Type |
Details |
Score |
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Takemoto K |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination. |
Volume: |
31 |
Issue: |
8 |
Pages: |
107686 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ploquin M |
Year: |
2007 |
Journal: |
Nucleic Acids Res |
Title: |
Stimulation of fission yeast and mouse Hop2-Mnd1 of the Dmc1 and Rad51 recombinases. |
Volume: |
35 |
Issue: |
8 |
Pages: |
2719-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zainu A |
Year: |
2024 |
Journal: |
Nat Commun |
Title: |
FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading. |
Volume: |
15 |
Issue: |
1 |
Pages: |
7015 |
|
•
•
•
•
•
|
QTL |
Type: |
QTL |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao W |
Year: |
2015 |
Journal: |
Nucleic Acids Res |
Title: |
Significance of ligand interactions involving Hop2-Mnd1 and the RAD51 and DMC1 recombinases in homologous DNA repair and XX ovarian dysgenesis. |
Volume: |
43 |
Issue: |
8 |
Pages: |
4055-66 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
p53 Protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Significance of ligand interactions involving Hop2-Mnd1 and the RAD51 and DMC1 recombinases in homologous DNA repair and XX ovarian dysgenesis. |
|
•
•
•
•
•
|
Publication |
First Author: |
Habu T |
Year: |
2004 |
Journal: |
Carcinogenesis |
Title: |
p53 Protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis. |
Volume: |
25 |
Issue: |
6 |
Pages: |
889-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bishop DK |
Year: |
1999 |
Journal: |
Genes Cells |
Title: |
High copy number suppression of the meiotic arrest caused by a dmc1 mutation: REC114 imposes an early recombination block and RAD54 promotes a DMC1-independent DSB repair pathway. |
Volume: |
4 |
Issue: |
8 |
Pages: |
425-44 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes Mei5 from budding yeasts and SFR1 from animals and fission yeasts. Although the fission yeast Swi5-Sfr1 complex is critical for homologous recombination repair, the budding yeast counterpart Sae3-Mei5 complex is meiosis-specific, interacts with Dmc1, and promotes assembly of Dmc1 on meiotic chromosomes [].SFR is a component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination []. Mei5 is one of a pair of meiosis-specific proteins which facilitate the loading of Dmc1 on to Rad51 on DNA at double-strand breaks during recombination. Recombination is carried out by a large protein complex based around the two RecA homologues, Rad51 and Dmc1 []. This complex may play both a catalytic and a structural role in the interaction between homologous chromosomes during meiosis. Mei5 is seen to contain a coiled-coli region. |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Homologous-pairing protein 2 (Hop2) is required for proper homologous pairing and efficient cross-over and intragenic recombination during meiosis [, , ].The mammalian HOP2 homologue, TBPIP, was first identified as a factor interacting with TBP-1, which binds to the human immunodeficiency virus, type 1 Tat protein []. Later, TBPIP was found to be an activator that specifically stimulates the homologous pairing catalyzed by DMC1 []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Tanaka T |
Year: |
1997 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Molecular cloning and characterization of a novel TBP-1 interacting protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP. |
Volume: |
239 |
Issue: |
1 |
Pages: |
176-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leu JY |
Year: |
1998 |
Journal: |
Cell |
Title: |
The meiosis-specific Hop2 protein of S. cerevisiae ensures synapsis between homologous chromosomes. |
Volume: |
94 |
Issue: |
3 |
Pages: |
375-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nabeshima K |
Year: |
2001 |
Journal: |
EMBO J |
Title: |
A novel meiosis-specific protein of fission yeast, Meu13p, promotes homologous pairing independently of homologous recombination. |
Volume: |
20 |
Issue: |
14 |
Pages: |
3871-81 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
600
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
106
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
605
