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Search results 301 to 355 out of 355 for Grk2

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Type

Details

Score

Publication

33548241 | J:306514

First Author:	Bledzka KM
Year:	2021
Journal:	J Mol Cell Cardiol
Title:	A peptide of the amino-terminus of GRK2 induces hypertrophy and yet elicits cardioprotection after pressure overload.
Volume:	154

Pages:	137-153

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Publication

37714510 | J:341111

First Author:	Manaserh IH
Year:	2023
Journal:	J Mol Cell Cardiol
Title:	A cardiac amino-terminal GRK2 peptide inhibits insulin resistance yet enhances maladaptive cardiovascular and brown adipose tissue remodeling in females during diet-induced obesity.
Volume:	183

Pages:	81-97

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Publication

24231349 | J:207756

First Author:	Wang H
Year:	2013
Journal:	J Clin Invest
Title:	Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.
Volume:	123
Issue:	12
Pages:	5023-34

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Publication

22179058 | J:192705

First Author:	Zhu W
Year:	2012
Journal:	Circ Res
Title:	Gi-biased β2AR signaling links GRK2 upregulation to heart failure.
Volume:	110
Issue:	2
Pages:	265-74

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HT Experiment

E-GEOD-41809 | Expression data from young (4 month-old) hearts from GRK2 heterozygous C57BL/6J mice and its wild type littermates

Series Id:	GSE41809
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

•

HT Experiment

E-GEOD-41706 | Expression data from adult (9 month-old) hearts from GRK2 heterozygous C57BL/6J mice and its wild type littermates

Series Id:	GSE41706
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

•

HT Experiment

E-GEOD-41808 | Expression data from adult (9 month-old) and young (4 month-old) hearts from GRK2 heterozygous C57BL/6J mice

Series Id:	GSE41808
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

•

Publication

30538174 | J:283625

First Author:	Sato PY
Year:	2018
Journal:	Sci Signal
Title:	Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation.
Volume:	11
Issue:	560

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Publication

31604529 | J:291827

First Author:	Maimari T
Year:	2019
Journal:	Biochem Biophys Res Commun
Title:	The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors.
Volume:	520
Issue:	2
Pages:	327-332

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Publication

36275707 | J:335113

First Author:	Thapaliya M
Year:	2022
Journal:	Front Immunol
Title:	GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2.
Volume:	13

Pages:	1032497

•

Publication

30076211 | J:266684

First Author:	Abraham AD
Year:	2018
Journal:	J Neurosci
Title:	Estrogen Regulation of GRK2 Inactivates Kappa Opioid Receptor Signaling Mediating Analgesia, But Not Aversion.
Volume:	38
Issue:	37
Pages:	8031-8043

•

Publication

21695114 | J:174005

First Author:	Chen Y
Year:	2011
Journal:	PLoS Biol
Title:	Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened.
Volume:	9
Issue:	6
Pages:	e1001083

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Interaction Experiment

Sanchez-Perez A (2007)

Description:

GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2.

•

Interaction Experiment

Eijkelkamp N (2010)

Description:

Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK.

•

Allele

Tg(Myh6-GRK2)18Wjk | MGI:7532568

Name:	transgene insertion 18, Walter J Koch
Allele Type:	Transgenic
Attribute String:	Inserted expressed sequence

•

Publication

25982117 | J:226132

First Author:	Zha Z
Year:	2015
Journal:	Mol Cell
Title:	A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation.
Volume:	58
Issue:	5
Pages:	794-803

•

Allele

Grk2<tm1Smoc> | MGI:7290023

Name:	G protein-coupled receptor kinase 2; targeted mutation 1, Shanghai Model Organisms Center
Allele Type:	Targeted
Attribute String:	Conditional ready, No functional change

•

HT Experiment

E-GEOD-41807 | Expression data from adult (9 month-old) and young (4 month-old) hearts from C57BL/6J mice

Series Id:	GSE41807
Experiment Type:	transcription profiling by array
Study Type:	Baseline
Source:	ArrayExpress

•

Publication

22375000 | -

First Author:	Moulédous L
Year:	2012
Journal:	J Biol Chem
Title:	GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF2) receptors.
Volume:	287
Issue:	16
Pages:	12736-49

