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Search results 301 to 359 out of 359 for Grp

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Type Details Score
Publication
- | J:307666
     
First Author: Melzer S
Year: 2021
Journal: bioRxiv
Title: Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories
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Protein Domain
IPR001966 | Gastrin_pep_rcpt
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [, , ].Bombesins are peptide neurotransmitters whose biological activity residesin a common C-terminal sequence, WAXGHXM. In the periphery, bombesin-related peptides stimulate smooth muscle and glandular secretion. In thebrain, these peptides are believed to play a role in homeostasis, thermoregulation and metabolism, and have been reported to elicit analgesia andexcessive grooming, together with central regulation of a variety ofperipheral effects.Mammalian bombesins are encoded by 2 genes. The preproGRP gene transcriptencodes a precursor of 147 amino acids, which gives GRP and GRP18-27. ThepreproNMB gene transcript encodes a precursor of 117 amino acids, which ismetabolised to neuromedin B. Receptors for these peptides have widespreaddistribution in peripheral tissue. High levels are found in smooth muscleand in the brain.The gastrin-releasing peptide receptor has a wide distribution in peripheraltissue. High levels are found in smooth muscle (e.g., intestine, stomachand bladder) and in secretory glands (e.g., pancreas). In the brain, it isfound in high levels in the hypothalamus, and is present in other areas inlower levels (e.g., the olfactory tract, dendate gyrus and cortex). Itis also found in various cell lines (e.g., Swiss 3T3 fibroblasts and small-cell lung carcinomas). GRP receptors activate the phosphoinositidepathway via a pertussis-toxin-insensitive G-protein, probably of the Gq/G11class.
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Publication
1671171 | J:28606
First Author: Battey JF
Year: 1991
Journal: Proc Natl Acad Sci U S A
Title: Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells.
Volume: 88
Issue: 2
Pages: 395-9
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Publication
19819238 | J:156613
First Author: Le Jeune M
Year: 2010
Journal: Exp Cell Res
Title: Identification of four alternatively spliced transcripts of the Ucma/GRP gene, encoding a new Gla-containing protein.
Volume: 316
Issue: 2
Pages: 203-15
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Publication
26612390 | J:244272
First Author: Freyburger M
Year: 2016
Journal: Sleep
Title: EphA4 is Involved in Sleep Regulation but Not in the Electrophysiological Response to Sleep Deprivation.
Volume: 39
Issue: 3
Pages: 613-24
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Publication
28957638 | J:271487
First Author: Mathews JA
Year: 2018
Journal: Am J Respir Cell Mol Biol
Title: Augmented Responses to Ozone in Obese Mice Require IL-17A and Gastrin-Releasing Peptide.
Volume: 58
Issue: 3
Pages: 341-351
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Publication
19428781 | J:150590
First Author: Osada N
Year: 2009
Journal: Neurochem Int
Title: Apolipoprotein E-deficient mice are more vulnerable to ER stress after transient forebrain ischemia.
Volume: 54
Issue: 7
Pages: 403-9
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Publication
24806094 | J:216781
First Author: Walton NM
Year: 2014
Journal: Stem Cells
Title: Gastrin-releasing peptide contributes to the regulation of adult hippocampal neurogenesis and neuronal development.
Volume: 32
Issue: 9
Pages: 2454-66
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Publication
25209280 | J:216292
First Author: Zhao ZQ
Year: 2014
Journal: J Neurosci
Title: Cross-inhibition of NMBR and GRPR signaling maintains normal histaminergic itch transmission.
Volume: 34
Issue: 37
Pages: 12402-14
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Publication
10939592 | J:63661
First Author: Carroll RE
Year: 2000
Journal: Cell Growth Differ
Title: Gastrin-releasing peptide is a mitogen and a morphogen in murine colon cancer.
Volume: 11
Issue: 7
Pages: 385-93
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Publication
24211692 | J:207857
 
First Author: Sakamoto H
Year: 2014
Journal: Neurosci Lett
Title: Androgen regulates development of the sexually dimorphic gastrin-releasing peptide neuron system in the lumbar spinal cord: evidence from a mouse line lacking androgen receptor in the nervous system.
Volume: 558
Pages: 109-14
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Publication
25523812 | J:357653
 
