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Search results 301 to 397 out of 397 for Dmc1

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0.024s
Type Details Score
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Takemoto K
Year: 2020
Journal: Cell Rep
Title: Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination.
Volume: 31
Issue: 8
Pages: 107686
Publication
First Author: Ploquin M
Year: 2007
Journal: Nucleic Acids Res
Title: Stimulation of fission yeast and mouse Hop2-Mnd1 of the Dmc1 and Rad51 recombinases.
Volume: 35
Issue: 8
Pages: 2719-33
Publication
First Author: Zainu A
Year: 2024
Journal: Nat Commun
Title: FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading.
Volume: 15
Issue: 1
Pages: 7015
QTL
Type: QTL
Organism: mouse, laboratory
Publication
First Author: Zhao W
Year: 2015
Journal: Nucleic Acids Res
Title: Significance of ligand interactions involving Hop2-Mnd1 and the RAD51 and DMC1 recombinases in homologous DNA repair and XX ovarian dysgenesis.
Volume: 43
Issue: 8
Pages: 4055-66
Interaction Experiment
Description: p53 Protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis.
Interaction Experiment
Description: Significance of ligand interactions involving Hop2-Mnd1 and the RAD51 and DMC1 recombinases in homologous DNA repair and XX ovarian dysgenesis.
Publication
First Author: Habu T
Year: 2004
Journal: Carcinogenesis
Title: p53 Protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis.
Volume: 25
Issue: 6
Pages: 889-93
Publication
First Author: Bishop DK
Year: 1999
Journal: Genes Cells
Title: High copy number suppression of the meiotic arrest caused by a dmc1 mutation: REC114 imposes an early recombination block and RAD54 promotes a DMC1-independent DSB repair pathway.
Volume: 4
Issue: 8
Pages: 425-44
Protein Domain
Type: Family
Description: This entry includes Mei5 from budding yeasts and SFR1 from animals and fission yeasts. Although the fission yeast Swi5-Sfr1 complex is critical for homologous recombination repair, the budding yeast counterpart Sae3-Mei5 complex is meiosis-specific, interacts with Dmc1, and promotes assembly of Dmc1 on meiotic chromosomes [].SFR is a component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination []. Mei5 is one of a pair of meiosis-specific proteins which facilitate the loading of Dmc1 on to Rad51 on DNA at double-strand breaks during recombination. Recombination is carried out by a large protein complex based around the two RecA homologues, Rad51 and Dmc1 []. This complex may play both a catalytic and a structural role in the interaction between homologous chromosomes during meiosis. Mei5 is seen to contain a coiled-coli region.
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Protein Domain
Type: Family
Description: Homologous-pairing protein 2 (Hop2) is required for proper homologous pairing and efficient cross-over and intragenic recombination during meiosis [, , ].The mammalian HOP2 homologue, TBPIP, was first identified as a factor interacting with TBP-1, which binds to the human immunodeficiency virus, type 1 Tat protein []. Later, TBPIP was found to be an activator that specifically stimulates the homologous pairing catalyzed by DMC1 [].
Publication
First Author: Tanaka T
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and characterization of a novel TBP-1 interacting protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP.
Volume: 239
Issue: 1
Pages: 176-81
Publication
First Author: Leu JY
Year: 1998
Journal: Cell
Title: The meiosis-specific Hop2 protein of S. cerevisiae ensures synapsis between homologous chromosomes.
Volume: 94
Issue: 3
Pages: 375-86
Publication
First Author: Nabeshima K
Year: 2001
Journal: EMBO J
Title: A novel meiosis-specific protein of fission yeast, Meu13p, promotes homologous pairing independently of homologous recombination.