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Brme1 (also known as Meiok21) is a component of meiotic recombination bridges involved in meiotic double-strand break repair [, ]. The C-terminal domain of Brme1 physically interacts with the N-terminal domain of HSF2BP []. BRME1 facilitates the loading of RAD51 and DMC1 recombinases onto DSBs (DNA double-strand breaks) through interaction with MEILB2/HSF2BP and replacing ssDNA binding proteins []. Brme1 is highly expressed in mice testes and fetal ovaries. Knockout of Brme1 results in male mice infertility []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Homologous-pairing protein 2 (Hop2) is required for proper homologous pairing and efficient cross-over and intragenic recombination during meiosis [, , ].The mammalian HOP2 homologue, TBPIP, was first identified as a factor interacting with TBP-1, which binds to the human immunodeficiency virus, type 1 Tat protein []. Later, TBPIP was found to be an activator that specifically stimulates the homologous pairing catalyzed by DMC1 []. This entry represents the winged helix domain found in Hop2. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
319
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
303
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Yuan J |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
The role of the human SWI5-MEI5 complex in homologous recombination repair. |
Volume: |
286 |
Issue: |
11 |
Pages: |
9888-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawabata M |
Year: |
1998 |
Journal: |
Biochim Biophys Acta |
Title: |
Sequence analysis and expression of a novel mouse homolog of Escherichia coli recA gene. |
Volume: |
1398 |
Issue: |
3 |
Pages: |
353-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
92
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang HA |
Year: |
2015 |
Journal: |
Nucleic Acids Res |
Title: |
Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination. |
Volume: |
43 |
Issue: |
7 |
Pages: |
3841-56 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This domain is found at the C-terminal region of Hop2 and Mnd1 proteins. In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex. Hop2 (for homologous pairing; also known as TBPIP) is expressed specifically during meiosis, same as Mnd1 (for meiotic nuclear divisions 1). The C-terminal region of both Hop2 and Mnd1, folds into three α-helices that are interrupted by two short non-helical regions. These α-helices of the two proteins together form a parallel coiled coil that provides the major interface for heterodimer formation. The non-helical regions form substantially kinked junctions between adjacent leucine zippers: the LZ1-LZ2 and LZ2-LZ3 junctions.This domain is the C-terminal segment of Hop2 and Mnd1 which folds back onto the C-terminal leucine zipper (LZ3) to form a helical bundle-like structure, hence designated LZ3wCH (for LZ3 with capping helices). The LZ3wCH region plays a role in interacting with the Dmc1 nucleofilament []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Wells D |
Year: |
2020 |
Journal: |
Elife |
Title: |
ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zamudio N |
Year: |
2015 |
Journal: |
Genes Dev |
Title: |
DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination. |
Volume: |
29 |
Issue: |
12 |
Pages: |
1256-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bai L |
Year: |
2024 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
BRCA1 safeguards genome integrity by activating chromosome asynapsis checkpoint to eliminate recombination-defective oocytes. |
Volume: |
121 |
Issue: |
19 |
Pages: |
e2401386121 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pacheco S |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
ATR is required to complete meiotic recombination in mice. |
Volume: |
9 |
Issue: |
1 |
Pages: |
2622 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abreu CM |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination. |
Volume: |
9 |
Issue: |
1 |
Pages: |
3961 |
|
•
•
•
•
•
|
Publication |
First Author: |
Romanienko PJ |
Year: |
2000 |
Journal: |
Mol Cell |
Title: |
The mouse Spo11 gene is required for meiotic chromosome synapsis. |
Volume: |
6 |
Issue: |
5 |
Pages: |
975-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jeon Y |
Year: |
2019 |
Journal: |
Biochem Biophys Res Commun |
Title: |
TopBP1 deficiency impairs the localization of proteins involved in early recombination and results in meiotic chromosome defects during spermatogenesis. |
Volume: |
508 |
Issue: |
3 |
Pages: |
722-728 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu C |
Year: |
2023 |
Journal: |
Nucleic Acids Res |
Title: |
RNase H1 facilitates recombinase recruitment by degrading DNA-RNA hybrids during meiosis. |
