Type |
Details |
Score |
Publication |
First Author: |
Qiao Y |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells. |
Volume: |
109 |
Issue: |
40 |
Pages: |
16264-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Green EA |
Year: |
2000 |
Journal: |
J Exp Med |
Title: |
Neonatal tumor necrosis factor alpha promotes diabetes in nonobese diabetic mice by CD154-independent antigen presentation to CD8(+) T cells. |
Volume: |
191 |
Issue: |
2 |
Pages: |
225-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Menezes S |
Year: |
2016 |
Journal: |
Immunity |
Title: |
The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells. |
Volume: |
45 |
Issue: |
6 |
Pages: |
1205-1218 |
|
•
•
•
•
•
|
Publication |
First Author: |
Benlagha K |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Mechanisms governing B cell developmental defects in invariant chain-deficient mice. |
Volume: |
172 |
Issue: |
4 |
Pages: |
2076-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baguet A |
Year: |
2004 |
Journal: |
J Exp Med |
Title: |
A Leishmania major response locus identified by interval-specific congenic mapping of a T helper type 2 cell bias-controlling quantitative trait locus. |
Volume: |
200 |
Issue: |
12 |
Pages: |
1605-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hussain S |
Year: |
1999 |
Journal: |
J Immunol |
Title: |
Mycobacterium avium infection of mouse macrophages inhibits IFN-gamma Janus kinase-STAT signaling and gene induction by down-regulation of the IFN-gamma receptor. |
Volume: |
163 |
Issue: |
4 |
Pages: |
2041-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pihlgren M |
Year: |
2013 |
Journal: |
Blood |
Title: |
TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice. |
Volume: |
121 |
Issue: |
1 |
Pages: |
85-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Irla M |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Antigen recognition by autoreactive CD4⁺ thymocytes drives homeostasis of the thymic medulla. |
Volume: |
7 |
Issue: |
12 |
Pages: |
e52591 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sawa S |
Year: |
2006 |
Journal: |
J Exp Med |
Title: |
Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. |
Volume: |
203 |
Issue: |
6 |
Pages: |
1459-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cui C |
Year: |
2021 |
Journal: |
Cell |
Title: |
Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses. |
Volume: |
184 |
Issue: |
25 |
Pages: |
6101-6118.e13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shang L |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. |
Volume: |
281 |
Issue: |
4 |
Pages: |
1876-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hepworth MR |
Year: |
2015 |
Journal: |
Science |
Title: |
Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells. |
Volume: |
348 |
Issue: |
6238 |
Pages: |
1031-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ochi A |
Year: |
2012 |
Journal: |
J Exp Med |
Title: |
MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. |
Volume: |
209 |
Issue: |
9 |
Pages: |
1671-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Toulmin SA |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Type II alveolar cell MHCII improves respiratory viral disease outcomes while exhibiting limited antigen presentation. |
Volume: |
12 |
Issue: |
1 |
Pages: |
3993 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takashima S |
Year: |
2016 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity. |
Volume: |
311 |
Issue: |
6 |
Pages: |
G1105-G1113 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zuklys S |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function. |
Volume: |
182 |
Issue: |
5 |
Pages: |
2997-3007 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ravasi T |
Year: |
2010 |
Journal: |
Cell |
Title: |
An atlas of combinatorial transcriptional regulation in mouse and man. |
Volume: |
140 |
Issue: |
5 |
Pages: |
744-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reed JC |
Year: |
2003 |
Journal: |
Genome Res |
Title: |
Comparative analysis of apoptosis and inflammation genes of mice and humans. |
Volume: |
13 |
Issue: |
6B |
Pages: |
1376-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kenney-Hunt JP |
Year: |
2006 |
Journal: |
Mamm Genome |
Title: |
Quantitative trait loci for body size components in mice. |
Volume: |
17 |
Issue: |
6 |
Pages: |
526-37 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 357, Cheong-Hee Chang |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Mammalian Functional Genomics Centre |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GO Central curators, GOA curators, Rhea curators |
Year: |
2020 |
|
Title: |
Automatic Gene Ontology annotation based on Rhea mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Yokoyama S |
Year: |
2009 |
Journal: |
Dev Cell |
Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
Volume: |
17 |
Issue: |
6 |
Pages: |
836-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators, MGI curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation based on Enzyme Commission mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Liu H |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
Osteocyte CIITA aggravates osteolytic bone lesions in myeloma. |
Volume: |
13 |
Issue: |
1 |
Pages: |
3684 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park WS |
Year: |
2004 |
Journal: |
Int Immunol |
Title: |
T cell expression of CIITA represses Th1 immunity. |
Volume: |
16 |
Issue: |
10 |
Pages: |
1355-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon AM |
Year: |
