|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 301 to 372 out of 372 for Hal

<< First    < Previous  |  Next >    Last >>
0.027s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
33931568 | J:341070
 
First Author: Ren GM
Year: 2021
Journal: Sci Immunol
Title: Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases.
Volume: 6
Issue: 58
•
•
•
•
•
Publication
26919428 | J:230797
First Author: Zhong Z
Year: 2016
Journal: Cell
Title: NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.
Volume: 164
Issue: 5
Pages: 896-910
•
•
•
•
•
Publication
33087357 | J:347953
 
First Author: Cui S
Year: 2020
Journal: Sci Adv
Title: CD1d1 intrinsic signaling in macrophages controls NLRP3 inflammasome expression during inflammation.
Volume: 6
Issue: 43
•
•
•
•
•
Publication
33523841 | J:307619
 
First Author: Navarro-Pando JM
Year: 2021
Journal: Sci Adv
Title: Inhibition of the NLRP3 inflammasome prevents ovarian aging.
Volume: 7
Issue: 1
•
•
•
•
•
Publication
30366764 | J:277657
First Author: Guo C
Year: 2018
Journal: Immunity
Title: Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages.
Volume: 49
Issue: 5
Pages: 842-856.e7
•
•
•
•
•
Publication
37256266 | J:340095
First Author: Kaufmann B
Year: 2023
Journal: J Immunol
Title: Antisense Oligonucleotide Therapy Decreases IL-1β Expression and Prolongs Survival in Mutant Nlrp3 Mice.
Volume: 211
Issue: 2
Pages: 287-294
•
•
•
•
•
Publication
26275995 | J:233392
First Author: de Almeida L
Year: 2015
Journal: Immunity
Title: The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.
Volume: 43
Issue: 2
Pages: 264-76
•
•
•
•
•
Publication
28130494 | J:247745
First Author: Rhoads JP
Year: 2017
Journal: J Immunol
Title: Oxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and FcγR Cooperation and Is Dependent on CARD9.
Volume: 198
Issue: 5
Pages: 2105-2114
•
•
•
•
•
Publication
28249154 | J:265972
First Author: Goldberg EL
Year: 2017
Journal: Cell Rep
Title: β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares.
Volume: 18
Issue: 9
Pages: 2077-2087
•
•
•
•
•
Publication
35654037 | J:327624
First Author: Panicker N
Year: 2022
Journal: Neuron
Title: Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease.
Volume: 110
Issue: 15
Pages: 2422-2437.e9
•
•
•
•
•
Publication
30982734 | J:276004
First Author: Sanchez-Lopez E
Year: 2019
Journal: Cell Metab
Title: Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production.
Volume: 29
Issue: 6
Pages: 1350-1362.e7
•
•
•
•
•
Publication
35779608 | J:337222
First Author: Shahzad K
Year: 2022
Journal: Kidney Int
Title: Podocyte-specific Nlrp3 inflammasome activation promotes diabetic kidney disease.
Volume: 102
Issue: 4
Pages: 766-779
•
•
•
•
•
Publication
29326099 | J:261562
First Author: Weiss ES
Year: 2018
Journal: Blood
Title: Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome.
Volume: 131
Issue: 13
Pages: 1442-1455
•
•
•
•
•
Genotype
Genotype
Symbol: Il1r1/Il1r1 Nlrp3/Nlrp3<+> Lyz2/Lyz2<+>
Background: involves: 129 * C57BL/6
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Nlrp3/Nlrp3<+> Pycard/Pycard Lyz2/Lyz2<+>
Background: involves: 129 * C57BL/6
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Protein
Q9D3I5
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: false
•
•
•
•
•
Publication
10220322 | -
First Author: Schwede TF
Year: 1999
Journal: Biochemistry
Title: Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile.
Volume: 38
Issue: 17
Pages: 5355-61
•
•
•
•
•
Publication
6614592 | J:7181
First Author: Juneja RK
Year: 1983
Journal: Anim Blood Groups Biochem Genet
Title: Genetic variation at a pig serum protein locus, Po-2 and its assignment to the Phi, Hal, S, H, Pgd linkage group.