Volume: |
51 |
Issue: |
14 |
Pages: |
7357-7375 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ghouil R |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination. |
Volume: |
12 |
Issue: |
1 |
Pages: |
4605 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao W |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing. |
Volume: |
42 |
Issue: |
2 |
Pages: |
906-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sansam CL |
Year: |
2015 |
Journal: |
FEBS J |
Title: |
Connecting by breaking and repairing: mechanisms of DNA strand exchange in meiotic recombination. |
Volume: |
282 |
Issue: |
13 |
Pages: |
2444-57 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
217
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
217
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
85
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Pezza RJ |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Molecular activities of meiosis-specific proteins Hop2, Mnd1, and the Hop2-Mnd1 complex. |
Volume: |
281 |
Issue: |
27 |
Pages: |
18426-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adelman CA |
Year: |
2008 |
Journal: |
PLoS Genet |
Title: |
ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over. |
Volume: |
4 |
Issue: |
3 |
Pages: |
e1000042 |
|
•
•
•
•
•
|
Publication |
First Author: |
Decarpentrie F |
Year: |
2016 |
Journal: |
Chromosoma |
Title: |
Recombination between the mouse Y chromosome short arm and an additional Y short arm-derived chromosomal segment attached distal to the X chromosome PAR. |
Volume: |
125 |
Issue: |
2 |
Pages: |
177-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moens PB |
Year: |
1999 |
Journal: |
Chromosoma |
Title: |
The association of ATR protein with mouse meiotic chromosome cores. |
Volume: |
108 |
Issue: |
2 |
Pages: |
95-102 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen RK |
Year: |
2016 |
Journal: |
Nat Cell Biol |
Title: |
SCAI promotes DNA double-strand break repair in distinct chromosomal contexts. |
Volume: |
18 |
Issue: |
12 |
Pages: |
1357-1366 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stielow B |
Year: |
2010 |
Journal: |
PLoS Genet |
Title: |
Epigenetic silencing of spermatocyte-specific and neuronal genes by SUMO modification of the transcription factor Sp3. |
Volume: |
6 |
Issue: |
11 |
Pages: |
e1001203 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kidane D |
Year: |
2010 |
Journal: |
EMBO J |
Title: |
DNA polymerase beta is critical for mouse meiotic synapsis. |
Volume: |
29 |
Issue: |
2 |
Pages: |
410-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Faieta M |
Year: |
2016 |
Journal: |
Chromosoma |
Title: |
A surge of late-occurring meiotic double-strand breaks rescues synapsis abnormalities in spermatocytes of mice with hypomorphic expression of SPO11. |
Volume: |
125 |
Issue: |
2 |
Pages: |
189-203 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pezza RJ |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The dual role of HOP2 in mammalian meiotic homologous recombination. |
Volume: |
42 |
Issue: |
4 |
Pages: |
2346-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vasileva A |
Year: |
2013 |
Journal: |
J Cell Sci |
Title: |
The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse. |
Volume: |
126 |
Issue: |
Pt 17 |
Pages: |
3927-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Menon DU |
Year: |
2024 |
Journal: |
Elife |
Title: |
ARID1A governs the silencing of sex-linked transcription during male meiosis in the mouse. |
Volume: |
12 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Takabayashi S |
Year: |
2009 |
Journal: |
Exp Biol Med (Maywood) |
Title: |
A spontaneous smc1b mutation causes cohesin protein dysfunction and sterility in mice. |
Volume: |
234 |
Issue: |
8 |
Pages: |
994-1001 |
|
•
•
•
•
•
|
Publication |
First Author: |
Petrillo C |
Year: |
2020 |
Journal: |
Chromosoma |
Title: |
shani mutation in mouse affects splicing of Spata22 and leads to impaired meiotic recombination. |
Volume: |
129 |
Issue: |
2 |
Pages: |
161-179 |
|
•
•
•
•
•
|
Publication |
First Author: |
Solinger JA |
Year: |
1999 |
Journal: |
Mol Cell Biol |
Title: |
Active-site mutations in the Xrn1p exoribonuclease of Saccharomyces cerevisiae reveal a specific role in meiosis. |
Volume: |
19 |
Issue: |
9 |
Pages: |
5930-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Menon DU |
Year: |
2024 |
Journal: |
bioRxiv |
Title: |
