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Search results 301 to 365 out of 365 for Drosha

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Type Details Score
Publication
33589748 | J:308178
First Author: Nguyen LXT
Year: 2021
Journal: Leukemia
Title: Cytoplasmic DROSHA and non-canonical mechanisms of MiR-155 biogenesis in FLT3-ITD acute myeloid leukemia.
Volume: 35
Issue: 8
Pages: 2285-2298
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Publication
33801773 | J:327795
 
First Author: Lam B
Year: 2021
Journal: Cells
Title: High Glucose Treatment Limits Drosha Protein Expression and Alters AngiomiR Maturation in Microvascular Primary Endothelial Cells via an Mdm2-dependent Mechanism.
Volume: 10
Issue: 4
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Publication
26906421 | J:249861
First Author: Francia S
Year: 2016
Journal: J Cell Sci
Title: DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors.
Volume: 129
Issue: 7
Pages: 1468-76
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Publication
29170488 | -
First Author: Partin AC
Year: 2017
Journal: Nat Commun
Title: Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs.
Volume: 8
Issue: 1
Pages: 1737
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Protein
Q5HZJ0
Organism: Mus musculus/domesticus
Length: 1373  
Fragment?: false
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Allele
Drosha<em1Smoc> | MGI:7289400
Name: drosha, ribonuclease type III; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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HT Experiment
GSE73824 | Next Generation Sequencing Facilitates Quantitative Analysis of oocyte, sperm, 2PN embryos derived from WT, Dicer cKO and Drosha cKO small non-coding RNAs
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
20226070 | -
First Author: Mueller GA
Year: 2010
Journal: Silence
Title: Solution structure of the Drosha double-stranded RNA-binding domain.
Volume: 1
Issue: 1
Pages: 2
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Publication
14508493 | -
First Author: Lee Y
Year: 2003
Journal: Nature
Title: The nuclear RNase III Drosha initiates microRNA processing.
Volume: 425
Issue: 6956
Pages: 415-9
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Strain
MGI:6770709 | C57BL/6JSmoc-Drosha<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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SO Term
SO:0001034 | miRtron
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SO Term
SO:0001244 | pre_miRNA
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HT Experiment
GSE64880 | RNA expression in mutants of the miRNA pathway during myelination
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
A0A338P691
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
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Publication
26027739 | -
First Author: Nguyen TA
Year: 2015
Journal: Cell
Title: Functional Anatomy of the Human Microprocessor.
Volume: 161
Issue: 6
Pages: 1374-87
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Protein Domain
IPR040375 | DGCR8
Type: Family
Description: Primary microRNA transcripts (pri-miRs) are cleaved by Microprocessor, a complex containing RNase III DROSHA and its cofactor DGCR8 []. DGCR8 functions as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs [, ]. DGCR8 binds heme, and this binding activates DGCR8 to recognize pri-miRs by specifically binding the terminal loop near the 3' single-stranded segment [].
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Allele
Gt(ROSA)26Sor<tm1.1(CAG-YFP/DROSHA*E1147K)Gess> | MGI:6887963
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Manfred Gessler
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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GO Term
GO:0070877 | microprocessor complex
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HT Experiment
GSE109075 | Transcriptome analyses of miRNA pathway mutants and injury response in developing and adult sciatic nerves
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
26748718 | -
First Author: Kwon SC
Year: 2016
Journal: Cell
Title: Structure of Human DROSHA.
Volume: 164
Issue: 1-2
Pages: 81-90
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HT Experiment
E-GEOD-20384 | Mammalian microRNAs: Experimental evaluation of novel and previously annotated genes
Series Id: GSE20384
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Six2-EGFP/cre)1Amc/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1
Zygosity: cn
Has Mutant Allele: true
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Protein
Q9EQM6
Organism: Mus musculus/domesticus
Length: 773  
Fragment?: false
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Publication
17259983 | J:141670
First Author: Wang Y
Year: 2007
Journal: Nat Genet
Title: DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.
Volume: 39
Issue: 3
Pages: 380-5
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Publication
24636259 | J:271380
First Author: Cheng TL
Year: 2014
Journal: Dev Cell
Title: MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex.
Volume: 28
Issue: 5
Pages: 547-60
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Publication
34010654 | J:306623
First Author: Nakashima H
Year: 2021
Journal: Cell Rep
Title: MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling.
Volume: 35
Issue: 7
Pages: 109124
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Publication
26344767 | J:256665
First Author: Tsujimura K
Year: 2015
Journal: Cell Rep
Title: miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes.
Volume: 12
Issue: 11
Pages: 1887-901
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Publication
25639470 | J:219960
First Author: Ye P
Year: 2015
Journal: Mol Cell
Title: An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino acid-deprivation.
Volume: 57
Issue: 4
Pages: 708-20
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Publication
27641147 | J:246331
First Author: Brandl A
Year: 2016
Journal: Eur J Immunol
Title: The microprocessor component, DGCR8, is essential for early B-cell development in mice.
Volume: 46
Issue: 12
Pages: 2710-2718
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Publication
22910415 | J:188129
First Author: Sohn EJ
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Accumulation of pre-let-7g and downregulation of mature let-7g with the depletion of EWS.
Volume: 426
Issue: 1
Pages: 89-93
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Publication
36591274 | J:332443
 
