| Type |
Details |
Score |
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2016 |
|
| Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stryke D |
| Year: |
2003 |
| Journal: |
Nucleic Acids Res |
| Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
| Volume: |
31 |
| Issue: |
1 |
| Pages: |
278-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bedogni F |
| Year: |
2021 |
| Journal: |
Front Mol Neurosci |
| Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
| Volume: |
14 |
|
| Pages: |
686034 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2009 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
1670-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2014 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
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|
|
•
•
•
•
•
|
| Publication |
| First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawai J |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Functional annotation of a full-length mouse cDNA collection. |
| Volume: |
409 |
| Issue: |
6821 |
| Pages: |
685-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zambrowicz BP |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
| Pages: |
14109-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wong WT |
| Year: |
1995 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution. |
| Volume: |
92 |
| Issue: |
21 |
| Pages: |
9530-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yamabhai M |
| Year: |
1998 |
| Journal: |
J Biol Chem |
| Title: |
Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains. |
| Volume: |
273 |
| Issue: |
47 |
| Pages: |
31401-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Curran J |
| Year: |
2015 |
| Journal: |
J Biol Chem |
| Title: |
Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria. |
| Volume: |
290 |
| Issue: |
19 |
| Pages: |
12210-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Confalonieri S |
| Year: |
2002 |
| Journal: |
FEBS Lett |
| Title: |
The Eps15 homology (EH) domain. |
| Volume: |
513 |
| Issue: |
1 |
| Pages: |
24-9 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
897
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wong WT |
| Year: |
1994 |
| Journal: |
Oncogene |
| Title: |
The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32. |
| Volume: |
9 |
| Issue: |
6 |
| Pages: |
1591-7 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
581
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
de Beer T |
| Year: |
1998 |
| Journal: |
Science |
| Title: |
Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain. |
| Volume: |
281 |
| Issue: |
5381 |
| Pages: |
1357-60 |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Eps15 is constitutively oligomerized due to homophilic interaction of its coiled-coil region. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kent HM |
| Year: |
2002 |
| Journal: |
Structure |
| Title: |
Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin. |
| Volume: |
10 |
| Issue: |
8 |
| Pages: |
1139-48 |
|
•
•
•
•
•
|
| GO Term |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Confalonieri S |
| Year: |
2000 |
| Journal: |
J Cell Biol |
| Title: |
Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis. |
| Volume: |
150 |
| Issue: |
4 |
| Pages: |
905-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Salcini AE |
| Year: |
2001 |
| Journal: |
Nat Cell Biol |
| Title: |
The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling. |
| Volume: |
3 |
| Issue: |
8 |
| Pages: |
755-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tebar F |
| Year: |
1997 |
| Journal: |
J Biol Chem |
| Title: |
Eps15 is constitutively oligomerized due to homophilic interaction of its coiled-coil region. |
| Volume: |
272 |
| Issue: |
24 |
| Pages: |
15413-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Whitehead B |
| Year: |
1999 |
| Journal: |
Biochemistry |
| Title: |
The EH1 domain of Eps15 is structurally classified as a member of the S100 subclass of EF-hand-containing proteins. |
| Volume: |
38 |
| Issue: |
35 |
| Pages: |
11271-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen H |
| Year: |
1999 |
| Journal: |
J Biol Chem |
| Title: |
The interaction of epsin and Eps15 with the clathrin adaptor AP-2 is inhibited by mitotic phosphorylation and enhanced by stimulation-dependent dephosphorylation in nerve terminals. |
| Volume: |
274 |
| Issue: |
6 |
| Pages: |
