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Search results 301 to 400 out of 711 for Furin

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Type Details Score
Gene
566557 | furina
Type: gene
Organism: zebrafish
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Gene
566591 | furinb
Type: gene
Organism: zebrafish
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Publication
33494095 | J:307033
First Author: Johnson BA
Year: 2021
Journal: Nature
Title: Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.
Volume: 591
Issue: 7849
Pages: 293-299
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UniProt Feature
UniProt Feature
Begin: 440
Description: Cleavage; by furin like-convertase
Type: site
End: 441
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UniProt Feature
UniProt Feature
Begin: 289
Description: Cleavage; by furin
Type: site
End: 290
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UniProt Feature
UniProt Feature
Begin: 51
Description: Cleavage; by furin
Type: site
End: 52
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UniProt Feature
UniProt Feature
Begin: 287
Description: Cleavage; by furin
Type: site
End: 288
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UniProt Feature
UniProt Feature
Begin: 76
Description: Cleavage; by FURIN
Type: site
End: 77
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UniProt Feature
UniProt Feature
Begin: 91
Description: Cleavage; by FURIN
Type: site
End: 92
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UniProt Feature
UniProt Feature
Begin: 32
Description: Cleavage; by furin
Type: site
End: 33
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UniProt Feature
UniProt Feature
Begin: 212
Description: Cleavage; by furin
Type: site
End: 213
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UniProt Feature
UniProt Feature
Begin: 28
Description: Removed by furin
Type: propeptide
End: 35
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UniProt Feature
UniProt Feature
Begin: 243
Description: Cleavage; by furin
Type: site
End: 244
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UniProt Feature
UniProt Feature
Begin: 44
Description: Cleavage; by furin
Type: site
End: 45
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UniProt Feature
UniProt Feature
Begin: 2733
Description: Cleavage; by furin
Type: site
End: 2734
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UniProt Feature
UniProt Feature
Begin: 296
Description: Cleavage; by FURIN
Type: site
End: 296
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UniProt Feature
UniProt Feature
Begin: 159
Description: Cleavage; by furin
Type: site
End: 160
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UniProt Feature
UniProt Feature
Begin: 112
Description: Cleavage; by furin
Type: site
End: 113
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UniProt Feature
UniProt Feature
Begin: 243
Description: Cleavage; by furin
Type: site
End: 244
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UniProt Feature
UniProt Feature
Begin: 554
Description: Cleavage; by furin
Type: site
End: 555
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UniProt Feature
UniProt Feature
Begin: 1333
Description: Cleavage; by FURIN
Type: site
End: 1333
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UniProt Feature
UniProt Feature
Begin: 225
Description: Cleavage; by furin
Type: site
End: 226
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UniProt Feature
UniProt Feature
Begin: 278
Description: Cleavage; by FURIN
Type: site
End: 279
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UniProt Feature
UniProt Feature
Begin: 95
Description: Cleavage; by furin
Type: site
End: 96
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Publication
21287546 | J:177020
First Author: Bossen C
Year: 2011
Journal: Eur J Immunol
Title: Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses.
Volume: 41
Issue: 3
Pages: 787-97
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Publication
9055814 | J:38546
First Author: Okada A
Year: 1997
Journal: Gene
Title: Rat stromelysin 3: cDNA cloning from healing skin wound, activation by furin and expression in rat tissues.
Volume: 185
Issue: 2
Pages: 187-93
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Strain
MGI:5498181 | B6;129P2-Lrp1<tm2Ajmr>/Orl
Attribute String: mutant stock, targeted mutation
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UniProt Feature
UniProt Feature
Begin: 214
Description: Cleavage; by furin and PCSK7
Type: site
End: 215
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UniProt Feature
UniProt Feature
Begin: 221
Description: Cleavage; by furin and PCSK5
Type: site
End: 222
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UniProt Feature
UniProt Feature
Begin: 71
Description: Cleavage; by furin and PCSK7
Type: site
End: 72
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UniProt Feature
UniProt Feature
Begin: 214
Description: Cleavage; by furin and PCSK7
Type: site
End: 215
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UniProt Feature
UniProt Feature
Begin: 214
Description: Cleavage; by furin and PCSK7
Type: site
End: 215
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Publication
17627939 | J:124934
First Author: Veit G
Year: 2007
Journal: J Biol Chem
Title: Shedding of collagen XXIII is mediated by furin and depends on the plasma membrane microenvironment.