1998 |
Journal: |
Immunogenetics |
Title: |
CIITA B-cell-specific promoter suppression in MHC class II-silenced cell hybrids. |
Volume: |
48 |
Issue: |
4 |
Pages: |
283-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sisk TJ |
Year: |
2001 |
Journal: |
Mol Cell Biol |
Title: |
Self-association of CIITA and its transactivation potential. |
Volume: |
21 |
Issue: |
15 |
Pages: |
4919-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao Y |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
ERK and p38 MAPK signaling pathways negatively regulate CIITA gene expression in dendritic cells and macrophages. |
Volume: |
177 |
Issue: |
1 |
Pages: |
70-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim TW |
Year: |
2006 |
Journal: |
J Korean Med Sci |
Title: |
Overexpression of CIITA in T cells aggravates Th2-mediated colitis in mice. |
Volume: |
21 |
Issue: |
5 |
Pages: |
877-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ito T |
Year: |
2009 |
Journal: |
Int Immunol |
Title: |
Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-gamma. |
Volume: |
21 |
Issue: |
7 |
Pages: |
803-16 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1155
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Towey M |
Year: |
2002 |
Journal: |
Mol Immunol |
Title: |
Nuclear localisation of CIITA is controlled by a carboxy terminal leucine-rich repeat region. |
Volume: |
38 |
Issue: |
8 |
Pages: |
627-34 |
|
•
•
•
•
•
|
Allele |
Name: |
class II transactivator; targeted mutation 1, Jenny P Y Ting |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Wright KL |
Year: |
1998 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
CIITA stimulation of transcription factor binding to major histocompatibility complex class II and associated promoters in vivo. |
Volume: |
95 |
Issue: |
11 |
Pages: |
6267-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Masternak K |
Year: |
2000 |
Journal: |
Genes Dev |
Title: |
CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex. |
Volume: |
14 |
Issue: |
9 |
Pages: |
1156-66 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1078
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1054
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
class II transactivator; targeted mutation 1, Cheong-Hee Chang |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
class II transactivator; targeted mutation 2, Walter Reith |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 16, Seong Park |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, transgenic |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
302
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
104
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
320
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kretsovali A |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Self-association of class II transactivator correlates with its intracellular localization and transactivation. |
Volume: |
276 |
Issue: |
34 |
Pages: |
32191-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Holling TM |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
Activated human T cells accomplish MHC class II expression through T cell-specific occupation of class II transactivator promoter III. |
Volume: |
168 |
Issue: |
2 |
Pages: |
763-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nagarajan UM |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
Class II transactivator is required for maximal expression of HLA-DOB in B cells. |
Volume: |
168 |
Issue: |
4 |
Pages: |
1780-6 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Class II transactivator (CIITA) determines the level, cell type specificity,inducibility and extinction of MHC-II expression. CIITA is also the obligatory mediator of INF-gamma inducible MHC-II expression. Thus controlof MHC-II expression is ultimately dependent on the control of expressionof the CIITA gene itself. Defective CIITA has been shown to be responsiblefor one class of base lymphocyte syndrome (BLS). BLS is an often fatal genetic defect, characterised by severe immunodeficiency as a result of failure to express MHC class II genes. Expression of CIITA is controlled byfour independent CIITA promoters, leading to CIITA transcripts with four distinct first exons. The individual promoters are used in an alternativeand tissue-specific manner. CIITA promoter (CIITA-P)I is the promoter usedin dentritic cells; CIITA-PII is expressed at insignificant levels and is as yet functionally poorly understood; CIITA-PIII is constitutivelyexpressed in B lymphocytes and can drive CIITA expression after INF-gammastimulation in a number of different cell types, including endothelial cellsand fibroblasts; and CIITA-PIV is the principal INF-gamma-inducible promoter.The cellular and temporal diversity in MHC class II expression is thus regulated via the different usage of the CIITA promoters[, , , , , ].CIITA contains four domains: acidic (A), proline-serine-threonine-rich (PST), GTP-binding (GBD), and leucine-rich repeat (LRR). All of these are requiredto activate the MHC class II promoter. The acidic transcriptional activationdomain interacts with TAFII32. Recruitment of the coactivator protein CBP bythe acidic domain has also been shown to lead to synergistic activation ofMHC class II promoters and the repression of the interleukin-4 promoter. ThePST domain is essential for CIITA function, but its exact role remains unknown. The central region containing the GTP-binding and LXXLL motifs plays an important role in CIITA self-association. This region