First Author: Haidet-Phillips AM
Year: 2015
Journal: Exp Neurol
Title: Human glial progenitor engraftment and gene expression is independent of the ALS environment.
Volume: 264
Pages: 188-99
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Publication
34359973 | J:351683
 
First Author: Kozlowska U
Year: 2021
Journal: Cells
Title: Assessment of Immunological Potential of Glial Restricted Progenitor Graft In Vivo-Is Immunosuppression Mandatory?
Volume: 10
Issue: 7
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Publication
16603607 | J:135752
First Author: Ashour K
Year: 2006
Journal: Am J Respir Crit Care Med
Title: Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice.
Volume: 173
Issue: 12
Pages: 1377-85
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Publication
9920658 | J:52410
First Author: Ohki-Hamazaki H
Year: 1999
Journal: J Neurosci
Title: Functional properties of two bombesin-like peptide receptors revealed by the analysis of mice lacking neuromedin B receptor.
Volume: 19
Issue: 3
Pages: 948-54
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Publication
16519669 | J:107143
First Author: Karatsoreos IN
Year: 2006
Journal: Eur J Neurosci
Title: Diurnal regulation of the gastrin-releasing peptide receptor in the mouse circadian clock.
Volume: 23
Issue: 4
Pages: 1047-53
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Publication
12239081 | J:79470
First Author: Persson K
Year: 2002
Journal: Endocrinology
Title: Islet function phenotype in gastrin-releasing peptide receptor gene-deficient mice.
Volume: 143
Issue: 10
Pages: 3717-26
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Publication
30283813 | J:266874
 
First Author: Varadarajan S
Year: 2018
Journal: eNeuro
Title: Connectome of the Suprachiasmatic Nucleus: New Evidence of the Core-Shell Relationship.
Volume: 5
Issue: 5
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Publication
15531362 | J:95027
First Author: Liu Y
Year: 2004
Journal: Dev Biol
Title: CD44 expression identifies astrocyte-restricted precursor cells.
Volume: 276
Issue: 1
Pages: 31-46
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Publication
37522391 | J:350963
First Author: Zhang ZJ
Year: 2023
Journal: EMBO Rep
Title: Descending dopaminergic pathway facilitates itch signal processing via activating spinal GRPR(+) neurons.
Volume: 24
Issue: 10
Pages: e56098
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Publication
25955385 | J:226002
First Author: Patricio ES
Year: 2015
Journal: J Invest Dermatol
Title: Mechanisms Underlying the Scratching Behavior Induced by the Activation of Proteinase-Activated Receptor-4 in Mice.
Volume: 135
Issue: 10
Pages: 2484-2491
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Publication
32764601 | J:299231
First Author: Bell AM
Year: 2020
Journal: Sci Rep
Title: Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse.
Volume: 10
Issue: 1
Pages: 13176
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Publication
20151358 | J:252944
First Author: Drouyer E
Year: 2010
Journal: J Comp Neurol
Title: Specializations of gastrin-releasing peptide cells of the mouse suprachiasmatic nucleus.
Volume: 518
Issue: 8
Pages: 1249-63
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Publication
36750092 | J:350034
First Author: Yao Y
Year: 2023
Journal: Curr Biol
Title: A carotid body-brainstem neural circuit mediates sighing in hypoxia.