3257-60 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Daumke O |
| Year: |
2007 |
| Journal: |
Nature |
| Title: |
Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling. |
| Volume: |
449 |
| Issue: |
7164 |
| Pages: |
923-7 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
124
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
25
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
135
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rumpf J |
| Year: |
2008 |
| Journal: |
EMBO J |
| Title: |
Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity. |
| Volume: |
27 |
| Issue: |
3 |
| Pages: |
558-69 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Stonin 2 is involved in clathrin mediated endocytosis []. It binds to Eps15 by its highly conserved NPF motif. The complex formed has been shown to directly associate with the clathrin adaptor complex AP-2, and to localize to clathrin-coated pits (CCPs) []. In addition, stonin2 was recently identified as a specific sorting adaptor for synaptotagmin, and may thus regulate synaptic vesicle recycling []. This entry represents the N-terminal domain of stonin-2. It is found in association with . |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Henne WM |
| Year: |
2010 |
| Journal: |
Science |
| Title: |
FCHo proteins are nucleators of clathrin-mediated endocytosis. |
| Volume: |
328 |
| Issue: |
5983 |
| Pages: |
1281-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim S |
| Year: |
2001 |
| Journal: |
Biochemistry |
| Title: |
Solution structure of the Reps1 EH domain and characterization of its binding to NPF target sequences. |
| Volume: |
40 |
| Issue: |
23 |
| Pages: |
6776-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sachs AB |
| Year: |
1992 |
| Journal: |
Cell |
| Title: |
Translation initiation requires the PAB-dependent poly(A) ribonuclease in yeast. |
| Volume: |
70 |
| Issue: |
6 |
| Pages: |
961-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Di Fiore PP |
| Year: |
1997 |
| Journal: |
Trends Biochem Sci |
| Title: |
EH: a novel protein-protein interaction domain potentially involved in intracellular sorting. |
| Volume: |
22 |
| Issue: |
11 |
| Pages: |
411-3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mayer BJ |
| Year: |
1999 |
| Journal: |
Curr Biol |
| Title: |
Endocytosis: EH domains lend a hand. |
| Volume: |
9 |
| Issue: |
2 |
| Pages: |
R70-3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Salcini AE |
| Year: |
1997 |
| Journal: |
Genes Dev |
| Title: |
Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. |
| Volume: |
11 |
| Issue: |
17 |
| Pages: |
2239-49 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Paoluzi S |
| Year: |
1998 |
| Journal: |
EMBO J |
| Title: |
Recognition specificity of individual EH domains of mammals and yeast. |
| Volume: |
17 |
| Issue: |
22 |
| Pages: |
6541-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Enmon JL |
| Year: |
2000 |
| Journal: |
Biochemistry |
| Title: |
Solution structure of Eps15's third EH domain reveals coincident Phe-Trp and Asn-Pro-Phe binding sites. |
| Volume: |
39 |
| Issue: |
15 |
| Pages: |
4309-19 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
The EH (for Eps15 Homology) domain is a protein-protein interaction module of approximately 95 residues which was originally identified as a repeated sequence present in three copies at the N terminus of the tyrosine kinase substrates Eps15 and Eps15R [, ]. The EH domain was subsequently found in several proteins implicated in endocytosis, vesicle transport and signal transduction in organisms ranging from yeast to mammals. EH domains are present in one to three copies and they may include calcium-binding domains of the EF-hand type [, ]. Eps15 is divided into three domains: domain I contains signatures of a regulatory domain, including a candidate tyrosine phosphorylation site and EF-hand-type calcium-binding domains, domain II presents the characteristic heptad repeats of coiled-coil rod-like proteins, and domain III displays a repeated aspartic acid-proline-phenylalanine motif similar to a consensus sequence of several methylases [].EH domains have been shown to bind specifically but with moderate affinity to peptides containing short, unmodified motifs through predominantly hydrophobic interactions. The target motifs are divided into three classes: class I consists of the concensus Asn-Pro-Phe (NPF) sequence; class II consists of aromatic and hydrophobic di- and tripeptide motifs, including the Phe-Trp (FW), Trp-Trp (WW), and Ser-Trp-Gly (SWG) motifs; and class III contains the His-(Thr/Ser)-Phe motif (HTF/HSF) [, ]. The structure of several EH domains has been solved by NMR spectroscopy. The fold consists of two helix-loop-helix characteristic of EF-hand domains, connected by a short antiparallel β-sheet. The target peptide is bound in a hydrophobic pocket between two alpha helices. Sequence analysis and structural data indicate that not all the EF-hands are capable of binding calcium because of substitutions of the calcium-liganding residues in the loop [, , ]. This domain is often implicated in the regulation of protein transport/sorting and membrane trafficking. Messenger RNA translation initiation and cytoplasmic poly(A) tail shortening require the poly(A)-binding protein (PAB) in yeast. The PAB-dependent poly(A) ribonuclease (PAN) is organised into distinct domains containing repeated sequence elements []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Trevaskis J |
| Year: |
2005 |
| Journal: |
Endocrinology |
| Title: |
Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance. |
| Volume: |
146 |
| Issue: |
9 |
| Pages: |
3757-64 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
SGIP1 is a member of the muniscin family. It is an endophilin-interacting protein that plays an obligatory role in the regulation of energy homeostasis [], and is also involved in clathrin-mediated endocytosis by interacting with phospholipids and eps15 [].The muniscins are a family of endocytic adaptors that is conserved from yeast to humans. Their C-terminal domain is structurally similar to mu homology domains (MHDs), and is the region of the muniscin proteins involved in the interactions with the endocytic adaptor-scaffold proteins Ede1-eps15 []. This entry represent the mu-homology domain (MHD) of SGIP1. Unlike other muniscins, SGIP1 does not contain the EFC/F-BAR domain, but does have a proline-rich domain (PRD) and a C-terminal MHD. |
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| Publication |
| First Author: |
Pucharcos C |
| Year: |
2000 |
| Journal: |
FEBS Lett |
| Title: |
Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis. |
| Volume: |
478 |
| Issue: |
1-2 |
| Pages: |
43-51 |
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•
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| Publication |
| First Author: |
Tsyba L |
| Year: |
2011 |
| Journal: |
Gene |
| Title: |
Intersectin multidomain adaptor proteins: regulation of functional diversity. |
| Volume: |
473 |
| Issue: |
2 |
| Pages: |
67-75 |
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| Publication |
| First Author: |
Rodriguez-Fraticelli AE |
| Year: |
2010 |
| Journal: |
J Cell Biol |
| Title: |
The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis. |
| Volume: |
189 |
| Issue: |
4 |
| Pages: |
725-38 |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
103
 |
| Fragment?: |
true |
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| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
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| Protein Domain |
| Type: |
Domain |
| Description: |
This is the AAA ATPase domain found at the C-terminal of plant senescence-associated proteins and spartin. In Hemerocallis, petals have a genetically based program that leads to senescence and cell death approximately 24 hours, after the flower opens, and it is believed that senescence proteins produced around that time have a role in this program []. This domain is also found at the C-terminal of Spartin, a protein from higher vertebrates associated with endosomal trafficking and microtubule dynamics []. Spartin functions presynaptically with endocytic adaptor Eps15 to regulate synaptic growth and function. Mutations in human spartin gene cause Troyer syndrome, a hereditary spastic paraplegia []. This AAA ATPase domain similar to other AAA proteins contain an α/β nucleotide-binding domain (NBD) and a smaller four-helix bundle domain (HBD) []. Uniquely among AAA structures, spastin has two helices (N-terminal α1 and C-terminal α11) that embrace the NBD []. |
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| Protein Domain |
| Type: |
Domain |
| Description: |