Volume: 20
Issue: 14
Pages: 3871-81
Protein
Organism: Mus musculus/domesticus
Length: 600  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 605  
Fragment?: false
Protein Domain
Type: Family
Description: Brme1 (also known as Meiok21) is a component of meiotic recombination bridges involved in meiotic double-strand break repair [, ]. The C-terminal domain of Brme1 physically interacts with the N-terminal domain of HSF2BP []. BRME1 facilitates the loading of RAD51 and DMC1 recombinases onto DSBs (DNA double-strand breaks) through interaction with MEILB2/HSF2BP and replacing ssDNA binding proteins []. Brme1 is highly expressed in mice testes and fetal ovaries. Knockout of Brme1 results in male mice infertility [].
Protein Domain
Type: Domain
Description: Homologous-pairing protein 2 (Hop2) is required for proper homologous pairing and efficient cross-over and intragenic recombination during meiosis [, , ].The mammalian HOP2 homologue, TBPIP, was first identified as a factor interacting with TBP-1, which binds to the human immunodeficiency virus, type 1 Tat protein []. Later, TBPIP was found to be an activator that specifically stimulates the homologous pairing catalyzed by DMC1 []. This entry represents the winged helix domain found in Hop2.
Protein
Organism: Mus musculus/domesticus
Length: 319  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
Publication
First Author: Yuan J
Year: 2011
Journal: J Biol Chem
Title: The role of the human SWI5-MEI5 complex in homologous recombination repair.
Volume: 286
Issue: 11
Pages: 9888-93
Publication
First Author: Kawabata M
Year: 1998
Journal: Biochim Biophys Acta
Title: Sequence analysis and expression of a novel mouse homolog of Escherichia coli recA gene.
Volume: 1398
Issue: 3
Pages: 353-8
Protein
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
Publication
First Author: Kang HA
Year: 2015
Journal: Nucleic Acids Res
Title: Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination.
Volume: 43
Issue: 7
Pages: 3841-56
Protein Domain
Type: Domain
Description: This domain is found at the C-terminal region of Hop2 and Mnd1 proteins. In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex. Hop2 (for homologous pairing; also known as TBPIP) is expressed specifically during meiosis, same as Mnd1 (for meiotic nuclear divisions 1). The C-terminal region of both Hop2 and Mnd1, folds into three α-helices that are interrupted by two short non-helical regions. These α-helices of the two proteins together form a parallel coiled coil that provides the major interface for heterodimer formation. The non-helical regions form substantially kinked junctions between adjacent leucine zippers: the LZ1-LZ2 and LZ2-LZ3 junctions.This domain is the C-terminal segment of Hop2 and Mnd1 which folds back onto the C-terminal leucine zipper (LZ3) to form a helical bundle-like structure, hence designated LZ3wCH (for LZ3 with capping helices). The LZ3wCH region plays a role in interacting with the Dmc1 nucleofilament [].
Publication    
First Author: Wells D
Year: 2020
Journal: Elife
Title: ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair.
Volume: 9
Publication
First Author: Zamudio N
Year: 2015
Journal: Genes Dev
Title: DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination.
Volume: 29
Issue: 12
Pages: 1256-70
Publication
First Author: Bai L
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: BRCA1 safeguards genome integrity by activating chromosome asynapsis checkpoint to eliminate recombination-defective oocytes.
Volume: 121
Issue: 19
Pages: e2401386121
Publication
First Author: Pacheco S
Year: 2018
Journal: Nat Commun
Title: ATR is required to complete meiotic recombination in mice.
Volume: 9
Issue: 1
Pages: 2622
Publication
First Author: Abreu CM
Year: 2018
Journal: Nat Commun
Title: Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination.
Volume: 9
Issue: 1
Pages: 3961
Publication
First Author: Romanienko PJ
Year: 2000
Journal: Mol Cell
Title: The mouse Spo11 gene is required for meiotic chromosome synapsis.
Volume: 6
Issue: 5
Pages: 975-87
Publication
First Author: Jeon Y
Year: 2019
Journal: Biochem Biophys Res Commun
Title: TopBP1 deficiency impairs the localization of proteins involved in early recombination and results in meiotic chromosome defects during spermatogenesis.
Volume: 508
Issue: 3
Pages: 722-728
Publication
First Author: Liu C
Year: 2023
Journal: Nucleic Acids Res
Title: RNase H1 facilitates recombinase recruitment by degrading DNA-RNA hybrids during meiosis.