interacts with itself, the N-terminal domain of CIITA (A/PST) and C-terminal LRR. In addition to their role in CIITA self-association, which is generally necessary for the association of the protein with the import machinery, bothGBD (where GTP binding is believed to cause a conformational change compatible with nuclear translocation) and LRR domains have been shown toplay important roles in the nuclear localisation of CIITA. Human CIITA appears to contain a NLS. Export of a protein depends on the presence of a specific export signal (NES). NESs are short leucine-rich motifs - in CIITA, they have the consensus LXXXLXXLXL, and arelocalised in the N- and C-terminal regions[, , ].Numerous in vitro and functional studies have implicated CIITA in multiplesteps of the transcriptional activation process: e.g., (i) it may facilitatechromatin remodelling, as it interacts with histone acetyltransferases;moreover, it has intrinsic acetyltransferase activity; (ii) it interactswith the general transcription factors TFIIB, HTAFII32 and HTAFI70, implyingthat it may recruit the transcriptional apparatus directly; (iii) itinteracts with TFIIH and P-TEFb, and may therefore enhance promoterclearance and transcription elongation. |
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Publication |
First Author: |
Li W |
Year: |
2007 |
Journal: |
Immunity |
Title: |
The SLAM-associated protein signaling pathway is required for development of CD4+ T cells selected by homotypic thymocyte interaction. |
Volume: |
27 |
Issue: |
5 |
Pages: |
763-74 |
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Genotype |
Symbol: |
Tg(CD4-CIITA)357Ccum/? |
Background: |
involves: C57BL/6 * C57BL/6J * SJL |
Zygosity: |
ot |
Has Mutant Allele: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
977
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
917
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1078
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1053
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1078
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1155
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1075
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Fragment?: |
false |
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Publication |
First Author: |
Li W |
Year: |
2009 |
Journal: |
Immunol Cell Biol |
Title: |
MHC class II-expressing thymocytes suppress invariant NKT cell development. |
Volume: |
87 |
Issue: |
2 |
Pages: |
186-9 |
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Publication |
First Author: |
Sofi MH |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
Induction and maintenance of IL-4 expression are regulated differently by the 3' enhancer in CD4 T cells. |
Volume: |
186 |
Issue: |
5 |
Pages: |
2792-9 |
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Publication |
First Author: |
Rohm B |
Year: |
2000 |
Journal: |
Mech Dev |
Title: |
Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A. |
Volume: |
93 |
Issue: |
1-2 |
Pages: |
95-104 |
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Publication |
First Author: |
Takegahara N |
Year: |
2006 |
Journal: |
Nat Cell Biol |
Title: |
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. |
Volume: |
8 |
Issue: |
6 |
Pages: |
615-22 |
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Publication |
First Author: |
O'Connor BP |
Year: |
2008 |
Journal: |
Immunol Res |
Title: |
The evolving role of semaphorins and plexins in the immune system: Plexin-A1 regulation of dendritic cell function. |
Volume: |
41 |
Issue: |
3 |
Pages: |
217-22 |
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Protein Domain |
Type: |
Domain |
Description: |
Plexin A1 is found in both the nervous and immune systems. Its external Sema domain is also shared by semaphorin proteins. In the nervous system, Plexin A1 mediates Sema3A axon guidance function by interacting with the Sema3A coreceptor neuropilin, resulting in actin depolarization and cell repulsion [, ]. In the immune system, Plexin A1 mediates Sema6D signaling by binding to the Sema6D-Trem2-DAP12 complex on immune cells and osteoclasts to promote Rac activation and DAP12 phosphorylation []. In gene profiling experiments, Plexin A1 was identified as a CIITA (class II transactivator) regulated gene in primary dendritic cells (DCs) []. The Sema domain is located at the N terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module. |
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Publication |
First Author: |
Zhu L |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
A transgenic TCR directs the development of IL-4+ and PLZF+ innate CD4 T cells. |
Volume: |
191 |
Issue: |
2 |
Pages: |
737-44 |
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Publication |
First Author: |
Georgiev H |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells. |
Volume: |
12 |
Issue: |
1 |
Pages: |
2308 |
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Publication |
First Author: |
He K |
Year: |
2023 |
Journal: |
Cell |
Title: |
Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine. |
Volume: |
186 |
Issue: |
14 |
Pages: |
3033-3048.e20 |
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Publication |
First Author: |
Peretti M |
Year: |
2001 |
Journal: |
Mol Cell Biol |
Title: |
Expression of the three human major histocompatibility complex class II isotypes exhibits a differential dependence on the transcription factor RFXAP. |
Volume: |
21 |
Issue: |
17 |
Pages: |
5699-709 |
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