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Search results 301 to 400 out of 479 for Cntf

0.019s
Type Details Score
GXD Expression  
Probe: MGI:3724389
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421049
Age: embryonic day 14.5
Image: MH468; Specimen C1185
Specimen Label: MH468; Specimen C1185
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3724389
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5421049
Age: embryonic day 14.5
Specimen Label: MH468; Specimen C1185
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724389
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5421049
Age: embryonic day 14.5
Specimen Label: MH468; Specimen C1185
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724389
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5421049
Age: embryonic day 14.5
Specimen Label: MH468; Specimen C1185
Detected: false
Specimen Num: 1
GXD Expression
Probe: MGI:3724389
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1768022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421049
Age: embryonic day 14.5
Image: MH468; Specimen C1185
Note: Expression was detected in the skull (base and vault).
Specimen Label: MH468; Specimen C1185
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3724389
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421049
Age: embryonic day 14.5
Image: MH468; Specimen C1185
Note: Expression was weak in whisker follicle.
Specimen Label: MH468; Specimen C1185
Detected: true
Specimen Num: 1
Publication
First Author: Mitsumoto H
Year: 1994
Journal: Ann Neurol
Title: The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease.
Volume: 36
Issue: 2
Pages: 142-8
Publication
First Author: Ikeda K
Year: 1995
Journal: Ann Neurol
Title: Histometric effects of ciliary neurotrophic factor in wobbler mouse motor neuron disease.
Volume: 37
Issue: 1
Pages: 47-54
Publication
First Author: Herrero-Herranz E
Year: 2007
Journal: Am J Pathol
Title: Re-expression of a developmentally restricted potassium channel in autoimmune demyelination: Kv1.4 is implicated in oligodendroglial proliferation.
Volume: 171
Issue: 2
Pages: 589-98
Publication
First Author: Henderson JT
Year: 1993
Journal: Mouse Genome
Title: The gene for ciliary neurotrophic factor maps distal to CD5 and Ly-10 on murine chromosome 19
Volume: 91
Issue: 3
Pages: 561-563
Publication
First Author: Saotome Y
Year: 1995
Journal: Gene
Title: A widely expressed novel C2H2 zinc-finger protein with multiple consensus phosphorylation sites is conserved in mouse and man.
Volume: 152
Issue: 2
Pages: 233-8
Publication
First Author: Cayouette M
Year: 1997
Journal: Hum Gene Ther
Title: Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse.
Volume: 8
Issue: 4
Pages: 423-30
Publication
First Author: Balasubramaniam V
Year: 2010
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Bone marrow-derived angiogenic cells restore lung alveolar and vascular structure after neonatal hyperoxia in infant mice.
Volume: 298
Issue: 3
Pages: L315-23
Publication  
First Author: Beatty J
Year: 2006
Journal: BMC Neurosci
Title: Genomic regulation of natural variation in cortical and noncortical brain volume.
Volume: 7
Pages: 16
Publication
First Author: Zou X
Year: 2009
Journal: Vet Pathol
Title: Neonatal death in mice lacking cardiotrophin-like cytokine is associated with multifocal neuronal hypoplasia.
Volume: 46
Issue: 3
Pages: 514-9
Publication
First Author: Gresle MM
Year: 2015
Journal: Glia
Title: Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor.
Volume: 63
Issue: 6
Pages: 1005-20
Publication
First Author: Tebar LA
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Deletion of the mouse RegIIIbeta (Reg2) gene disrupts ciliary neurotrophic factor signaling and delays myelination of mouse cranial motor neurons.
Volume: 105
Issue: 32
Pages: 11400-5
Publication
First Author: Conover JC
Year: 1993
Journal: Development
Title: Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells.
Volume: 119
Issue: 3
Pages: 559-65
Publication
First Author: Cook SA
Year: 1995
Journal: Mamm Genome
Title: Neuromuscular degeneration (nmd): a mutation on mouse chromosome 19 that causes motor neuron degeneration.
Volume: 6
Issue: 3
Pages: 187-91
Publication
First Author: Emery B
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination.
