Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Cytochrome c oxidase assembly protein COX15 homolog |
Type: |
chain |
End: |
413 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
413
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Glerum DM |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
COX15 codes for a mitochondrial protein essential for the assembly of yeast cytochrome oxidase. |
Volume: |
272 |
Issue: |
30 |
Pages: |
19088-94 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
396
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
cytochrome c oxidase assembly protein 15; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Mueller JP |
Year: |
1989 |
Journal: |
J Bacteriol |
Title: |
Isolation and sequence of ctaA, a gene required for cytochrome aa3 biosynthesis and sporulation in Bacillus subtilis. |
Volume: |
171 |
Issue: |
9 |
Pages: |
4967-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barros MH |
Year: |
2001 |
Journal: |
FEBS Lett |
Title: |
Involvement of mitochondrial ferredoxin and Cox15p in hydroxylation of heme O. |
Volume: |
492 |
Issue: |
1-2 |
Pages: |
133-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Swenson S |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
Analysis of Oligomerization Properties of Heme a Synthase Provides Insights into Its Function in Eukaryotes. |
Volume: |
291 |
Issue: |
19 |
Pages: |
10411-25 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This is a family of integral membrane proteins. CtaA (also known as heme A synthase) is required for cytochrome aa3 oxidase assembly in Bacillus subtilis []. COX15 is required for cytochrome c oxidase assembly [], and is involved in the synthesis of heme A [, , ]. COX15 forms highly stable complexes through hydrophobic interactions, and this multimerization is evolutionarily conserved, independent of heme levels and heme a synthase catalytic activity. There are four conserved histidine residues critical for eukaryotic heme a synthase activity []. Mutations of COX15 are associated with fatal infantile hypertrophic cardiomyopathy and the neurological disorder Leigh syndrome, due to impaired stability (S344P) or catalytic function (R217W).In some cases, heme A synthase is found fused to protoheme IX farnesyltransferase, an enzyme that converts protoheme IX to heme O. |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE14481 |
Experiment Type: |
transcription profiling by array |
Study Type: |
Baseline |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|