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Search results 301 to 385 out of 385 for Gdf11

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Type Details Score
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691398
Age: postnatal adult
Image: BCM_2399044
Specimen Label: BCM_2399044
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691398
Age: postnatal adult
Image: BCM_2399046
Specimen Label: BCM_2399046
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:1339584
Assay Type: RNA in situ
Annotation Date: 2002-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1638817
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:2446450
Age: embryonic day 10.5
Image: 3D
Specimen Label: 3D
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:2664232
Assay Type: RNA in situ
Annotation Date: 2003-07-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1657718
Pattern: Not Specified
Stage: TS18
Assay Id: MGI:2665145
Age: embryonic day 10.5
Image: 2B
Specimen Label: 2B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6273787
Assay Type: RNA in situ
Annotation Date: 2019-01-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3705414
Pattern: Not Specified
Stage: TS14
Assay Id: MGI:6273791
Age: embryonic day 9.0-9.5
Image: 2C
Note: Expression in presomitic mesoderm and tail bud.
Specimen Label: 2C
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7627294
Assay Type: RNA in situ
Annotation Date: 2024-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3826813
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:7627408
Age: embryonic day 8.5
Image: 2Fa
Specimen Label: 2Fa
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7627294
Assay Type: RNA in situ
Annotation Date: 2024-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3826813
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:7627408
Age: embryonic day 8.5
Image: 2Fb
Specimen Label: 2Fb
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7627294
Assay Type: RNA in situ
Annotation Date: 2024-05-06
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3826813
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:7627408
Age: embryonic day 8.5
Image: 2Fc
Specimen Label: 2Fc
Detected: true
Specimen Num: 3
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Publication
36522318 | J:332213
First Author: Chang YC
Year: 2022
Journal: Nat Commun
Title: Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development.
Volume: 13
Issue: 1
Pages: 7766
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Publication
17878677 | J:127783
First Author: Takehara-Kasamatsu Y
Year: 2007
Journal: J Med Invest
Title: Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development.
Volume: 54
Issue: 3-4
Pages: 276-88
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Publication
30279140 | J:270171
First Author: Shen GS
Year: 2018
Journal: Biochim Biophys Acta Mol Basis Dis
Title: The GDF11-FTO-PPARγ axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis.
Volume: 1864
Issue: 12
Pages: 3644-3654
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Publication
18596030 | J:162988
First Author: Kondás K
Year: 2008
Journal: J Biol Chem
Title: Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11.
Volume: 283
Issue: 35
Pages: 23677-84
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Publication
27148972 | J:232558
First Author: Lamar KM
Year: 2016
Journal: PLoS Genet
Title: Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ.
Volume: 12
Issue: 5
Pages: e1006019
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Publication
31187730 | J:276801
   
