Type |
Details |
Score |
QTL |
Type: |
QTL |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
QTL |
Type: |
QTL |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
QTL |
Type: |
QTL |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Bolte C |
Year: |
2015 |
Journal: |
J Biol Chem |
Title: |
Forkhead box F2 regulation of platelet-derived growth factor and myocardin/serum response factor signaling is essential for intestinal development. |
Volume: |
290 |
Issue: |
12 |
Pages: |
7563-75 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This is an F2 lobe domain consisting of an acyl-CoA binding protein fold found in FERM region of Jak-family tyrosine kinases []. Multidomain JAK molecules interact with receptors through their FERM and SH2-like domains, triggering a series of phosphorylation events, resulting in the activation of their kinase domains []. Overall, the FERM region maintains the typical three-lobed architecture, with an F1 lobe consisting of a ubiquitin-like fold, an F2 lobe consisting of an acyl-CoA binding protein fold, and an F3 lobe consisting of a pleckstrin-homology (PH) fold. JAK1 FERM-F2 domain has been shown to act as the interaction site for the IFNLR1 box1 motif (PxxLxF) of class II cytokine receptors which is essential for kinase activation []. |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
22 |
Description: |
Prostaglandin F2 receptor negative regulator |
Type: |
chain |
End: |
879 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
19 |
Description: |
Adhesion G-protein coupled receptor F2 |
Type: |
chain |
End: |
644 |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
pancreas |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
pancreas |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
lung |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
lung |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
pituitary gland |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
adrenal gland |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
adrenal gland |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
stomach |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
heart |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
liver |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
ovary |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
ovary |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
small intestine |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
small intestine |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
heart |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
brain |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8 |
Stage: |
28 |
Structure . Name: |
brain |
|
Curation Status: |
Curated |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE13745 |
Experiment Type: |
transcription profiling by array |
Study Type: |
Baseline |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE13752 |
Experiment Type: |
transcription profiling by array |
Study Type: |
Baseline |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE13746 |
Experiment Type: |
transcription profiling by array |
Study Type: |
Baseline |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3842083 |
Assay Type: |
Western blot |
Annotation Date: |
2009-04-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360411 |
|
Stage: |
TS01 |
Assay Id: |
MGI:3842105 |
Age: |
embryonic day 0.5 |
|
|
Specimen Label: |
F2 Fresh 1-C |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3842083 |
Assay Type: |
Western blot |
Annotation Date: |
2009-04-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360422 |
|
Stage: |
TS02 |
Assay Id: |
MGI:3842105 |
Age: |
embryonic day 1.0 |
|
|
Specimen Label: |
F2 Fresh 2-C |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3842083 |
Assay Type: |
Western blot |
Annotation Date: |
2009-04-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360443 |
|
Stage: |
TS03 |
Assay Id: |
MGI:3842105 |
Age: |
embryonic day 2.5 |
|
|
Specimen Label: |
F2 Fresh 8-C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3842083 |
Assay Type: |
Western blot |
Annotation Date: |
2009-04-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:3842105 |
Age: |
embryonic day 3.5 |
|
|
Specimen Label: |
F2 Fresh BL |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3842086 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2009-04-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360354 |
Pattern: |
Not Specified |
Stage: |
TS04 |
Assay Id: |
MGI:3842125 |
Age: |
embryonic day 3.5 |
|
|
Specimen Label: |
F2 Fresh (left) |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3842086 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2009-04-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360354 |
Pattern: |
Not Specified |
Stage: |
TS04 |
Assay Id: |
MGI:3842125 |
Age: |
embryonic day 3.5 |
|
|
Specimen Label: |
F2 Fresh (center) |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3842086 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2009-04-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360354 |
Pattern: |
Not Specified |
Stage: |
TS04 |
Assay Id: |
MGI:3842125 |
Age: |
embryonic day 3.5 |
|
|
Specimen Label: |
F2 Fresh (right) |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3842083 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2009-04-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360354 |