Volume: 33
Issue: 5
Pages: 827-837.e4
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Publication
34000759 | J:353186
First Author: Kiguchi N
Year: 2021
Journal: Pharmacol Res Perspect
Title: Chemogenetic activation of central gastrin-releasing peptide-expressing neurons elicits itch-related scratching behavior in male and female mice.
Volume: 9
Issue: 3
Pages: e00790
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Publication
10590839 | J:60123
First Author: Barnes JA
Year: 1999
Journal: Cell Stress Chaperones
Title: Expression of glucose-regulated proteins (GRP78 and GRP94) in hearts and fore-limb buds of mouse embryos exposed to hypoglycemia in vitro.
Volume: 4
Issue: 4
Pages: 250-8
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Publication
8238311 | J:15444
First Author: Kusano K
Year: 1993
Journal: Am J Physiol
Title: Receptor-activated currents in mouse fibroblasts expressing transfected bombesin receptor subtype cDNAs.
Volume: 265
Issue: 4 Pt 1
Pages: C869-76
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Publication
9334249 | J:43621
First Author: Otto C
Year: 1997
Journal: J Biol Chem
Title: Absence of glucocorticoid receptor-beta in mice.
Volume: 272
Issue: 42
Pages: 26665-8
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Publication
15680955 | J:95567
First Author: Kamichi S
Year: 2005
Journal: Brain Res
Title: Immunohistochemical localization of gastrin-releasing peptide receptor in the mouse brain.
Volume: 1032
Issue: 1-2
Pages: 162-70
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Publication
15670577 | J:98067
First Author: Nakagawa T
Year: 2005
Journal: Biochem Pharmacol
Title: Identification of key amino acids in the gastrin-releasing peptide receptor (GRPR) responsible for high affinity binding of gastrin-releasing peptide (GRP).
Volume: 69
Issue: 4
Pages: 579-93
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Publication
15897896 | J:100111
First Author: Benali-Furet NL
Year: 2005
Journal: Oncogene
Title: Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion.
Volume: 24
Issue: 31
Pages: 4921-33
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Publication
22203955 | J:179982
First Author: Czepielewski RS
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils.
Volume: 109
Issue: 2
Pages: 547-52
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Publication
24133281 | J:204687
First Author: Wang J
Year: 2013
Journal: J Neurosci
Title: Oligodendrocyte/type-2 astrocyte progenitor cells and glial-restricted precursor cells generate different tumor phenotypes in response to the identical oncogenes.
Volume: 33
Issue: 42
Pages: 16805-17
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Publication
24333860 | J:210027
First Author: Kaminski MT
Year: 2014
Journal: Biochim Biophys Acta
Title: Glucose-induced dissociation of glucokinase from its regulatory protein in the nucleus of hepatocytes prior to nuclear export.
Volume: 1843
Issue: 3
Pages: 554-64
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Publication
31773089 | J:303527
First Author: Abu-Toamih Atamni HJ
Year: 2019
Journal: Animal Model Exp Med
Title: Efficient protocols and methods for high-throughput utilization of the Collaborative Cross mouse model for dissecting the genetic basis of complex traits.
Volume: 2
Issue: 3
Pages: 137-149
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Publication
38098939 | J:343685
 
