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Search results 301 to 388 out of 388 for Ggt1

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
Strain
MGI:2162274 | C3Sn;129-Del(Lrrc75b-Ggt5)1Bayer/J
Attribute String: mutant stock, spontaneous mutation
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Publication
- | J:97928
     
First Author: Davis AC
Year: 2005
Journal: MGI Direct Data Submission
Title: Dwarf Grey Bayer, A remutation of the dwg locus
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Strain
MGI:4454266 | STOCK Tg(Ggt1-cre)M3Egn/J
Attribute String: transgenic, mutant stock
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Publication
37794057 | J:343159
First Author: Yang J
Year: 2023
Journal: Cell Death Dis
Title: PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy.
Volume: 14
Issue: 10
Pages: 649
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Publication
34789720 | J:315033
First Author: Wang H
Year: 2021
Journal: Cell Death Dis
Title: PTEN alleviates maladaptive repair of renal tubular epithelial cells by restoring CHMP2A-mediated phagosome closure.
Volume: 12
Issue: 12
Pages: 1087
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Publication
35133431 | J:325414
First Author: Li C
Year: 2022
Journal: Diabetes
Title: PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.
Volume: 71
Issue: 5
Pages: 1034-1050
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Publication
35230975 | J:325452
 
First Author: McCrimmon A
Year: 2022
Journal: JCI Insight
Title: Intact mitochondrial substrate efflux is essential for prevention of tubular injury in a sex-dependent manner.
Volume: 7
Issue: 7
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Strain
MGI:6438825 | C57BL/6-Tg(Alb-GGT1)53Mrl/Tac
Attribute String: mutant strain, coisogenic, transgenic
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Strain
MGI:6438827 | C57BL/6-Tg(Alb-GGT1)161Mrl/Tac
Attribute String: mutant strain, coisogenic, transgenic
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Genotype
Genotype
Symbol: Del(Lrrc75b-Ggt5)1Bayer/Del(Lrrc75b-Ggt5)1Bayer
Background: STOCK dwg
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(Lrrc75b-Ggt5)1Bayer/Del(Lrrc75b-Ggt5)1Bayer
Background: 129S/SvEv-dwg
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Ggt1-cre)M3Egn/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Ggt1-cre)M3Egn/?
Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Publication
22020205 | J:177858
First Author: Berndt N
Year: 2011
Journal: Nat Rev Cancer
Title: Targeting protein prenylation for cancer therapy.
Volume: 11
Issue: 11
Pages: 775-91
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Publication
31320136 | J:290888
First Author: Inoue T
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Cellular communication network factor 2 (CCN2) promotes the progression of acute kidney injury to chronic kidney disease.
Volume: 517
Issue: 1
Pages: 96-102
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Publication
24692544 | J:214127
First Author: Koraishy FM
Year: 2014
Journal: J Biol Chem
Title: Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling.
Volume: 289
Issue: 20
Pages: 14341-50
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Publication
22418982 | J:198183
First Author: Chen J
Year: 2012
Journal: Kidney Int
Title: Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury.
Volume: 82
Issue: 1
Pages: 45-52
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Publication
22785175 | J:198166
First Author: Howard C
Year: 2012
Journal: Kidney Int
Title: Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice.
Volume: 82
Issue: 9
Pages: 1000-9
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Publication
20680007 | J:167190
First Author: Ge Y
Year: 2011
Journal: Lab Invest
Title: Conditional ablation of glycogen synthase kinase 3β in postnatal mouse kidney.
Volume: 91
Issue: 1
Pages: 85-96
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Strain
MGI:5296810 | 129.Cg-Ddc<tm1.1Rhrs> Tg(Ggt1-cre)M3Egn
Attribute String: congenic, mutant strain, transgenic, targeted mutation
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Publication
37894939 | J:358071
 
First Author: Zhang C
Year: 2023
Journal: Int J Mol Sci
Title: Proximal Tubular Lats2 Ablation Exacerbates Ischemia/Reperfusion Injury (IRI)-Induced Renal Maladaptive Repair through the Upregulation of P53.
Volume: 24
Issue: 20
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Publication
35563783 | J:327549
 
First Author: Jin J
Year: 2022
Journal: Cells
Title: Loss of Proximal Tubular Sirtuin 6 Aggravates Unilateral Ureteral Obstruction-Induced Tubulointerstitial Inflammation and Fibrosis by Regulation of β-Catenin Acetylation.
Volume: 11
Issue: 9
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Genotype
Genotype
Symbol: Ddc/Ddc Tg(Ggt1-cre)M3Egn/?
Background: 129.Cg-Ddc Tg(Ggt1-cre)M3Egn
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ddc/Ddc Tg(Ggt1-cre)M3Egn/?
Background: involves: 129 * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gsk3b/Gsk3b Tg(Ggt1-cre)M3Egn/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crat/Crat Tg(Ggt1-cre)M3Egn/?
Background: involves: C57BL/6J * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
24141423 | J:203764
First Author: Hasegawa K
Year: 2013
Journal: Nat Med
Title: Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.
Volume: 19
Issue: 11
Pages: 1496-504
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Publication
29769449 | J:291021
 
