Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:4422613 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1768022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422043 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in the skull (base and vault). |
Specimen Label: |
EN1167; Specimen N533 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1868228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6693057 |
Age: |
postnatal adult |
Image: |
UC Davis_1876906 |
|
Specimen Label: |
UC Davis_1876906 |
Detected: |
true |
Specimen Num: |
28 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1868228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6693057 |
Age: |
postnatal adult |
Image: |
UC Davis_1876907 |
|
Specimen Label: |
UC Davis_1876907 |
Detected: |
true |
Specimen Num: |
29 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1868228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6693057 |
Age: |
postnatal adult |
Image: |
UC Davis_1876908 |
|
Specimen Label: |
UC Davis_1876908 |
Detected: |
true |
Specimen Num: |
30 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422613 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2672022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422043 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in whisker follicle. |
Specimen Label: |
EN1167; Specimen N533 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7378467 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-11-08 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3727825 |
|
Stage: |
TS25 |
Assay Id: |
MGI:7380300 |
Age: |
embryonic day 17.5 |
|
|
Specimen Label: |
not shown E17.5 |
Detected: |
false |
Specimen Num: |
11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lazenka MF |
Year: |
2015 |
Journal: |
J Pharmacol Exp Ther |
Title: |
Role of Dopamine Type 1 Receptors and Dopamine- and cAMP-Regulated Phosphoprotein Mr 32 kDa in Δ9-Tetrahydrocannabinol-Mediated Induction of ΔFosB in the Mouse Forebrain. |
Volume: |
354 |
Issue: |
3 |
Pages: |
316-27 |
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•
•
•
•
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Publication |
First Author: |
Geisler JG |
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1998 |
Journal: |
Mamm Genome |
Title: |
Molecular cloning of a novel mouse gene with predominant muscle and neural expression. |
Volume: |
9 |
Issue: |
4 |
Pages: |
274-82 |
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•
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Publication |
First Author: |
Shiromani PJ |
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2000 |
Journal: |
Brain Res Mol Brain Res |
Title: |
Sleep and wakefulness in c-fos and fos B gene knockout mice. |
Volume: |
80 |
Issue: |
1 |
Pages: |
75-87 |
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Publication |
First Author: |
Radwanska K |
Year: |
2006 |
Journal: |
Neuroscience |
Title: |
Regulation of cocaine-induced activator protein 1 transcription factors by the extracellular signal-regulated kinase pathway. |
Volume: |
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Issue: |
1 |
Pages: |
253-64 |
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Publication |
First Author: |
You JC |
Year: |
2017 |
Journal: |
Nat Med |
Title: |
Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits. |
Volume: |
23 |
Issue: |
11 |
Pages: |
1377-1383 |
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Publication |
First Author: |
Idelevich A |
Year: |
2019 |
Journal: |
J Bone Miner Res |
Title: |
ΔFosB Requires Galanin, but not Leptin, to Increase Bone Mass via the Hypothalamus, but both are needed to increase Energy expenditure. |
Volume: |
34 |
Issue: |
9 |
Pages: |
1707-1720 |
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Publication |
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Lim JH |
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Journal: |
Mol Cell |
Title: |
Chromosomal protein HMGN1 modulates histone H3 phosphorylation. |
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•
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Publication |
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2022 |
Journal: |
Nature |
Title: |
Fos ensembles encode and shape stable spatial maps in the hippocampus. |
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609 |
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7926 |
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327-334 |
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•
•
•
•
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Publication |
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2002 |
Journal: |
Radiat Res |
Title: |
Bone tumorigenesis induced by alpha-particle radiation: mapping of genetic loci influencing predisposition in mice. |
Volume: |
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4 |
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•
•
•
•
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Publication |
First Author: |
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Year: |
2003 |
Journal: |
J Biol Chem |
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The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1. |
Volume: |
278 |
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12 |
Pages: |
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•
•
•
•
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Publication |
First Author: |
Mondino A |
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1996 |
Journal: |
J Immunol |
Title: |
Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells. |
Volume: |
157 |
Issue: |
5 |
Pages: |
2048-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Unterwald EM |
Year: |
2003 |
Journal: |
Brain Res Dev Brain Res |
Title: |
Prenatal exposure to cocaine decreases adenylyl cyclase activity in embryonic mouse striatum. |
Volume: |
147 |
Issue: |
1-2 |
Pages: |
67-75 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
