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Search results 301 to 366 out of 366 for Cxcl9

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Type Details Score
Publication
36355429 | J:339848
 
First Author: Riedel JH
Year: 2023
Journal: JCI Insight
Title: Glucocorticoids target the CXCL9/CXCL10-CXCR3 axis and confer protection against immune-mediated kidney injury.
Volume: 8
Issue: 1
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Publication
27385779 | J:288200
First Author: Liu JQ
Year: 2016
Journal: J Immunol
Title: A Critical Role for CD200R Signaling in Limiting the Growth and Metastasis of CD200+ Melanoma.
Volume: 197
Issue: 4
Pages: 1489-97
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Publication
29295842 | J:261967
First Author: Girard-Guyonvarc'h C
Year: 2018
Journal: Blood
Title: Unopposed IL-18 signaling leads to severe TLR9-induced macrophage activation syndrome in mice.
Volume: 131
Issue: 13
Pages: 1430-1441
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Publication
30347820 | J:279105
 
First Author: Chaly Y
Year: 2018
Journal: Int J Mol Sci
Title: Type I Interferon Signaling Is Required for Dacryoadenitis in the Nonobese Diabetic Mouse Model of Sjögren Syndrome.
Volume: 19
Issue: 10
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Publication
11564831 | J:71623
First Author: Liu MT
Year: 2001
Journal: J Immunol
Title: Neutralization of the chemokine CXCL10 reduces inflammatory cell invasion and demyelination and improves neurological function in a viral model of multiple sclerosis.
Volume: 167
Issue: 7
Pages: 4091-7
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Publication
15585884 | J:94852
First Author: Fulkerson PC
Year: 2004
Journal: J Immunol
Title: Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gamma.
Volume: 173
Issue: 12
Pages: 7565-74
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Publication
18941191 | J:140744
First Author: Ding W
Year: 2008
Journal: J Immunol
Title: Calcitonin gene-related peptide biases Langerhans cells toward Th2-type immunity.
Volume: 181
Issue: 9
Pages: 6020-6
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Publication
17878349 | J:152351
First Author: Zhai Y
Year: 2007
Journal: J Immunol
Title: Defective alloreactive CD8 T cell function and memory response in allograft recipients in the absence of CD4 help.
Volume: 179
Issue: 7
Pages: 4529-34
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Publication
21640974 | J:173302
First Author: Ramaprakash H
Year: 2011
Journal: Am J Pathol
Title: Targeting ST2L potentiates CpG-mediated therapeutic effects in a chronic fungal asthma model.
Volume: 179
Issue: 1
Pages: 104-15
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Publication
24038090 | J:206276
First Author: Fairfax KC
Year: 2013
Journal: J Immunol
Title: Regulation of the development of the hepatic B cell compartment during Schistosoma mansoni infection.
Volume: 191
Issue: 8
Pages: 4202-10
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Publication
25485859 | J:217800
First Author: Ohama H
Year: 2015
Journal: Am J Pathol
Title: M2b macrophage elimination and improved resistance of mice with chronic alcohol consumption to opportunistic infections.
Volume: 185
Issue: 2
Pages: 420-31
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Publication
26392743 | J:227074
 
First Author: Camelo S
Year: 2015
Journal: Mol Vis
Title: Thinning of the RPE and choroid associated with T lymphocyte recruitment in aged and light-challenged mice.
Volume: 21
Pages: 1051-9
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Publication
27139489 | J:234786
First Author: Zeng Z
Year: 2016
Journal: J Exp Med
Title: Interferon-γ facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance.
Volume: 213
Issue: 6
Pages: 1079-93
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Publication
37365574 | J:359039
First Author: Xiong W
Year: 2023
Journal: J Transl Med
Title: Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration.
Volume: 21
Issue: 1
Pages: 416
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Publication
26646682 | J:245858
First Author: Westman J
Year: 2015
Journal: PLoS Pathog
Title: Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo.
Volume: 11
Issue: 12
Pages: e1005319
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Publication
28698228 | J:248405
First Author: Mižíková I
Year: 2017
Journal: Physiol Genomics
Title: Perturbations to lysyl oxidase expression broadly influence the transcriptome of lung fibroblasts.
Volume: 49
Issue: 8
Pages: 416-429
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Publication
28397794 | J:255749
 
