296
First Author: Hong C
Year: 2022
Journal: Nature
Title: cGAS-STING drives the IL-6-dependent survival of chromosomally instable cancers.
Volume: 607
Issue: 7918
Pages: 366-373
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Publication
36681781 | J:332894
   
First Author: Liu H
Year: 2023
Journal: Cell Death Differ
Title: CD-NTase family member MB21D2 promotes cGAS-mediated antiviral and antitumor immunity.
Pages: 1-13
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Publication
37597406 | J:339666
 
First Author: An C
Year: 2023
Journal: Int Immunopharmacol
Title: IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis.
Volume: 123
Pages: 110795
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Publication
37290532 | J:346045
First Author: Luan C
Year: 2023
Journal: J Biol Chem
Title: PCSK9 inhibition interrupts the cross-talk between keratinocytes and macrophages and prevents UVB-induced skin damage.
Volume: 299
Issue: 7
Pages: 104895
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Publication
35438208 | J:344900
First Author: Shi C
Year: 2022
Journal: EMBO J
Title: ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation.
Volume: 41
Issue: 11
Pages: e109272
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Publication
31603920 | J:354798
First Author: Parekh NJ
Year: 2019
Journal: PLoS Pathog
Title: Type I interferon-dependent CCL4 is induced by a cGAS/STING pathway that bypasses viral inhibition and protects infected tissue, independent of viral burden.
Volume: 15
Issue: 10
Pages: e1007778
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Publication
36656972 | J:337558
First Author: Chen R
Year: 2023
Journal: Circ Res
Title: Mechanistic Insights of the LEMD2 p.L13R Mutation and Its Role in Cardiomyopathy.
Volume: 132
Issue: 2
Pages: e43-e58
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Publication
28570638 | J:246603
First Author: Webster SJ
Year: 2017
Journal: PLoS Pathog
Title: Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection.
Volume: 13
Issue: 6
Pages: e1006383
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Publication
33827893 | J:309824
First Author: Chen X
Year: 2021
Journal: J Immunol
Title: Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2'3'-Cyclic GMP-AMP and Cisplatin under Steady State and Inflammation.
Volume: 206
Issue: 9
Pages: 2061-2074
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Publication
37781354 | J:341362
 
First Author: Yang Y
Year: 2023
Journal: Front Immunol
Title: cGAS-STING signaling pathway in intestinal homeostasis and diseases.
Volume: 14
Pages: 1239142
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37600809 | J:339289
 
First Author: Jin X
Year: 2023
Journal: Front Immunol
Title: The battle between the innate immune cGAS-STING signaling pathway and human herpesvirus infection.
Volume: 14
Pages: 1235590
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Publication
35338116 | J:322882
First Author: Messaoud-Nacer Y
Year: 2022
Journal: Cell Death Dis
Title: STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS).
Volume: 13
Issue: 3
Pages: 269
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Publication
35604097 | J:326781
First Author: Xu L
Year: 2022
Journal: mBio
Title: Salmonella Induces the cGAS-STING-Dependent Type I Interferon Response in Murine Macrophages by Triggering mtDNA Release.
Volume: 13
Issue: 3
Pages: e0363221
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