Pattern: |
Not Specified |
Stage: |
TS04 |
Assay Id: |
MGI:3842130 |
Age: |
embryonic day 3.5 |
|
|
Specimen Label: |
F2 Fresh (left) |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3842083 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2009-04-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360354 |
Pattern: |
Not Specified |
Stage: |
TS04 |
Assay Id: |
MGI:3842130 |
Age: |
embryonic day 3.5 |
|
|
Specimen Label: |
F2 Fresh (center) |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3842083 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2009-04-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360354 |
Pattern: |
Not Specified |
Stage: |
TS04 |
Assay Id: |
MGI:3842130 |
Age: |
embryonic day 3.5 |
|
|
Specimen Label: |
F2 Fresh (right) |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
446
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
156
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
673
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Solute carrier family 35 member F2 |
Type: |
chain |
End: |
375 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wergedal JE |
Year: |
2006 |
Journal: |
J Bone Miner Res |
Title: |
Femur mechanical properties in the F2 progeny of an NZB/B1NJ x RF/J cross are regulated predominantly by genetic loci that regulate bone geometry. |
Volume: |
21 |
Issue: |
8 |
Pages: |
1256-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Unezaki S |
Year: |
1996 |
Journal: |
Biol Reprod |
Title: |
Characterization of prostaglandin F2 alpha production in pregnant and cycling mice. |
Volume: |
55 |
Issue: |
4 |
Pages: |
889-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu X |
Year: |
2003 |
Journal: |
Brain Res Bull |
Title: |
An exploratory factor analysis of the Tail Suspension Test in 12 inbred strains of mice and an F2 intercross. |
Volume: |
60 |
Issue: |
3 |
Pages: |
223-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stylianou IM |
Year: |
2006 |
Journal: |
Genetics |
Title: |
Complex genetic architecture revealed by analysis of high-density lipoprotein cholesterol in chromosome substitution strains and F2 crosses. |
Volume: |
174 |
Issue: |
2 |
Pages: |
999-1007 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weng L |
Year: |
2000 |
Journal: |
J Bone Miner Res |
Title: |
The monoclonal antibodies 18d7/91f2 recognize a receptor regulatory protein on mouse bone marrow stromal cells. |
Volume: |
15 |
Issue: |
7 |
Pages: |
1286-300 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
879
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
644
|
Fragment?: |
false |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Publication |
First Author: |
Mock B |
Year: |
1993 |
Journal: |
Eur J Immunogenet |
Title: |
Genetic control of Leishmania major infection in congenic, recombinant inbred and F2 populations of mice. |
Volume: |
20 |
Issue: |
5 |
Pages: |
335-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lake S |
Year: |
1994 |
Journal: |
FEBS Lett |
Title: |
Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. |
Volume: |
355 |
Issue: |
3 |
Pages: |
317-25 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic, insertion, F2 hybrid |
|
•
•
•
•
•
|
Publication |
First Author: |
Mähler M |
Year: |
2002 |
Journal: |
Genomics |
Title: |
Genetics of colitis susceptibility in IL-10-deficient mice: backcross versus F2 results contrasted by principal component analysis. |
Volume: |
80 |
Issue: |
3 |
Pages: |
274-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin C |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
QTL analysis of dietary obesity in C57BL/6byj X 129P3/J F2 mice: diet- and sex-dependent effects. |
Volume: |
8 |
Issue: |
7 |
Pages: |
e68776 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hitzemann R |
Year: |
1998 |
Journal: |
Mamm Genome |
Title: |
Genetics of ethanol-induced locomotor activation: detection of QTLs in a C57BL/6J x DBA/2J F2 intercross. |
Volume: |
9 |
Issue: |
12 |
Pages: |
956-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suto J |
Year: |
2004 |
Journal: |
Biochem Genet |
Title: |
Quantitative trait locus analysis of plasma cholesterol and triglyceride levels in C57BL/6J x RR F2 mice. |
Volume: |
42 |
Issue: |
9-10 |
Pages: |
347-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Parker CC |
Year: |
2014 |
Journal: |
Genetics |
Title: |
High-resolution genetic mapping of complex traits from a combined analysis of F2 and advanced intercross mice. |
Volume: |
198 |
Issue: |
1 |
Pages: |
103-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suto J |
Year: |
2003 |
Journal: |
Biochem Genet |
Title: |
Quantitative trait locus analysis of plasma cholesterol and triglyceride levels in KK x RR F2 mice. |
Volume: |
41 |
Issue: |
9-10 |
Pages: |
325-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
York B |
Year: |
1997 |
Journal: |
Mamm Genome |
Title: |
Inherited non-autosomal effects on body fat in F2 mice derived from an AKR/J x SWR/J cross. |
Volume: |
8 |
Issue: |
10 |
Pages: |
726-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Johansson AC |
Year: |
2002 |
Journal: |
Eur J Immunol |
Title: |
The genetic control of sialadenitis versus arthritis in a NOD.QxB10.Q F2 cross. |
Volume: |
32 |
Issue: |
1 |
Pages: |
243-50 |
|
•
•
•
•
•
|