First Author: Losada-Barragán M
Year: 2017
Journal: Sci Rep
Title: Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum.
Volume: 7
Pages: 45991
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29680668 | J:270460
First Author: Zhou J
Year: 2018
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Anti-IL-7 receptor-α treatment ameliorates newly established Sjögren's-like exocrinopathy in non-obese diabetic mice.
Volume: 1864
Issue: 7
Pages: 2438-2447
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Publication
30461288 | J:269588
First Author: Britto CJ
Year: 2019
Journal: Am J Physiol Lung Cell Mol Physiol
Title: BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation.
Volume: 316
Issue: 2
Pages: L321-L333
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Publication
34803491 | J:314766
First Author: Zhao M
Year: 2021
Journal: Int J Biol Sci
Title: Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice.
Volume: 17
Issue: 15
Pages: 4176-4191
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Publication
27325565 | J:318385
First Author: Burke SJ
Year: 2016
Journal: Biofactors
Title: Pancreatic β-Cell production of CXCR3 ligands precedes diabetes onset.
Volume: 42
Issue: 6
Pages: 703-715
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Publication
29041928 | J:271935
First Author: Ono J
Year: 2017
Journal: J Biomed Sci
Title: The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice.
Volume: 24
Issue: 1
Pages: 79
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Publication
24147035 | J:209104
First Author: Jin JO
Year: 2013
Journal: PLoS One
Title: Innate immune signaling induces interleukin-7 production from salivary gland cells and accelerates the development of primary Sjögren's syndrome in a mouse model.
Volume: 8
Issue: 10
Pages: e77605
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Publication
20585034 | J:162468
First Author: Ellis SL
Year: 2010
Journal: J Immunol
Title: The cell-specific induction of CXC chemokine ligand 9 mediated by IFN-gamma in microglia of the central nervous system is determined by the myeloid transcription factor PU.1.
Volume: 185
Issue: 3
Pages: 1864-77
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Publication
27709605 | J:246260
First Author: Rodríguez M
Year: 2017
Journal: Immunology
Title: Fungal pattern receptors down-regulate the inflammatory response by a cross-inhibitory mechanism independent of interleukin-10 production.
Volume: 150
Issue: 2
Pages: 184-198
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Publication
38426749 | J:361379
First Author: Philip DT
Year: 2024
Journal: mBio
Title: Interferon lambda restricts herpes simplex virus skin disease by suppressing neutrophil-mediated pathology.
Volume: 15
Issue: 4
Pages: e0262323
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Publication
27696085 | J:288155
First Author: Ashton KJ
Year: 2017
Journal: Purinergic Signal
Title: Transcriptomic effects of adenosine 2A receptor deletion in healthy and endotoxemic murine myocardium.
Volume: 13
Issue: 1
Pages: 27-49
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Publication
37746718 | J:357407
First Author: Ma P
Year: 2024
Journal: Circulation
Title: Expansion of Pathogenic Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis.
Volume: 149
Issue: 1
Pages: 48-66
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Publication
27727269 | J:254475
First Author: Liu Z
Year: 2016
Journal: PLoS One
Title: Characteristics of Allergic Pulmonary Inflammation in CXCR3Knockout Mice Sensitized and Challenged with House Dust Mite Protein.
Volume: 11
Issue: 10
Pages: e0162905
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Publication
37296899 | J:336635
 
First Author: Tang X
Year: 2023
Journal: Cancers (Basel)
Title: Autotaxin Inhibition with IOA-289 Decreases Breast Tumor Growth in Mice Whereas Knockout of Autotaxin in Adipocytes Does Not.
Volume: 15
Issue: 11
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Publication
34884512 | J:328129
 
First Author: Magnusen AF
Year: 2021
Journal: Int J Mol Sci
Title: C-X-C Motif Chemokine Ligand 9 and Its CXCR3 Receptor Are the Salt and Pepper for T Cells Trafficking in a Mouse Model of Gaucher Disease.
Volume: 22
Issue: 23
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Publication
22615863 | J:187233
First Author: Chen SH
Year: 2012
Journal: PLoS One
Title: Persistent hepatitis B viral replication in a FVB/N mouse model: impact of host and viral factors.
Volume: 7
Issue: 5
Pages: e36984
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Publication
30274824 | J:295253
 