Volume: 51
Issue: 14
Pages: 7357-7375
Publication
First Author: Ghouil R
Year: 2021
Journal: Nat Commun
Title: BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination.
Volume: 12
Issue: 1
Pages: 4605
Publication
First Author: Zhao W
Year: 2014
Journal: Nucleic Acids Res
Title: Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing.
Volume: 42
Issue: 2
Pages: 906-17
Publication
First Author: Sansam CL
Year: 2015
Journal: FEBS J
Title: Connecting by breaking and repairing: mechanisms of DNA strand exchange in meiotic recombination.
Volume: 282
Issue: 13
Pages: 2444-57
Protein
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: false
Publication
First Author: Pezza RJ
Year: 2006
Journal: J Biol Chem
Title: Molecular activities of meiosis-specific proteins Hop2, Mnd1, and the Hop2-Mnd1 complex.
Volume: 281
Issue: 27
Pages: 18426-34
Publication
First Author: Adelman CA
Year: 2008
Journal: PLoS Genet
Title: ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over.
Volume: 4
Issue: 3
Pages: e1000042
Publication
First Author: Decarpentrie F
Year: 2016
Journal: Chromosoma
Title: Recombination between the mouse Y chromosome short arm and an additional Y short arm-derived chromosomal segment attached distal to the X chromosome PAR.
Volume: 125
Issue: 2
Pages: 177-88
Publication
First Author: Moens PB
Year: 1999
Journal: Chromosoma
Title: The association of ATR protein with mouse meiotic chromosome cores.
Volume: 108
Issue: 2
Pages: 95-102
Publication
First Author: Hansen RK
Year: 2016
Journal: Nat Cell Biol
Title: SCAI promotes DNA double-strand break repair in distinct chromosomal contexts.
Volume: 18
Issue: 12
Pages: 1357-1366
Publication
First Author: Stielow B
Year: 2010
Journal: PLoS Genet
Title: Epigenetic silencing of spermatocyte-specific and neuronal genes by SUMO modification of the transcription factor Sp3.
Volume: 6
Issue: 11
Pages: e1001203
Publication
First Author: Kidane D
Year: 2010
Journal: EMBO J
Title: DNA polymerase beta is critical for mouse meiotic synapsis.
Volume: 29
Issue: 2
Pages: 410-23
Publication
First Author: Faieta M
Year: 2016
Journal: Chromosoma
Title: A surge of late-occurring meiotic double-strand breaks rescues synapsis abnormalities in spermatocytes of mice with hypomorphic expression of SPO11.
Volume: 125
Issue: 2
Pages: 189-203
Publication
First Author: Pezza RJ
Year: 2014
Journal: Nucleic Acids Res
Title: The dual role of HOP2 in mammalian meiotic homologous recombination.
Volume: 42
Issue: 4
Pages: 2346-57
Publication
First Author: Vasileva A
Year: 2013
Journal: J Cell Sci
Title: The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse.
Volume: 126
Issue: Pt 17
Pages: 3927-38
Publication    
First Author: Menon DU
Year: 2024
Journal: Elife
Title: ARID1A governs the silencing of sex-linked transcription during male meiosis in the mouse.
Volume: 12
Publication
First Author: Takabayashi S
Year: 2009
Journal: Exp Biol Med (Maywood)
Title: A spontaneous smc1b mutation causes cohesin protein dysfunction and sterility in mice.
Volume: 234
Issue: 8
Pages: 994-1001
Publication
First Author: Petrillo C
Year: 2020
Journal: Chromosoma
Title: shani mutation in mouse affects splicing of Spata22 and leads to impaired meiotic recombination.
Volume: 129
Issue: 2
Pages: 161-179
Publication
First Author: Solinger JA
Year: 1999
Journal: Mol Cell Biol
Title: Active-site mutations in the Xrn1p exoribonuclease of Saccharomyces cerevisiae reveal a specific role in meiosis.