First Author: Li Y
Year: 2018
Journal: JCI Insight
Title: Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control.
Volume: 3
Issue: 10
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Publication
22306733 | J:181483
First Author: Sugimoto H
Year: 2012
Journal: Nat Med
Title: Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis.
Volume: 18
Issue: 3
Pages: 396-404
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Publication
23739236 | J:235558
First Author: Guo JK
Year: 2013
Journal: Kidney Int
Title: The Terminator mouse is a diphtheria toxin-receptor knock-in mouse strain for rapid and efficient enrichment of desired cell lineages.
Volume: 84
Issue: 5
Pages: 1041-6
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Publication
24573392 | J:208410
First Author: Sörensen-Zender I
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Renal tubular Notch signaling triggers a prosenescent state after acute kidney injury.
Volume: 306
Issue: 8
Pages: F907-15
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Publication
23949800 | J:346545
First Author: Chen J
Year: 2013
Journal: J Am Soc Nephrol
Title: Survivin mediates renal proximal tubule recovery from AKI.
Volume: 24
Issue: 12
Pages: 2023-33
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Publication
29664738 | J:265483
First Author: Tampe B
Year: 2018
Journal: J Clin Invest
Title: Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure.
Volume: 128
Issue: 7
Pages: 3053-3070
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Publication
24115477 | J:323151
First Author: Ranganathan P
Year: 2014
Journal: J Am Soc Nephrol
Title: UNC5B receptor deletion exacerbates tissue injury in response to AKI.
Volume: 25
Issue: 2
Pages: 239-49
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Publication
22785176 | J:277953
First Author: Inoue T
Year: 2012
Journal: Kidney Int
Title: Targeted expression of a pan-caspase inhibitor in tubular epithelium attenuates interstitial inflammation and fibrogenesis in nephritic but not nephrotic mice.
Volume: 82
Issue: 9
Pages: 980-9
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Genotype
Genotype
Symbol: Snai1/Snai1 Tg(Ggt1-cre)M3Egn/?
Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Twist1/Twist1 Tg(Ggt1-cre)M3Egn/?
Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
28701516 | J:274985
First Author: Nlandu-Khodo S
Year: 2017
Journal: J Am Soc Nephrol
Title: Blocking TGF-β and β-Catenin Epithelial Crosstalk Exacerbates CKD.
Volume: 28
Issue: 12
Pages: 3490-3503
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Publication
25934441 | J:316139
First Author: Yi Y
Year: 2015
Journal: J Urol
Title: A Murine Model of K-RAS and β-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor.
Volume: 194
Issue: 6
Pages: 1762-70
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Publication
17356303 | J:137094
First Author: Dworniczak B
Year: 2007
Journal: Nephron Exp Nephrol
Title: Inducible Cre/loxP recombination in the mouse proximal tubule.
Volume: 106
Issue: 1
Pages: e11-20
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Publication
24509849 | J:212444
First Author: Elias BC
Year: 2014
Journal: J Biol Chem
Title: The integrin β1 subunit regulates paracellular permeability of kidney proximal tubule cells.
Volume: 289
Issue: 12
Pages: 8532-44
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Publication
18667485 | J:153791
First Author: Kimura K
Year: 2008
Journal: Am J Physiol Renal Physiol
Title: Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis.
Volume: 295
Issue: 4
Pages: F1023-9
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Publication
25985273 | J:222929
First Author: Chen JK
Year: 2015
Journal: J Clin Invest
Title: Phosphatidylinositol 3-kinase signaling determines kidney size.
Volume: 125
Issue: 6
Pages: 2429-44
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Publication
36232551 | J:330223
 