Intersectin-2 (ITSN2) is an adaptor protein that functions in exo- and endocytosis, actin cytoskeletal reorganization, and signal transduction []. It plays a role in clathrin-coated pit (CCP) formation []. It binds to many proteins through its multidomain structure and facilitates the assembly of multimeric complexes. ITSN2 also functions as a specific GEF for Cdc42 activation in epithelial morphogenesis, and is required in mitotic spindle orientation []. It exists in alternatively spliced short and long isoforms. The short isoform contains two Eps15 homology domains (EH1 and EH2), a coiled-coil region and five SH3 domains (SH3A-E), while the long isoform, in addition, contains RhoGEF (also called Dbl-homologous or DH), Pleckstrin homology (PH) and C2 domains. This entry represents the first SH3 domain of ITSN2. |
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| Protein Domain |
| Type: |
Domain |
| Description: |
Intersectin-2 (ITSN2) is an adaptor protein that functions in exo- and endocytosis, actin cytoskeletal reorganization, and signal transduction []. It plays a role in clathrin-coated pit(CCP) formation []. It binds to many proteins through its multidomain structure and facilitates the assembly of multimeric complexes. ITSN2 also functions as a specific GEF for Cdc42 activation in epithelial morphogenesis, and is required in mitotic spindle orientation []. It exists in alternatively spliced short and long isoforms. The short isoform contains two Eps15 homology domains (EH1 and EH2), a coiled-coil region and five SH3 domains (SH3A-E), while the long isoform, in addition, contains RhoGEF (also called Dbl-homologous or DH), Pleckstrin homology (PH) and C2 domains. This entry represents the second SH3 domain of ITSN2. |
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| Protein Domain |
| Type: |
Domain |
| Description: |
Intersectin-2 (ITSN2) is an adaptor protein that functions in exo- and endocytosis, actin cytoskeletal reorganization, and signal transduction []. It plays a role in clathrin-coated pit (CCP) formation []. It binds to many proteins through its multidomain structure and facilitates the assembly of multimeric complexes. ITSN2 also functions as a specific GEF for Cdc42 activation in epithelial morphogenesis, and is required in mitotic spindle orientation []. It exists in alternatively spliced short and long isoforms. The short isoform contains two Eps15 homology domains (EH1 and EH2), a coiled-coil region and five SH3 domains (SH3A-E), while the long isoform, in addition, contains RhoGEF (also called Dbl-homologous or DH), Pleckstrin homology (PH) and C2 domains. This entry represents the third SH3 domain of ITSN2. |
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| Protein Domain |
| Type: |
Domain |
| Description: |
Intersectin-2 (ITSN2) is an adaptor protein that functions in exo- and endocytosis, actin cytoskeletal reorganization, and signal transduction []. It plays a role in clathrin-coated pit (CCP) formation []. It binds to many proteins through its multidomain structure and facilitates the assembly of multimeric complexes. ITSN2 also functions as a specific GEF for Cdc42 activation in epithelial morphogenesis, and is required in mitotic spindle orientation []. It exists in alternatively spliced short and long isoforms. The short isoform contains two Eps15 homology domains (EH1 and EH2), a coiled-coil region and five SH3 domains (SH3A-E), while the long isoform, in addition, contains RhoGEF (also called Dbl-homologous or DH), Pleckstrin homology (PH) and C2 domains. This entry represents the fourth SH3 domain of ITSN2. |
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| Protein Domain |
| Type: |
Domain |
| Description: |
Intersectin-2 (ITSN2) is an adaptor protein that functions in exo- and endocytosis, actin cytoskeletal reorganization, and signal transduction []. It plays a role in clathrin-coated pit (CCP) formation []. It binds to many proteins through its multidomain structure and facilitates the assembly of multimeric complexes. ITSN2 also functions as a specific GEF for Cdc42 activation in epithelial morphogenesis, and is required in mitotic spindle orientation []. It exists in alternatively spliced short and long isoforms. The short isoform contains two Eps15 homology domains (EH1 and EH2), a coiled-coil region and five SH3 domains (SH3A-E), while the long isoform, in addition, contains RhoGEF (also called Dbl-homologous or DH), Pleckstrin homology (PH) and C2 domains. This entry represents the fifth SH3 domain of ITSN2. |