First Author: Daum P
Year: 2022
Journal: Front Immunol
Title: The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response.
Volume: 13
Pages: 991347
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Publication
16882971 | J:111684
First Author: Thomson JM
Year: 2006
Journal: Genes Dev
Title: Extensive post-transcriptional regulation of microRNAs and its implications for cancer.
Volume: 20
Issue: 16
Pages: 2202-7
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Publication
19854141 | J:154163
First Author: Yamagata K
Year: 2009
Journal: Mol Cell
Title: Maturation of microRNA is hormonally regulated by a nuclear receptor.
Volume: 36
Issue: 2
Pages: 340-7
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Publication
23863840 | J:210405
First Author: Mattioli C
Year: 2013
Journal: Nucleic Acids Res
Title: A competitive regulatory mechanism discriminates between juxtaposed splice sites and pri-miRNA structures.
Volume: 41
Issue: 18
Pages: 8680-91
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Publication
26302406 | J:227348
First Author: Kourtidis A
Year: 2015
Journal: Nat Cell Biol
Title: Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity.
Volume: 17
Issue: 9
Pages: 1145-57
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Publication
18268334 | J:132169
First Author: Du Z
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage.
Volume: 105
Issue: 7
Pages: 2391-6
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Publication
17459947 | J:125844
First Author: McCarthy JJ
Year: 2007
Journal: Am J Physiol Cell Physiol
Title: MicroRNA-206 is overexpressed in the diaphragm but not the hindlimb muscle of mdx mouse.
Volume: 293
Issue: 1
Pages: C451-7
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Publication
30985893 | J:277152
First Author: Chen Y
Year: 2019
Journal: Biol Reprod
Title: CFTR mutation compromises spermatogenesis by enhancing miR-15b maturation and suppressing its regulatory target CDC25A†.
Volume: 101
Issue: 1
Pages: 50-62
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Publication
25944670 | J:249044
First Author: Elgheznawy A
Year: 2015
Journal: Circ Res
Title: Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes.
Volume: 117
Issue: 2
Pages: 157-65
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Publication
22511778 | J:186203
First Author: Chen Z
Year: 2012
Journal: J Biol Chem
Title: DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice.
Volume: 287
Issue: 23
Pages: 19018-28
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Publication
26833131 | J:251593
 
First Author: Kim YS
Year: 2016
Journal: Sci Rep
Title: Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice.
Volume: 6
Pages: 20242
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Publication
28232627 | J:241293
First Author: Marinaro F
Year: 2017
Journal: EMBO Rep
Title: MicroRNA-independent functions of DGCR8 are essential for neocortical development and TBR1 expression.
Volume: 18
Issue: 4
Pages: 603-618
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Publication
35412895 | J:329928
First Author: Hoang DH
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: MicroRNA networks in FLT3-ITD acute myeloid leukemia.
Volume: 119
Issue: 16
Pages: e2112482119
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Publication
22745822 | J:187930
First Author: Messina V
Year: 2012
Journal: PLoS One
Title: The RNA binding protein SAM68 transiently localizes in the chromatoid body of male germ cells and influences expression of select microRNAs.
Volume: 7
Issue: 6
Pages: e39729
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Publication
29760646 | J:264394
 
