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Search results 301 to 400 out of 409 for Cth

0.033s
Type Details Score
GXD Expression  
Probe: MGI:293144
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1768023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824103
Age: embryonic day 14.5
Image: euxassay_000513_11
Specimen Label: euxassay_000513_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:293144
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1768023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824103
Age: embryonic day 14.5
Image: euxassay_000513_20
Specimen Label: euxassay_000513_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:293144
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1768023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824103
Age: embryonic day 14.5
Image: euxassay_000513_21
Specimen Label: euxassay_000513_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:293144
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1768023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824103
Age: embryonic day 14.5
Image: euxassay_000513_22
Specimen Label: euxassay_000513_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:293144
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1768023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824103
Age: embryonic day 14.5
Image: euxassay_000513_23
Specimen Label: euxassay_000513_23
Detected: true
Specimen Num: 23
GXD Expression  
Probe: MGI:293144
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1768023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824103
Age: embryonic day 14.5
Image: euxassay_000513_24
Specimen Label: euxassay_000513_24
Detected: true
Specimen Num: 24
GXD Expression
Probe: MGI:5309771
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1768022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423100
Age: embryonic day 14.5
Image: EH750; Specimen C2440
Note: Expression was strong in the skull (base and vault).
Specimen Label: EH750; Specimen C2440
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:293144
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824103
Age: embryonic day 14.5
Image: euxassay_000513_11
Specimen Label: euxassay_000513_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:293144
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824103
Age: embryonic day 14.5
Image: euxassay_000513_12
Specimen Label: euxassay_000513_12
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:293144
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824103
Age: embryonic day 14.5
Image: euxassay_000513_13
Specimen Label: euxassay_000513_13
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:293144
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824103
Age: embryonic day 14.5
Image: euxassay_000513_14
Specimen Label: euxassay_000513_14
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:293144
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824103
Age: embryonic day 14.5
Image: euxassay_000513_15
Specimen Label: euxassay_000513_15
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:293144
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824103
Age: embryonic day 14.5
Image: euxassay_000513_16
Specimen Label: euxassay_000513_16
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:5309771
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5423100
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: EH750; Specimen C2440
Detected: false
Specimen Num: 1
Publication
First Author: Mustafa AK
Year: 2009
Journal: Sci Signal
Title: H2S signals through protein S-sulfhydration.
Volume: 2
Issue: 96
Pages: ra72
Publication
First Author: Kuo MM
Year: 2016
Journal: Am J Physiol Heart Circ Physiol
Title: MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery.
Volume: 310
Issue: 1
Pages: H71-9
Publication  
First Author: Drekolia MK
Year: 2024
Journal: Redox Biol
Title: Loss of cardiac mitochondrial complex I persulfidation impairs NAD(+) homeostasis in aging.
Volume: 69
Pages: 103014
Publication  
First Author: Akahoshi N
Year: 2020
Journal: Int J Mol Sci
Title: Increased Urinary 3-Mercaptolactate Excretion and Enhanced Passive Systemic Anaphylaxis in Mice Lacking Mercaptopyruvate Sulfurtransferase, a Model of Mercaptolactate-Cysteine Disulfiduria.
Volume: 21
Issue: 3
Publication
First Author: Ding Y
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Sulfhydration of perilipin 1 is involved in the inhibitory effects of cystathionine gamma lyase/hydrogen sulfide on adipocyte lipolysis.
Volume: 521
Issue: 3
Pages: 786-790
Publication
First Author: Sen N
Year: 2012
Journal: Mol Cell
Title: Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions.
Volume: 45
Issue: 1
Pages: 13-24
Publication
First Author: Akahoshi N
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria.
Volume: 306
Issue: 12
Pages: F1462-76
Publication  
First Author: Ning N
Year: 2014
Journal: Nat Commun
Title: Dysregulation of hydrogen sulphide metabolism impairs oviductal transport of embryos.
Volume: 5
Pages: 4107
Publication
First Author: Yamada H
Year: 2012
Journal: Free Radic Biol Med
Title: Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria.
Volume: 52
Issue: 9
Pages: 1716-26
Publication  
First Author: Ishii I
Year: 2022
Journal: Int J Mol Sci
Title: A High-Methionine Diet for One-Week Induces a High Accumulation of Methionine in the Cerebrospinal Fluid and Confers Bipolar Disorder-like Behavior in Mice.
Volume: 23
Issue: 2
Publication
First Author: Ishii I
Year: 2010
Journal: J Biol Chem
Title: Cystathionine gamma-Lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury.
Volume: 285
Issue: 34
Pages: 26358-68
Publication  
First Author: Macabrey D
Year: 2022
Journal: EBioMedicine
Title: Sodium thiosulfate acts as a hydrogen sulfide mimetic to prevent intimal hyperplasia via inhibition of tubulin polymerisation.
Volume: 78
Pages: 103954
Publication
First Author: Sha L
Year: 2014
Journal: J Physiol
Title: Effect of endogenous hydrogen sulfide on the transwall gradient of the mouse colon circular smooth muscle.
Volume: 592
Issue: 5
Pages: 1077-89
Publication
First Author: King AL
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent.
Volume: 111
Issue: 8
Pages: 3182-7
Publication
First Author: Dickhout JG
Year: 2012
Journal: J Biol Chem
Title: Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism.
Volume: 287
Issue: 10
Pages: 7603-14
Publication
First Author: Bucci M
Year: 2012
Journal: PLoS One
Title: cGMP-dependent protein kinase contributes to hydrogen sulfide-stimulated vasorelaxation.
