| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:4422613 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1768022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422043 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression was not detected in the skull (base and vault). |
| Specimen Label: |
EN1167; Specimen N533 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1868228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693057 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1876906 |
|
| Specimen Label: |
UC Davis_1876906 |
| Detected: |
true |
| Specimen Num: |
28 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1868228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693057 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1876907 |
|
| Specimen Label: |
UC Davis_1876907 |
| Detected: |
true |
| Specimen Num: |
29 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1868228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693057 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1876908 |
|
| Specimen Label: |
UC Davis_1876908 |
| Detected: |
true |
| Specimen Num: |
30 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4422613 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2672022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422043 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression was not detected in whisker follicle. |
| Specimen Label: |
EN1167; Specimen N533 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7378467 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2022-11-08 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3727825 |
|
| Stage: |
TS25 |
| Assay Id: |
MGI:7380300 |
| Age: |
embryonic day 17.5 |
|
|
| Specimen Label: |
not shown E17.5 |
| Detected: |
false |
| Specimen Num: |
11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lazenka MF |
| Year: |
2015 |
| Journal: |
J Pharmacol Exp Ther |
| Title: |
Role of Dopamine Type 1 Receptors and Dopamine- and cAMP-Regulated Phosphoprotein Mr 32 kDa in Δ9-Tetrahydrocannabinol-Mediated Induction of ΔFosB in the Mouse Forebrain. |
| Volume: |
354 |
| Issue: |
3 |
| Pages: |
316-27 |
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•
•
•
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Geisler JG |
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1998 |
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Mamm Genome |
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Molecular cloning of a novel mouse gene with predominant muscle and neural expression. |
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9 |
| Issue: |
4 |
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Shiromani PJ |
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2000 |
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Brain Res Mol Brain Res |
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Radwanska K |
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2006 |
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Neuroscience |
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•
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Idelevich A |
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J Bone Miner Res |
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ΔFosB Requires Galanin, but not Leptin, to Increase Bone Mass via the Hypothalamus, but both are needed to increase Energy expenditure. |
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Mol Cell |
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Chromosomal protein HMGN1 modulates histone H3 phosphorylation. |
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Nature |
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J Biol Chem |
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The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1. |
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278 |
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12 |
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•
•
•
•
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1996 |
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J Immunol |
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Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells. |
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157 |
| Issue: |
5 |
| Pages: |
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•
•
•
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Unterwald EM |
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Brain Res Dev Brain Res |
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Prenatal exposure to cocaine decreases adenylyl cyclase activity in embryonic mouse striatum. |
| Volume: |
147 |
| Issue: |
1-2 |
| Pages: |
67-75 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
FosB is a metallothiol transferase which confers resistance to the antiobiotic fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin []. L-cysteine is thought to be the physiological thiol donor. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yap EL |
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2021 |
| Journal: |
Nature |
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Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network. |
| Volume: |
590 |
| Issue: |
7844 |
| Pages: |
115-121 |
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•
•
•
•
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Bard-Chapeau EA |
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2012 |
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Proc Natl Acad Sci U S A |
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Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors. |
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109 |
| Issue: |
6 |
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2168-73 |
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•
•
•
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2023 |
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PLoS One |
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Retinal transcriptome of neonatal mice after optic nerve injury. |
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e0286344 |
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Proc Natl Acad Sci U S A |
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6130-5 |
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•
•
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Physiol Genomics |
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New Dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice. |
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| Pages: |
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•
•
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PLoS Genet |
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Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity. |
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e1008916 |
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•
•
•
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2002 |
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Arch Biochem Biophys |
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Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. |
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405 |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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| HT Experiment |
| Series Id: |
GSE37056 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
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| Publication |
| First Author: |
Cao M |
| Year: |
2001 |
| Journal: |
J Bacteriol |
| Title: |
FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis. |
| Volume: |
183 |
| Issue: |
7 |
| Pages: |
2380-3 |
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•
•
•
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| Publication |
| First Author: |
Ulery PG |
| Year: |
2006 |
| Journal: |
J Neurosci |
| Title: |
Regulation of DeltaFosB stability by phosphorylation. |
| Volume: |
26 |
| Issue: |
19 |
| Pages: |
5131-42 |
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•
•
•
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| Publication |
| First Author: |
Ulery PG |
| Year: |
2007 |
| Journal: |
Eur J Neurosci |
| Title: |
Regulation of DeltaFosB transcriptional activity by Ser27 phosphorylation. |
| Volume: |
25 |
| Issue: |
1 |
| Pages: |
224-30 |
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•
•
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| Publication |
| First Author: |
Eagle AL |
| Year: |
2015 |
| Journal: |
J Neurosci |
| Title: |
Experience-Dependent Induction of Hippocampal ΔFosB Controls Learning. |
| Volume: |
35 |
| Issue: |
40 |
| Pages: |
13773-83 |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
25
 |
| Fragment?: |
true |
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•
•
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| HT Experiment |
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| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
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•
•
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| Publication |
| First Author: |
Ahmed MR |
| Year: |
2019 |
| Journal: |
Neurobiol Aging |
| Title: |
Pharmacological antagonism of histamine H2R ameliorated L-DOPA-induced dyskinesia via normalization of GRK3 and by suppressing FosB and ERK in PD. |
| Volume: |
81 |
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| Pages: |
177-189 |
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•
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| Allele |
| Name: |
transgene insertion 4468, Eric Nestler |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
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•
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| Publication |
| First Author: |
Drisaldi B |
| Year: |
2020 |
| Journal: |
Front Cell Neurosci |
| Title: |
Cytoplasmic Polyadenylation Element Binding Proteins CPEB1 and CPEB3 Regulate the Translation of FosB and Are Required for Maintaining Addiction-Like Behaviors Induced by Cocaine. |
| Volume: |
14 |
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| Pages: |
207 |
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| Strain |
| Attribute String: |
congenic, mutant strain, transgenic |
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•
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| Publication |
| First Author: |
Kumar A |
| Year: |
2005 |
| Journal: |
Neuron |
| Title: |
Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. |
| Volume: |
48 |
| Issue: |
2 |
| Pages: |
303-14 |
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•
•
•
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| Publication |
| First Author: |
Gajewski PA |
| Year: |
2019 |
| Journal: |
J Neurosci |
| Title: |
Epigenetic Regulation of Hippocampal Fosb Expression Controls Behavioral Responses to Cocaine. |
| Volume: |
39 |
| Issue: |
42 |
| Pages: |
8305-8314 |
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•
•
•
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| Publication |
| First Author: |
Donahue RJ |
| Year: |
2014 |
| Journal: |
Biol Psychiatry |
| Title: |
Effects of striatal ΔFosB overexpression and ketamine on social defeat stress-induced anhedonia in mice. |
| Volume: |
76 |
| Issue: |
7 |
| Pages: |
550-8 |
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•
•
•
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| Publication |
| First Author: |
Kelz MB |
| Year: |
1999 |
| Journal: |
Nature |
| Title: |
Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. |
| Volume: |
401 |
| Issue: |
6750 |
| Pages: |
272-6 |
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•
•
•
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| Publication |
| First Author: |
Olausson P |
| Year: |
2006 |
| Journal: |
J Neurosci |
| Title: |
DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation. |
| Volume: |
26 |
| Issue: |
36 |
| Pages: |
9196-204 |
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•
•
•
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| Publication |
| First Author: |
Sims NA |
| Year: |
2002 |
| Journal: |
Bone |
| Title: |
Regulating DeltaFosB expression in adult Tet-Off-DeltaFosB transgenic mice alters bone formation and bone mass. |
| Volume: |
30 |
| Issue: |
1 |
| Pages: |
32-9 |
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•
•
•
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| Publication |
| First Author: |
Rowe GC |
| Year: |
2009 |
| Journal: |
Endocrinology |
| Title: |
Increased energy expenditure and insulin sensitivity in the high bone mass DeltaFosB transgenic mice. |
| Volume: |
150 |
| Issue: |
1 |
| Pages: |
135-43 |
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•
•
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| Publication |
| First Author: |
Colby CR |
| Year: |
2003 |
| Journal: |
J Neurosci |
| Title: |
Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine. |
| Volume: |
23 |
| Issue: |
6 |
| Pages: |
2488-93 |
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•
•
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| Publication |
| First Author: |
Maze I |
| Year: |
2010 |
| Journal: |
Science |
| Title: |
Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. |
| Volume: |
327 |
| Issue: |
5962 |
| Pages: |
213-6 |
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•
•
•
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| Allele |
| Name: |
transgene insertion 5, Eric Nestler |
| Allele Type: |
Transgenic |
| Attribute String: |
Dominant negative, Inducible, Inserted expressed sequence |
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•
•
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| Publication |
| First Author: |
Zachariou V |
| Year: |
2006 |
| Journal: |
Nat Neurosci |
| Title: |
An essential role for DeltaFosB in the nucleus accumbens in morphine action. |
| Volume: |
9 |
| Issue: |
2 |
| Pages: |
205-11 |
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•
•
•
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| Publication |
| First Author: |
McClung CA |
| Year: |
2003 |
| Journal: |
Nat Neurosci |
| Title: |
Regulation of gene expression and cocaine reward by CREB and DeltaFosB. |
| Volume: |
6 |
| Issue: |
11 |
| Pages: |
1208-15 |
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•
•
•
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| Publication |
| First Author: |
Chen J |
| Year: |
1998 |
| Journal: |
Mol Pharmacol |
| Title: |
Transgenic animals with inducible, targeted gene expression in brain. |
| Volume: |
54 |
| Issue: |
3 |
| Pages: |
495-503 |
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| Strain |
| Attribute String: |
transgenic, mutant strain, coisogenic |
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| Publication |
| First Author: |
Peakman MC |
| Year: |
2003 |
| Journal: |
Brain Res |
| Title: |
Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. |
| Volume: |
970 |
| Issue: |
1-2 |
| Pages: |
73-86 |
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•
•
•
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| Publication |
| First Author: |
Beharry Z |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
Functional analysis of active site residues of the fosfomycin resistance enzyme FosA from Pseudomonas aeruginosa. |
| Volume: |
280 |
| Issue: |
18 |
| Pages: |
17786-91 |
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| Protein Domain |
| Type: |
Domain |
| Description: |
Glyoxalase I () (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway. S-lactoylglutathione is then converted by glyoxalase II to lactic acid [].Glyoxalase I is an ubiquitous enzyme which binds one mole of zincper subunit. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric. The sequence of glyoxalase I is well conserved.The domain represented by this entry is found in glyoxalase I and in other related proteins, including fosfomycin resistance proteins FosB [], FosA [], FosX []and dioxygenases (eg. 4-hydroxyphenylpyruvate dioxygenase). |
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| HT Experiment |
| Series Id: |
GSE85308 |
| Experiment Type: |
RNA-Seq |
| Study Type: |
Baseline |
| Source: |
ArrayExpress |
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•
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•
•
•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
124
 |
| Fragment?: |
false |
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•
•
•
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| Publication |
| First Author: |
Fillgrove KL |
| Year: |
2007 |
| Journal: |
Biochemistry |
| Title: |
Structure and mechanism of the genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes. |
| Volume: |
46 |
| Issue: |
27 |
| Pages: |
8110-20 |
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