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Search results 301 to 400 out of 437 for Csk

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Type Details Score
Interaction Experiment
Baumeister U (2005)
Description: Association of Csk to VE-cadherin and inhibition of cell proliferation.
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Interaction Experiment
Brian BF (2022)
Description: SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding.
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UniProt Feature
UniProt Feature
Begin: 508
Description: Phosphotyrosine; by autocatalysis, CSK and MATK
Type: modified residue
End: 508
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Allele
Scimp<+> | MGI:5441326
 
Name: SLP adaptor and CSK interacting membrane protein; wild type
Allele Type: Not Specified
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Publication
27288407 | J:235794
First Author: Kralova J
Year: 2016
Journal: J Biol Chem
Title: The Transmembrane Adaptor Protein SCIMP Facilitates Sustained Dectin-1 Signaling in Dendritic Cells.
Volume: 291
Issue: 32
Pages: 16530-40
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Publication
10790433 | J:71006
First Author: Brdicka T
Year: 2000
Journal: J Exp Med
Title: Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.
Volume: 191
Issue: 9
Pages: 1591-604
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Allele
Scimp<tm1a(KOMP)Wtsi> | MGI:4362812
Name: SLP adaptor and CSK interacting membrane protein; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Scimp<tm1Lex> | MGI:5007004
Name: SLP adaptor and CSK interacting membrane protein; targeted mutation 1, Lexicon Pharmaceuticals
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Scimp<em1Adiuj> | MGI:6444735
Name: SLP adaptor and CSK interacting membrane protein; endonuclease-mediated mutation 1, MODEL-AD Center
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Scimp<em1Smoc> | MGI:7292191
Name: SLP adaptor and CSK interacting membrane protein; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Protein Coding Gene
MGI:99259 | Matk
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
35393453 | -
First Author: Brian BF 4th
Year: 2022
Journal: Sci Rep
Title: SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding.
Volume: 12
Issue: 1
Pages: 5875
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Interaction Experiment
Vuica M (1997)
Description: Differential effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)-associated p62.
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Strain
MGI:6335670 | C57BL/6NTac-Scimp<tm1a(KOMP)Wtsi>/Wtsi
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:7451329 | C57BL/6NTac-Scimp<tm1a(KOMP)Wtsi>/WtsiOulu
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:6347227 | C57BL/6N-Scimp<tm1a(KOMP)Wtsi>/Mmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:5559051 | B6;129S5-Scimp<tm1Lex>/Mmucd
Attribute String: mutant stock, targeted mutation
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Strain
MGI:6476228 | C57BL/6JSmoc-Scimp<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Scimp/Scimp
Background: B6;129S5-Scimp/Mmucd
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:7571032 | C57BL/6N-A<tm1Brd> Hps3<tm2a(KOMP)Wtsi>/WtsiOrl
Attribute String: coisogenic, mutant strain, targeted mutation
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GO Term
GO:0070214 | CSK-GAP-A.p62 complex
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Publication
9221755 | -
First Author: Vuica M
Year: 1997
Journal: J Exp Med
Title: Differential effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)-associated p62.
Volume: 186
Issue: 2
Pages: 259-67
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Publication
37279110 | J:354741
First Author: Ramirez-Valdez RA
Year: 2023
Journal: Cell Rep
Title: Intravenous heterologous prime-boost vaccination activates innate and adaptive immunity to promote tumor regression.
Volume: 42
Issue: 6
Pages: 112599
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Publication
28098138 | J:244275
 
First Author: Luo L
Year: 2017
Journal: Nat Commun
Title: SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages.
Volume: 8
Pages: 14133
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Strain
MGI:6444736 | B6.Cg-Apoe<tm1.1(APOE*4)Adiuj> Scimp<em1Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: congenic, endonuclease-mediated mutation, mutant strain, targeted mutation
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Publication
39283743 | J:354592
First Author: Sandovici I
Year: 2024
Journal: Cell Rep
Title: Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and leads to developmental growth restriction and metabolic dysfunction in mice.
Volume: 43
Issue: 9
Pages: 114750
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Allele
Tg(Csk*)2Weis | MGI:5563915
Name: transgene insertion 2, Arthur Weiss
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
9858471 | -
 