First Author: Zhou T
Year: 2022
Journal: Int J Mol Sci
Title: Renal Corin Is Essential for Normal Blood Pressure and Sodium Homeostasis.
Volume: 23
Issue: 19
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Publication
22169008 | J:181977
First Author: Yang S
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Intrarenal dopamine modulates progressive angiotensin II-mediated renal injury.
Volume: 302
Issue: 6
Pages: F742-9
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Publication
22688335 | J:208535
First Author: Zhang MZ
Year: 2012
Journal: Diabetes
Title: Intrarenal dopamine inhibits progression of diabetic nephropathy.
Volume: 61
Issue: 10
Pages: 2575-84
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Publication
26839958 | J:248880
First Author: Han X
Year: 2016
Journal: PLoS One
Title: Conditional Deletion of Fgfr1 in the Proximal and Distal Tubule Identifies Distinct Roles in Phosphate and Calcium Transport.
Volume: 11
Issue: 2
Pages: e0147845
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Publication
30644120 | J:294502
First Author: Kumari M
Year: 2019
Journal: J Cell Biochem
Title: Deletion of insulin receptor in the proximal tubule and fasting augment albumin excretion.
Volume: 120
Issue: 6
Pages: 10688-10696
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Publication
23723425 | J:338281
First Author: Tiwari S
Year: 2013
Journal: J Am Soc Nephrol
Title: Deletion of the insulin receptor in the proximal tubule promotes hyperglycemia.
Volume: 24
Issue: 8
Pages: 1209-14
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Publication
36921719 | J:339773
First Author: Kim JY
Year: 2023
Journal: Kidney Int
Title: Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury.
Volume: 103
Issue: 6
Pages: 1093-1104
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Publication
26296742 | J:291268
First Author: Wu H
Year: 2016
Journal: J Am Soc Nephrol
Title: Blocking rpS6 Phosphorylation Exacerbates Tsc1 Deletion-Induced Kidney Growth.
Volume: 27
Issue: 4
Pages: 1145-58
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Publication
30943401 | J:280488
First Author: Muraoka H
Year: 2019
Journal: Cell Rep
Title: Role of Nampt-Sirt6 Axis in Renal Proximal Tubules in Extracellular Matrix Deposition in Diabetic Nephropathy.
Volume: 27
Issue: 1
Pages: 199-212.e5
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Publication
29759484 | J:276193
 
First Author: Zhou T
Year: 2018
Journal: EBioMedicine
Title: Runt-Related Transcription Factor 1 (RUNX1) Promotes TGF-β-Induced Renal Tubular Epithelial-to-Mesenchymal Transition (EMT) and Renal Fibrosis through the PI3K Subunit p110δ.
Volume: 31
Pages: 217-225
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Publication
21701066 | J:175630
First Author: Zhang MZ
Year: 2011
Journal: J Clin Invest
Title: Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice.
Volume: 121
Issue: 7
Pages: 2845-54
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Ggt1-cre)M3Egn/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1 Tg(Ggt1-cre)M3Egn/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Ggt1-cre/ERT2)1Pepe/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Protein
Q61239
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
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Protein
A0A494B9V8
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
A0A494BBC8
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Protein
Q541Z2
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
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Protein
E9QAB6
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: false
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Publication
1622936 | -
First Author: Boguski MS
Year: 1992
Journal: New Biol
Title: Novel repetitive sequence motifs in the alpha and beta subunits of prenyl-protein transferases and homology of the alpha subunit to the MAD2 gene product of yeast.
Volume: 4
Issue: 4
Pages: 408-11
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Protein Domain
IPR002088 | Prenyl_trans_a
Type: Repeat
Description: Protein prenylation is the posttranslational attachment of either a farnesyl group or a geranylgeranyl group via a thioether linkage (-C-S-C-) to a cysteine at or near the carboxyl terminus of the protein. Farnesyl and geranylgeranyl groups are polyisoprenes, unsaturated hydrocarbons with a multiple of five carbons; the chain is 15 carbons long in the farnesyl moiety and 20 carbons long in the geranylgeranyl moiety. There are three different protein prenyltransferases in humans: farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) share the same motif (the CaaX box) around the cysteine in their substrates, and are thus called CaaX prenyltransferases, whereas geranylgeranyltransferase 2 (GGT2, also called Rab geranylgeranyltransferase) recognises a different motif and is thus called a non-CaaX prenyltransferase. Protein prenyltransferases are currently known only in eukaryotes, but they are widespread, being found in vertebrates, insects, nematodes, plants, fungi and protozoa, including several parasites. Each protein consists of two subunits, alpha and beta; the alpha subunit of FT and GGT1 is encoded by the same gene, FNTA. The alpha subunit is thought to participate in a stable complex with the isoprenyl substrate; the beta subunit binds the peptide substrate. In the alpha subunits of both types of protein prenyltransferases, seven tetratricopeptide repeats are formed by pairs of helices that are stabilised by conserved intercalating residues. The alpha subunits of GGT2 in mammals and plants also have an immunoglobulin-like domain between the fifth and sixth tetratricopeptide repeat, as well as leucine-rich repeats at the carboxyl terminus. The functions of these additional domains in GGT2 are as yet undefined, but they are apparently not directly involved in the interaction with substrates and Rab escort proteins. The tetratricopeptide repeats of the alpha subunit form a right-handed superhelix, which embraces the (α-α)6 barrel of the beta subunit [].
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Publication
23143303 | J:193980
First Author: Zhang MZ
Year: 2012
Journal: J Clin Invest
Title: CSF-1 signaling mediates recovery from acute kidney injury.
Volume: 122
Issue: 12
Pages: 4519-32
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Publication
32369448 | J:330775
 