Volume: 14
Issue: 1
Pages: 27-36
•
•
•
•
•
Publication
9671748 | J:49341
First Author: Baross-Francis A
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability.
Volume: 95
Issue: 15
Pages: 8739-43
•
•
•
•
•
Protein
P35492
Organism: Mus musculus/domesticus
Length: 657  
Fragment?: false
•
•
•
•
•
Protein
Q8CE60
Organism: Mus musculus/domesticus
Length: 657  
Fragment?: false
•
•
•
•
•
Protein
B2RXW1
Organism: Mus musculus/domesticus
Length: 657  
Fragment?: false
•
•
•
•
•
Publication
23064362 | J:193548
First Author: Tortola L
Year: 2012
Journal: J Clin Invest
Title: Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk.
Volume: 122
Issue: 11
Pages: 3965-76
•
•
•
•
•
Publication
28327619 | J:256437
First Author: Harusato A
Year: 2017
Journal: Mucosal Immunol
Title: IL-36γ signaling controls the induced regulatory T cell-Th9 cell balance via NFκB activation and STAT transcription factors.
Volume: 10
Issue: 6
Pages: 1455-1467
•
•
•
•
•
Publication
29760082 | J:263562
First Author: Ngo VL
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage.
Volume: 115
Issue: 22
Pages: E5076-E5085
•
•
•
•
•
Publication
28882883 | J:252638
First Author: Nazir S
Year: 2017
Journal: Blood
Title: Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition.
Volume: 130
Issue: 24
Pages: 2664-2677
•
•
•
•
•
Publication
27569535 | J:247029
First Author: Agoro R
Year: 2016
Journal: Eur J Immunol
Title: IL-1R1-MyD88 axis elicits papain-induced lung inflammation.
Volume: 46
Issue: 11
Pages: 2531-2541
•
•
•
•
•
Publication
27010854 | J:268803
 
First Author: Wang C
Year: 2016
Journal: Cell Death Dis
Title: Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation.
Volume: 7
Pages: e2153
•
•
•
•
•
Publication
28687790 | J:253714
First Author: Wang C
Year: 2017
Journal: Sci Rep
Title: Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells.
Volume: 7
Issue: 1
Pages: 4880
•
•
•
•
•
Publication
26056255 | J:325815
First Author: Yao Y
Year: 2015
Journal: J Immunol
Title: Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism.
Volume: 195
Issue: 2
Pages: 488-97
•
•
•
•
•
Publication
8204579 | -
First Author: Langer M
Year: 1994
Journal: Biochemistry
Title: Identification of serine-143 as the most likely precursor of dehydroalanine in the active site of histidine ammonia-lyase. A study of the overexpressed enzyme by site-directed mutagenesis.
Volume: 33
Issue: 21
Pages: 6462-7
•
•
•
•
•
Publication
8050576 | -
First Author: Schuster B
Year: 1994
Journal: FEBS Lett
Title: Serine-202 is the putative precursor of the active site dehydroalanine of phenylalanine ammonia lyase. Site-directed mutagenesis studies on the enzyme from parsley (Petroselinum crispum L.).
Volume: 349
Issue: 2
Pages: 252-4
•
•
•
•
•
Publication
2120224 | -
First Author: Taylor RG
Year: 1990
Journal: J Biol Chem
Title: Cloning and expression of rat histidase. Homology to two bacterial histidases and four phenylalanine ammonia-lyases.
Volume: 265
Issue: 30
Pages: 18192-9
•
•
•
•
•
Publication
7961661 | -
First Author: Taylor RG
Year: 1994
Journal: J Biol Chem
Title: Site-directed mutagenesis of conserved serines in rat histidase. Identification of serine 254 as an essential active site residue.