Volume: 7
Issue: 12
Pages: e53319
Publication
First Author: Makarenko VV
Year: 2015
Journal: Am J Physiol Cell Physiol
Title: CaV3.2 T-type Ca²⁺ channels in H₂S-mediated hypoxic response of the carotid body.
Volume: 308
Issue: 2
Pages: C146-54
Publication
First Author: Longchamp A
Year: 2018
Journal: Cell
Title: Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production.
Volume: 173
Issue: 1
Pages: 117-129.e14
Publication
First Author: Renga B
Year: 2015
Journal: Am J Physiol Heart Circ Physiol
Title: Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids.
Volume: 309
Issue: 1
Pages: H114-26
Publication
First Author: Tang G
Year: 2013
Journal: Diabetologia
Title: Hydrogen sulfide-induced inhibition of L-type Ca2+ channels and insulin secretion in mouse pancreatic beta cells.
Volume: 56
Issue: 3
Pages: 533-41
Publication
First Author: Li H
Year: 2012
Journal: PLoS One
Title: Interaction of hydrogen sulfide and estrogen on the proliferation of vascular smooth muscle cells.
Volume: 7
Issue: 8
Pages: e41614
Publication
First Author: Guo W
Year: 2019
Journal: FASEB J
Title: Cystathionine γ-lyase deficiency aggravates obesity-related insulin resistance via FoxO1-dependent hepatic gluconeogenesis.
Volume: 33
Issue: 3
Pages: 4212-4224
Publication
First Author: Hu TX
Year: 2019
Journal: Endocr J
Title: Reduced cystathionine-γ-lyase (CSE) expression is involved in high glucose induced MMP14 expression in adipocytes and adipose tissues.
Volume: 66
Issue: 11
Pages: 1029-1037
Publication
First Author: Kaneko Y
Year: 2009
Journal: FEBS Lett
Title: Glucose-induced production of hydrogen sulfide may protect the pancreatic beta-cells from apoptotic cell death by high glucose.
Volume: 583
Issue: 2
Pages: 377-82
Publication
First Author: Wu DD
Year: 2023
Journal: Cell Rep
Title: Hydrogen sulfide functions as a micro-modulator bound at the copper active site of Cu/Zn-SOD to regulate the catalytic activity of the enzyme.
Volume: 42
Issue: 7
Pages: 112750
Publication  
First Author: Shentu Y
Year: 2024
Journal: Exp Neurol
Title: Hydrogen sulfide ameliorates lipopolysaccharide-induced anxiety-like behavior by inhibiting checkpoint kinase 1 activation in the hippocampus of mice.
Volume: 371
Pages: 114586
Publication
First Author: Bibli SI
Year: 2019
Journal: Circulation
Title: Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis.
Volume: 139
Issue: 1
Pages: 101-114
Publication
First Author: Mani S
Year: 2013
Journal: Circulation
Title: Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis.
Volume: 127
Issue: 25
Pages: 2523-34
Publication
First Author: Du HP
Year: 2016
Journal: Biochem Biophys Res Commun
Title: DNA methylation in cystathionine-γ-lyase (CSE) gene promoter induced by ox-LDL in macrophages and in apoE knockout mice.
Volume: 469
Issue: 3
Pages: 776-82
Publication
First Author: Cheung SH
Year: 2014
Journal: PLoS One
Title: Anti-atherogenic effect of hydrogen sulfide by over-expression of cystathionine gamma-lyase (CSE) gene.
Volume: 9
Issue: 11
Pages: e113038
Publication  
First Author: Borowczyk K
Year: 2018
Journal: Int J Genomics
Title: Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice.
Volume: 2018
Pages: 7570850
Publication
First Author: Morikawa T
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway.
Volume: 109
Issue: 4
Pages: 1293-8
Publication
First Author: Maclean KN
Year: 2019
Journal: FASEB J
Title: Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine β-synthase-deficient homocystinuria.
Volume: 33
Issue: 5
Pages: 6339-6353
Publication
First Author: Yuan G
Year: 2015
Journal: Sci Signal
Title: Protein kinase G-regulated production of H2S governs oxygen sensing.
Volume: 8
Issue: 373
Pages: ra37
Publication
First Author: Rakoczy J
Year: 2015
Journal: Placenta
Title: Placental and fetal cysteine dioxygenase gene expression in mouse gestation.
Volume: 36
Issue: 8
Pages: 956-9
Publication
First Author: Cai J
Year: 2016
Journal: Biochim Biophys Acta
Title: Cystathionine γ lyase-hydrogen sulfide increases peroxisome proliferator-activated receptor γ activity by sulfhydration at C139 site thereby promoting glucose uptake and lipid storage in adipocytes.
Volume: 1861
Issue: 5
Pages: 419-29
Publication
First Author: Hine C
Year: 2015
Journal: Cell
Title: Endogenous hydrogen sulfide production is essential for dietary restriction benefits.
Volume: 160
Issue: 1-2
Pages: 132-44
Publication
First Author: Hine C
Year: 2017
Journal: Cell Metab
Title: Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.
Volume: 25
Issue: 6
Pages: 1320-1333.e5
Publication
First Author: Yamaguchi H
Year: 2022
Journal: Dev Dyn
Title: Disruption of Trip11 in cranial neural crest cells is associated with increased ER and Golgi stress contributing to skull defects in mice.
Volume: 251
Issue: 7
Pages: 1209-1222
Publication
First Author: Dutchak PA
Year: 2015
Journal: Cell Rep
Title: Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.
Volume: 12
Issue: 3
Pages: 371-9
Publication
First Author: Tarantino C
Year: 2010
Journal: FASEB J
Title: miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells.
Volume: 24
Issue: 9
Pages: 3255-63
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication      
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication        
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
Publication        
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Author
Allele
Name: cystathionine gamma lyase; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain