| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
1 |
| Description: |
Cytochrome c oxidase assembly protein COX15 homolog |
| Type: |
chain |
| End: |
413 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
413
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Glerum DM |
| Year: |
1997 |
| Journal: |
J Biol Chem |
| Title: |
COX15 codes for a mitochondrial protein essential for the assembly of yeast cytochrome oxidase. |
| Volume: |
272 |
| Issue: |
30 |
| Pages: |
19088-94 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
396
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Allele |
| Name: |
cytochrome c oxidase assembly protein 15; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mueller JP |
| Year: |
1989 |
| Journal: |
J Bacteriol |
| Title: |
Isolation and sequence of ctaA, a gene required for cytochrome aa3 biosynthesis and sporulation in Bacillus subtilis. |
| Volume: |
171 |
| Issue: |
9 |
| Pages: |
4967-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Barros MH |
| Year: |
2001 |
| Journal: |
FEBS Lett |
| Title: |
Involvement of mitochondrial ferredoxin and Cox15p in hydroxylation of heme O. |
| Volume: |
492 |
| Issue: |
1-2 |
| Pages: |
133-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Swenson S |
| Year: |
2016 |
| Journal: |
J Biol Chem |
| Title: |
Analysis of Oligomerization Properties of Heme a Synthase Provides Insights into Its Function in Eukaryotes. |
| Volume: |
291 |
| Issue: |
19 |
| Pages: |
10411-25 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This is a family of integral membrane proteins. CtaA (also known as heme A synthase) is required for cytochrome aa3 oxidase assembly in Bacillus subtilis []. COX15 is required for cytochrome c oxidase assembly [], and is involved in the synthesis of heme A [, , ]. COX15 forms highly stable complexes through hydrophobic interactions, and this multimerization is evolutionarily conserved, independent of heme levels and heme a synthase catalytic activity. There are four conserved histidine residues critical for eukaryotic heme a synthase activity []. Mutations of COX15 are associated with fatal infantile hypertrophic cardiomyopathy and the neurological disorder Leigh syndrome, due to impaired stability (S344P) or catalytic function (R217W).In some cases, heme A synthase is found fused to protoheme IX farnesyltransferase, an enzyme that converts protoheme IX to heme O. |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE14481 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
Baseline |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gerhard DS |
| Year: |
2004 |
| Journal: |
Genome Res |
| Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| Volume: |
14 |
| Issue: |
10B |
| Pages: |
2121-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huttlin EL |
| Year: |
2010 |
| Journal: |
Cell |
| Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
| Volume: |
143 |
| Issue: |
7 |
| Pages: |
1174-89 |
|
•
•
•
•
•
|