Volume: 19
Issue: 9
Pages: 5930-42
Publication      
First Author: Menon DU
Year: 2024
Journal: bioRxiv
Title: ARID1A governs the silencing of sex-linked transcription during male meiosis in the mouse.
Protein
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 992  
Fragment?: true
Publication
First Author: Seeliger K
Year: 2012
Journal: New Phytol
Title: BRCA2 is a mediator of RAD51- and DMC1-facilitated homologous recombination in Arabidopsis thaliana.
Volume: 193
Issue: 2
Pages: 364-75
Protein Domain
Type: Family
Description: The breast cancer type 2 susceptibility protein (BRCA2) is a breast tumour suppressor involved in double-strand break repair and/or homologous recombination []. BRCA2 gene expression is regulated in a cell-cycle dependent manner and peak expression of BRCA2 mRNA occurring in S phase, suggesting BRCA2 may participate in regulating cell proliferation. BRCA2, and related protein BRCA1, have transcriptional activation potential and the two proteins are associated with the activation of double-strand break repair and/or homologous recombination. The two proteins have been shown to coexist and colocalize in a biochemical complex. BRCA2 has a number of 39 amino acid repeats []that are critical for binding to RAD51 (a key protein in DNA recombinational repair) and resistance to methyl methanesulphonate treatment [, , ]. There are eight repeats in BRCA2 designated as BRC1 to BRC8. BRC1, BRC2, BRC3, BRC4, BRC7, and BRC8 have high sequence identity and bind to Rad51, whereas BRC5 and BRC6 are less well conserved and are unable to bind Rad51 []. It has been suggested that BRCA2 plays a role in positioning Rad51 at the site of DNA repair or in removing Rad51 from DNA once repair has been completed.Mutations in BRCA1 and BRCA2 have been linked to an elevated risk of young onset breast cancer and confer a high risk of the disease through a dominantly inherited fashion []. BRCA2 mutations are typically microdeletions.Homologues exist in plants: the BRCA2A and BRCA2B proteins from Arabidopsis thalianaare required for repair of breaks in double-stranded DNA and homologous recombination and in the prophase stage of meiosis are required for formation of RAD51 and DMC1 foci in males [].
Publication
First Author: Carofiglio F
Year: 2013
Journal: PLoS Genet
Title: SPO11-independent DNA repair foci and their role in meiotic silencing.
Volume: 9
Issue: 6
Pages: e1003538
Publication
First Author: Koornneef L
Year: 2022
Journal: PLoS Genet
Title: Multi-color dSTORM microscopy in Hormad1-/- spermatocytes reveals alterations in meiotic recombination intermediates and synaptonemal complex structure.
Volume: 18
Issue: 7
Pages: e1010046
Publication
First Author: Bork P
Year: 1996
Journal: Nat Genet
Title: Internal repeats in the BRCA2 protein sequence.
Volume: 13
Issue: 1
Pages: 22-3
Publication
First Author: Wong AK
Year: 1997
Journal: J Biol Chem
Title: RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2.
Volume: 272
Issue: 51
Pages: 31941-4
Publication
First Author: Chen PL
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment.
Volume: 95
Issue: 9
Pages: 5287-92
Publication
First Author: Marmorstein LY
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The BRCA2 gene product functionally interacts with p53 and RAD51.
Volume: 95
Issue: 23
Pages: 13869-74
Publication
First Author: Chen CF
Year: 1999
Journal: J Biol Chem
Title: Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control.
Volume: 274
Issue: 46
Pages: 32931-5
Publication
First Author: Walker LC
Year: 2010
Journal: Hum Mutat
Title: Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: implications for prediction of pathogenicity.
Volume: 31
Issue: 6
Pages: E1484-505
Protein
Organism: Mus musculus/domesticus
Length: 747  
Fragment?: true
Publication
First Author: Pellegrini L
Year: 2002
Journal: Nature
Title: Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Volume: 420
Issue: 6913
Pages: 287-93
Protein
Organism: Mus musculus/domesticus
Length: 3329  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1180  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 3329  
Fragment?: false
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
Publication
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89