First Author: Takanami K
Year: 2023
Journal: Front Mol Neurosci
Title: Function of gastrin-releasing peptide receptors in ocular itch transmission in the mouse trigeminal sensory system.
Volume: 16
Pages: 1280024
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Publication
22509372 | J:187094
First Author: Chaperon F
Year: 2012
Journal: PLoS One
Title: Gastrin-releasing peptide signaling plays a limited and subtle role in amygdala physiology and aversive memory.
Volume: 7
Issue: 4
Pages: e34963
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Publication
30655357 | J:273606
First Author: Albisetti GW
Year: 2019
Journal: J Neurosci
Title: Dorsal Horn Gastrin-Releasing Peptide Expressing Neurons Transmit Spinal Itch But Not Pain Signals.
Volume: 39
Issue: 12
Pages: 2238-2250
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Publication
27030714 | J:247556
   
First Author: Gutierrez-Mecinas M
Year: 2016
Journal: Mol Pain
Title: A quantitative study of neurochemically defined excitatory interneuron populations in laminae I-III of the mouse spinal cord.
Volume: 12
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Publication
30455627 | J:310556
 
First Author: Yuan XS
Year: 2018
Journal: Front Neurosci
Title: Whole-Brain Monosynaptic Afferent Projections to the Cholecystokinin Neurons of the Suprachiasmatic Nucleus.
Volume: 12
Pages: 807
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Publication
17316383 | J:118367
First Author: Blum M
Year: 2007
Journal: Differentiation
Title: Ciliation and gene expression distinguish between node and posterior notochord in the mammalian embryo.
Volume: 75
Issue: 2
Pages: 133-46
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Protein Domain
IPR001642 | NeuroB_rcpt
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [, , ].Bombesins are peptide neurotransmitters whose biological activity residesin a common C-terminal sequence, WAXGHXM. In the periphery, bombesin-related peptides stimulate smooth muscle and glandular secretion. In thebrain, these peptides are believed to play a role in homeostasis, thermoregulation and metabolism, and have been reported to elicit analgesia andexcessive grooming, together with central regulation of a variety ofperipheral effects.Mammalian bombesins are encoded by 2 genes. The preproGRP gene transcriptencodes a precursor of 147 amino acids, which gives GRP and GRP18-27. ThepreproNMB gene transcript encodes a precursor of 117 amino acids, which ismetabolised to neuromedin B. Receptors for these peptides have widespreaddistribution in peripheral tissue. High levels are found in smooth muscleand in the brain.The neuromedin B receptor has been characterised in rat oesophagus and raturinary bladder. It is widespread in the CNS, and is found in highlevels in olfactory nucleus and thalamic regions, and in lower levels inthe frontal cortex, dendate gyrus, amygdala and dorsal raphe. Thereceptor activates the phosphoinositide pathway through a pertussis-toxin-insensitive G-protein, probably of the Gq/G11 class.
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Protein Domain
IPR001560 | Bombesin_rcpt_3
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [, , ].Bombesins are peptide neurotransmitters whose biological activity residesin a common C-terminal sequence, WAXGHXM. In the periphery, bombesin-related peptides stimulate smooth muscle and glandular secretion. In thebrain, these peptides are believed to play a role in homeostasis, thermo-regulation and metabolism, and have been reported to elicit analgesia andexcessive grooming, together with central regulation of a variety ofperipheral effects.Mammalian bombesins are encoded by 2 genes. The preproGRP gene transcriptencodes a precursor of 147 amino acids, which gives GRP and GRP18-27. ThepreproNMB gene transcript encodes a precursor of 117 amino acids, which ismetabolised to neuromedin B. Receptors for these peptides have widespreaddistribution in peripheral tissue. High levels are found in smooth muscleand in the brain.The recently-identified BRS-3 bombesin receptor subtype is found in germcells in testis and in uteri of pregnant animals; it is also present in avariety of lung carcinoma cell lines. The receptor is believed to playa role in sperm cell division and maturation. Its action is mediated byassociation with G-proteins that activate a phosphatidylinositol-calciumsecond messenger system.
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Protein
P21729
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: false
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Protein
O54798
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: false
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Protein
O54799
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
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Protein
A0A087WQJ7
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: false
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Protein
A0A087WP36
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: false
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Protein
Q0VEH1
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
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Publication
2111655 | -
 
First Author: Birnbaumer L
Year: 1990
Journal: Annu Rev Pharmacol Toxicol
Title: G proteins in signal transduction.
Volume: 30
Pages: 675-705
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Publication
2830256 | -
First Author: Casey PJ
Year: 1988
Journal: J Biol Chem
Title: G protein involvement in receptor-effector coupling.
Volume: 263
Issue: 6
Pages: 2577-80
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Publication
8386361 | -
First Author: Attwood TK
Year: 1993
Journal: Protein Eng
Title: Design of a discriminating fingerprint for G-protein-coupled receptors.
Volume: 6
Issue: 2
Pages: 167-76
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Publication
12679517 | J:83410
First Author: Vassilatis DK
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: The G protein-coupled receptor repertoires of human and mouse.
Volume: 100
Issue: 8
Pages: 4903-8
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Publication
8170923 | -
First Author: Attwood TK
Year: 1994
Journal: Protein Eng
Title: Fingerprinting G-protein-coupled receptors.
Volume: 7
Issue: 2
Pages: 195-203
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Publication
8081729 | -
First Author: Kolakowski LF Jr
Year: 1994
Journal: Receptors Channels
Title: GCRDb: a G-protein-coupled receptor database.
Volume: 2
Issue: 1
Pages: 1-7
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Publication
15914470 | -
First Author: Foord SM
Year: 2005
Journal: Pharmacol Rev
Title: International Union of Pharmacology. XLVI. G protein-coupled receptor list.
Volume: 57
Issue: 2
Pages: 279-88
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Publication
18948278 | -
First Author: Harmar AJ
Year: 2009
Journal: Nucleic Acids Res
Title: IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.
Volume: 37
Issue: Database issue
Pages: D680-5
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Publication
16753280 | J:115055
First Author: Bjarnadóttir TK
Year: 2006
Journal: Genomics
Title: Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse.
Volume: 88
Issue: 3
Pages: 263-73
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Publication
23020293 | -
 
First Author: Civelli O
Year: 2013
Journal: Annu Rev Pharmacol Toxicol
Title: G protein-coupled receptor deorphanizations.
Volume: 53
Pages: 127-46
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