FosB is a metallothiol transferase which confers resistance to the antiobiotic fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin []. L-cysteine is thought to be the physiological thiol donor. |
|
•
•
•
•
•
|
Publication |
First Author: |
Yap EL |
Year: |
2021 |
Journal: |
Nature |
Title: |
Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network. |
Volume: |
590 |
Issue: |
7844 |
Pages: |
115-121 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bard-Chapeau EA |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors. |
Volume: |
109 |
Issue: |
6 |
Pages: |
2168-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao SQ |
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2023 |
Journal: |
PLoS One |
Title: |
Retinal transcriptome of neonatal mice after optic nerve injury. |
Volume: |
18 |
Issue: |
5 |
Pages: |
e0286344 |
|
•
•
•
•
•
|
Publication |
First Author: |
Malik M |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation. |
Volume: |
109 |
Issue: |
16 |
Pages: |
6130-5 |
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•
•
•
•
•
|
Publication |
First Author: |
Ivandic BT |
Year: |
2001 |
Journal: |
Physiol Genomics |
Title: |
New Dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice. |
Volume: |
6 |
Issue: |
3 |
Pages: |
137-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liang ZS |
Year: |
2020 |
Journal: |
PLoS Genet |
Title: |
Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity. |
Volume: |
16 |
Issue: |
9 |
Pages: |
e1008916 |
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•
•
•
•
•
|
Publication |
First Author: |
Gong P |
Year: |
2002 |
Journal: |
Arch Biochem Biophys |
Title: |
Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. |
Volume: |
405 |
Issue: |
2 |
Pages: |
265-74 |
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•
•
•
•
•
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Publication |
First Author: |
Glass DA 2nd |
Year: |
2005 |
Journal: |
Dev Cell |
Title: |
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. |
Volume: |
8 |
Issue: |
5 |
Pages: |
751-64 |
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•
•
•
•
|
Publication |
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Eferl R |
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1999 |
Journal: |
J Cell Biol |
Title: |
Functions of c-Jun in liver and heart development. |
Volume: |
145 |
Issue: |
5 |
Pages: |
1049-61 |
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•
•
•
•
|
Publication |
First Author: |
Millien G |
Year: |
2006 |
Journal: |
BMC Dev Biol |
Title: |
Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development. |
Volume: |
6 |
|
Pages: |
35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sah RK |
Year: |
2019 |
Journal: |
PLoS One |
Title: |
Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing. |
Volume: |
14 |
Issue: |
7 |
Pages: |
e0213702 |
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•
•
•
•
•
|
Publication |
First Author: |
Herdegen T |
Year: |
1998 |
Journal: |
Brain Res Brain Res Rev |
Title: |
Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. |
Volume: |
28 |
Issue: |
3 |
Pages: |
370-490 |
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•
•
•
•
•
|
Publication |
First Author: |
Ezhkova E |
Year: |
2009 |
Journal: |
Cell |
Title: |
Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. |
Volume: |
136 |
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6 |
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1122-35 |
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•
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Publication |
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Development |
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Differentiation and molecular heterogeneity of inhibitory and excitatory neurons associated with midbrain dopaminergic nuclei. |
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143 |
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516-29 |
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•
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Publication |
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2013 |
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Genes Dev |
Title: |
c-Jun is required for the specification of joint cell fates. |
Volume: |
27 |
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5 |
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514-24 |
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Publication |
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2015 |
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Nat Commun |
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Maternal bile acid transporter deficiency promotes neonatal demise. |
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6 |
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Pages: |
8186 |
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Publication |
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2022 |
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Development |
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FGFR2 signaling enhances the SHH-BMP4 signaling axis in early ureter development. |
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149 |
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1 |
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Publication |
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Guo G |
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2010 |
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Dev Cell |
Title: |
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. |
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18 |
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675-85 |
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Nature |
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High-throughput discovery of novel developmental phenotypes. |
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537 |
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7621 |