Volume: 269
Issue: 44
Pages: 27473-7
•
•
•
•
•
Protein Domain
IPR022313 | Phe/His_NH3-lyase_AS
Type: Active_site
Description: This entry represents the active site of phenylalanine ammonia-lyase (PAL; ) and the mechanistically related protein histidine ammonia lyase (HAL; ). Both contain a catalytic Ala-Ser-Gly triad that is post-translationally cyclised []. PAL is a key biosynthetic catalyst in phenylpropanoid assembly in plants and fungi, and is involved in the biosynthesis of a wide variety of secondary metabolites such as flavanoids, furanocoumarin phytoalexins and cell wall components. These compounds are important for normal growth and in responses to environmental stress. PAL catalyses the removal of an ammonia group from phenylalanine to form trans-cinnamate. HAL catalyses the first step in histidine degradation, the removal of an ammonia group from histidine to produce urocanic acid. The core domain in PAL and Hal share about 30% sequence identity, with PAL containing an additional approximately 160 residues extending from the common fold [].The two types of enzymes are functionally and structurally related []. They are the only enzymes which are known to have the modified amino acid dehydro-alanine (DHA) in their active site. A serine residue has been shown [, , ]to be the precursor of this essential electrophilic moiety. The region around the active site serine is well conserved and has been used as the signature pattern for this entry.
•
•
•
•
•
Publication
12502351 | -
First Author: Moore BS
Year: 2002
Journal: J Nat Prod
Title: Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone.
Volume: 65
Issue: 12
Pages: 1956-62
•
•
•
•
•
Publication
15350127 | -
First Author: Calabrese JC
Year: 2004
Journal: Biochemistry
Title: Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
Volume: 43
Issue: 36
Pages: 11403-16
•
•
•
•
•
Publication
16478474 | -
First Author: Pilbák S
Year: 2006
Journal: FEBS J
Title: The essential tyrosine-containing loop conformation and the role of the C-terminal multi-helix region in eukaryotic phenylalanine ammonia-lyases.
Volume: 273
Issue: 5
Pages: 1004-19
•
•
•
•
•
Publication
22387558 | J:183090
First Author: Norton JT
Year: 2012
Journal: J Immunol
Title: Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1.
Volume: 188
Issue: 7
Pages: 2977-80
•
•
•
•
•
Publication
19501000 | J:150054
First Author: Brydges SD
Year: 2009
Journal: Immunity
Title: Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.
Volume: 30
Issue: 6
Pages: 875-87
•
•
•
•
•
Publication
33798492 | J:332510
First Author: Wang G
Year: 2021
Journal: Cell Host Microbe
Title: Bacteria induce skin regeneration via IL-1β signaling.
Volume: 29
Issue: 5
Pages: 777-791.e6
•
•
•
•
•
Publication
29120743 | J:278147
First Author: Liu H
Year: 2017
Journal: Cell Host Microbe
Title: Staphylococcus aureus Epicutaneous Exposure Drives Skin Inflammation via IL-36-Mediated T Cell Responses.
Volume: 22
Issue: 5
Pages: 653-666.e5
•
•
•
•
•
Protein
F8WH73
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: false
•
•
•
•
•
Publication
31127135 | J:278639
First Author: Guma E
Year: 2019
Journal: Sci Rep
Title: Role of D3 dopamine receptors in modulating neuroanatomical changes in response to antipsychotic administration.
Volume: 9
Issue: 1
Pages: 7850
•
•
•
•
•
Publication
9221926 | J:41519
First Author: Shearman LP
Year: 1997
Journal: Brain Res Mol Brain Res
Title: Haloperidol regulates neurotensin gene expression in striatum of c-fos-deficient mice.
Volume: 47
Issue: 1-2
Pages: 275-85
•
•
•
•
•
Publication
21245496 | J:171014
First Author: Dugan CM
Year: 2011
Journal: Toxicol Sci
Title: Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis.
