| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:3724389 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757722 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421049 |
| Age: |
embryonic day 14.5 |
| Image: |
MH468; Specimen C1185 |
|
| Specimen Label: |
MH468; Specimen C1185 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724389 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757522 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421049 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH468; Specimen C1185 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724389 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1738322 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421049 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH468; Specimen C1185 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724389 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1802422 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421049 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH468; Specimen C1185 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724389 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1768022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421049 |
| Age: |
embryonic day 14.5 |
| Image: |
MH468; Specimen C1185 |
| Note: |
Expression was detected in the skull (base and vault). |
| Specimen Label: |
MH468; Specimen C1185 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724389 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2672022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421049 |
| Age: |
embryonic day 14.5 |
| Image: |
MH468; Specimen C1185 |
| Note: |
Expression was weak in whisker follicle. |
| Specimen Label: |
MH468; Specimen C1185 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
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Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
198
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| Fragment?: |
false |
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| Publication |
| First Author: |
Subang MC |
| Year: |
1997 |
| Journal: |
J Neurosci Res |
| Title: |
Delay of CNTF decrease following peripheral nerve injury in C57BL/Wld mice. |
| Volume: |
49 |
| Issue: |
5 |
| Pages: |
563-8 |
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| Publication |
| First Author: |
Stefater MA |
| Year: |
2012 |
| Journal: |
Endocrinology |
| Title: |
The anorectic effect of CNTF does not require action in leptin-responsive neurons. |
| Volume: |
153 |
| Issue: |
6 |
| Pages: |
2647-54 |
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| Publication |
| First Author: |
Mitsumoto H |
| Year: |
1994 |
| Journal: |
Science |
| Title: |
Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF. |
| Volume: |
265 |
| Issue: |
5175 |
| Pages: |
1107-10 |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
372
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| Fragment?: |
false |
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| Publication |
| First Author: |
Bucher F |
| Year: |
2016 |
| Journal: |
Invest Ophthalmol Vis Sci |
| Title: |
CNTF Attenuates Vasoproliferative Changes Through Upregulation of SOCS3 in a Mouse-Model of Oxygen-Induced Retinopathy. |
| Volume: |
57 |
| Issue: |
10 |
| Pages: |
4017-26 |
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| Publication |
| First Author: |
Bucher F |
| Year: |
2020 |
| Journal: |
Invest Ophthalmol Vis Sci |
| Title: |
CNTF Prevents Development of Outer Retinal Neovascularization Through Upregulation of CxCl10. |
| Volume: |
61 |
| Issue: |
10 |
| Pages: |
20 |
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| Publication |
| First Author: |
Guillet C |
| Year: |
2002 |
| Journal: |
Eur J Biochem |
| Title: |
Functionally active fusion protein of the novel composite cytokine CLC/soluble CNTF receptor. |
| Volume: |
269 |
| Issue: |
7 |
| Pages: |
1932-41 |
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| Publication |
| First Author: |
McGill TJ |
| Year: |
2007 |
| Journal: |
Invest Ophthalmol Vis Sci |
| Title: |
Intraocular CNTF reduces vision in normal rats in a dose-dependent manner. |
| Volume: |
48 |
| Issue: |
12 |
| Pages: |
5756-66 |
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| Publication |
| First Author: |
Cao W |
| Year: |
1997 |
| Journal: |
Exp Eye Res |
| Title: |
Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina. |
| Volume: |
65 |
| Issue: |
2 |
| Pages: |
241-8 |
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| Publication |
| First Author: |
Aslam SA |
| Year: |
2013 |
| Journal: |
Invest Ophthalmol Vis Sci |
| Title: |
Cone photoreceptor neuroprotection conferred by CNTF in a novel in vivo model of battlefield retinal laser injury. |
| Volume: |
54 |
| Issue: |
8 |
| Pages: |
5456-65 |
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| Publication |
| First Author: |
Jankowiak W |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
Sustained Neural Stem Cell-Based Intraocular Delivery of CNTF Attenuates Photoreceptor Loss in the nclf Mouse Model of Neuronal Ceroid Lipofuscinosis. |
| Volume: |
10 |
| Issue: |
5 |
| Pages: |
e0127204 |
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| Publication |
| First Author: |
Xie L |
| Year: |
2021 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Chemokine CCL5 promotes robust optic nerve regeneration and mediates many of the effects of CNTF gene therapy. |
| Volume: |
118 |
| Issue: |
9 |
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| Publication |
| First Author: |
Lemper M |
| Year: |
2016 |
| Journal: |
Diabetologia |
| Title: |
A combination of cytokines EGF and CNTF protects the functional beta cell mass in mice with short-term hyperglycaemia. |