First Author: Prajapati-DiNubila M
Year: 2019
Journal: Elife
Title: A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea.
Volume: 8
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Publication
35017475 | J:317804
First Author: Hauswirth GM
Year: 2022
Journal: Nat Commun
Title: Breaking constraint of mammalian axial formulae.
Volume: 13
Issue: 1
Pages: 243
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Publication
24019467 | J:201148
First Author: Lee YS
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2.
Volume: 110
Issue: 39
Pages: E3713-22
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Publication
17537792 | J:122519
First Author: Linton JM
Year: 2007
Journal: Development
Title: The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression.
Volume: 134
Issue: 13
Pages: 2501-9
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Publication
16267092 | J:103123
First Author: Kawauchi S
Year: 2005
Journal: Development
Title: Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse.
Volume: 132
Issue: 23
Pages: 5211-23
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Publication
31155355 | J:294396
First Author: Chang KC
Year: 2019
Journal: Curr Biol
Title: Opposing Effects of Growth and Differentiation Factors in Cell-Fate Specification.
Volume: 29
Issue: 12
Pages: 1963-1975.e5
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Publication
16806156 | J:119289
First Author: Dudas M
Year: 2006
Journal: Dev Biol
Title: Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion.
Volume: 296
Issue: 2
Pages: 298-314
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Publication
16435884 | J:107099
First Author: Smart NG
Year: 2006
Journal: PLoS Biol
Title: Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus.
Volume: 4
Issue: 2
Pages: e39
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Publication
27453501 | J:236309
First Author: Aires R
Year: 2016
Journal: Dev Cell
Title: Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity.
Volume: 38
Issue: 3
Pages: 262-74
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Publication
18787044 | J:142530
First Author: Pitera JE
Year: 2008
Journal: Hum Mol Genet
Title: Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli.
Volume: 17
Issue: 24
Pages: 3953-64
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Publication
19853565 | J:154781
First Author: Young T
Year: 2009
Journal: Dev Cell
Title: Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos.
Volume: 17
Issue: 4
Pages: 516-26
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Publication
25152336 | J:216160
First Author: Jurberg AD
Year: 2014
Journal: Dev Biol
Title: Compartment-dependent activities of Wnt3a/β-catenin signaling during vertebrate axial extension.
Volume: 394
Issue: 2
Pages: 253-63
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Publication
20692344 | J:171312
First Author: Sammeta N
Year: 2010
Journal: Mol Cell Neurosci
Title: Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium.
Volume: 45
Issue: 4
Pages: 398-407
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Publication
19487809 | J:152582
First Author: Oliver-Krasinski JM
Year: 2009
Journal: J Clin Invest
Title: The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice.
Volume: 119
Issue: 7
Pages: 1888-98
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Publication
18787067 | J:141248
First Author: Mao CA
Year: 2008
Journal: Development
Title: Rewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5.
Volume: 135
Issue: 20
Pages: 3379-88
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Publication
31311865 | J:278336
First Author: Wang W
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage.
Volume: 116
Issue: 31
Pages: 15570-15579
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Publication
23918385 | J:200671
First Author: Economides AN
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Conditionals by inversion provide a universal method for the generation of conditional alleles.
Volume: 110
Issue: 34
Pages: E3179-88
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Publication
21786021 | J:177082
First Author: Yang Y
Year: 2011
Journal: Diabetologia
Title: The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice.
Volume: 54
Issue: 10
Pages: 2595-605
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Publication
32597756 | J:294824
   
First Author: Dias A
Year: 2020
Journal: Elife
Title: A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation.
Volume: 9
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Publication
39348458 | J:357284
 
First Author: Lo Giudice Q
Year: 2024
Journal: Development
Title: Developmental emergence of first- and higher-order thalamic neuron molecular identities.
Volume: 151
Issue: 18
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Publication
20843830 | J:166958
First Author: Yates LL
Year: 2010
Journal: Hum Mol Genet
Title: The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation.
Volume: 19
Issue: 23
Pages: 4663-76
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Publication
22682244 | J:186161
First Author: Hu B
Year: 2012
Journal: Cell
Title: Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling.
Volume: 149
Issue: 6
Pages: 1207-20
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
31395583 | J:280056
First Author: Camaschella C
Year: 2019
Journal: Blood
Title: GDF11 is not the target of luspatercept.
Volume: 134
Issue: 6
Pages: 500-501
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Publication
24797481 | J:211283
First Author: Sinha M
Year: 2014
Journal: Science
Title: Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle.
Volume: 344
Issue: 6184
Pages: 649-52
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Publication
27653144 | J:242177
 
First Author: Liu W
Year: 2016
Journal: Nat Commun
Title: GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation.
Volume: 7
Pages: 12794
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Publication
29161592 | J:248586
First Author: Bajikar SS
Year: 2017
Journal: Dev Cell
Title: Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer.
Volume: 43
Issue: 4
Pages: 418-435.e13
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DO Term
DOID:0070418 | vertebral hypersegmentation and orofacial anomalies
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Publication
15988002 | -
First Author: Ge G
Year: 2005
Journal: Mol Cell Biol
Title: GDF11 forms a bone morphogenetic protein 1-activated latent complex that can modulate nerve growth factor-induced differentiation of PC12 cells.
Volume: 25
Issue: 14
Pages: 5846-58
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Allele
Mstn<em2(Gdf11)Rlee> | MGI:7568819
 