First Author: Thomas SM
Year: 1999
Journal: J Cell Sci
Title: Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin.
Volume: 112 ( Pt 2)
Pages: 181-90
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Publication
31932281 | J:285330
First Author: Park JE
Year: 2020
Journal: J Biol Chem
Title: Leukocyte-associated immunoglobulin-like receptor 1 inhibits T-cell signaling by decreasing protein phosphorylation in the T-cell signaling pathway.
Volume: 295
Issue: 8
Pages: 2239-2247
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Publication
14657239 | J:90046
First Author: Di Stefano P
Year: 2004
Journal: Mol Biol Cell
Title: P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading.
Volume: 15
Issue: 2
Pages: 787-800
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Publication
19146815 | J:166009
First Author: Jaworski J
Year: 2009
Journal: Neuron
Title: Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity.
Volume: 61
Issue: 1
Pages: 85-100
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Publication
18662323 | J:164775
First Author: Ito H
Year: 2008
Journal: J Neurochem
Title: Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex.
Volume: 107
Issue: 1
Pages: 61-72
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Publication
10625663 | -
First Author: Chin LS
Year: 2000
Journal: J Biol Chem
Title: SNIP, a novel SNAP-25-interacting protein implicated in regulated exocytosis.
Volume: 275
Issue: 2
Pages: 1191-200
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Protein Domain
IPR026727 | Srcin1
Type: Family
Description: SRC kinase signalling inhibitor 1 (also known as SNAP-25-interacting protein, SNIP) acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signalling, leading to impaired cell spreading and migration [, ]. It regulates dendritic spine morphology []. It is involved in calcium-dependent exocytosis and may play a role in neurotransmitter release or synapse maintenance [, ].
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Publication
11884384 | -
First Author: Ogawa A
Year: 2002
Journal: J Biol Chem
Title: Structure of the carboxyl-terminal Src kinase, Csk.
Volume: 277
Issue: 17
Pages: 14351-4
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Publication
20476842 | -
First Author: Ia KK
Year: 2010
Journal: Growth Factors
Title: Structural elements and allosteric mechanisms governing regulation and catalysis of CSK-family kinases and their inhibition of Src-family kinases.
Volume: 28
Issue: 5
Pages: 329-50
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Publication
21393838 | -
First Author: Gunn NJ
Year: 2011
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun
Title: Purification, crystallization, small-angle X-ray scattering and preliminary X-ray diffraction analysis of the SH2 domain of the Csk-homologous kinase.
Volume: 67
Issue: Pt 3
Pages: 336-9
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Protein Domain
IPR035027 | Csk-like_SH2
Type: Domain
Description: This entry represents the SH2 domain found in CSK and CHK. Both the C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK) are members of the CSK-family of protein tyrosine kinases. These proteins suppress activity of Src-family kinases (SFK) by selectively phosphorylating the conserved C-terminal tail regulatory tyrosine by a similar mechanism []. CHK is also capable of inhibiting SFKs by a non-catalytic mechanism that involves binding of CHK to SFKs to form stable protein complexes. The unphosphorylated form of SFKs is inhibited by CSK and CHK by a two-step mechanism. The first step involves the formation of a complex of SFKs with CSK/CHK with the SFKs in the complex are inactive. The second step, involves the phosphorylation of the C-terminal tail tyrosine of SFKs, which then dissociates and adopt an inactive conformation. The structural basis of how the phosphorylated SFKs dissociate from CSK/CHK to adopt the inactive conformation is not known. The inactive conformation of SFKs is stabilized by two intramolecular inhibitory interactions: (a) the pYT:SH2 interaction in which the phosphorylated C-terminal tail tyrosine (YT) binds to the SH2 domain, and (b) the linker:SH3 interaction of which the SH2-kinase domain linker binds to the SH3 domain. SFKs are activated by multiple mechanisms including binding of the ligands to the SH2 and SH3 domains to displace the two inhibitory intramolecular interactions, autophosphorylation, and dephosphorylation of YT. By selective phosphorylation and the non-catalytic inhibitory mechanism CSK and CHK are able to inhibit the active forms of SFKs []. CSK and CHK are regulated by phosphorylation and inter-domain interactions. They both contain SH3, SH2, and kinase domains separated by the SH3-SH2 connector and SH2 kinase linker, intervening segments separating the three domains. They lack a conserved tyrosine phosphorylation site in the kinase domain and the C-terminal tail regulatory tyrosine phosphorylation site. The CSK SH2 domain is crucial for stabilizing the kinase domain in the active conformation. A disulfide bond here regulates CSK kinase activity. The subcellular localization and activity of CSK are regulated by its SH2 domain []. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites [].
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Strain
MGI:5563908 | B6.Cg-Csk<tm1Sor> Tg(Csk*)2Weis/WeisJ
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Publication
31641081 | J:284396
 