Volume: 120
Issue: 2
Pages: 507-18
•
•
•
•
•
Publication
29704613 | J:307738
 
First Author: Guma E
Year: 2018
Journal: Neuroimage
Title: Regional brain volume changes following chronic antipsychotic administration are mediated by the dopamine D2 receptor.
Volume: 176
Pages: 226-238
•
•
•
•
•
Publication
27702890 | J:238630
First Author: Lin WH
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Hypoxia-activated cytotoxic agent tirapazamine enhances hepatic artery ligation-induced killing of liver tumor in HBx transgenic mice.
Volume: 113
Issue: 42
Pages: 11937-11942
•
•
•
•
•
Publication
- | J:49722
First Author: Moussa NM
Year: 1998
Journal: M S Med Sci
Title: The role of the Agouti protein in the yellow mouse obesity syndrome.
Volume: 14
Issue: 8-9
Pages: 898-906
•
•
•
•
•
Protein
Q99NH2
Organism: Mus musculus/domesticus
Length: 1333  
Fragment?: false
•
•
•
•
•
Protein
Q9CSB4
Organism: Mus musculus/domesticus
Length: 1203  
Fragment?: false
•
•
•
•
•
Protein
Q5SV55
Organism: Mus musculus/domesticus
Length: 1141  
Fragment?: false
•
•
•
•
•
Protein
B7ZNY3
Organism: Mus musculus/domesticus
Length: 1319  
Fragment?: false
•
•
•
•
•
Protein
A5D6P2
Organism: Mus musculus/domesticus
Length: 1334  
Fragment?: false
•
•
•
•
•
Protein
G3XA13
Organism: Mus musculus/domesticus
Length: 1333  
Fragment?: false
•
•
•
•
•
Protein
E0CXR8
Organism: Mus musculus/domesticus
Length: 990  
Fragment?: true
•
•
•
•
•
Protein
Q8BPQ4
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
•
•
•
•
•
Protein
E9PYJ2
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
•
•
•
•
•
Protein
E0CX45
Organism: Mus musculus/domesticus
Length: 943  
Fragment?: true
•
•
•
•
•
Protein
F6TSJ9
Organism: Mus musculus/domesticus
Length: 984  
Fragment?: true
•
•
•
•
•
Protein
Q8BPQ6
Organism: Mus musculus/domesticus
Length: 721  
Fragment?: false
•
•
•
•
•
Protein
F6S7Z1
Organism: Mus musculus/domesticus
Length: 1324  
Fragment?: true
•
•
•
•
•
Protein
E0CY24
Organism: Mus musculus/domesticus
Length: 1247  
Fragment?: false
•
•
•
•
•
Protein
E0CXL4
Organism: Mus musculus/domesticus
Length: 1289  
Fragment?: false
•
•
•
•
•
Protein
F6UGU7
Organism: Mus musculus/domesticus
Length: 919  
Fragment?: true
•
•
•
•
•
Protein
E0CZ83
Organism: Mus musculus/domesticus
Length: 1094  
Fragment?: true
•
•
•
•
•
Protein
B2RUK1
Organism: Mus musculus/domesticus
Length: 1304  
Fragment?: false
•
•
•
•
•
Protein
E0CZE2
Organism: Mus musculus/domesticus
Length: 1024  
Fragment?: true
•
•
•
•
•
Protein
Q5SV54
Organism: Mus musculus/domesticus
Length: 1104  
Fragment?: false
•
•
•
•
•
Publication
22297845 | J:181354
First Author: Henao-Mejia J
Year: 2012
Journal: Nature
Title: Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Volume: 482
Issue: 7384
Pages: 179-85
•
•
•
•
•
Publication
30937919 | J:346788
First Author: Schwartz C
Year: 2019
Journal: Allergy
Title: Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β.
Volume: 74
Issue: 10
Pages: 1920-1933
•
•
•
•
•
Publication
- | J:38102
First Author: Peters J
Year: 1996
Journal: Mouse Genome
Title: New Gene Symbols
Volume: 94
Issue: 4
Pages: 700-14
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom