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Search results 301 to 400 out of 475 for Dot1l

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Type Details Score
GXD Expression  
Probe: MGI:4844669
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1611815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848554
Age: embryonic day 9.5
Note: Staining is present in the mandibular arch.
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4844669
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1611817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848554
Age: embryonic day 10.5
Note: Staining is present in the mandibular arch.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4844669
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1611819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848554
Age: embryonic day 11.5
Note: Staining is present in the mandibular arch.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691621
Stage: TS21
Assay Id: MGI:3507583
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691627
Stage: TS27
Assay Id: MGI:3507583
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1777821
Stage: TS21
Assay Id: MGI:3507583
Age: embryonic day 13.5
Image: 1
Note: The tissue was olfactory epithelium and/or bulb.
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754921
Stage: TS21
Assay Id: MGI:3507583
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754927
Stage: TS27
Assay Id: MGI:3507583
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:4844669
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1640517
Pattern: Non-Uniform
Stage: TS17
Assay Id: MGI:4848554
Age: embryonic day 10.5
Note: Staining is strong in the posterior limb and moderate in the anterior limb.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697421
Stage: TS21
Assay Id: MGI:3507583
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697427
Stage: TS27
Assay Id: MGI:3507583
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2769723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539154
Age: embryonic day 15.5
Image: GUDMAP:5350
Specimen Label: GUDMAP:5350
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2021-03-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3152723
Stage: TS23
Assay Id: MGI:6513438
Age: embryonic day 15.5
Specimen Label: Table S1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1665921
Stage: TS21
Assay Id: MGI:3507583
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1665927
Stage: TS27
Assay Id: MGI:3507583
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716821
Stage: TS21
Assay Id: MGI:3507583
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716827
Stage: TS27
Assay Id: MGI:3507583
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619321
Stage: TS21
Assay Id: MGI:3507583
Age: embryonic day 13.5
Image: 1
Note: The tissue was inner ear and ear structures.
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619327
Stage: TS27
Assay Id: MGI:3507583
Age: postnatal newborn
Image: 2
Note: The tissue was inner ear and ear structures.
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2853323
Stage: TS23
Assay Id: MGI:5539154
Age: embryonic day 15.5
Image: GUDMAP:5350
Specimen Label: GUDMAP:5350
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2845723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539154
Age: embryonic day 15.5
Image: GUDMAP:5350
Specimen Label: GUDMAP:5350
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753621
Stage: TS21
Assay Id: MGI:3507583
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753627
Stage: TS27
Assay Id: MGI:3507583
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5539154
Age: embryonic day 15.5
Image: GUDMAP:5350
Specimen Label: GUDMAP:5350
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4844669
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1735919
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848554
Age: embryonic day 11.5
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1778727
Stage: TS27
Assay Id: MGI:3507583
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:3507583
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:3507583
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1869223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539154
Age: embryonic day 15.5
Image: GUDMAP:5350
Specimen Label: GUDMAP:5350
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4844669
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3270515
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:4848554
Age: embryonic day 9.5
Note: Staining is present in the distal limb.
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4844669
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3270517
Pattern: Non-Uniform
Stage: TS17
Assay Id: MGI:4848554
Age: embryonic day 10.5
Note: Staining is strong in the progress zone and moderate in the middle and proximal limb.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4844669
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3270519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4848554
Age: embryonic day 11.5
Note: Staining is present in the middle limb.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4844669
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848554
Age: embryonic day 11.5
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666821
Stage: TS21
Assay Id: MGI:3507583
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666827
Stage: TS27
Assay Id: MGI:3507583
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647021
Stage: TS21
Assay Id: MGI:3507583
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647027
Stage: TS27
Assay Id: MGI:3507583
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1647017
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3508794
Age: embryonic day 10.5
Image: 1
Note: Authors stated that in some instances they could not determine expression levels with certainty.
Specimen Label: 1
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:3507583
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185827
Stage: TS27
Assay Id: MGI:3507583
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:4844669
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1684619
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848554
Age: embryonic day 11.5
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2762123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539154
Age: embryonic day 15.5
Image: GUDMAP:5350
Specimen Label: GUDMAP:5350
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4844669
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1627215
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848554
Age: embryonic day 9.5
Note: Staining is present in the hyoid arch.
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4844669
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1627217
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848554
Age: embryonic day 10.5
Note: Staining is present in the hyoid arch.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4844669
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1627219
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848554
Age: embryonic day 11.5
Note: Staining is present in the hyoid arch.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1797223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539154
Age: embryonic day 15.5
Image: GUDMAP:5350
Specimen Label: GUDMAP:5350
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1832123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539154
Age: embryonic day 15.5
Image: GUDMAP:5350
Specimen Label: GUDMAP:5350
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2851823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539154
Age: embryonic day 15.5
Image: GUDMAP:5350
Specimen Label: GUDMAP:5350
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754021
Stage: TS21
Assay Id: MGI:3507583
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754027
Stage: TS27
Assay Id: MGI:3507583
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2760523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539154
Age: embryonic day 15.5
Image: GUDMAP:5350
Specimen Label: GUDMAP:5350
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280927
Stage: TS27
Assay Id: MGI:3507583
Age: postnatal newborn
Image: 2
Note: The tissue was olfactory epithelium and/or bulb.