Volume: 103
Issue: 20
Pages: 7859-64
Publication
First Author: Poirier C
Year: 1998
Journal: Mamm Genome
Title: A high-resolution genetic map of mouse chromosome 19 encompassing the muscle-deficient osteochondrodystrophy (mdf-ocd) region.
Volume: 9
Issue: 5
Pages: 390-1
Publication  
First Author: Jin D
Year: 2015
Journal: Nat Commun
Title: Restoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3.
Volume: 6
Pages: 8074
Publication
First Author: Yoshimura A
Year: 1996
Journal: EMBO J
Title: Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway.
Volume: 15
Issue: 5
Pages: 1055-63
Publication
First Author: Sedehizade F
Year: 1997
Journal: Muscle Nerve
Title: Expression of nerve-regulated genes in muscles of mouse mutants affected by spinal muscular atrophies and muscular dystrophies.
Volume: 20
Issue: 2
Pages: 186-94
Publication
First Author: Kim EY
Year: 2006
Journal: Exp Mol Med
Title: Downregulation of neurotrophic factors in the brain of a mouse model of Gaucher disease; implications for neuronal loss in Gaucher disease.
Volume: 38
Issue: 4
Pages: 348-56
Publication
First Author: Ozawa Y
Year: 2004
Journal: Mol Cell Neurosci
Title: Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina.
Volume: 26
Issue: 2
Pages: 258-70
Publication  
First Author: Qin S
Year: 2013
Journal: Nat Commun
Title: Cross-talk between KLF4 and STAT3 regulates axon regeneration.
Volume: 4
Pages: 2633
Publication
First Author: Wahlin KJ
Year: 2001
Journal: Exp Eye Res
Title: Neurotrophic signaling in normal and degenerating rodent retinas.
Volume: 73
Issue: 5
Pages: 693-701
Publication
First Author: Gadomski S
Year: 2022
Journal: Cell Stem Cell
Title: A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.
Volume: 29
Issue: 4
Pages: 528-544.e9
Publication
First Author: Valenzuela DM
Year: 2003
Journal: Nat Biotechnol
Title: High-throughput engineering of the mouse genome coupled with high-resolution expression analysis.
Volume: 21
Issue: 6
Pages: 652-9
Publication
First Author: Kawamura Y
Year: 2017
Journal: FEBS Lett
Title: Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain.
Volume: 591
Issue: 22
Pages: 3709-3720
Publication
First Author: Sun W
Year: 2003
Journal: J Neurosci
Title: Neuromuscular development after the prevention of naturally occurring neuronal death by Bax deletion.
Volume: 23
Issue: 19
Pages: 7298-310
Publication
First Author: Lord-Grignon J
Year: 2006
Journal: Gene Expr Patterns
Title: Identification of genes expressed in retinal progenitor/stem cell colonies isolated from the ocular ciliary body of adult mice.
Volume: 6
Issue: 8
Pages: 992-9
Publication
First Author: Musselman AC
Year: 1994
Journal: Reprod Toxicol
Title: Preliminary evidence of phenytoin-induced alterations in embryonic gene expression in a mouse model.
Volume: 8
Issue: 5
Pages: 383-95
Publication
First Author: Nadeau JH
Year: 2003
Journal: Curr Opin Genet Dev
Title: Modifier genes and protective alleles in humans and mice.
Volume: 13
Issue: 3
Pages: 290-5
Publication
First Author: Wang H
Year: 2014
Journal: Cell Rep
Title: Gli3 repressor controls cell fates and cell adhesion for proper establishment of neurogenic niche.
Volume: 8
Issue: 4
Pages: 1093-104
Publication
First Author: Feng S
Year: 2017
Journal: Sci Rep
Title: Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII.
Volume: 7
Issue: 1
Pages: 5282
Publication
First Author: Wu H
Year: 2012
Journal: Development
Title: β-Catenin gain of function in muscles impairs neuromuscular junction formation.
Volume: 139
Issue: 13
Pages: 2392-404
Publication
First Author: Ueno M
Year: 2013
Journal: Nat Neurosci
Title: Layer V cortical neurons require microglial support for survival during postnatal development.
Volume: 16
Issue: 5
Pages: 543-51
Publication
First Author: Taylor LE
Year: 1995
Journal: J Craniofac Genet Dev Biol
Title: Altered gene expression in murine branchial arches following in utero exposure to retinoic acid.
Volume: 15
Issue: 1
Pages: 13-25
Publication
First Author: Craig JC
Year: 1997
Journal: Biochem Mol Med
Title: Developmental expression of morphoregulatory genes in the mouse embryo: an analytical approach using a novel technology.
Volume: 60
Issue: 2
Pages: 81-91
Publication
First Author: Visel A
Year: 2007
Journal: PLoS Genet
Title: Regulatory pathway analysis by high-throughput in situ hybridization.
Volume: 3
Issue: 10
Pages: 1867-83
Publication
First Author: Alldred MJ
Year: 2015
Journal: J Comp Neurol
Title: Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice.
Volume: 523
Issue: 1
Pages: 61-74
GO Term
Publication
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Protein
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
Publication
First Author: Subang MC
Year: 1997
Journal: J Neurosci Res
Title: Delay of CNTF decrease following peripheral nerve injury in C57BL/Wld mice.
Volume: 49
Issue: 5
Pages: 563-8
Publication
First Author: Stefater MA
Year: 2012
Journal: Endocrinology
Title: The anorectic effect of CNTF does not require action in leptin-responsive neurons.
Volume: 153
Issue: 6
Pages: 2647-54
Publication
First Author: Mitsumoto H
Year: 1994
Journal: Science
Title: Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF.
Volume: 265
Issue: 5175
Pages: 1107-10
Protein
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: false
Publication
First Author: Bucher F
Year: 2016
Journal: Invest Ophthalmol Vis Sci
Title: CNTF Attenuates Vasoproliferative Changes Through Upregulation of SOCS3 in a Mouse-Model of Oxygen-Induced Retinopathy.
Volume: 57
Issue: 10
Pages: 4017-26
Publication
First Author: Bucher F
Year: 2020
Journal: Invest Ophthalmol Vis Sci
Title: CNTF Prevents Development of Outer Retinal Neovascularization Through Upregulation of CxCl10.
Volume: 61
Issue: 10
Pages: 20
Publication
First Author: Guillet C
Year: 2002
Journal: Eur J Biochem
Title: Functionally active fusion protein of the novel composite cytokine CLC/soluble CNTF receptor.
Volume: 269
Issue: 7
Pages: 1932-41
Publication
First Author: McGill TJ
Year: 2007
Journal: Invest Ophthalmol Vis Sci
Title: Intraocular CNTF reduces vision in normal rats in a dose-dependent manner.
Volume: 48
Issue: 12
Pages: 5756-66
Publication
First Author: Cao W
Year: 1997
Journal: Exp Eye Res
Title: Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina.
Volume: 65
Issue: 2
Pages: 241-8
Publication
First Author: Aslam SA
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Cone photoreceptor neuroprotection conferred by CNTF in a novel in vivo model of battlefield retinal laser injury.
Volume: 54
Issue: 8
Pages: 5456-65
Publication
First Author: Jankowiak W
Year: 2015
Journal: PLoS One
Title: Sustained Neural Stem Cell-Based Intraocular Delivery of CNTF Attenuates Photoreceptor Loss in the nclf Mouse Model of Neuronal Ceroid Lipofuscinosis.
Volume: 10
Issue: 5
Pages: e0127204
Publication  
First Author: Xie L
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Chemokine CCL5 promotes robust optic nerve regeneration and mediates many of the effects of CNTF gene therapy.
Volume: 118
Issue: 9
Publication
First Author: Lemper M
Year: 2016
Journal: Diabetologia
Title: A combination of cytokines EGF and CNTF protects the functional beta cell mass in mice with short-term hyperglycaemia.
Volume: 59
Issue: 9
Pages: 1948-58
Publication
First Author: Ishiyama T
Year: 1997
Journal: Exp Neurol
Title: Genetic transfer of the wobbler gene to a C57BL/6J x NZB hybrid stock: natural history of the motor neuron disease and response to CNTF and BDNF cotreatment.