ARID1A governs the silencing of sex-linked transcription during male meiosis in the mouse. |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
205
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
992
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Seeliger K |
Year: |
2012 |
Journal: |
New Phytol |
Title: |
BRCA2 is a mediator of RAD51- and DMC1-facilitated homologous recombination in Arabidopsis thaliana. |
Volume: |
193 |
Issue: |
2 |
Pages: |
364-75 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The breast cancer type 2 susceptibility protein (BRCA2) is a breast tumour suppressor involved in double-strand break repair and/or homologous recombination []. BRCA2 gene expression is regulated in a cell-cycle dependent manner and peak expression of BRCA2 mRNA occurring in S phase, suggesting BRCA2 may participate in regulating cell proliferation. BRCA2, and related protein BRCA1, have transcriptional activation potential and the two proteins are associated with the activation of double-strand break repair and/or homologous recombination. The two proteins have been shown to coexist and colocalize in a biochemical complex. BRCA2 has a number of 39 amino acid repeats []that are critical for binding to RAD51 (a key protein in DNA recombinational repair) and resistance to methyl methanesulphonate treatment [, , ]. There are eight repeats in BRCA2 designated as BRC1 to BRC8. BRC1, BRC2, BRC3, BRC4, BRC7, and BRC8 have high sequence identity and bind to Rad51, whereas BRC5 and BRC6 are less well conserved and are unable to bind Rad51 []. It has been suggested that BRCA2 plays a role in positioning Rad51 at the site of DNA repair or in removing Rad51 from DNA once repair has been completed.Mutations in BRCA1 and BRCA2 have been linked to an elevated risk of young onset breast cancer and confer a high risk of the disease through a dominantly inherited fashion []. BRCA2 mutations are typically microdeletions.Homologues exist in plants: the BRCA2A and BRCA2B proteins from Arabidopsis thalianaare required for repair of breaks in double-stranded DNA and homologous recombination and in the prophase stage of meiosis are required for formation of RAD51 and DMC1 foci in males []. |
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•
•
•
•
•
|
Publication |
First Author: |
Carofiglio F |
Year: |
2013 |
Journal: |
PLoS Genet |
Title: |
SPO11-independent DNA repair foci and their role in meiotic silencing. |
Volume: |
9 |
Issue: |
6 |
Pages: |
e1003538 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koornneef L |
Year: |
2022 |
Journal: |
PLoS Genet |
Title: |
Multi-color dSTORM microscopy in Hormad1-/- spermatocytes reveals alterations in meiotic recombination intermediates and synaptonemal complex structure. |
Volume: |
18 |
Issue: |
7 |
Pages: |
e1010046 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bork P |
Year: |
1996 |
Journal: |
Nat Genet |
Title: |
Internal repeats in the BRCA2 protein sequence. |
Volume: |
13 |
Issue: |
1 |
Pages: |
22-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wong AK |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2. |
Volume: |
272 |
Issue: |
51 |
Pages: |
31941-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen PL |
Year: |
1998 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. |
Volume: |
95 |
Issue: |
9 |
Pages: |
5287-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marmorstein LY |
Year: |
1998 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The BRCA2 gene product functionally interacts with p53 and RAD51. |
Volume: |
95 |
Issue: |
23 |
Pages: |
13869-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen CF |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control. |
Volume: |
274 |
Issue: |
46 |
Pages: |
32931-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Walker LC |
Year: |
2010 |
Journal: |
Hum Mutat |
Title: |
Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: implications for prediction of pathogenicity. |
Volume: |
31 |
Issue: |
6 |
Pages: |
E1484-505 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
747
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Pellegrini L |
Year: |
2002 |
Journal: |
Nature |
Title: |
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. |
Volume: |
420 |
Issue: |
6913 |
Pages: |
287-93 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
3329
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1180
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
3329
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|