Type |
Details |
Score |
Publication |
First Author: |
Mitsui Y |
Year: |
2015 |
Journal: |
BMC Cancer |
Title: |
CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma. |
Volume: |
15 |
|
Pages: |
942 |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
McNamara LK |
Year: |
2009 |
Journal: |
Acta Crystallogr D Biol Crystallogr |
Title: |
Structural insight into nucleotide recognition by human death-associated protein kinase. |
Volume: |
65 |
Issue: |
Pt 3 |
Pages: |
241-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kögel D |
Year: |
2001 |
Journal: |
Bioessays |
Title: |
The DAP kinase family of pro-apoptotic proteins: novel players in the apoptotic game. |
Volume: |
23 |
Issue: |
4 |
Pages: |
352-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shiloh R |
Year: |
2014 |
Journal: |
Apoptosis |
Title: |
The DAPK family: a structure-function analysis. |
Volume: |
19 |
Issue: |
2 |
Pages: |
286-97 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the catalytic domain of DAPK3, which is a member of the Ca(2+)/calmodulin-regulated family of serine/threonine protein kinases [, ].STKs (serine/threonine kinases) catalyse the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumour suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles []. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK1 is the prototypical member of the DAPK family and is also simply referred to as DAPK. DAPK2 is also called DAPK-related protein 1 (DRP-1), while DAPK3 has also been named DAP-like kinase (DLK) and zipper-interacting protein kinase (ZIPk). These proteins are ubiquitously expressed in adult tissues, are capable of cross talk with each other, and may act synergistically in regulating cell death []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Geering B |
Year: |
2014 |
Journal: |
J Leukoc Biol |
Title: |
DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants. |
Volume: |
95 |
Issue: |
2 |
Pages: |
293-303 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tereshko V |
Year: |
2001 |
Journal: |
Nat Struct Biol |
Title: |
Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression. |
Volume: |
8 |
Issue: |
10 |
Pages: |
899-907 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu X |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Lipopolysaccharides-Induced Suppression of Innate-Like B Cell Apoptosis Is Enhanced by CpG Oligodeoxynucleotide and Requires Toll-Like Receptors 2 and 4. |
Volume: |
11 |
Issue: |
11 |
Pages: |
e0165862 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gade P |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
An IFN-γ-stimulated ATF6-C/EBP-β-signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy. |
Volume: |
109 |
Issue: |
26 |
Pages: |
10316-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takeshima H |
Year: |
2012 |
Journal: |
Carcinogenesis |
Title: |
Induction of aberrant trimethylation of histone H3 lysine 27 by inflammation in mouse colonic epithelial cells. |
Volume: |
33 |
Issue: |
12 |
Pages: |
2384-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qiu C |
Year: |
2021 |
Journal: |
Sci Transl Med |
Title: |
Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice. |
Volume: |
13 |
Issue: |
596 |
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
448
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
448
 |
Fragment?: |
false |
|
•
•
•
•
•
|