First Author: Courtney AH
Year: 2019
Journal: Sci Signal
Title: CD45 functions as a signaling gatekeeper in T cells.
Volume: 12
Issue: 604
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Protein
Q3UU41
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
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Protein
F8WHN0
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: false
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Protein Domain
IPR028181 | SCIMP
Type: Family
Description: SLP adapter and CSK-interacting membrane protein (SCIMP) is a lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex class II (MHC-II) signaling transduction []. SCIMP is expressed in B cells and other professional antigen-presenting cells (APCs) and is localised in the immunological synapse. Upon MHC-II stimulation, phosphorylated SCIMP binds to the SLP65 and to the inhibitorykinase Csk. SLP65 binding initiates the downstream signaling cascades, while Csk binding functions as a negative regulatory loop [].
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Publication
7498479 | J:29791
First Author: Ershler MA
Year: 1995
Journal: FEBS Lett
Title: Genomic structure and alternative splicing of the murine bhk/ctk/ntk gene.
Volume: 375
Issue: 1-2
Pages: 50-2
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Publication
12577064 | -
First Author: Gasman S
Year: 2003
Journal: Nat Cell Biol
Title: RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase.
Volume: 5
Issue: 3
Pages: 195-204
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Protein Domain
IPR027644 | DIAPH2
Type: Family
Description: DIAPH2 belongs to the formin homology family, Diaphanous subfamily (also known as the Diaphanous-related formins, Drfs). In addition to the FH1 and FH2 domains, Drfs contain an N-terminal GTPase-binding domain (mDiaN) and a C-terminal Diaphanous-autoregulatory domain (DAD).DIAPH2 may be involved in oogenesis and in the regulation of endosome dynamics. In humans, DIAPH2 has three isoforms produced by alternative splicing. Its isoform3, DIA2C, together with CSK are sequentially activated by GTPase RhoD to regulate the motility of early endosomes through interactions with the actin cytoskeleton [].
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Publication
14610046 | J:289012
First Author: Brdicková N
Year: 2003
Journal: J Exp Med
Title: LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.
Volume: 198
Issue: 10
Pages: 1453-62
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Publication
26517880 | J:227852
   
First Author: Freedman TS
Year: 2015
Journal: Elife
Title: LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.
Volume: 4
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Publication
31282857 | J:277695
   
First Author: Brian BF 4th
Year: 2019
Journal: Elife
Title: Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells.
Volume: 8
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Protein
Q9QWI6
Organism: Mus musculus/domesticus
Length: 1250  
Fragment?: false
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Protein
B1AQX8
Organism: Mus musculus/domesticus
Length: 473  
Fragment?: true
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Protein
A0A571BDG6
Organism: Mus musculus/domesticus
Length: 1205  
Fragment?: false
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Protein
A0A571BDG0
Organism: Mus musculus/domesticus
Length: 1225  
Fragment?: false
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Protein
A0A571BG39
Organism: Mus musculus/domesticus
Length: 1357  
Fragment?: false
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Protein
B1AQX6
Organism: Mus musculus/domesticus
Length: 1174  
Fragment?: false
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Protein
B1AQX7
Organism: Mus musculus/domesticus
Length: 1198  
Fragment?: false
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Protein
A0A571BG20
Organism: Mus musculus/domesticus
Length: 1055  
Fragment?: false
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Protein
B1AQX9
Organism: Mus musculus/domesticus
Length: 1217  
Fragment?: false
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Publication
35857476 | J:327552
First Author: Tawaratsumida K
Year: 2022
Journal: Sci Adv
Title: A phospho-tyrosine-based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity.
Volume: 8
Issue: 27
Pages: eabq0084
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Publication
16574955 | J:109203
First Author: Lee BC
Year: 2006
Journal: Blood
Title: Identification of the nonreceptor tyrosine kinase MATK/CHK as an essential regulator of immune cells using Matk/CHK-deficient mice.
Volume: 108
Issue: 3
Pages: 904-7
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Publication
7590263 | J:29202
First Author: Brinkley PM
Year: 1995
Journal: Gene
Title: Structure and developmental regulation of the murine ctk gene.
Volume: 163
Issue: 2
Pages: 179-84
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Publication
21917715 | J:260269
First Author: Schoenborn JR
Year: 2011
Journal: Sci Signal
Title: Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling.
Volume: 4
Issue: 190
Pages: ra59
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Publication
17905674 | -
First Author: Ingley E
Year: 2008
Journal: Biochim Biophys Acta
Title: Src family kinases: regulation of their activities, levels and identification of new pathways.
Volume: 1784
Issue: 1
Pages: 56-65
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Publication
18563293 | -
First Author: Engen JR
Year: 2008
Journal: Cell Mol Life Sci
Title: Structure and dynamic regulation of Src-family kinases.
Volume: 65
Issue: 19
Pages: 3058-73
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Publication
11007759 | -
First Author: Ochi H
Year: 2000
Journal: Int Immunol
Title: Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity.
Volume: 12
Issue: 10
Pages: 1417-23
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Publication
15664155 | J:96277
First Author: Xu Y
Year: 2005
Journal: Immunity
Title: Lyn tyrosine kinase: accentuating the positive and the negative.
Volume: 22
Issue: 1
Pages: 9-18
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Publication
17127394 | -
 
First Author: Sampson M
Year: 2007
Journal: Front Biosci
Title: Src kinases in G-CSF receptor signaling.
Volume: 12
Pages: 1463-74
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Publication
17118402 | -
First Author: Romir J
Year: 2007
Journal: J Mol Biol
Title: Crystal structure analysis and solution studies of human Lck-SH3; zinc-induced homodimerization competes with the binding of proline-rich motifs.
Volume: 365
Issue: 5
Pages: 1417-28
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Publication
17998336 | -
First Author: Li M
Year: 2008
Journal: Mol Cell Biol
Title: The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1.
Volume: 28
Issue: 2
Pages: 630-41
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Publication
16257509 | -
First Author: Fukushima A
Year: 2006
Journal: Cell Signal
Title: Lck couples Shc to TCR signaling.
Volume: 18
Issue: 8
Pages: 1182-9
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Publication
21983898 | -
First Author: Patrussi L
Year: 2012
Journal: Apoptosis
Title: p66Shc-dependent apoptosis requires Lck and CamKII activity.
Volume: 17
Issue: 2
Pages: 174-86
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Publication
15489916 | -
First Author: Palacios EH
Year: 2004
Journal: Oncogene
Title: Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
Volume: 23
Issue: 48
Pages: 7990-8000
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Publication
28033507 | -
 
First Author: Zahratka JA
Year: 2017
Journal: Neurobiol Aging
Title: Regulatory region genetic variation is associated with FYN expression in Alzheimer's disease.
Volume: 51
Pages: 43-53
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Publication
26157004 | J:225820
First Author: Panicker N
Year: 2015
Journal: J Neurosci
Title: Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease.
Volume: 35
Issue: 27
Pages: 10058-77
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Publication
10716632 | -
First Author: Martins-Green M
Year: 2000
Journal: Int J Biochem Cell Biol
Title: Tissue specific expression of Yrk kinase: implications for differentiation and inflammation.
Volume: 32
Issue: 3
Pages: 351-64
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Protein Domain
IPR035748 | Lyn_SH3
Type: Domain
Description: Lyn is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lyn is expressed in B lymphocytes and myeloid cells. It exhibits both positive and negative regulatory roles in B cell receptor (BCR) signaling. Lyn, as well as Fyn and Blk, promotes B cell activation by phosphorylating ITAMs (immunoreceptor tyr activation motifs) in CD19 and in Ig components of BCR []. It negatively regulates signaling by its unique ability to phosphorylate ITIMs (immunoreceptor tyr inhibition motifs) in cell surface receptors like CD22 and CD5 []. Lyn also plays an important role in G-CSF receptor signaling by phosphorylating a variety of adaptor molecules []. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction [, ].
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Protein Domain
IPR035749 | Lck_SH3
Type: Domain
Description: Lck is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lck is expressed in T-cellsand natural killer cells. It plays a critical role in T-cell maturation, activation, and T-cell receptor (TCR) signaling [, ]. Lck phosphorylates ITAM (immunoreceptor tyr activation motif) sequences on several subunits of TCRs, leading to the activation of different second messenger cascades. Phosphorylated ITAMs serve as binding sites for other signaling factor such as Syk and ZAP-70, leading to their activation and propagation of downstream events []. In addition, Lck regulates drug-induced apoptosis by interfering with the mitochondrial death pathway. The apototic role of Lck is independent of its primary function in T-cell signaling []. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction [, ].
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Protein Domain
IPR035750 | Fyn/Yrk_SH3
Type: Domain
Description: Fyn and Yrk (Yes-related kinase) are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Fyn, together with Lck, plays a critical role in T-cell signal transduction by phosphorylating ITAM (immunoreceptor tyr activation motif) sequences on T-cell receptors, ultimately leading to the proliferation and differentiation of T-cells []. In addition, Fyn is involved in the myelination of neurons, and is implicated in Alzheimer's []and Parkinson's diseases []. Yrk has been detected only in chickens. It is primarily found in neuronal and epithelial cells and in macrophages. It may play a role in inflammation and in response to injury [].Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction [, ].
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Publication
11940607 | J:180490
First Author: Obergfell A
Year: 2002
Journal: J Cell Biol
Title: Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.
Volume: 157
Issue: 2
Pages: 265-75
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Publication
14739300 | J:89495
First Author: Miyazaki T
Year: 2004
Journal: J Biol Chem
Title: Src kinase activity is essential for osteoclast function.
Volume: 279
Issue: 17
Pages: 17660-6
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Publication
19776266 | J:153045
First Author: Relucio J
Year: 2009
Journal: J Neurosci
Title: Laminin alters fyn regulatory mechanisms and promotes oligodendrocyte development.
Volume: 29
Issue: 38
Pages: 11794-806
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Publication
19211560 | J:149065
First Author: Zaas DW
Year: 2009
Journal: J Biol Chem
Title: Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa.
Volume: 284
Issue: 15
Pages: 9955-64
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Publication
36376335 | J:341740
First Author: Sridaran D
Year: 2022
Journal: Nat Commun
Title: Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance.
Volume: 13
Issue: 1
Pages: 6929
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Publication
19857202 | J:170137
First Author: Stokka AJ
Year: 2009
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