Name: myostatin; endonuclease-mediated mutation 2, Richard T Lee
Allele Type: Endonuclease-mediated
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Publication
21936825 | -
First Author: Kondás K
Year: 2011
Journal: Biochem Soc Trans
Title: Biological functions of the WAP domain-containing multidomain proteins WFIKKN1 and WFIKKN2.
Volume: 39
Issue: 5
Pages: 1416-20
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Publication
11928817 | -
First Author: Trexler M
Year: 2002
Journal: Biol Chem
Title: Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules.
Volume: 383
Issue: 1
Pages: 223-8
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Protein Domain
IPR033638 | WFIKKN1/2
Type: Family
Description: WFIKKN proteins are secreted multidomain proteins containing a WAP (whey acidic protein)-, a follistatin/Kazal-, an immunoglobulin-, two Kunitz-type protease inhibitor-domains, and an NTR (netrin) domain. They have been reported to inhibit the activity of trypsin, and to bind GDF11 (growth and differentiation factor 11) and myostatin (GDF8) []. Due to the presence of multiple domains that frequently serve as protease inhibitors, WFIKKN proteins are presumed to control the action of diverse serine proteases as well as metalloproteinases [].In humans, WFIKKN1 expression is observed in pancreas, liver, thymus, kidney, testis and lung and WFIKKN2 (also known as WFIKKNRP) expression is observed in ovary, testis, pancreas, brain and lung [].
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HT Experiment
E-TABM-443 | Transcription profiling by array of wild type and Pcsk5 Vcc mutant mouse embryos
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
28257634 | J:242410
First Author: Walker RG
Year: 2017
Journal: BMC Biol
Title: Structural basis for potency differences between GDF8 and GDF11.
Volume: 15
Issue: 1
Pages: 19
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Publication
18047832 | J:130374
First Author: Nomura T
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Skeletal muscle-derived progenitors capable of differentiating into cardiomyocytes proliferate through myostatin-independent TGF-beta family signaling.
Volume: 365
Issue: 4
Pages: 863-9
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Publication
26317549 | J:318350
First Author: Wang F
Year: 2015
Journal: Oncotarget
Title: Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice.
Volume: 6
Issue: 25
Pages: 20851-62
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Publication
39702818 | J:359961
First Author: Hung YS
Year: 2024
Journal: Commun Biol
Title: Protogenin facilitates trunk-to-tail HOX code transition via modulating GDF11/SMAD2 signaling in mammalian embryos.
Volume: 7
Issue: 1
Pages: 1669
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Publication
18535106 | J:138157
First Author: Schneyer AL
Year: 2008
Journal: Endocrinology
Title: Differential antagonism of activin, myostatin and growth and differentiation factor 11 by wild-type and mutant follistatin.
Volume: 149
Issue: 9
Pages: 4589-95
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Publication
27034276 | J:253955
First Author: Harper SC
Year: 2016
Journal: Circ Res
Title: Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects?
Volume: 118
Issue: 7
Pages: 1143-50; discussion 1150
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Protein
K4HPC7
Organism: Mus musculus/domesticus
Length: 272  
Fragment?: true
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Protein
Q8R0S6
Organism: Mus musculus/domesticus
Length: 552  
Fragment?: false
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Protein
Q7TQN3
Organism: Mus musculus/domesticus
Length: 571  
Fragment?: false
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Protein
A0A498WFR4
Organism: Mus musculus/domesticus
Length: 518  
Fragment?: false
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Protein
K4HPC4
Organism: Mus musculus/domesticus
Length: 571  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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