Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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•
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Publication |
First Author: |
Kolla V |
Year: |
2014 |
Journal: |
Cancer Res |
Title: |
Role of CHD5 in human cancers: 10 years later. |
Volume: |
74 |
Issue: |
3 |
Pages: |
652-8 |
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•
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Interaction Experiment |
Description: |
CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression. |
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Allele |
Name: |
deletion, Chr 4, Alea A Mills 2; deletion, chr 4, Alea A Mills 2 |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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Genotype |
Symbol: |
Del(4D4Mit190-D4Mit51)2Aam/Del(4D4Mit190-D4Mit51)2Aam |
Background: |
involves: 129S7/SvEvBrd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
•
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•
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Genotype |
Symbol: |
Del(4D4Mit190-D4Mit51)2Aam/+ |
Background: |
involves: 129S7/SvEvBrd |
Zygosity: |
ht |
Has Mutant Allele: |
true |
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•
•
•
•
•
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Genotype |
Symbol: |
Dp(4D4Mit190-D4Mit51)1Aam/? Del(4D4Mit190-D4Mit51)2Aam/? |
Background: |
involves: 129S7/SvEvBrd |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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•
•
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HT Experiment |
Series Id: |
GSE70298 |
Experiment Type: |
transcription profiling by array |
Study Type: |
Baseline |
Source: |
ArrayExpress |
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•
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•
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Publication |
First Author: |
Bagchi A |
Year: |
2008 |
Journal: |
Cancer Res |
Title: |
The quest for the 1p36 tumor suppressor. |
Volume: |
68 |
Issue: |
8 |
Pages: |
2551-6 |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
295
 |
Fragment?: |
false |
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•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
240
 |
Fragment?: |
false |
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•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
385
 |
Fragment?: |
true |
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•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
342
 |
Fragment?: |
true |
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•
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•
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the N-terminal domain of CHD (Chromodomain, Helicase, DNA-binding) proteins. CHD3 and CHD4 belong to the class II subfamily of CHD ATPases, and each is present as a core catalytic subunit in separate NuRD complexes, which regulate chromatin organisation and gene transcription []. CHD5 forms a NuRD-type chromatin remodeling complex and acts as a tumour suppressor []. There are nine members of the Chromodomain, Helicase, DNA-binding (CHD) family. They are characterised by two chromodomains arranged in tandem, N-terminal to the ATPase/helicase domain. Chromodomains are comprised of a β-sheet folded against an α-helix that collectively mediates binding to methyl-lysine residues []. |
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the C-terminal domain of CHD (Chromodomain, Helicase, DNA-binding) proteins. CHD3 and CHD4 belong to the class II subfamily of CHD ATPases, and each is present as a core catalytic subunit in separate NuRD complexes, which regulate chromatin organisation and gene transcription []. CHD5 forms a NuRD-type chromatin remodeling complex and acts as a tumour suppressor []. There are nine members of the Chromodomain, Helicase, DNA-binding (CHD) family. They are characterised by two chromodomains arranged in tandem, N-terminal to the ATPase/helicase domain. Chromodomains are comprised of a β-sheet folded against an α-helix that collectively mediates binding to methyl-lysine residues []. |
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Publication |
First Author: |
Allen HF |
Year: |
2013 |
Journal: |
Cell Mol Life Sci |
Title: |
The NuRD architecture. |
Volume: |
70 |
Issue: |
19 |
Pages: |
3513-24 |
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Publication |
First Author: |
Mallette FA |
Year: |
2012 |
Journal: |
Cell Rep |
Title: |
JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5. |
Volume: |
2 |
Issue: |
5 |
Pages: |
1233-43 |
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Publication |
First Author: |
Kusevic D |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
Substrate Specificity of the HEMK2 Protein Glutamine Methyltransferase and Identification of Novel Substrates. |
Volume: |
291 |
Issue: |
12 |
Pages: |
6124-33 |
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Publication |
First Author: |
Elgueta R |
Year: |
2016 |
Journal: |
J Immunol |
Title: |
Endothelial Plasmalemma Vesicle-Associated Protein Regulates the Homeostasis of Splenic Immature B Cells and B-1 B Cells. |
Volume: |
197 |
Issue: |
10 |
Pages: |
3970-3981 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
829
 |
Fragment?: |
true |
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•
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Publication |
First Author: |
van der Weyden L |
Year: |
2013 |
Journal: |
J Pathol |
Title: |
Cancer of mice and men: old twists and new tails. |
Volume: |
230 |
Issue: |
1 |
Pages: |
4-16 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1915
 |
Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1945
 |
Fragment?: |
true |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2021
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1886
 |
Fragment?: |
true |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2055
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1902
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1922
 |
Fragment?: |
false |
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•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
708
 |
Fragment?: |
true |
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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