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| Publication |
| First Author: |
Poupon V |
| Year: |
1999 |
| Journal: |
J Biol Chem |
| Title: |
Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase. |
| Volume: |
274 |
| Issue: |
27 |
| Pages: |
19188-94 |
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| Publication |
| First Author: |
Yamaguchi A |
| Year: |
1997 |
| Journal: |
J Biol Chem |
| Title: |
An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1. |
| Volume: |
272 |
| Issue: |
50 |
| Pages: |
31230-4 |
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| Publication |
| First Author: |
George M |
| Year: |
2011 |
| Journal: |
PLoS One |
| Title: |
Renal thrombotic microangiopathy in mice with combined deletion of endocytic recycling regulators EHD3 and EHD4. |
| Volume: |
6 |
| Issue: |
3 |
| Pages: |
e17838 |
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| Publication |
| First Author: |
Guilherme A |
| Year: |
2004 |
| Journal: |
J Biol Chem |
| Title: |
Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes. |
| Volume: |
279 |
| Issue: |
38 |
| Pages: |
40062-75 |
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| Publication |
| First Author: |
Nakashima S |
| Year: |
1999 |
| Journal: |
EMBO J |
| Title: |
Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors. |
| Volume: |
18 |
| Issue: |
13 |
| Pages: |
3629-42 |
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| Publication |
| First Author: |
Doherty KR |
| Year: |
2008 |
| Journal: |
J Biol Chem |
| Title: |
The endocytic recycling protein EHD2 interacts with myoferlin to regulate myoblast fusion. |
| Volume: |
283 |
| Issue: |
29 |
| Pages: |
20252-60 |
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| Publication |
| First Author: |
Page LJ |
| Year: |
1999 |
| Journal: |
J Cell Biol |
| Title: |
Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. |
| Volume: |
146 |
| Issue: |
5 |
| Pages: |
993-1004 |
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| Publication |
| First Author: |
Rosenthal JA |
| Year: |
1999 |
| Journal: |
J Biol Chem |
| Title: |
The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. |
| Volume: |
274 |
| Issue: |
48 |
| Pages: |
33959-65 |
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| Publication |
| First Author: |
Rainey MA |
| Year: |
2010 |
| Journal: |
BMC Dev Biol |
| Title: |
The endocytic recycling regulator EHD1 is essential for spermatogenesis and male fertility in mice. |
| Volume: |
10 |
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| Pages: |
37 |
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| Publication |
| First Author: |
Juneja SC |
| Year: |
2005 |
| Journal: |
Hum Reprod |
| Title: |
A mouse model of familial oligoasthenoteratozoospermia. |
| Volume: |
20 |
| Issue: |
4 |
| Pages: |
881-93 |
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| Publication |
| First Author: |
Tang J |
| Year: |
2021 |
| Journal: |
Neurobiol Dis |
| Title: |
ALS-causing SOD1 mutants regulate occludin phosphorylation/ubiquitination and endocytic trafficking via the ITCH/Eps15/Rab5 axis. |
| Volume: |
153 |
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| Pages: |
105315 |
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| Publication |
| First Author: |
Fan G |
| Year: |
2020 |
| Journal: |
Aging Cell |
| Title: |
Age attenuates the T-type CaV 3.2-RyR axis in vascular smooth muscle. |
| Volume: |
19 |
| Issue: |
4 |
| Pages: |
e13134 |
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| Publication |
| First Author: |
Arya P |
| Year: |
2015 |
| Journal: |
Dev Biol |
| Title: |
The endocytic recycling regulatory protein EHD1 Is required for ocular lens development. |
| Volume: |
408 |
| Issue: |
1 |
| Pages: |
41-55 |
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| Publication |
| First Author: |
Bejarano E |
| Year: |
2012 |
| Journal: |
Mol Biol Cell |
| Title: |
Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner. |
| Volume: |
23 |
| Issue: |
11 |
| Pages: |
2156-69 |
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| Publication |
| First Author: |
Demonbreun AR |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
Eps 15 Homology Domain (EHD)-1 Remodels Transverse Tubules in Skeletal Muscle. |
| Volume: |
10 |
| Issue: |
9 |
| Pages: |
e0136679 |
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