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Search results 301 to 330 out of 330 for Ghsr

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0.019s

Type

Details

Score

Genotype

Symbol:	Ghsr/Ghsr<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background:	involves: 129S6/SvEvTac * 129X1/SvJ
Zygosity:	cn
Has Mutant Allele:	true

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Publication

21835225 | J:251985

First Author:	Furness JB
Year:	2011
Journal:	Neuroscience
Title:	Investigation of the presence of ghrelin in the central nervous system of the rat and mouse.
Volume:	193

Pages:	1-9

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Publication

22521145 | J:250529

First Author:	Spencer SJ
Year:	2012
Journal:	Biol Psychiatry
Title:	Ghrelin regulates the hypothalamic-pituitary-adrenal axis and restricts anxiety after acute stress.
Volume:	72
Issue:	6
Pages:	457-65

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Publication

24100676 | -

First Author:	Pradhan G
Year:	2013
Journal:	Curr Opin Clin Nutr Metab Care
Title:	Ghrelin: much more than a hunger hormone.
Volume:	16
Issue:	6
Pages:	619-24

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Genotype

Symbol:	Ghsr/Ghsr<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background:	involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity:	cn
Has Mutant Allele:	true

•

Publication

16628271 | -

First Author:	Lengyel AM
Year:	2006
Journal:	Arq Bras Endocrinol Metabol
Title:	From growth hormone-releasing peptides to ghrelin: discovery of new modulators of GH secretion.
Volume:	50
Issue:	1
Pages:	17-24

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Protein Domain

IPR003905 | GHS-R/MTLR

Type:

Family

Description:

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [, , ].Growth hormone secretagogue receptor (GHSR) is a class A GPCR that stimulates food intake by binding to its peptide ligand, ghrelin []. Ghrelin also increases growth hormone (GH) release []. The motilin receptor, also known as GPR38, shares significant amino acid sequence identity with GHSR [].

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Protein

Q99P50

Organism:	Mus musculus/domesticus
Length:	364
Fragment?:	false

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Protein

Q0VBE5

Organism:	Mus musculus/domesticus
Length:	364
Fragment?:	false

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Protein

Q80UB2

Organism:	Mus musculus/domesticus
Length:	123
Fragment?:	true

•

Publication

32165171 | J:296868

First Author:	Ogawa S
Year:	2020
Journal:	Mol Cell Endocrinol
Title:	Abundant expression of the membrane-anchored protease-regulator RECK in the anterior pituitary gland and its implication in the growth hormone/insulin-like growth factor 1 axis in mice.
Volume:	508

Pages:	110790

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Publication

36387867 | J:331439

First Author:	Chu G
Year:	2022
Journal:	Front Endocrinol (Lausanne)
Title:	Involvement of POMC neurons in LEAP2 regulation of food intake and body weight.
Volume:	13

Pages:	932761

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Publication

33972988 | J:309892

First Author:	Wasinski F
Year:	2021
Journal:	Endocrinology
Title:	Ghrelin-induced Food Intake, but not GH Secretion, Requires the Expression of the GH Receptor in the Brain of Male Mice.
Volume:	162
Issue:	7

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Publication

39331742 | J:360432

First Author:	Varshney S
Year:	2024
Journal:	Endocrinology
Title:	The LEAP2 Response to Cancer-Related Anorexia-Cachexia Syndrome in Male Mice and Patients.
Volume:	165
Issue:	11

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Publication

11813507 | -

First Author:	Depoortere I
Year:	2001
Journal:	Verh K Acad Geneeskd Belg
Title:	Motilin and motilin receptors: characterization and functional significance.
Volume:	63
Issue:	6
Pages:	511-29

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Publication

28547758 | J:247911

First Author:	Chen SR
Year:	2017
Journal:	J Neurochem
Title:	Ghrelin receptors mediate ghrelin-induced excitation of agouti-related protein/neuropeptide Y but not pro-opiomelanocortin neurons.
Volume:	142
Issue:	4
Pages:	512-520

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Publication

22465164 | J:272353

First Author:	Nunoi H
Year:	2012
Journal:	Regul Pept
Title:	A relationship between motilin and growth hormone secretagogue receptors.
Volume:	176
Issue:	1-3
Pages:	28-35

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Publication

37772438 | J:350169

First Author:	Ringuet MT
Year:	2023
Journal:	J Physiol
Title:	Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin receptors in the rodent lumbosacral defecation centre.
Volume:	601
Issue:	23
Pages:	5195-5211

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Publication

34428557 | J:322589

First Author:	Shankar K
Year:	2021
Journal:	Mol Metab
Title:	LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue.
Volume:	53

Pages:	101327

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Publication

2111655 | -

First Author:	Birnbaumer L
Year:	1990
Journal:	Annu Rev Pharmacol Toxicol
Title:	G proteins in signal transduction.
Volume:	30

Pages:	675-705

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Publication

2830256 | -

First Author:	Casey PJ
Year:	1988
Journal:	J Biol Chem
Title:	G protein involvement in receptor-effector coupling.
Volume:	263
Issue:	6
Pages:	2577-80

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Publication

8386361 | -

First Author:	Attwood TK
Year:	1993
Journal:	Protein Eng
Title:	Design of a discriminating fingerprint for G-protein-coupled receptors.
Volume:	6
Issue:	2
Pages:	167-76

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Publication

12679517 | J:83410

First Author:	Vassilatis DK
Year:	2003
Journal:	Proc Natl Acad Sci U S A
Title:	The G protein-coupled receptor repertoires of human and mouse.
Volume:	100
Issue:	8
Pages:	4903-8

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Publication

8170923 | -

First Author:	Attwood TK
Year:	1994
Journal:	Protein Eng
Title:	Fingerprinting G-protein-coupled receptors.
Volume:	7
Issue:	2
Pages:	195-203

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Publication

8081729 | -

First Author:	Kolakowski LF Jr
Year:	1994
Journal:	Receptors Channels
Title:	GCRDb: a G-protein-coupled receptor database.
Volume:	2
Issue:	1
Pages:	1-7

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Publication

15914470 | -

First Author:	Foord SM
Year:	2005
Journal:	Pharmacol Rev
Title:	International Union of Pharmacology. XLVI. G protein-coupled receptor list.
Volume:	57
Issue:	2
Pages:	279-88

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Publication

18948278 | -

First Author:	Harmar AJ
Year:	2009
Journal:	Nucleic Acids Res
Title:	IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.
Volume:	37
Issue:	Database issue
Pages:	D680-5

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Publication

16753280 | J:115055

First Author:	Bjarnadóttir TK
Year:	2006
Journal:	Genomics
Title:	Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse.
Volume:	88
Issue:	3
Pages:	263-73

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Publication

23020293 | -

First Author:	Civelli O
Year:	2013
Journal:	Annu Rev Pharmacol Toxicol
Title:	G protein-coupled receptor deorphanizations.
Volume:	53

Pages:	127-46

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Publication

- | J:100256

First Author:	The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year:	2005
Journal:	Database Download
Title:	MGI download of GENSAT transgene data

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