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Publication |
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Science |
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Mouse brain organization revealed through direct genome-scale TF expression analysis. |
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Publication |
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Koscielny G |
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2014 |
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Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
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Database issue |
Pages: |
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Publication |
First Author: |
Visel A |
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Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
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Issue: |
Database issue |
Pages: |
D552-6 |
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Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
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Publication |
First Author: |
International Mouse Strain Resource |
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Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
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Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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•
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Publication |
First Author: |
GUDMAP Consortium |
Year: |
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www.gudmap.org |
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GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
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Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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Publication |
First Author: |
The Gene Ontology Consortium |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
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First Author: |
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Journal: |
Nature |
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A conditional knockout resource for the genome-wide study of mouse gene function. |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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The Gene Ontology Consortium |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Database Download |
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MGI-UniGene Interconnection Effort |
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Allen Institute for Brain Science |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
|
HT Experiment |
Series Id: |
GSE37056 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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•
•
•
•
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Publication |
First Author: |
Cao M |
Year: |
2001 |
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J Bacteriol |
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FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis. |
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J Neurosci |
Title: |
Regulation of DeltaFosB stability by phosphorylation. |
Volume: |
26 |
Issue: |
19 |
Pages: |
5131-42 |
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•
•
•
•
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Publication |
First Author: |
Ulery PG |
Year: |
2007 |
Journal: |
Eur J Neurosci |
Title: |
Regulation of DeltaFosB transcriptional activity by Ser27 phosphorylation. |
Volume: |
25 |
Issue: |
1 |
Pages: |
224-30 |
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•
•
•
•
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Publication |
First Author: |
Eagle AL |
Year: |
2015 |
Journal: |
J Neurosci |
Title: |
Experience-Dependent Induction of Hippocampal ΔFosB Controls Learning. |
Volume: |
35 |
Issue: |
40 |
Pages: |
13773-83 |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
25
 |
Fragment?: |
true |
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•
•
•
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HT Experiment |
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Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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•
•
•
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Publication |
First Author: |
Ahmed MR |
Year: |
2019 |
Journal: |
Neurobiol Aging |
Title: |
Pharmacological antagonism of histamine H2R ameliorated L-DOPA-induced dyskinesia via normalization of GRK3 and by suppressing FosB and ERK in PD. |
Volume: |
81 |
|
Pages: |
177-189 |
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•
•
•
•
•
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Allele |
Name: |
transgene insertion 4468, Eric Nestler |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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•
•
•
•
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Publication |
First Author: |
Drisaldi B |
Year: |
2020 |
Journal: |
Front Cell Neurosci |
Title: |
Cytoplasmic Polyadenylation Element Binding Proteins CPEB1 and CPEB3 Regulate the Translation of FosB and Are Required for Maintaining Addiction-Like Behaviors Induced by Cocaine. |
Volume: |
14 |
|
Pages: |
207 |
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•
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•
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Strain |
Attribute String: |
congenic, mutant strain, transgenic |
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•
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•
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Publication |
First Author: |
Kumar A |
Year: |
2005 |
Journal: |
Neuron |
Title: |
Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. |
Volume: |
48 |
Issue: |
2 |
Pages: |
303-14 |
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•
•
•
•
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Publication |
First Author: |
Gajewski PA |
Year: |
2019 |
Journal: |
J Neurosci |
Title: |
Epigenetic Regulation of Hippocampal Fosb Expression Controls Behavioral Responses to Cocaine. |
Volume: |
39 |
Issue: |
42 |
Pages: |
8305-8314 |
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•
•
•
•
•
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Publication |
First Author: |
Donahue RJ |
Year: |
2014 |
Journal: |
Biol Psychiatry |
Title: |
Effects of striatal ΔFosB overexpression and ketamine on social defeat stress-induced anhedonia in mice. |
Volume: |
76 |
Issue: |
7 |
Pages: |
550-8 |
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•
•
•
•
•
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Publication |
First Author: |
Kelz MB |
Year: |
1999 |
Journal: |
Nature |
Title: |
Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. |
Volume: |
401 |
Issue: |
6750 |
Pages: |
272-6 |
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•
•
•
•
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Publication |
First Author: |
Olausson P |
Year: |
2006 |
Journal: |
J Neurosci |
Title: |
DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation. |
Volume: |
26 |
Issue: |
36 |
Pages: |
9196-204 |
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•
•
•
•
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Publication |
First Author: |
Sims NA |
Year: |
2002 |
Journal: |
Bone |
Title: |
Regulating DeltaFosB expression in adult Tet-Off-DeltaFosB transgenic mice alters bone formation and bone mass. |
Volume: |
30 |
Issue: |
1 |
Pages: |
32-9 |
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•
•
•
•
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Publication |
First Author: |
Rowe GC |
Year: |
2009 |
Journal: |
Endocrinology |
Title: |
Increased energy expenditure and insulin sensitivity in the high bone mass DeltaFosB transgenic mice. |
Volume: |
150 |
Issue: |
1 |
Pages: |
135-43 |
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•
•
•
•
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Publication |
First Author: |
Colby CR |
Year: |
2003 |
Journal: |
J Neurosci |
Title: |
Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine. |
Volume: |
23 |
Issue: |
6 |
Pages: |
2488-93 |
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•
•
•
•
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Publication |
First Author: |
Maze I |
Year: |
2010 |
Journal: |
Science |
Title: |
Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. |
Volume: |
327 |
Issue: |
5962 |
Pages: |
213-6 |
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•
•
•
•
•
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Allele |
Name: |
transgene insertion 5, Eric Nestler |
Allele Type: |
Transgenic |
Attribute String: |
Dominant negative, Inducible, Inserted expressed sequence |
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•
•
•
•
•
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Publication |
First Author: |
Zachariou V |
Year: |
2006 |
Journal: |
Nat Neurosci |
Title: |
An essential role for DeltaFosB in the nucleus accumbens in morphine action. |
Volume: |
9 |
Issue: |
2 |
Pages: |
205-11 |
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•
•
•
•
•
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Publication |
First Author: |
McClung CA |
Year: |
2003 |
Journal: |
Nat Neurosci |
Title: |
Regulation of gene expression and cocaine reward by CREB and DeltaFosB. |
Volume: |
6 |
Issue: |
11 |
Pages: |
1208-15 |
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•
•
•
•
•
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Publication |
First Author: |
Chen J |
Year: |
1998 |
Journal: |
Mol Pharmacol |
Title: |
Transgenic animals with inducible, targeted gene expression in brain. |
Volume: |
54 |
Issue: |
3 |
Pages: |
495-503 |
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•
•
•
•
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Strain |
Attribute String: |
transgenic, mutant strain, coisogenic |
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•
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Publication |
First Author: |
Peakman MC |
Year: |
2003 |
Journal: |
Brain Res |
Title: |
Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. |
Volume: |
970 |
Issue: |
1-2 |
Pages: |
73-86 |
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•
•
•
•
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Publication |
First Author: |
Beharry Z |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Functional analysis of active site residues of the fosfomycin resistance enzyme FosA from Pseudomonas aeruginosa. |
Volume: |
280 |
Issue: |
18 |
Pages: |
17786-91 |
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Protein Domain |
Type: |
Domain |
Description: |
Glyoxalase I () (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway. S-lactoylglutathione is then converted by glyoxalase II to lactic acid [].Glyoxalase I is an ubiquitous enzyme which binds one mole of zincper subunit. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric. The sequence of glyoxalase I is well conserved.The domain represented by this entry is found in glyoxalase I and in other related proteins, including fosfomycin resistance proteins FosB [], FosA [], FosX []and dioxygenases (eg. 4-hydroxyphenylpyruvate dioxygenase). |
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HT Experiment |
Series Id: |
GSE85308 |
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
ArrayExpress |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
124
 |
Fragment?: |
false |
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•
•
•
•
•
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Publication |
First Author: |
Fillgrove KL |
Year: |
2007 |
Journal: |
Biochemistry |
Title: |
Structure and mechanism of the genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes. |
Volume: |
46 |
Issue: |
27 |
Pages: |
8110-20 |
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