Volume: 148
Issue: 1
Pages: 247-55
Allele
Name: ciliary neurotrophic factor; targeted mutation 1, Esther Asan
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
GO Term
Publication
First Author: Donaldson DH
Year: 1993
Journal: Genomics
Title: Localization of the gene for the ciliary neurotrophic factor receptor (CNTFR) to human chromosome 9.
Volume: 17
Issue: 3
Pages: 782-4
Publication
First Author: Giovannini M
Year: 1993
Journal: Cytogenet Cell Genet
Title: Tandem linkage of genes coding for leukemia inhibitory factor (LIF) and oncostatin M (OSM) on human chromosome 22.
Volume: 64
Issue: 3-4
Pages: 240-4
Publication
First Author: Winter CG
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury.
Volume: 92
Issue: 13
Pages: 5865-9
Publication
First Author: Stahl N
Year: 1994
Journal: Science
Title: Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.
Volume: 263
Issue: 5143
Pages: 92-5
Publication
First Author: Gearing DP
Year: 1991
Journal: Cell
Title: Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor.
Volume: 66
Issue: 1
Pages: 9-10
Protein Domain
Type: Conserved_site
Description: A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors []and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two major structural groups: Large/long and small/short hematopoietins.One subset of individual receptor chains that are part of receptor complexes for large hematopoietins contain common structural elements in their extracellular parts: an immunoglobulin-like domain at the N-terminal end of the hematopoietin receptor domain (except for the EBCV-induced interleukin-12beta chain) and a short (or no) cytoplasmic domain. They define a structural subgroup containing the following chains: Interleukin-6 receptor alpha chain (IL6RA). Interleukin-11 receptor alpha chain (IL11RA), Ciliary neurotrophic factor receptor alpha chain (CNTFRA), Interleukin-12 beta chain p40 (IL12BC), Interleukin-12 beta chain induced by Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4).Members of this subgroup bind to their cognate cytokines with low affinity and possess transmembrane and short cytoplasmic domains (IL6RA and IL11RA), or are GPi-linked membrane proteins (CNTFRA). Truncated soluble forms of IL-6 and CNTF receptors alpha chains are physiologically active []. IL-12 is an heterodimeric cytokine made of an alpha chain (p35) and a beta chain (p40). p40 (IL12BC) can be regarded as an alpha chain receptor devoid of cytoplasmic domain []. Members of this family have the ability to bind corresponding cytokines with no signalling function.
Publication
First Author: Young WJ
Year: 1998
Journal: J Biol Chem
Title: A bidirectional regulation between the TR2/TR4 orphan receptors (TR2/TR4) and the ciliary neurotrophic factor (CNTF) signaling pathway.
Volume: 273
Issue: 33
Pages: 20877-85
Publication
First Author: Findeisen M
Year: 2019
Journal: Nature
Title: Treatment of type 2 diabetes with the designer cytokine IC7Fc.
Volume: 574
Issue: 7776
Pages: 63-68
Publication
First Author: Do Rhee K
Year: 2022
Journal: Nat Commun
Title: Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas.
Volume: 13
Issue: 1
Pages: 7037
Publication
First Author: Selvaraj BT
Year: 2012
Journal: J Cell Biol
Title: Local axonal function of STAT3 rescues axon degeneration in the pmn model of motoneuron disease.
Volume: 199
Issue: 3
Pages: 437-51
Publication  
First Author: Lee N
Year: 2019
Journal: Exp Neurol
Title: Muscle ciliary neurotrophic factor receptor α helps maintain choline acetyltransferase levels in denervated motor neurons following peripheral nerve lesion.
Volume: 317
Pages: 202-205
Publication
First Author: Smith PD
Year: 2009
Journal: Neuron
Title: SOCS3 deletion promotes optic nerve regeneration in vivo.
Volume: 64
Issue: 5
Pages: 617-23
Publication
First Author: Janoschek R
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor.
Volume: 103
Issue: 28
Pages: 10707-12