First Author: Hoffmann N
Year: 2018
Journal: Front Neurosci
Title: DGCR8 Promotes Neural Progenitor Expansion and Represses Neurogenesis in the Mouse Embryonic Neocortex.
Volume: 12
Pages: 281
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Publication
29362439 | J:259678
First Author: Zou Y
Year: 2018
Journal: Sci Rep
Title: Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation.
Volume: 8
Issue: 1
Pages: 1468
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Publication
26126715 | J:259443
First Author: Tu CC
Year: 2015
Journal: Sci Signal
Title: The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage.
Volume: 8
Issue: 383
Pages: ra64
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Publication
19458619 | J:150365
First Author: Trabucchi M
Year: 2009
Journal: Nature
Title: The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs.
Volume: 459
Issue: 7249
Pages: 1010-4
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Publication
20413612 | J:160145
First Author: Chiang HR
Year: 2010
Journal: Genes Dev
Title: Mammalian microRNAs: experimental evaluation of novel and previously annotated genes.
Volume: 24
Issue: 10
Pages: 992-1009
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Publication
20624952 | J:162379
First Author: Ling SC
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.
Volume: 107
Issue: 30
Pages: 13318-23
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Publication
22086916 | J:178957
First Author: Dai L
Year: 2011
Journal: J Biol Chem
Title: Testis-specific miRNA-469 up-regulated in gonadotropin-regulated testicular RNA helicase (GRTH/DDX25)-null mice silences transition protein 2 and protamine 2 messages at sites within coding region: implications of its role in germ cell development.
Volume: 286
Issue: 52
Pages: 44306-18
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Publication
23296057 | J:194285
First Author: Rask L
Year: 2013
Journal: Gene
Title: Development of a metastatic fluorescent Lewis Lung carcinoma mouse model: identification of mRNAs and microRNAs involved in tumor invasion.
Volume: 517
Issue: 1
Pages: 72-81
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Publication
22270084 | J:197722
First Author: Havens MA
Year: 2012
Journal: Nucleic Acids Res
Title: Biogenesis of mammalian microRNAs by a non-canonical processing pathway.
Volume: 40
Issue: 10
Pages: 4626-40
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Publication
22844086 | J:199666
First Author: Dueck A
Year: 2012
Journal: Nucleic Acids Res
Title: microRNAs associated with the different human Argonaute proteins.
Volume: 40
Issue: 19
Pages: 9850-62
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Publication
24334028 | J:223705
First Author: Kim IM
Year: 2014
Journal: Circ Res
Title: β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing.
Volume: 114
Issue: 5
Pages: 833-44
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Publication
25057983 | J:224135
First Author: Wang K
Year: 2014
Journal: PLoS Genet
Title: MDRL lncRNA regulates the processing of miR-484 primary transcript by targeting miR-361.
Volume: 10
Issue: 7
Pages: e1004467
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Publication
25887159 | J:230535
First Author: García R
Year: 2015
Journal: Biochim Biophys Acta
Title: p-SMAD2/3 and DICER promote pre-miR-21 processing during pressure overload-associated myocardial remodeling.
Volume: 1852
Issue: 7
Pages: 1520-30
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Publication
26976605 | J:232041
First Author: Kim YK
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Re-evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis.
Volume: 113
Issue: 13
Pages: E1881-9
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Publication
21518849 | J:234608
First Author: Ko JK
Year: 2011
Journal: FASEB J
Title: A versatile single-plasmid system for tissue-specific and inducible control of gene expression in transgenic mice.
Volume: 25
Issue: 8
Pages: 2638-49
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Publication
28486664 | J:245073
First Author: Han X
Year: 2017
Journal: Biol Reprod
Title: MicroRNA-21 plays a pivotal role in the oocyte-secreted factor-induced suppression of cumulus cell apoptosis.
Volume: 96
Issue: 6
Pages: 1167-1180
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Publication
25260591 | J:356922
First Author: Vesely C
Year: 2014
Journal: Nucleic Acids Res
Title: ADAR2 induces reproducible changes in sequence and abundance of mature microRNAs in the mouse brain.
Volume: 42
Issue: 19
Pages: 12155-68
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Protein Coding Gene
MGI:2151114 | Dgcr8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
25881298 | J:233486
 
First Author: Bartram MP
Year: 2015
Journal: BMC Nephrol
Title: Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation.
Volume: 16
Pages: 55
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Publication
26675618 | J:244796
First Author: He M
Year: 2015
Journal: PLoS One
Title: GTPase Activating Protein (Sh3 Domain) Binding Protein 1 Regulates the Processing of MicroRNA-1 during Cardiac Hypertrophy.
Volume: 10
Issue: 12
Pages: e0145112
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Publication
29627294 | J:261785
 
First Author: Teoh JP
Year: 2018
Journal: J Mol Cell Cardiol
Title: β-arrestin-biased agonism of β-adrenergic receptor regulates Dicer-mediated microRNA maturation to promote cardioprotective signaling.
Volume: 118
Pages: 225-236
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