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Search results 301 to 316 out of 316 for Cox15

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Type Details Score
Gene
Type: gene
Organism: frog, African clawed
Gene
Type: gene
Organism: frog, African clawed
UniProt Feature
Begin: 1
Description: Cytochrome c oxidase assembly protein COX15 homolog
Type: chain
End: 413
Protein
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
Publication
First Author: Glerum DM
Year: 1997
Journal: J Biol Chem
Title: COX15 codes for a mitochondrial protein essential for the assembly of yeast cytochrome oxidase.
Volume: 272
Issue: 30
Pages: 19088-94
Protein
Organism: Mus musculus/domesticus
Length: 396  
Fragment?: false
Allele
Name: cytochrome c oxidase assembly protein 15; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
DO Term
Publication
First Author: Mueller JP
Year: 1989
Journal: J Bacteriol
Title: Isolation and sequence of ctaA, a gene required for cytochrome aa3 biosynthesis and sporulation in Bacillus subtilis.
Volume: 171
Issue: 9
Pages: 4967-78
Publication
First Author: Barros MH
Year: 2001
Journal: FEBS Lett
Title: Involvement of mitochondrial ferredoxin and Cox15p in hydroxylation of heme O.
Volume: 492
Issue: 1-2
Pages: 133-8
Publication
First Author: Swenson S
Year: 2016
Journal: J Biol Chem
Title: Analysis of Oligomerization Properties of Heme a Synthase Provides Insights into Its Function in Eukaryotes.
Volume: 291
Issue: 19
Pages: 10411-25
Protein Domain
Type: Family
Description: This is a family of integral membrane proteins. CtaA (also known as heme A synthase) is required for cytochrome aa3 oxidase assembly in Bacillus subtilis []. COX15 is required for cytochrome c oxidase assembly [], and is involved in the synthesis of heme A [, , ]. COX15 forms highly stable complexes through hydrophobic interactions, and this multimerization is evolutionarily conserved, independent of heme levels and heme a synthase catalytic activity. There are four conserved histidine residues critical for eukaryotic heme a synthase activity []. Mutations of COX15 are associated with fatal infantile hypertrophic cardiomyopathy and the neurological disorder Leigh syndrome, due to impaired stability (S344P) or catalytic function (R217W).In some cases, heme A synthase is found fused to protoheme IX farnesyltransferase, an enzyme that converts protoheme IX to heme O.
HT Experiment
Series Id: GSE14481
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
Publication
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89