First Author: Nlandu-Khodo S
Year: 2020
Journal: JCI Insight
Title: Tubular β-catenin and FoxO3 interactions protect in chronic kidney disease.
Volume: 5
Issue: 10
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Publication
21983638 | J:180084
First Author: Clark PE
Year: 2011
Journal: Am J Pathol
Title: β-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors.
Volume: 179
Issue: 6
Pages: 3045-55
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Publication
12163453 | J:111660
First Author: Iwano M
Year: 2002
Journal: J Clin Invest
Title: Evidence that fibroblasts derive from epithelium during tissue fibrosis.
Volume: 110
Issue: 3
Pages: 341-50
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Publication
23160515 | J:330776
First Author: Gewin L
Year: 2012
Journal: J Am Soc Nephrol
Title: Deleting the TGF-β receptor attenuates acute proximal tubule injury.
Volume: 23
Issue: 12
Pages: 2001-11
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Publication
32887795 | J:299472
First Author: Kim JY
Year: 2020
Journal: J Biol Chem
Title: SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells.
Volume: 295
Issue: 48
Pages: 16328-16341
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Publication
32317630 | J:293496
First Author: Kim JY
Year: 2020
Journal: Nat Commun
Title: A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.
Volume: 11
Issue: 1
Pages: 1924
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Publication
21982831 | J:180092
First Author: Qin Y
Year: 2011
Journal: Am J Pathol
Title: Focal adhesion kinase signaling mediates acute renal injury induced by ischemia/reperfusion.
Volume: 179
Issue: 6
Pages: 2766-78
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Publication
26236991 | J:228823
First Author: Lovisa S
Year: 2015
Journal: Nat Med
Title: Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis.
Volume: 21
Issue: 9
Pages: 998-1009
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Publication
30072422 | J:289172
First Author: Chen J
Year: 2018
Journal: J Am Soc Nephrol
Title: EGF Receptor-Dependent YAP Activation Is Important for Renal Recovery from AKI.
Volume: 29
Issue: 9
Pages: 2372-2385
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Publication
20847140 | J:185903
First Author: Inoue T
Year: 2010
Journal: J Am Soc Nephrol
Title: Fibroblast expression of an IκB dominant-negative transgene attenuates renal fibrosis.
Volume: 21
Issue: 12
Pages: 2047-52
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Publication
30728184 | J:273068
First Author: Kruger C
Year: 2019
Journal: Diabetes
Title: Proximal Tubular Cell-Specific Ablation of Carnitine Acetyltransferase Causes Tubular Disease and Secondary Glomerulosclerosis.
Volume: 68
Issue: 4
Pages: 819-831
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Publication
25902541 | J:221419
First Author: Hathaway CK
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice.
Volume: 112
Issue: 18
Pages: 5815-20
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Publication
20705705 | J:185908
First Author: Luyten A
Year: 2010
Journal: J Am Soc Nephrol
Title: Aberrant regulation of planar cell polarity in polycystic kidney disease.
Volume: 21
Issue: 9
Pages: 1521-32
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Publication
28244683 | J:265516
First Author: Li A
Year: 2017
Journal: J Cell Mol Med
Title: Rapamycin treatment dose-dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell-cycle-associated CDK1/cyclin axis.
Volume: 21
Issue: 8
Pages: 1619-1635
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Protein
Q921J9
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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Publication
23817022 | J:200001
First Author: LeBleu VS
Year: 2013
Journal: Nat Med
Title: Origin and function of myofibroblasts in kidney fibrosis.
Volume: 19
Issue: 8
Pages: 1047-53
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Publication
19939939 | J:166881
First Author: Kim I
Year: 2009
Journal: J Am Soc Nephrol
Title: Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin.
Volume: 20
Issue: 12
Pages: 2556-69
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Publication
32518142 | J:328476
 
First Author: Lovisa S
Year: 2020
Journal: Sci Signal
Title: Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis.
Volume: 13
Issue: 635
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Publication
35290476 | J:328310
First Author: de Souza Cordeiro LM
Year: 2022
Journal: Diabetologia
Title: Loss of function of renal Glut2 reverses hyperglycaemia and normalises body weight in mouse models of diabetes and obesity.
Volume: 65
Issue: 6
Pages: 1032-1047
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Protein
Q9JHK4
Organism: Mus musculus/domesticus
Length: 567  
Fragment?: false
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Protein
Q3UIH7
Organism: Mus musculus/domesticus
Length: 567  
Fragment?: false
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Publication
18385665 | J:140012
First Author: Starremans PG
Year: 2008
Journal: Kidney Int
Title: A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5' end of Pkd1.
Volume: 73
Issue: 12
Pages: 1394-405
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Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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