Volume: 282
Issue: 37
Pages: 27424-35
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Publication
11940668 | J:78932
First Author: Zhao M
Year: 2002
Journal: Mol Cell Biol
Title: Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice.
Volume: 22
Issue: 9
Pages: 3111-20
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Publication
15102434 | -
First Author: Rockwell NC
Year: 2004
Journal: Trends Biochem Sci
Title: The kindest cuts of all: crystal structures of Kex2 and furin reveal secrets of precursor processing.
Volume: 29
Issue: 2
Pages: 80-7
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Publication
2169760 | J:10744
First Author: Seidah NG
Year: 1990
Journal: DNA Cell Biol
Title: cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
Volume: 9
Issue: 6
Pages: 415-24
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Interaction Experiment
Liu G (1997)
Description: Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway.
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Allele
Tg(Zp3-EGFP)1Dean | MGI:3624514
Name: transgene insertion 1, Jurrien Dean
Allele Type: Transgenic
Attribute String: Reporter
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Transgene
MGI:3624513 | Tg(Zp3-EGFP)1Dean
Type: transgene
Organism: mouse, laboratory
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Protein
P63239
Organism: Mus musculus/domesticus
Length: 753  
Fragment?: false
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Publication
12006600 | -
First Author: Kang T
Year: 2002
Journal: J Biol Chem
Title: Intracellular activation of human adamalysin 19/disintegrin and metalloproteinase 19 by furin occurs via one of the two consecutive recognition sites.
Volume: 277
Issue: 28
Pages: 25583-91
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Publication
18505722 | -
First Author: Remacle AG
Year: 2008
Journal: J Biol Chem
Title: Substrate cleavage analysis of furin and related proprotein convertases. A comparative study.
Volume: 283
Issue: 30
Pages: 20897-906
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Allele
Col13a1<tm2Pih> | MGI:4838408
Name: collagen, type XIII, alpha 1; targeted mutation 2, Taina Pihlajaniemi
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Publication
2264933 | -
First Author: Seidah NG
Year: 1990
Journal: DNA Cell Biol
Title: cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
Volume: 9
Issue: 10
Pages: 789
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Publication
20608975 | -
First Author: Roghi C
Year: 2010
Journal: FEBS J
Title: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen.
Volume: 277
Issue: 15
Pages: 3158-75
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Strain
MGI:6122543 | B6.129S6-Col13a1<tm2Pih>/Oulu
Attribute String: mutant strain, congenic, targeted mutation
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Strain
MGI:6122821 | FVB.129S6(B6)-Col13a1<tm2Pih>/Oulu
Attribute String: mutant strain, congenic, targeted mutation
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Allele
Col25a1<tm1.1Tiwa> | MGI:5781011
Name: collagen, type XXV, alpha 1; targeted mutation 1.1, Takeshi Iwatsubo
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Col13a1/Col13a1
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Allele
Bmp4<tm5Bhr> | MGI:4460791
Name: bone morphogenetic protein 4; targeted mutation 5, Richard R Behringer
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Ngf<tm1.1Blhe> | MGI:5461488
 
Name: nerve growth factor; targeted mutation 1.1, Barbara L Hempstead
Allele Type: Targeted
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Allele
Pax1<tm2.1Tlu> | MGI:5502389
Name: paired box 1; targeted mutation 2.1, Thomas Lufkin
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:5781119 | B6.Cg-Col25a1<tm1.1Tiwa>
Attribute String: targeted mutation, mutant strain, congenic
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Allele
Pax9<tm1.1Tlu> | MGI:6200895
Name: paired box 9; targeted mutation 1.1, Thomas Lufkin
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Pax1<tm3.1Tlu> | MGI:6200898
Name: paired box 1; targeted mutation 3.1, Thomas Lufkin
Allele Type: Targeted
Attribute String: No functional change, Reporter
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Allele
Zpld1<sprl> | MGI:6356635
Name: zona pellucida like domain containing 1; spiral
Allele Type: Spontaneous
