| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:6259753 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-12-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3786528 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6259762 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
4A |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vong QP |
| Year: |
2006 |
| Journal: |
J Androl |
| Title: |
Structural characterization and expression studies of Dby and its homologs in the mouse. |
| Volume: |
27 |
| Issue: |
5 |
| Pages: |
653-61 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
2 |
| Description: |
ATP-dependent RNA helicase DDX3X |
| Type: |
chain |
| End: |
662 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ushakov K |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
Genome-wide identification and expression profiling of long non-coding RNAs in auditory and vestibular systems. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
8637 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bermingham NA |
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1996 |
| Journal: |
Mamm Genome |
| Title: |
The gene encoding tripeptidyl peptidase II maps to chromosome 1 in the mouse. |
| Volume: |
7 |
| Issue: |
5 |
| Pages: |
390 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Olson TM |
| Year: |
1998 |
| Journal: |
Genomics |
| Title: |
Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively. |
| Volume: |
51 |
| Issue: |
1 |
| Pages: |
148-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wei C |
| Year: |
2024 |
| Journal: |
Mol Cell |
| Title: |
Imprinted X chromosome inactivation at the gamete-to-embryo transition. |
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•
•
•
•
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Neppl RL |
| Year: |
2017 |
| Journal: |
J Cell Biol |
| Title: |
lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy. |
| Volume: |
216 |
| Issue: |
11 |
| Pages: |
3497-3507 |
|
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•
•
•
•
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| Publication |
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Briard B |
| Year: |
2020 |
| Journal: |
Nature |
| Title: |
Galactosaminogalactan activates the inflammasome to provide host protection. |
| Volume: |
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| Issue: |
7839 |
| Pages: |
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•
•
•
•
•
|
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Sowden JC |
| Year: |
1997 |
| Journal: |
Mamm Genome |
| Title: |
The identification of novel sequences expressed in the mouse notochord. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
42-4 |
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•
•
•
•
•
|
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Li S |
| Year: |
2017 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis. |
| Volume: |
114 |
| Issue: |
34 |
| Pages: |
E7111-E7120 |
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•
•
•
•
•
|
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Xu J |
| Year: |
2002 |
| Journal: |
Hum Mol Genet |
| Title: |
Sex differences in sex chromosome gene expression in mouse brain. |
| Volume: |
11 |
| Issue: |
12 |
| Pages: |
1409-19 |
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•
•
•
•
•
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Guthridge MA |
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1996 |
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Oncogene |
| Title: |
Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts. |
| Volume: |
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| Issue: |
6 |
| Pages: |
1267-78 |
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•
•
•
•
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Williams LH |
| Year: |
2011 |
| Journal: |
Development |
| Title: |
Transcription precedes loss of Xist coating and depletion of H3K27me3 during X-chromosome reprogramming in the mouse inner cell mass. |
| Volume: |
138 |
| Issue: |
10 |
| Pages: |
2049-57 |
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•
•
•
•
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Pang CJ |
| Year: |
2012 |
| Journal: |
Mol Cell Biol |
| Title: |
Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis. |
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| Issue: |
13 |
| Pages: |
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•
•
•
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| Publication |
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Xiao C |
| Year: |
2007 |
| Journal: |
Cell |
| Title: |
The XIST noncoding RNA functions independently of BRCA1 in X inactivation. |
| Volume: |
128 |
| Issue: |
5 |
| Pages: |
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•
•
•
•
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Kazi S |
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2022 |
| Journal: |
FASEB J |
| Title: |
MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice. |
| Volume: |
36 |
| Issue: |
9 |
| Pages: |
e22479 |
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•
•
•
•
|
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| First Author: |
Kalantry S |
| Year: |
2009 |
| Journal: |
Nature |
| Title: |
Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation. |
| Volume: |
460 |
| Issue: |
7255 |
| Pages: |
647-51 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Mugford JW |
| Year: |
2012 |
| Journal: |
Development |
| Title: |
Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation. |
| Volume: |
139 |
| Issue: |
12 |
| Pages: |
2130-8 |
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•
•
•
•
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| Publication |
| First Author: |
Hildebrandt MR |
| Year: |
2019 |
| Journal: |
Dev Biol |
| Title: |
Cytoplasmic aggregation of DDX1 in developing embryos: Early embryonic lethality associated with Ddx1 knockout. |
| Volume: |
455 |
| Issue: |
2 |
| Pages: |
420-433 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory |
| Year: |
2005 |
| Journal: |
Unpublished |
| Title: |
Information obtained from The Jackson Laboratory, Bar Harbor, ME |
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•
•
•
•
•
|
| Publication |
| First Author: |
Bulfone A |
| Year: |
2005 |
| Journal: |
J Neurosci |
| Title: |
Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. |
| Volume: |
25 |
| Issue: |
33 |
| Pages: |
7586-600 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Freeman TC |
| Year: |
1998 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Expression Mapping of Mouse Genes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Mouse Synonym Curation |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Hansen J |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
| Volume: |
100 |
| Issue: |
17 |
| Pages: |
9918-22 |
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•
•
•
•
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| Publication |
| First Author: |
Visel A |
| Year: |
2004 |
| Journal: |
Nucleic Acids Res |
| Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
| Volume: |
32 |
| Issue: |
Database issue |
| Pages: |
D552-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bedogni F |
| Year: |
2021 |
| Journal: |
Front Mol Neurosci |
| Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
| Volume: |
14 |
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| Pages: |
686034 |
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•
•
•
•
|
| Publication |
| First Author: |
MGD Nomenclature Committee |
| Year: |
1995 |
|
| Title: |
Nomenclature Committee Use |
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•
•
•
•
•
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| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
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| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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•
•
•
•
|
| Publication |
| First Author: |
Helmholtz Zentrum Muenchen GmbH |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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•
•
•
•
•
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| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
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| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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•
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
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| Title: |
MGI Sequence Curation Reference |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
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| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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•
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| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
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| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
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| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
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| Title: |
Annotation inferences using phylogenetic trees |
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| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
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Allen Institute for Brain Science |
| Year: |
2004 |
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Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
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Mouse Genome Informatics Scientific Curators |
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2009 |
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Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
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| Title: |
Consensus CDS project |
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| Year: |
2003 |
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Automatic Encodes (AutoE) Reference |
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2005 |
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Database Download |
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MGI-UniGene Interconnection Effort |
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•
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•
•
•
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| Allele |
| Name: |
DEAD box helicase 3, X-linked; endonuclease-mediated mutation 1.1, Thirumala-Devi Kanneganti |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang W |
| Year: |
2021 |
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Sci Adv |
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RNF39 mediates K48-linked ubiquitination of DDX3X and inhibits RLR-dependent antiviral immunity. |
| Volume: |
7 |
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10 |
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•
•
•
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Fu X |
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2024 |
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Exp Neurol |
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DDX3X overexpression decreases dipeptide repeat proteins in a mouse model of C9ORF72-ALS/FTD. |
| Volume: |
376 |
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| Pages: |
114768 |
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•
•
•
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Yagüe J |
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2000 |
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J Exp Med |
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| Volume: |
191 |
| Issue: |
12 |
| Pages: |
2083-92 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
662
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gong C |
| Year: |
2021 |
| Journal: |
Mol Cell |
| Title: |
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis. |
| Volume: |
81 |
| Issue: |
19 |
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4059-4075.e11 |
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•
•
•
•
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| Publication |
| First Author: |
Liu C |
| Year: |
2023 |
| Journal: |
Theranostics |
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Kindlin-2 enhances c-Myc translation through association with DDX3X to promote pancreatic ductal adenocarcinoma progression. |
| Volume: |
13 |
| Issue: |
13 |
| Pages: |
4333-4355 |
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•
•
•
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Doñate-Macián P |
| Year: |
2018 |
| Journal: |
Nat Commun |
| Title: |
The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
2307 |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
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•
•
•
•
|
| Publication |
| First Author: |
Sekiguchi T |
| Year: |
2004 |
| Journal: |
Exp Cell Res |
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Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation. |
| Volume: |
300 |
| Issue: |
1 |
| Pages: |
213-22 |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Allele |
| Name: |
DEAD box helicase 3, X-linked; endonuclease-mediated mutation 1, Cathy Lutz |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, Humanized sequence |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
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•
•
•
|
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Dardaei L |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
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Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis. |
| Volume: |
111 |
| Issue: |
10 |
| Pages: |
E896-905 |
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•
•
•
•
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| Publication |
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Randolph ME |
| Year: |
2024 |
| Journal: |
iScience |
| Title: |
RNA helicase DDX3 regulates RAD51 localization and DNA damage repair in Ewing sarcoma. |
| Volume: |
27 |
| Issue: |
2 |
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108925 |
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Nguyen LXT |
| Year: |
2021 |
| Journal: |
Leukemia |
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Cytoplasmic DROSHA and non-canonical mechanisms of MiR-155 biogenesis in FLT3-ITD acute myeloid leukemia. |
| Volume: |
35 |
| Issue: |
8 |
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•
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Wang J |
| Year: |
2017 |
| Journal: |
J Clin Invest |
| Title: |
RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs. |
| Volume: |
127 |
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•
•
•
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| First Author: |
Werler S |
| Year: |
2011 |
| Journal: |
Acta Paediatr |
| Title: |
Expression of selected genes escaping from X inactivation in the 41, XX(Y)* mouse model for Klinefelter's syndrome. |
| Volume: |
100 |
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•
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Shang C |
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Cancer Lett |
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CXCL10 conditions alveolar macrophages within the premetastatic niche to promote metastasis. |
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215667 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Leroy P |
| Year: |
1989 |
| Journal: |
Cell |
| Title: |
The protein encoded by a murine male germ cell-specific transcript is a putative ATP-dependent RNA helicase. |
| Volume: |
57 |
| Issue: |
4 |
| Pages: |
549-59 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Session DR |
| Year: |
2001 |
| Journal: |
Fertil Steril |
| Title: |
Characterization of D1Pas1, a mouse autosomal homologue of the human AZFa region DBY, as a nuclear protein in spermatogenic cells. |
| Volume: |
76 |
| Issue: |
4 |
| Pages: |
804-11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Leroy P |
| Year: |
1987 |
| Journal: |
Development |
| Title: |
Testis-specific transcripts detected by a human Y-DNA-derived probe. |
| Volume: |
101 Suppl |
|
| Pages: |
177-83 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5614795 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2015-02-09 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689428 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5614893 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Brain |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|