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267921
Stage: TS21
Assay Id: MGI:3507583
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267927
Stage: TS27
Assay Id: MGI:3507583
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539154
Age: embryonic day 15.5
Image: GUDMAP:5350
Specimen Label: GUDMAP:5350
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757721
Stage: TS21
Assay Id: MGI:3507583
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757727
Stage: TS27
Assay Id: MGI:3507583
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3506086
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539154
Age: embryonic day 15.5
Image: GUDMAP:5350
Specimen Label: GUDMAP:5350
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4844669
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1638815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848554
Age: embryonic day 9.5
Note: Staining is present in the maxillary process.
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4844669
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1638817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848554
Age: embryonic day 10.5
Note: Staining is present in the maxillary process.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
Publication
First Author: Wang E
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia.
Volume: 110
Issue: 10
Pages: 3901-6
Publication
First Author: Cao K
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation.
Volume: 117
Issue: 44
Pages: 27365-27373
Publication      
First Author: Song R
Year: 2024
Journal: Pediatr Res
Title: Deletion of the prorenin receptor in the ureteric bud in mice inhibits Dot1/H3K79 pathway.
Protein
Organism: Mus musculus/domesticus
Length: 1840  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 946  
Fragment?: true
Publication
First Author: Liu Z
Year: 2014
Journal: J Biol Chem
Title: Structural and functional insights into the human Börjeson-Forssman-Lehmann syndrome-associated protein PHF6.
Volume: 289
Issue: 14
Pages: 10069-83
Publication
First Author: Chen S
Year: 2015
Journal: Mol Cell
Title: The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.
Volume: 60
Issue: 2
Pages: 319-27
Publication
First Author: Klein BJ
Year: 2016
Journal: Nucleic Acids Res
Title: Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation.
Volume: 44
Issue: 1
Pages: 472-84
Protein Domain
Type: Domain
Description: The extended plant homeodomain (ePHD) domain contains an N-terminal pre-PHD (C2HC zinc finger), a long linker, and a noncanonical PHD finger (C4HC3 zinc finger). The ePHD domain can bind dsDNA but not histones [, , , ].The pre-PHD-type C2HC zinc finger and the PHD finger in the ePHD domain are associated with each other via extensive hydrophobic interactions and numerous hydrogen bonding interactions and folded as an intact structural module. The pre-PHD-type C2HC zinc finger consists of two α-helices separated by an anti-parallel β-sheet. Three cysteine residues and one histidine residue from the N-terminal loop, β2-strand, and α2-helix coordinate one zinc ion (designated Zn1). The C-terminal part of the ePHD domain is a PHD finger, consisting of one short antiparallel β-sheet and one long antiparallel β-sheet that are linked by one α-helix. Like other PHD fingers, the PHD finger of the ePHD domain consists of two interleaved zinc fingers. A pair of bound zinc ions (designated Zn2 and Zn3) specifically stabilizes the characteristic cross-braced folding topology of the PHD finger. Each zinc ion is coordinated by a combination of four cysteine and histidine residues in which the Zn3 ion is coordinated by a C3H motif instead of a C4 motif [, ].Some proteins known to contain a ePHD domain are listed below:Vertebrate plant homeodomain finger 6 (PHF6), a multidomain protein that comprises four nuclear localization signals and two ePHD domains. It is implicated in chromatin regulation and neural development.Vertebrate MLL1/2/3/4, histone methyltransferases.Vertebrate JMJD2A/B/C, histone demethylases.Vertebrate Bromodomain- and PHD finger-containing protein 1, 2, and 3 (BRPF1/2/3), a component of MOZ (monocytic leukemia zinc finger)/MORF (MOZ- related factor) histone acetyltransferase complex.Vertebrate JADE1/2/3, components of the HBO1 complex which has a histone H4-specific acetyltransferase activity.AF10/17, subunits of the multimeric DOT1L complex that mediates H3K79 methylation.Caenorhabditis elegansprotein lin-49, a component of a histone modifying complex.Yeast NuA3 HAT complex component NTO1.
Publication
First Author: Deshpande AJ
Year: 2011
Journal: Leukemia
Title: The clathrin-binding domain of CALM and the OM-LZ domain of AF10 are sufficient to induce acute myeloid leukemia in mice.
Volume: 25
Issue: 11
Pages: 1718-27
Publication
First Author: Liu L
Year: 2012
Journal: J Struct Biol
Title: Solution structure of an atypical PHD finger in BRPF2 and its interaction with DNA.
Volume: 180
Issue: 1
Pages: 165-73
Publication
First Author: Linder B
Year: 1998
Journal: Biochim Biophys Acta
Title: Expression pattern and cellular distribution of the murine homologue of AF10.
Volume: 1443
Issue: 3
Pages: 285-96
Protein
Organism: Mus musculus/domesticus
Length: 293  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1889  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 364  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1889  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 567  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 567  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1987  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 990  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 998  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1725  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1068  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 339  
Fragment?: false
Publication
First Author: Nishimura H
Year: 2023
Journal: Genes Cells
Title: Maternal epigenetic factors in embryonic and postnatal development.
Volume: 28
Issue: 6
Pages: 422-432
Publication
First Author: Lau MS
Year: 2017
Journal: Science
Title: Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning.
Volume: 355
Issue: 6329
Pages: 1081-1084
Protein
Organism: Mus musculus/domesticus
Length: 543  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 544  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1068  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1086  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1054  
Fragment?: false