Attribute String: Null/knockout
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Allele
Sema6a<tm1(cre/ERT2)Alk> | MGI:7488666
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A; targeted mutation 1, Alex L Kolodkin
Allele Type: Targeted
Attribute String: Inducible, Recombinase
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Allele
Atp6ap2<em1Tiy> | MGI:7490239
Name: ATPase, H+ transporting, lysosomal accessory protein 2; endonuclease-mediated mutation 1, Tianxin Yang
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Atp6ap2<em1Nira> | MGI:7490116
Name: ATPase, H+ transporting, lysosomal accessory protein 2; endonuclease-mediated mutation 1, Nirupama Ramkumar
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Sema6a<tm1.1(cre/ERT2)Alk> | MGI:7718586
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A; targeted mutation 1.1, Alex L Kolodkin
Allele Type: Targeted
Attribute String: No functional change, Recombinase
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Allele
Disp1<em2Ogd> | MGI:7580473
 
Name: dispatched RND transporter family member 1; endonuclease-mediated mutation 2, Stacey K. Ogden
Allele Type: Endonuclease-mediated
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Allele
Pten<tm1.1Ayr> | MGI:7714642
Name: phosphatase and tensin homolog; targeted mutation 1.1, Alexander Y Rudensky
Allele Type: Targeted
Attribute String: Reporter
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Genotype
Genotype
Symbol: Col25a1/Col25a1
Background: B6.Cg-Col25a1
Zygosity: hm
Has Mutant Allele: true
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Publication
10600506 | J:66294
First Author: Hermey G
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Identification and characterization of SorCS, a third member of a novel receptor family.
Volume: 266
Issue: 2
Pages: 347-51
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Publication
11673514 | J:67032
First Author: Mueller CG
Year: 2001
Journal: J Immunol
Title: Mannose receptor ligand-positive cells express the metalloprotease decysin in the B cell follicle.
Volume: 167
Issue: 9
Pages: 5052-60
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Publication
9748307 | J:50328
First Author: Lum L
Year: 1998
Journal: J Biol Chem
Title: Intracellular maturation of the mouse metalloprotease disintegrin MDC15.
Volume: 273
Issue: 40
Pages: 26236-47
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Allele
Bmp4<tm5.1Bhr> | MGI:4460795
Name: bone morphogenetic protein 4; targeted mutation 5.1, Richard R Behringer
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:5461537 | B6.Cg-Ngf<tm1.1Blhe>
Attribute String: targeted mutation, congenic, mutant strain
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Allele
Col13a1<tm4.1Pih> | MGI:6116692
 
Name: collagen, type XIII, alpha 1; targeted mutation 4.1, Taina Pihlajaniemi
Allele Type: Targeted
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Strain
MGI:6358215 | B6(129S4)-Zpld1<sprl>/Kjn
Attribute String: spontaneous mutation, mutant strain
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Publication
34024121 | J:324586
First Author: Wang F
Year: 2021
Journal: Hypertension
Title: Mutagenesis of the Cleavage Site of Pro Renin Receptor Abrogates Angiotensin II-Induced Hypertension in Mice.
Volume: 78
Issue: 1
Pages: 115-127
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Strain
MGI:7491683 | C57BL/6J-Atp6ap2<em1Nira>
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
33890822 | J:324587
First Author: Ramkumar N
Year: 2021
Journal: Circ Res
Title: Loss of Soluble (Pro)renin Receptor Attenuates Angiotensin-II Induced Hypertension and Renal Injury.
Volume: 129
Issue: 1
Pages: 50-62
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Allele
Tg(Ccl2-EGFP)1Pame | MGI:7509722
Name: transgene insertion 1, Eric G Pamer
Allele Type: Transgenic
Attribute String: Epitope tag, Reporter
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Strain
MGI:7788392 | C57BL/6J-Tg(Ccl2-EGFP)1Pame/J
Attribute String: mutant strain, coisogenic, transgenic
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Publication
25041478 | J:337982
First Author: Wojczyk BS
Year: 2014
Journal: Transfusion
Title: Macrophages clear refrigerator storage-damaged red blood cells and subsequently secrete cytokines in vivo, but not in vitro, in a murine model.
