Type |
Details |
Score |
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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•
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Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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•
•
•
•
•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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•
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•
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Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
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•
•
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•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
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Title: |
Cyagen Biosciences Website. |
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
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•
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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•
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
•
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•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
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•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
•
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•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
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•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
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•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
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•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
600
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
349
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
440
 |
Fragment?: |
false |
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•
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Publication |
First Author: |
Mattila SO |
Year: |
2016 |
Journal: |
J Cell Sci |
Title: |
The Parkinson's-disease-associated receptor GPR37 undergoes metalloproteinase-mediated N-terminal cleavage and ectodomain shedding. |
Volume: |
129 |
Issue: |
7 |
Pages: |
1366-77 |
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•
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Interaction Experiment |
Description: |
CASPR2 forms a complex with GPR37 via MUPP1 but not with GPR37(R558Q), an autism spectrum disorder-related mutation. |
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Protein Domain |
Type: |
Family |
Description: |
G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [, , ].Several 7TM receptors have been cloned but their endogenous ligands areunknown; these have been termed orphan receptors. GPR37 was isolated from aset of human brain frontal lobe expressed sequence tags. The GPR37 genomicsequence was subsequently mapped to chromosome 7. A putative orthologue, 83%identical to the human form in terms of predicted amino acid sequence, hassince been identified in the mouse genome and mapped to chromosome 6. Northern blot analyses revealed a highly expressed 3.8kb mRNA and a less abundant 8kb mRNA in both human and mouse brain. The 3.8kb mRNA was also less abundantly expressed in human liver and placenta, and a further 3kb mRNA was found in mouse testis []. |
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Publication |
First Author: |
Schmidt AL |
Year: |
2024 |
Journal: |
Glia |
Title: |
The myelination-associated G protein-coupled receptor 37 is regulated by Zfp488, Nkx2.2, and Sox10 during oligodendrocyte differentiation. |
Volume: |
72 |
Issue: |
7 |
Pages: |
1304-1318 |
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•
•
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•
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Publication |
First Author: |
Masukawa D |
Year: |
2023 |
Journal: |
J Neurochem |
Title: |
Coupling between GPR143 and dopamine D2 receptor is required for selective potentiation of dopamine D2 receptor function by L-3,4-dihydroxyphenylalanine in the dorsal striatum. |
Volume: |
165 |
Issue: |
2 |
Pages: |
177-195 |
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•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
481
 |
Fragment?: |
false |
|
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
348
 |
Fragment?: |
false |
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•
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•
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Publication |
First Author: |
Birnbaumer L |
Year: |
1990 |
Journal: |
Annu Rev Pharmacol Toxicol |
Title: |
G proteins in signal transduction. |
Volume: |
30 |
|
Pages: |
675-705 |
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•
•
•
•
•
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Publication |
First Author: |
Casey PJ |
Year: |
1988 |
Journal: |
J Biol Chem |
Title: |
G protein involvement in receptor-effector coupling. |
Volume: |
263 |
Issue: |
6 |
Pages: |
2577-80 |
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•
•
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•
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Publication |
First Author: |
Attwood TK |
Year: |
1993 |
Journal: |
Protein Eng |
Title: |
Design of a discriminating fingerprint for G-protein-coupled receptors. |
Volume: |
6 |
Issue: |
2 |
Pages: |
167-76 |
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•
•
•
•
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Publication |
First Author: |
Vassilatis DK |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The G protein-coupled receptor repertoires of human and mouse. |
Volume: |
100 |
Issue: |
8 |
Pages: |
4903-8 |
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•
•
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•
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Publication |
First Author: |
Attwood TK |
Year: |
1994 |
Journal: |
Protein Eng |
Title: |
Fingerprinting G-protein-coupled receptors. |
Volume: |
7 |
Issue: |
2 |
Pages: |
195-203 |
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•
•
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•
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Publication |
First Author: |
Kolakowski LF Jr |
Year: |
1994 |
Journal: |
Receptors Channels |
Title: |
GCRDb: a G-protein-coupled receptor database. |
Volume: |
2 |
Issue: |
1 |
Pages: |
1-7 |
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•
•
•
•
•
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Publication |
First Author: |
Foord SM |
Year: |
2005 |
Journal: |
Pharmacol Rev |
Title: |
International Union of Pharmacology. XLVI. G protein-coupled receptor list. |
Volume: |
57 |
Issue: |
2 |
Pages: |
279-88 |
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•
•
•
•
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Publication |
First Author: |
Harmar AJ |
Year: |
2009 |
Journal: |
Nucleic Acids Res |
Title: |
IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels. |
Volume: |
37 |
Issue: |
Database issue |
Pages: |
D680-5 |
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•
•
•
•
•
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Publication |
First Author: |
Bjarnadóttir TK |
Year: |
2006 |
Journal: |
Genomics |
Title: |
Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse. |
Volume: |
88 |
Issue: |
3 |
Pages: |
263-73 |
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•
•
•
•
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Publication |
First Author: |
Civelli O |
Year: |
2013 |
Journal: |
Annu Rev Pharmacol Toxicol |
Title: |
G protein-coupled receptor deorphanizations. |
Volume: |
53 |
|
Pages: |
127-46 |
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•
•
•
•
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Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
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•
•
•
•
•
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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