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Search results 301 to 400 out of 411 for Eif4ebp1

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Type Details Score
Publication
28880149 | J:248325
   
First Author: Figlia G
Year: 2017
Journal: Elife
Title: Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system.
Volume: 6
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Publication
28069738 | J:244710
 
First Author: Yamauchi T
Year: 2017
Journal: Mol Cell Biol
Title: FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.
Volume: 37
Issue: 8
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Publication
32043969 | J:290269
   
First Author: Garg A
Year: 2020
Journal: Elife
Title: Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.
Volume: 9
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Publication
27807348 | J:242729
 
First Author: Ding X
Year: 2016
Journal: Nat Commun
Title: mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation.
Volume: 7
Pages: 13226
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Publication
35341793 | J:333283
First Author: Guan N
Year: 2022
Journal: Kidney Int
Title: Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency.
Volume: 102
Issue: 1
Pages: 108-120
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Publication
23071096 | J:192856
First Author: George NM
Year: 2012
Journal: Mol Cell Biol
Title: Hippo signaling regulates pancreas development through inactivation of Yap.
Volume: 32
Issue: 24
Pages: 5116-28
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Publication
30081710 | J:306954
First Author: Zecchini S
Year: 2019
Journal: Autophagy
Title: Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism.
Volume: 15
Issue: 1
Pages: 58-77
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Publication
19841136 | J:153804
First Author: Vijayaraj P
Year: 2009
Journal: J Cell Biol
Title: Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor.
Volume: 187
Issue: 2
Pages: 175-84
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Publication
37812701 | J:342544
First Author: Radzishevsky I
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Impairment of serine transport across the blood-brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction.
Volume: 120
Issue: 42
Pages: e2302780120
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Publication
36198274 | J:329967
First Author: Li H
Year: 2022
Journal: Cell Rep
Title: Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival.
Volume: 41
Issue: 1
Pages: 111435
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Publication
33372189 | J:313922
First Author: Kuiper-Makris C
Year: 2020
Journal: Sci Rep
Title: Mendelian randomization and experimental IUGR reveal the adverse effect of low birth weight on lung structure and function.
Volume: 10
Issue: 1
Pages: 22395
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Publication
29975682 | J:263684
First Author: Nie X
Year: 2018
Journal: PLoS Genet
Title: mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development.
Volume: 14
Issue: 7
Pages: e1007491
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Publication
36656901 | J:332969
First Author: Comerford SA
Year: 2023
Journal: PLoS Genet
Title: Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent.
Volume: 19
Issue: 1
Pages: e1010595
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Publication
34157307 | J:308817
First Author: Fu Y
Year: 2021
Journal: Mol Cell
Title: OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin.
Volume: 81
Issue: 15
Pages: 3187-3204.e7
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Publication
34193412 | J:314221
 
First Author: Wang Q
Year: 2021
Journal: Sci Adv
Title: Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling.
Volume: 7
Issue: 27
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Publication
23342106 | J:195854
First Author: Zhu Y
Year: 2013
Journal: PLoS One
Title: Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth.
Volume: 8
Issue: 1
Pages: e54221
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Publication
39747033 | J:360776
First Author: Di Michele M
Year: 2025
Journal: Nat Commun
Title: E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development.
Volume: 16
Issue: 1
Pages: 67
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Publication
32747435 | J:295894
 
First Author: Wei G
Year: 2020
Journal: Development
Title: Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation.
Volume: 147
Issue: 17
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
18554416 | J:139177
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Eif4ebp1<em1Smoc> | MGI:7289468
Name: eukaryotic translation initiation factor 4E binding protein 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6428568 | C57BL/6JSmoc-Eif4Ebp1<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Tg(CAG-GFP,-EIF4EBP1)2877Als | MGI:5896794
Name: transgene insertion 2877, Albert La Spada
Allele Type: Transgenic
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter
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Allele
Tg(CAG-GFP,-EIF4EBP1*)2969Als | MGI:5896791
Name: transgene insertion 2969, Albert La Spada
Allele Type: Transgenic
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter
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Strain
MGI:5896793 | B6.Cg-Tg(CAG-GFP,-EIF4EBP1*)2969Als/J
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:5896815 | B6.Cg-Tg(CAG-GFP,-EIF4EBP1)2877Als/J
Attribute String: transgenic, mutant strain, congenic
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Publication
31650481 | J:285112
First Author: Dai DF
Year: 2019
Journal: Geroscience
Title: Differential effects of various genetic mouse models of the mechanistic target of rapamycin complex I inhibition on heart failure.
Volume: 41
Issue: 6
Pages: 847-860
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Publication
15728574 | -
First Author: Yu Y
Year: 2005
Journal: J Biol Chem
Title: Structural basis for the unique biological function of small GTPase RHEB.
Volume: 280
Issue: 17
Pages: 17093-100
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Publication
12869586 | -
First Author: Inoki K
Year: 2003
Journal: Genes Dev
Title: Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Volume: 17
Issue: 15
Pages: 1829-34
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Publication
15854902 | -
First Author: Long X
Year: 2005
Journal: Curr Biol
Title: Rheb binds and regulates the mTOR kinase.
Volume: 15
Issue: 8
Pages: 702-13
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Publication
16098514 | -
First Author: Tee AR
Year: 2005
Journal: FEBS Lett
Title: Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.
Volume: 579
Issue: 21
Pages: 4763-8
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Publication
29104218 | -
 
