Type |
Details |
Score |
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3281228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065913 |
|
Specimen Label: |
RBRC_1065913 |
Detected: |
true |
Specimen Num: |
207 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3281228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065915 |
|
Specimen Label: |
RBRC_1065915 |
Detected: |
true |
Specimen Num: |
208 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2991528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065845 |
|
Specimen Label: |
RBRC_1065845 |
Detected: |
true |
Specimen Num: |
173 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065665 |
|
Specimen Label: |
RBRC_1065665 |
Detected: |
true |
Specimen Num: |
83 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065667 |
|
Specimen Label: |
RBRC_1065667 |
Detected: |
true |
Specimen Num: |
84 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065669 |
|
Specimen Label: |
RBRC_1065669 |
Detected: |
true |
Specimen Num: |
85 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065671 |
|
Specimen Label: |
RBRC_1065671 |
Detected: |
true |
Specimen Num: |
86 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065673 |
|
Specimen Label: |
RBRC_1065673 |
Detected: |
true |
Specimen Num: |
87 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065675 |
|
Specimen Label: |
RBRC_1065675 |
Detected: |
true |
Specimen Num: |
88 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065677 |
|
Specimen Label: |
RBRC_1065677 |
Detected: |
true |
Specimen Num: |
89 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065679 |
|
Specimen Label: |
RBRC_1065679 |
Detected: |
true |
Specimen Num: |
90 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065681 |
|
Specimen Label: |
RBRC_1065681 |
Detected: |
true |
Specimen Num: |
91 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065683 |
|
Specimen Label: |
RBRC_1065683 |
Detected: |
true |
Specimen Num: |
92 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065685 |
|
Specimen Label: |
RBRC_1065685 |
Detected: |
true |
Specimen Num: |
93 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065687 |
|
Specimen Label: |
RBRC_1065687 |
Detected: |
true |
Specimen Num: |
94 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065689 |
|
Specimen Label: |
RBRC_1065689 |
Detected: |
true |
Specimen Num: |
95 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065691 |
|
Specimen Label: |
RBRC_1065691 |
Detected: |
true |
Specimen Num: |
96 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065865 |
|
Specimen Label: |
RBRC_1065865 |
Detected: |
true |
Specimen Num: |
183 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065867 |
|
Specimen Label: |
RBRC_1065867 |
Detected: |
true |
Specimen Num: |
184 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065869 |
|
Specimen Label: |
RBRC_1065869 |
Detected: |
true |
Specimen Num: |
185 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065871 |
|
Specimen Label: |
RBRC_1065871 |
Detected: |
true |
Specimen Num: |
186 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065873 |
|
Specimen Label: |
RBRC_1065873 |
Detected: |
true |
Specimen Num: |
187 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065875 |
|
Specimen Label: |
RBRC_1065875 |
Detected: |
true |
Specimen Num: |
188 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065877 |
|
Specimen Label: |
RBRC_1065877 |
Detected: |
true |
Specimen Num: |
189 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065879 |
|
Specimen Label: |
RBRC_1065879 |
Detected: |
true |
Specimen Num: |
190 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065881 |
|
Specimen Label: |
RBRC_1065881 |
Detected: |
true |
Specimen Num: |
191 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065883 |
|
Specimen Label: |
RBRC_1065883 |
Detected: |
true |
Specimen Num: |
192 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065885 |
|
Specimen Label: |
RBRC_1065885 |
Detected: |
true |
Specimen Num: |
193 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065887 |
|
Specimen Label: |
RBRC_1065887 |
Detected: |
true |
Specimen Num: |
194 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065889 |
|
Specimen Label: |
RBRC_1065889 |
Detected: |
true |
Specimen Num: |
195 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065891 |
|
Specimen Label: |
RBRC_1065891 |
Detected: |
true |
Specimen Num: |
196 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065893 |
|
Specimen Label: |
RBRC_1065893 |
Detected: |
true |
Specimen Num: |
197 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065839 |
|
Specimen Label: |
RBRC_1065839 |
Detected: |
true |
Specimen Num: |
170 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065841 |
|
Specimen Label: |
RBRC_1065841 |
Detected: |
true |
Specimen Num: |
171 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1868228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1066041 |
|
Specimen Label: |
RBRC_1066041 |
Detected: |
true |
Specimen Num: |
271 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1881228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065707 |
|
Specimen Label: |
RBRC_1065707 |
Detected: |
true |
Specimen Num: |
104 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1881228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691103 |
Age: |
postnatal adult |
Image: |
RBRC_1065907 |
|
Specimen Label: |
RBRC_1065907 |
Detected: |
true |
Specimen Num: |
204 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abe TK |
Year: |
2008 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Dynactin is essential for growth cone advance. |
Volume: |
372 |
Issue: |
3 |
Pages: |
418-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoogenraad CC |
Year: |
2001 |
Journal: |
EMBO J |
Title: |
Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes. |
Volume: |
20 |
Issue: |
15 |
Pages: |
4041-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu M |
Year: |
2013 |
Journal: |
Biochim Biophys Acta |
Title: |
Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes. |
Volume: |
1833 |
Issue: |
12 |
Pages: |
3228-3236 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moore CA |
Year: |
2005 |
Journal: |
Reproduction |
Title: |
PAR-1 and the microtubule-associated proteins CLASP2 and dynactin-p50 have specific localisation on mouse meiotic and first mitotic spindles. |
Volume: |
130 |
Issue: |
3 |
Pages: |
311-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dixit R |
Year: |
2008 |
Journal: |
Science |
Title: |
Differential regulation of dynein and kinesin motor proteins by tau. |
Volume: |
319 |
Issue: |
5866 |
Pages: |
1086-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Splinter D |
Year: |
2012 |
Journal: |
Mol Biol Cell |
Title: |
BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures. |
Volume: |
23 |
Issue: |
21 |
Pages: |
4226-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohbayashi N |
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Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
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Helmholtz Zentrum Muenchen GmbH |
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MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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The Gene Ontology Consortium |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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Publication |
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Mouse Genome Informatics Scientific Curators |
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2003 |
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Title: |
MGI Sequence Curation Reference |
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Functional annotation of a full-length mouse cDNA collection. |
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Proc Natl Acad Sci U S A |
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
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Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
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Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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UniProt-GOA |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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The Gene Ontology Consortium |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Mouse Genome Informatics Scientific Curators |
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Mouse Genome Informatics Computational Sequence to Gene Associations |
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Mouse Genome Informatics Scientific Curators |
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Database Download |
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Allen Brain Atlas: mouse riboprobes |
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Mouse Genome Informatics |
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1999 |
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J Cell Biol |
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307-20 |
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|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
402
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
402
 |
Fragment?: |
false |
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•
•
•
•
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Publication |
First Author: |
Jin T |
Year: |
2002 |
Journal: |
J Biol Chem |
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Dynamitin controls Beta 2 integrin avidity by modulating cytoskeletal constraint on integrin molecules. |
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Publication |
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Kardon JR |
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2009 |
Journal: |
Nat Rev Mol Cell Biol |
Title: |
Regulators of the cytoplasmic dynein motor. |
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10 |
Issue: |
12 |
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854-65 |
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•
•
•
•
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Publication |
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Holleran EA |
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1998 |
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Int Rev Cytol |
Title: |
The role of the dynactin complex in intracellular motility. |
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182 |
|
Pages: |
69-109 |
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•
•
•
•
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Publication |
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Karki S |
Year: |
1999 |
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Curr Opin Cell Biol |
Title: |
Cytoplasmic dynein and dynactin in cell division and intracellular transport. |
Volume: |
11 |
Issue: |
1 |
Pages: |
45-53 |
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Protein Domain |
Type: |
Family |
Description: |
Dynactin is a multiprotein complex necessary for the function of microtubule motor protein dynein. The dynein-dynactin complex is involved in a variety of cellular events, includingmembrane vesicle transport, mitotic spindle assembly and centrosome separation [, , ].Dynamitin (dynactin subunit 2, DCTN2) is a subunit of the dynactin complex. In Saccharomyces cerevisiae it is also known as Jnm1. Dynactin contains two distinct structural domains: a projecting sidearm that interacts with dynein and an actin-like minifilament backbone that is thought to bind cargo. Dynamitin holds together both structural domains []. Dynamitin is implicated in cell adhesion by binding to macrophage-enriched myristoylated alanine-rice C kinase substrate (MacMARCKS) []. In mice, DCTN2 is involved in anchoring microtubules to centrosomes and may play a role in synapse formation during brain development []. |
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