Volume: 54
Issue: 12
Pages: 3186-97
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Strain
MGI:7718587 | B6.Cg-Sema6a<tm1.1(cre/ERT2)Alk>/J
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:7714644 | STOCK Pten<tm1.1Ayr>/J
Attribute String: targeted mutation, mutant stock
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Genotype
Genotype
Symbol: Atp6ap2/?
Background: C57BL/6J-Atp6ap2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ngf/Ngf<+>
Background: B6.Cg-Ngf
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pax1/Pax1
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Zpld1/Zpld1
Background: B6(129S4)-Zpld1/Kjn
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sema6a/Sema6a<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pax1/Pax1
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pax1/Pax1<+>
Background: involves: 129 * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pax1/Pax1<+>
Background: involves: 129 * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Disp1/Disp1
Background: involves: C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Protein Domain
IPR034182 | Kexin/furin
Type: Domain
Description: This entry represents the catalytic domain of kexin, furin and related proteins []. Protein convertases, whose members include furin (MEROPS identifier S08.071) and kexin (S08.070), are members of the peptidase S8 or subtilase family of peptidases []. Kexins are involved in the activation of peptide hormones, growth factors, and viral proteins. Furin cleaves cell surface vasoactive peptides and proteins involved in cardiovascular tissue remodeling in the TGN, at cell surface, or in endosomes but rarely in the ER. Furin also plays a key role in blood pressure regulation though the activation of transforming growth factor (TGF)-beta. High specificity is seen for cleavage after dibasic (Lys-Arg or Arg-Arg) or multiple basic residues in protein convertases [].The subtilisin family is one of the largest serine peptidase families characterised to date. Over 200 subtilises are presently known, more than 170 of which with their complete amino acid sequence []. It is widespread, being found in eubacteria, archaebacteria, eukaryotes and viruses []. The vast majority of the family are endopeptidases, although there is an exopeptidase, tripeptidyl peptidase [, ]. Structures have been determined for several members of the subtilisin family: they exploit the same catalytic triad as the chymotrypsins, although the residues occur in a different order (HDS in chymotrypsin and DHS in subtilisin), but the structures show no other similarity [, ]. Some subtilisins are mosaic proteins, while others contain N- and C-terminal extensions that show no sequence similarity to any other known protein [].
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Protein Domain
IPR042552 | ALPHA_CORONA_SPIKE
Type: Family
Description: Coronovirus enter target cells through fusion of viral and cellular membranesmediated by the viral envelope glycoprotein S. Trimers of Coronovirus S glycoprotein constitute the typical viral spikes. The precursor S protein is processed by host cell furin or furin-like protease to yield the mature S1 and S2 proteins [].This entry represents the spike glycoprotein from Alphacoronavirus.
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Strain
MGI:5781123 | B6.Cg-Col25a1<tm1.1Tiwa> Bax<tm1Sjk>
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:5461697 | B6.Cg-Ngf<tm1.1Blhe> Sort1<tm1Tew>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:6335272 | FVB.129S6(B6)-Col13a1<tm4.1Pih>/Oulu
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:6335219 | B6JOlaHsd.129S6-Col13a1<tm4.1Pih>/Oulu
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Bmp4/Bmp4
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ngf/Ngf<+> Sort1/Sort1
Background: B6.Cg-Ngf Sort1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bax/Bax Col25a1/Col25a1
Background: B6.Cg-Col25a1 Bax
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bax/Bax Col25a1/Col25a1<+>
Background: B6.Cg-Col25a1 Bax
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Col13a1/Col13a1
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bmp4/Bmp4<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster
Zygosity: ht
Has Mutant Allele: true
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Publication
28250125 | -
 
First Author: Liu Y
Year: 2017
Journal: J Virol
Title: Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer.
Volume: 91
Issue: 10
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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