Type |
Details |
Score |
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
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•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Allele |
Name: |
Eph receptor A6; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
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Publication |
First Author: |
Hafner C |
Year: |
2004 |
Journal: |
Clin Chem |
Title: |
Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers. |
Volume: |
50 |
Issue: |
3 |
Pages: |
490-9 |
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•
•
•
•
•
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Publication |
First Author: |
Janes PW |
Year: |
2008 |
Journal: |
Curr Cancer Drug Targets |
Title: |
Eph/ephrin signalling and function in oncogenesis: lessons from embryonic development. |
Volume: |
8 |
Issue: |
6 |
Pages: |
473-9 |
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•
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•
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the SAM (sterile alpha motif) domain of EPH-A6 (Ephrin type-A receptor 6), a receptor tyrosine kinase. It is a C-terminal potential protein-protein interaction domain located in the cytoplasmic region of EPH-A6 receptors and appears to mediate cell-cell initiated signal transduction []. Eph-A6 gene is preferentially expressed in the nervous system. EPH-A6 receptors are involved in primate retina vascular and axon guidance, and in neural circuits responsible for learning and memory []. EphA6 gene was significantly down regulated in colorectal cancer and in malignant melanomas. It is a potential molecular marker for these cancers [, ]. |
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Publication |
First Author: |
Kozulin P |
Year: |
2009 |
Journal: |
Mol Vis |
Title: |
Gradients of Eph-A6 expression in primate retina suggest roles in both vascular and axon guidance. |
Volume: |
15 |
|
Pages: |
2649-62 |
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•
•
•
•
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the ligand-binding domain found in ephrin type-A receptor 6 (EphA6). EphA6, like other Eph receptors and their ephrin ligands, seems to play a role in neural development, underlying learning and memory []. EphA6 has also been implicated in retinal vascular patterning [].Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands [, ]. Ephrin receptors (EphRs) comprise the largest subfamily of receptor tyrosine kinases (RTKs). EphRs contain a ligand binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyrosine kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling) []. |
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Publication |
First Author: |
O'Neal WT |
Year: |
2014 |
Journal: |
Front Physiol |
Title: |
Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy. |
Volume: |
5 |
|
Pages: |
132 |
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•
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•
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Publication |
First Author: |
Schultz J |
Year: |
1997 |
Journal: |
Protein Sci |
Title: |
SAM as a protein interaction domain involved in developmental regulation. |
Volume: |
6 |
Issue: |
1 |
Pages: |
249-53 |
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•
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Publication |
First Author: |
Lackmann M |
Year: |
2008 |
Journal: |
Sci Signal |
Title: |
Eph, a protein family coming of age: more confusion, insight, or complexity? |
Volume: |
1 |
Issue: |
15 |
Pages: |
re2 |
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Publication |
First Author: |
Himanen JP |
Year: |
2003 |
Journal: |
Trends Neurosci |
Title: |
Eph signaling: a structural view. |
Volume: |
26 |
Issue: |
1 |
Pages: |
46-51 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1035
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1130
 |
Fragment?: |
false |
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•
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