First Author: Tatebe H
Year: 2017
Journal: Biomolecules
Title: Evolutionary Conservation of the Components in the TOR Signaling Pathways.
Volume: 7
Issue: 4
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Protein Domain
IPR037586 | RHEB
Type: Family
Description: Rheb is a Ras-like small GTPase essential for TORC1 activity in mammals []. Rheb activates the protein kinase activity of mTORC1 (rapamycin), and in turn stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling [, , ]. Rheb alternates between an inactive form bound to GDP and an active form bound to GTP. It is inactivated by TSC1-TSC2 via the GTPase activating protein (GAP) domain of TSC2 []. The mechanism of action of Rheb has been determined from the tertiary structure [].
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HT Experiment
E-GEOD-23497 | Identification of genes that elicit disuse muscle atrophy via the transcription factors p50 and Bcl-3
Series Id: GSE23497
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
24728038 | J:213611
First Author: Han B
Year: 2014
Journal: Hum Mol Genet
Title: TGFBI (βIG-H3) is a diabetes-risk gene based on mouse and human genetic studies.
Volume: 23
Issue: 17
Pages: 4597-611
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Protein
B2RX86
Organism: Mus musculus/domesticus
Length: 563  
Fragment?: false
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Protein
Q3U5E2
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: true
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Publication
8806680 | -
First Author: Wienecke R
Year: 1996
Journal: Oncogene
Title: Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus.
Volume: 13
Issue: 5
Pages: 913-23
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Protein Domain
IPR027107 | Tuberin/Ral-act_asu
Type: Family
Description: The activity of GTPases is regulated by the opposing effects of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Tuberin (tuberous sclerosis 2 protein or Tsc2) is believed to be a tumor suppressor and is able to stimulate specific GTPases. It stimulates the intrinsic GTPase activity of the Ras-related protein Rap1A and Rab5 [, ]. In complex with Tsc1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. It acts as a GTPase-activating protein (GAP) for the small GTPase RheB, a direct activator of the protein kinase activity of mTORC1 [, ]. Ral GTPase-activating protein subunit alpha is the catalytic subunit of the heterodimeric RalGAP complex which acts as a GTPase activator for the Ras-like small GTPases RalA and RalB []. RalGAP complexes share structural and catalytic similarities with the tuberous sclerosis tumor suppressor complex [].
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Publication
31538542 | J:306961
First Author: Barroso-Chinea P
Year: 2020
Journal: Autophagy
Title: DRD3 (dopamine receptor D3) but not DRD2 activates autophagy through MTORC1 inhibition preserving protein synthesis.
Volume: 16
Issue: 7
Pages: 1279-1295
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Publication
21249144 | J:180832
First Author: Wu CL
Year: 2011
Journal: PLoS One
Title: Identification of genes that elicit disuse muscle atrophy via the transcription factors p50 and Bcl-3.
Volume: 6
Issue: 1
Pages: e16171
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Publication
19520869 | -
First Author: Shirakawa R
Year: 2009
Journal: J Biol Chem
Title: Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases.
Volume: 284
Issue: 32
Pages: 21580-8
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Protein
A0A1W2P7Y4
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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Protein
A0A1W2P6Q0
Organism: Mus musculus/domesticus
Length: 49  
Fragment?: true
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Protein
A0A1W2P7P2
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
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Protein
Q925J1
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
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Publication
15340059 | -
First Author: Li Y
Year: 2004
Journal: Mol Cell Biol
Title: Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.
Volume: 24
Issue: 18
Pages: 7965-75
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Publication
12271141 | -
First Author: Tee AR
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
Volume: 99
Issue: 21
Pages: 13571-6
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Protein
Q3TP98
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
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Protein
Q3TQ10
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: true
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Protein
Q6GYP7
Organism: Mus musculus/domesticus
Length: 2035  
Fragment?: false
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Protein
A3KGS3
Organism: Mus musculus/domesticus
Length: 1872  
Fragment?: false
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Protein
A0A2I3BRX9
Organism: Mus musculus/domesticus
Length: 2538  
Fragment?: false
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Protein
Q3UI96
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: false
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Protein
A0A2I3BPE9
Organism: Mus musculus/domesticus
Length: 1359  
Fragment?: true
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Protein
A0A0A0MQD7
Organism: Mus musculus/domesticus
Length: 1910  
Fragment?: false
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Protein
A0A1W2P712
Organism: Mus musculus/domesticus
Length: 2082  
Fragment?: false
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Protein
Q3UG84
Organism: Mus musculus/domesticus
Length: 1359  
Fragment?: true
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Protein
Q3TBX9
Organism: Mus musculus/domesticus
Length: 1416  
Fragment?: true
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Protein
A0A2I3BPN8
Organism: Mus musculus/domesticus
Length: 1957  
Fragment?: false
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Protein
F7AI67
Organism: Mus musculus/domesticus
Length: 834  
Fragment?: true
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Protein
B7ZNA3
Organism: Mus musculus/domesticus
Length: 2082  
Fragment?: false
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Protein
A0A1W2P832
Organism: Mus musculus/domesticus
Length: 2082  
Fragment?: false
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Protein
F7CGP0
Organism: Mus musculus/domesticus
Length: 1567  
Fragment?: true
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Publication
9045618 | -
First Author: Xiao GH
Year: 1997
Journal: J Biol Chem
Title: The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis.
Volume: 272
Issue: 10
Pages: 6097-100
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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