•

GO Term

GO:0047696 | beta-adrenergic receptor kinase activity

•

Publication

30668961 | J:282551

First Author:	Riedemann T
Year:	2019
Journal:	Neurosci Lett
Title:	Long-lasting actions of somatostatin on pyramidal cell excitability in the mouse cingulate cortex.
Volume:	698

Pages:	217-223

•

Publication

17006543 | J:129776

First Author:	Salcedo A
Year:	2006
Journal:	EMBO J
Title:	Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2.
Volume:	25
Issue:	20
Pages:	4752-62

•

Publication

22447027 | J:185374

First Author:	Liu X
Year:	2012
Journal:	Nat Immunol
Title:	Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases.
Volume:	13
Issue:	5
Pages:	457-64

•

Publication

25881508 | J:228381

First Author:	Ohba Y
Year:	2015
Journal:	Biochem Biophys Res Commun
Title:	GRK6 phosphorylates IκBα at Ser(32)/Ser(36) and enhances TNF-α-induced inflammation.
Volume:	461
Issue:	2
Pages:	307-13

•

Publication

18760699 | J:149875

First Author:	Wang H
Year:	2008
Journal:	Neuron
Title:	FMRP acts as a key messenger for dopamine modulation in the forebrain.
Volume:	59
Issue:	4
Pages:	634-47

•

Publication

- | J:61322

First Author:	Montgomery JC
Year:	2000
Journal:	MGI Direct Data Submission
Title:	Chromosomal localization of the mouse G protein-coupled receptor kinase 5 and 6 genes

•

Publication

18711143 | J:138970

First Author:	Martini JS
Year:	2008
Journal:	Proc Natl Acad Sci U S A
Title:	Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes.
Volume:	105
Issue:	34
Pages:	12457-62

•

Publication

9325250 | J:43423

First Author:	Peppel K
Year:	1997
Journal:	J Biol Chem
Title:	G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization.
Volume:	272
Issue:	41
Pages:	25425-8

•

Publication

15637145 | J:97178

First Author:	Pi M
Year:	2005
Journal:	Mol Endocrinol
Title:	Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.
Volume:	19
Issue:	4
Pages:	1078-87

•

Publication

28162981 | J:240924

First Author:	Liu S
Year:	2017
Journal:	Am J Pathol
Title:	Caveolin 1 and G-Protein-Coupled Receptor Kinase-2 Coregulate Endothelial Nitric Oxide Synthase Activity in Sinusoidal Endothelial Cells.
Volume:	187
Issue:	4
Pages:	896-907

•

Publication

19234125 | J:146272

First Author:	Alves-Filho JC
Year:	2009
Journal:	Proc Natl Acad Sci U S A
Title:	Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis.
Volume:	106
Issue:	10
Pages:	4018-23

•

Publication

23499767 | J:328441

First Author:	Mahavadi S
Year:	2013
Journal:	Peptides
Title:	Caveolae-dependent internalization and homologous desensitization of VIP/PACAP receptor, VPAC₂, in gastrointestinal smooth muscle.
Volume:	43

Pages:	137-45

•

Publication

25404319 | J:216731

First Author:	Sikka G
Year:	2014
Journal:	Proc Natl Acad Sci U S A
Title:	Melanopsin mediates light-dependent relaxation in blood vessels.
Volume:	111
Issue:	50
Pages:	17977-82

•

Publication

17018529 | J:117638

First Author:	Wu JH
Year:	2006
Journal:	J Biol Chem
Title:	Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2.
Volume:	281
Issue:	49
Pages:	37758-72

•

Publication

28878120 | J:287974

First Author:	Jean-Charles PY
Year:	2017
Journal:	JCI Insight
Title:	Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.
Volume:	2
Issue:	17

•

Publication

28112221 | J:275322

First Author:	Lee WB
Year:	2017
Journal:	Sci Rep
Title:	Mincle activation enhances neutrophil migration and resistance to polymicrobial septic peritonitis.
Volume:	7

Pages:	41106

•

Publication

26282875 | J:227561

First Author:	Lee SK
Year:	2015
Journal:	J Exp Med
Title:	Phospholipase D2 drives mortality in sepsis by inhibiting neutrophil extracellular trap formation and down-regulating CXCR2.
Volume:	212
Issue:	9
Pages:	1381-90

•

Publication

10446210 | J:200338

First Author:	Hall RA
Year:	1999
Journal:	J Biol Chem
Title:	G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction.
Volume:	274
Issue:	34
Pages:	24328-34

•

Publication

11579104 | J:72965

First Author:	Baig AH
Year:	2001
Journal:	J Biol Chem
Title:	Desensitization of the Y1 cell adrenocorticotropin receptor: evidence for a restricted heterologous mechanism implying a role for receptor-effector complexes.
Volume:	276
Issue:	48
Pages:	44792-7

•

Publication

9892019 | J:51863

First Author:	Lembo PM
Year:	1999
Journal:	Mol Endocrinol
Title:	Receptor selectivity of the cloned opossum G protein-coupled receptor kinase 2 (GRK2) in intact opossum kidney cells: role in desensitization of endogenous alpha2C-adrenergic but not serotonin 1B receptors.
Volume:	13
Issue:	1
Pages:	138-47

•

Publication

16980301 | J:117364

First Author:	Parameswaran N
Year:	2006
Journal:	J Biol Chem
Title:	Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages.
Volume:	281
Issue:	45
Pages:	34159-70

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Publication

18425130 | J:136690

First Author:	Liggett SB
Year:	2008
Journal:	Nat Med
Title:	A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure.
Volume:	14
Issue:	5
Pages:	510-7

•

Publication

18936096 | J:144554

First Author:	Shankaranarayanan A
Year:	2008
Journal:	J Biol Chem
Title:	Assembly of high order G alpha q-effector complexes with RGS proteins.
Volume:	283
Issue:	50
Pages:	34923-34

•

Publication

19913059 | J:164827

First Author:	Kahsai AW
Year:	2010
Journal:	Biochim Biophys Acta
Title:	G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells.
Volume:	1803
Issue:	2
Pages:	300-10

•

Publication

26670611 | J:230921

First Author:	Abd Alla J
Year:	2016
Journal:	J Biol Chem
Title:	Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice.
Volume:	291
Issue:	6
Pages:	2583-600

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Publication

27815373 | J:260784

First Author:	Wang Q
Year:	2017
Journal:	Circulation
Title:	Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction.
Volume:	135
Issue:	1
Pages:	73-88

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Publication

31268780 | J:287763

First Author:	Manfredi LH
Year:	2019
Journal:	Am J Physiol Cell Physiol
Title:	G protein-coupled receptor kinase 2 regulates mitochondrial bioenergetics and impairs myostatin-mediated autophagy in muscle cells.
Volume:	317
Issue:	4
Pages:	C674-C686

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Publication

30687708 | J:284381

First Author:	Wolf S
Year:	2018
Journal:	Front Med (Lausanne)
Title:	Sensitization of the Angiotensin II AT1 Receptor Contributes to RKIP-Induced Symptoms of Heart Failure.
Volume:	5

Pages:	359

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Publication

29438014 | J:330076

First Author:	Pusapati GV
Year:	2018
Journal:	Sci Signal
Title:	G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.
Volume:	11
Issue:	516

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Publication

21376255 | J:173682

First Author:	Liu J
Year:	2011
Journal:	Arch Med Res
Title:	S100B transgenic mice develop features of Parkinson's disease.
Volume:	42
Issue:	1
Pages:	1-7

•

Publication

22634615 | J:188953

First Author:	Aziz M
Year:	2012
Journal:	J Immunol
Title:	Milk fat globule-epidermal growth factor-factor 8 attenuates neutrophil infiltration in acute lung injury via modulation of CXCR2.
Volume:	189
Issue:	1
Pages:	393-402

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Publication

20814022 | J:178191

First Author:	Brinks H
Year:	2010
Journal:	Circ Res
Title:	Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms.
Volume:	107
Issue:	9
Pages:	1140-9

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Publication

25332207 | J:251001

First Author:	Hullmann JE
Year:	2014
Journal:	Circ Res
Title:	GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity.
Volume:	115
Issue:	12
Pages:	976-85

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Publication

18165681 | J:136530

First Author:	Vinge LE
Year:	2008
Journal:	J Biol Chem
Title:	Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness.
Volume:	283
Issue:	16
Pages:	10601-10

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Publication

11901213 | J:139482

First Author:	Eckhart AD
Year:	2002
Journal:	Mol Pharmacol
Title:	Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure.
Volume:	61
Issue:	4
Pages:	749-58

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