First Author: Hsueh YH
Year: 2018
Journal: J Autoimmun
Title: Endogenous IL-10 maintains immune tolerance but IL-10 gene transfer exacerbates autoimmune cholangitis.
Volume: 95
Pages: 159-170
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Publication
32991819 | J:331824
First Author: Han K
Year: 2021
Journal: Am J Respir Cell Mol Biol
Title: Lung Expression of Human Angiotensin-Converting Enzyme 2 Sensitizes the Mouse to SARS-CoV-2 Infection.
Volume: 64
Issue: 1
Pages: 79-88
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Publication
37162929 | J:356834
     
First Author: Ma P
Year: 2023
Journal: bioRxiv
Title: Expansion of Disease Specific Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis.
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Publication
32460031 | J:304664
First Author: Lian J
Year: 2020
Journal: Cell Rep
Title: Targeting Lymph Node Niches Enhances Type 1 Immune Responses to Immunization.
Volume: 31
Issue: 8
Pages: 107679
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Publication
9625760 | -
First Author: Cole KE
Year: 1998
Journal: J Exp Med
Title: Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3.
Volume: 187
Issue: 12
Pages: 2009-21
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Publication
9660793 | -
First Author: Weng Y
Year: 1998
Journal: J Biol Chem
Title: Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
Volume: 273
Issue: 29
Pages: 18288-91
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Publication
9064356 | -
First Author: Loetscher M
Year: 1996
Journal: J Exp Med
Title: Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.
Volume: 184
Issue: 3
Pages: 963-9
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Publication
11310833 | -
First Author: García-López MA
Year: 2001
Journal: Lab Invest
Title: CXCR3 chemokine receptor distribution in normal and inflamed tissues: expression on activated lymphocytes, endothelial cells, and dendritic cells.
Volume: 81
Issue: 3
Pages: 409-18
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Publication
12173928 | -
First Author: Booth V
Year: 2002
Journal: Biochemistry
Title: The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions.
Volume: 41
Issue: 33
Pages: 10418-25
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Publication
10233762 | -
First Author: Tensen CP
Year: 1999
Journal: J Invest Dermatol
Title: Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3).
Volume: 112
Issue: 5
Pages: 716-22
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Publication
12750173 | -
First Author: Smit MJ
Year: 2003
Journal: Blood
Title: CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase.
Volume: 102
Issue: 6
Pages: 1959-65
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Publication
11085753 | J:65916
First Author: Hancock WW
Year: 2000
Journal: J Exp Med
Title: Requirement of the chemokine receptor CXCR3 for acute allograft rejection.
Volume: 192
Issue: 10
Pages: 1515-20
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Publication
10525042 | -
First Author: Mach F
Year: 1999
Journal: J Clin Invest
Title: Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells.
Volume: 104
Issue: 8
Pages: 1041-50
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Publication
15254596 | J:91359
First Author: Jiang D
Year: 2004
Journal: J Clin Invest
Title: Regulation of pulmonary fibrosis by chemokine receptor CXCR3.
Volume: 114
Issue: 2
Pages: 291-9
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Publication
17538187 | J:153194
First Author: Panzer U
Year: 2007
Journal: J Am Soc Nephrol
Title: Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice.
Volume: 18
Issue: 7
Pages: 2071-84
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Publication
9466968 | -
First Author: Qin S
Year: 1998
Journal: J Clin Invest
Title: The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.
Volume: 101
Issue: 4
Pages: 746-54
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Publication
16127166 | -
First Author: Curbishley SM
Year: 2005
Journal: Am J Pathol
Title: CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow.
Volume: 167
Issue: 3
Pages: 887-99
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Publication
10605606 | -
 
