Type |
Details |
Score |
Publication |
First Author: |
Malty RH |
Year: |
2017 |
Journal: |
Cell Syst |
Title: |
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. |
Volume: |
5 |
Issue: |
6 |
Pages: |
564-577.e12 |
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•
•
•
•
•
|
Publication |
First Author: |
Kim JG |
Year: |
1997 |
Journal: |
J Neurosci Res |
Title: |
Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. |
Volume: |
50 |
Issue: |
2 |
Pages: |
272-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peng MZ |
Year: |
2022 |
Journal: |
Cell Mol Life Sci |
Title: |
Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism. |
Volume: |
79 |
Issue: |
7 |
Pages: |
375 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ayyangar U |
Year: |
2024 |
Journal: |
EMBO J |
Title: |
Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin. |
Volume: |
43 |
Issue: |
7 |
Pages: |
1113-1134 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lyu MS |
Year: |
1996 |
Journal: |
Mamm Genome |
Title: |
Genetic mapping of the human and mouse phospholipase C genes. |
Volume: |
7 |
Issue: |
7 |
Pages: |
501-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Di Michele M |
Year: |
2025 |
Journal: |
Nat Commun |
Title: |
E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development. |
Volume: |
16 |
Issue: |
1 |
Pages: |
67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cankaya M |
Year: |
2007 |
Journal: |
BMC Genomics |
Title: |
An analysis of expression patterns of genes encoding proteins with catalytic activities. |
Volume: |
8 |
|
Pages: |
232 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bowman CE |
Year: |
2016 |
Journal: |
Mol Cell Biol |
Title: |
Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. |
Volume: |
36 |
Issue: |
15 |
Pages: |
2089-104 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bulusu V |
Year: |
2017 |
Journal: |
Dev Cell |
Title: |
Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. |
Volume: |
40 |
Issue: |
4 |
Pages: |
331-341.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Werner HB |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. |
Volume: |
27 |
Issue: |
29 |
Pages: |
7717-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mootha VK |
Year: |
2003 |
Journal: |
Cell |
Title: |
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. |
Volume: |
115 |
Issue: |
5 |
Pages: |
629-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pagliarini DJ |
Year: |
2008 |
Journal: |
Cell |
Title: |
A mitochondrial protein compendium elucidates complex I disease biology. |
Volume: |
134 |
Issue: |
1 |
Pages: |
112-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
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|
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•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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|
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•
•
•
•
•
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Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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|
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•
•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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|
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•
•
•
•
•
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Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
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•
•
•
•
•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
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|
|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
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•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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|
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
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•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
484
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kato O |
Year: |
2010 |
Journal: |
BMC Microbiol |
Title: |
Quinone-dependent D-lactate dehydrogenase Dld (Cg1027) is essential for growth of Corynebacterium glutamicum on D-lactate. |
Volume: |
10 |
|
Pages: |
321 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
This superfamily represents the death-like domain (DLD) of Spt6 (Suppressor of Ty 6, originally discovered in Saccharomyces cerevisiae), a gene that influences general transcription through manipulation of chromatin structure at upstream promoter elements [].This DLD domain maintains the characteristic overall topology of death domains, as it consists of a six-helix bundle with three stacked antiparallel helices and an additional helix inserted between the final two helices of the bundle. The Spt6 DLD prominent location and the observation that it displays the most highly conserved region of the Spt6 surface suggest that it mediates important intermolecular interactions [, ]. |
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•
•
•
•
•
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Publication |
First Author: |
Kiely CM |
Year: |
2011 |
Journal: |
Mol Cell Biol |
Title: |
Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe. |
Volume: |
31 |
Issue: |
20 |
Pages: |
4193-204 |
|
•
•
•
•
•
|
Publication |
First Author: |
Flick MJ |
Year: |
2002 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Identification of putative mammalian D-lactate dehydrogenase enzymes. |
Volume: |
295 |
Issue: |
4 |
Pages: |
910-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
McDonald SM |
Year: |
2010 |
Journal: |
Mol Cell |
Title: |
Structure and biological importance of the Spn1-Spt6 interaction, and its regulatory role in nucleosome binding. |
Volume: |
40 |
Issue: |
5 |
Pages: |
725-35 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
D-lactate dehydrogenases catalyse the reversible oxidation of D-lactate to pyruvate. This entry represents the NADH-independent D-lactate dehydrogenases found in many bacterial species. These are membrane-associated respiratory enzymes which contain an FAD cofactor and transfer electrons derived from susbstrate oxidation to the electron transfer chain. The energy derived from this reaction can be coupled either to ATP generation or the active uptake of solutes. The Escherichia coli enzyme () is a peripheral membrane enzyme located on the cyctoplasmic side of the inner membrane, which passes the electrons derived from substrate oxidation to the quinone component of the electron transfer chain []. It is composed of three domains: an FAD-binding domain, a cap domain and a membrane-binding domain. The FAD-binding domain has a similar fold to that of other FAD-linked enzymes, being composed of two α-β subdomains, with the FAD cofactor being accommodated between them. The cap domain forms an α-β-alpha sandwich, while the membrane-binding region is composed of four alpha helices which show an excess of basic residues over acidic ones. The enzyme is thought to be anchored to the membrane by electrostatic interactions between these basic reidues and the negatively charged phospholipid head groups of the membrane. The active site of the enzyme is not known, but is thought to be located close to the FAD-binding site, at the interface of all three domains.Proteins in this entry also include quinone-dependent D-lactate dehydrogenase Dld from Corynebacterium glutamicum. It is essential for growth with D-lactate as sole carbon source []. |
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•
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•
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Publication |
First Author: |
Yang HS |
Year: |
1999 |
Journal: |
Biochem J |
Title: |
Roles of an Ets motif and a novel CACGAC direct repeat in transcription of the murine dihydrolipoamide dehydrogenase (Dld) gene. |
Volume: |
338 ( Pt 3) |
|
Pages: |
667-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Close D |
Year: |
2011 |
Journal: |
J Mol Biol |
Title: |
Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. |
Volume: |
408 |
Issue: |
4 |
Pages: |
697-713 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
658
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Dym O |
Year: |
2000 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The crystal structure of D-lactate dehydrogenase, a peripheral membrane respiratory enzyme. |
Volume: |
97 |
Issue: |
17 |
Pages: |
9413-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1726
 |
Fragment?: |
false |
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•
•
•
•
|