| Volume: |
59 |
| Issue: |
9 |
| Pages: |
1948-58 |
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| Publication |
| First Author: |
Ishiyama T |
| Year: |
1997 |
| Journal: |
Exp Neurol |
| Title: |
Genetic transfer of the wobbler gene to a C57BL/6J x NZB hybrid stock: natural history of the motor neuron disease and response to CNTF and BDNF cotreatment. |
| Volume: |
148 |
| Issue: |
1 |
| Pages: |
247-55 |
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| Allele |
| Name: |
ciliary neurotrophic factor; targeted mutation 1, Esther Asan |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
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| GO Term |
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| Publication |
| First Author: |
Donaldson DH |
| Year: |
1993 |
| Journal: |
Genomics |
| Title: |
Localization of the gene for the ciliary neurotrophic factor receptor (CNTFR) to human chromosome 9. |
| Volume: |
17 |
| Issue: |
3 |
| Pages: |
782-4 |
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| Publication |
| First Author: |
Giovannini M |
| Year: |
1993 |
| Journal: |
Cytogenet Cell Genet |
| Title: |
Tandem linkage of genes coding for leukemia inhibitory factor (LIF) and oncostatin M (OSM) on human chromosome 22. |
| Volume: |
64 |
| Issue: |
3-4 |
| Pages: |
240-4 |
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| Publication |
| First Author: |
Winter CG |
| Year: |
1995 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury. |
| Volume: |
92 |
| Issue: |
13 |
| Pages: |
5865-9 |
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| Publication |
| First Author: |
Stahl N |
| Year: |
1994 |
| Journal: |
Science |
| Title: |
Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. |
| Volume: |
263 |
| Issue: |
5143 |
| Pages: |
92-5 |
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| Publication |
| First Author: |
Gearing DP |
| Year: |
1991 |
| Journal: |
Cell |
| Title: |
Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. |
| Volume: |
66 |
| Issue: |
1 |
| Pages: |
9-10 |
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| Protein Domain |
| Type: |
Conserved_site |
| Description: |
A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors []and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two major structural groups: Large/long and small/short hematopoietins.One subset of individual receptor chains that are part of receptor complexes for large hematopoietins contain common structural elements in their extracellular parts: an immunoglobulin-like domain at the N-terminal end of the hematopoietin receptor domain (except for the EBCV-induced interleukin-12beta chain) and a short (or no) cytoplasmic domain. They define a structural subgroup containing the following chains: Interleukin-6 receptor alpha chain (IL6RA). Interleukin-11 receptor alpha chain (IL11RA), Ciliary neurotrophic factor receptor alpha chain (CNTFRA), Interleukin-12 beta chain p40 (IL12BC), Interleukin-12 beta chain induced by Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4).Members of this subgroup bind to their cognate cytokines with low affinity and possess transmembrane and short cytoplasmic domains (IL6RA and IL11RA), or are GPi-linked membrane proteins (CNTFRA). Truncated soluble forms of IL-6 and CNTF receptors alpha chains are physiologically active []. IL-12 is an heterodimeric cytokine made of an alpha chain (p35) and a beta chain (p40). p40 (IL12BC) can be regarded as an alpha chain receptor devoid of cytoplasmic domain []. Members of this family have the ability to bind corresponding cytokines with no signalling function. |
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| Publication |
| First Author: |
Young WJ |
| Year: |
1998 |
| Journal: |
J Biol Chem |
| Title: |
A bidirectional regulation between the TR2/TR4 orphan receptors (TR2/TR4) and the ciliary neurotrophic factor (CNTF) signaling pathway. |
| Volume: |
273 |
| Issue: |
33 |
| Pages: |
20877-85 |
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| Publication |
| First Author: |
Findeisen M |
| Year: |
2019 |
| Journal: |
Nature |
| Title: |
Treatment of type 2 diabetes with the designer cytokine IC7Fc. |
| Volume: |
574 |
| Issue: |
7776 |
| Pages: |
63-68 |
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| Publication |
| First Author: |
Do Rhee K |
| Year: |
2022 |
| Journal: |
Nat Commun |
| Title: |
Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
7037 |
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| Publication |
| First Author: |
Selvaraj BT |
| Year: |
2012 |
| Journal: |
J Cell Biol |
| Title: |
Local axonal function of STAT3 rescues axon degeneration in the pmn model of motoneuron disease. |
| Volume: |
199 |
| Issue: |
3 |
| Pages: |
437-51 |
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| Publication |
| First Author: |
Lee N |
| Year: |
2019 |
| Journal: |
Exp Neurol |
| Title: |
Muscle ciliary neurotrophic factor receptor α helps maintain choline acetyltransferase levels in denervated motor neurons following peripheral nerve lesion. |
| Volume: |
317 |
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| Pages: |
202-205 |
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| Publication |
| First Author: |
Smith PD |
| Year: |
2009 |
| Journal: |
Neuron |
| Title: |
SOCS3 deletion promotes optic nerve regeneration in vivo. |
| Volume: |
64 |
| Issue: |
5 |
| Pages: |
617-23 |
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| Publication |
| First Author: |
Janoschek R |
| Year: |
2006 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor. |
| Volume: |
103 |
| Issue: |
28 |
| Pages: |
10707-12 |
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