First Author: Loetscher P
Year: 2000
Journal: Adv Immunol
Title: Chemokines and their receptors in lymphocyte traffic and HIV infection.
Volume: 74
Pages: 127-80
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Publication
9987599 | -
First Author: Zlotnik A
Year: 1999
Journal: Crit Rev Immunol
Title: Recent advances in chemokines and chemokine receptors.
Volume: 19
Issue: 1
Pages: 1-47
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Publication
17600132 | J:123926
First Author: Yates CC
Year: 2007
Journal: Am J Pathol
Title: Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor.
Volume: 171
Issue: 2
Pages: 484-95
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Publication
12884299 | -
First Author: Xanthou G
Year: 2003
Journal: Eur J Immunol
Title: CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11.
Volume: 33
Issue: 8
Pages: 2241-50
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Protein Domain
IPR004070 | Chemokine_CXCR3
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.This entry represents CXCR3, which is expressed in natural killer cells and activated T lymphocytes but not in resting T lymphocytes, B lymphocytes, monocytes or granulocytes [, ]. CXCR3 also appears to be constitutively expressed on endothelial cells of medium and large blood vessels []. CXCR3 is able to regulate leukocyte trafficking and binding to various chemokines inducing various cellular responses, most notably integrin activation, cytoskeletal changes and chemotactic migration [, , , ]. The main role of CXCR3 is the selective recruitment of effector T cells in both normal tissues and inflammation []and it is involved in a number of T cell-mediated inflammatory diseases, such as autoimmune diseases, delayed-type hypersensitivity responses, certain viral diseases and acute transplant rejection []. It has been implicated in atherosclerosis [], pulmonary fibrosis [], type 1 diabetes []and nephrotoxic nephritis [], and has been implicated in wound healing [].CXCR3 is the receptor for CXCL9 (Mig), CXCL10 (IP10) and CXCL11 (I-TAC), [, , , ], which are upregulated in response to interferon-gamma and are potent chemoattractants for activated T cells [, ]. All three chemokines elicit an increase in intracellular Ca2+ levels and activate phosphoinositide 3-kinase and mitogen-activated protein kinase (MAPK) []. CXCR3 is also capable of binding a number of CC chemokines with moderate affinity, including CCL11 (eotaxin), CCL13, CCL20, CCL7, CCL5 []. However, it has been reported that CCL11, despite binding with high affinity, may be neither an agonist or an antagonist of the CXCR3 receptor, but sequesters available CCL11 resulting in a lowered response at other receptors [].
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Publication
24930935 | J:336548
 
First Author: Krauthausen M
Year: 2014
Journal: J Neuroinflammation
Title: CXCR3 modulates glial accumulation and activation in cuprizone-induced demyelination of the central nervous system.
Volume: 11
Pages: 109
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Publication
30915078 | J:295867
 
First Author: Berretta F
Year: 2019
Journal: Front Immunol
Title: Plasmodium chabaudi AS Infection Induces CD4+ Th1 Cells and Foxp3+T-bet+ Regulatory T Cells That Express CXCR3 and Migrate to CXCR3 Ligands.
Volume: 10
Pages: 425
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Publication
26311879 | J:230082
First Author: Parker ZM
Year: 2015
Journal: J Virol
Title: Role of the DNA Sensor STING in Protection from Lethal Infection following Corneal and Intracerebral Challenge with Herpes Simplex Virus 1.
Volume: 89
Issue: 21
Pages: 11080-91
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Publication
38879499 | J:351123
First Author: Syage AR
Year: 2024
Journal: J Neuroinflammation
Title: Cystatin F attenuates neuroinflammation and demyelination following murine coronavirus infection of the central nervous system.
Volume: 21
Issue: 1
Pages: 157
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Publication
10699158 | -
First Author: Murphy PM
Year: 2000
Journal: Pharmacol Rev
Title: International union of pharmacology. XXII. Nomenclature for chemokine receptors.
Volume: 52
Issue: 1
Pages: 145-76
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Protein
O88410
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: false
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Publication
9689100 | J:49070
First Author: Ma Q
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Volume: 95
Issue: 16
Pages: 9448-53
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Publication
11544102 | -
First Author: Horuk R
Year: 2001
Journal: Cytokine Growth Factor Rev
Title: Chemokine receptors.
Volume: 12
Issue: 4
Pages: 313-35
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Publication
10601351 | -
First Author: Charbonnier AS
Year: 1999
Journal: J Exp Med
Title: Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells.
Volume: 190
Issue: 12
Pages: 1755-68
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Publication
9500790 | -
First Author: Sallusto F
Year: 1998
Journal: J Exp Med
Title: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
Volume: 187
Issue: 6
Pages: 875-83
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Publication
7592998 | -
First Author: Strieter RM
Year: 1995
Journal: J Biol Chem
Title: The functional role of the ELR motif in CXC chemokine-mediated angiogenesis.
Volume: 270
Issue: 45
Pages: 27348-57
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Publication
10714678 | -
First Author: Zlotnik A
Year: 2000
Journal: Immunity
Title: Chemokines: a new classification system and their role in immunity.
Volume: 12
Issue: 2
Pages: 121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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