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Search results 301 to 400 out of 423 for Hdac4

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Type Details Score
Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
21731673 | J:174767
First Author: Tang F
Year: 2011
Journal: PLoS One
Title: Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Volume: 6
Issue: 6
Pages: e21208
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
27106144 | J:256821
First Author: Chen C
Year: 2016
Journal: Biochim Biophys Acta
Title: Compression regulates gene expression of chondrocytes through HDAC4 nuclear relocation via PP2A-dependent HDAC4 dephosphorylation.
Volume: 1863
Issue: 7 Pt A
Pages: 1633-42
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HT Experiment
E-GEOD-49383 | Gene expression data from mouse HDAC4 KO pups, postnatal day 3
Series Id: GSE49383
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
30427927 | J:267332
First Author: Worton LE
Year: 2018
Journal: PLoS One
Title: Botulinum toxin A-induced muscle paralysis stimulates Hdac4 and differential miRNA expression.
Volume: 13
Issue: 11
Pages: e0207354
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Publication
26272629 | J:224989
 
First Author: Guo X
Year: 2015
Journal: Nat Commun
Title: A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa.
Volume: 6
Pages: 8005
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Publication
19071119 | J:142663
First Author: Seo HW
Year: 2009
Journal: FEBS Lett
Title: Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1.
Volume: 583
Issue: 1
Pages: 55-60
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Publication
33148508 | J:301206
 
First Author: Nishimori S
Year: 2021
Journal: Bone
Title: PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate.
Volume: 142
Pages: 115709
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Publication
31040226 | J:294485
First Author: Federspiel JD
Year: 2019
Journal: Mol Cell Proteomics
Title: Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.
Volume: 18
Issue: 8 suppl 1
Pages: S92-S113
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Publication
26619800 | J:255673
First Author: Fang M
Year: 2016
Journal: Biochim Biophys Acta
Title: HDAC4 mediates IFN-γ induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells.
Volume: 1859
Issue: 2
Pages: 294-305
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UniProt Feature
UniProt Feature
Begin: 389
Description: In HD; disrupts sequence-specific DNA-binding; no effect on homodimerization or interaction with HDAC4 and HDAC5.
Type: sequence variant
End: 389
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Publication
28157489 | J:242327
First Author: Yang Z
Year: 2017
Journal: Am J Pathol
Title: Cathepsin H-Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases.
Volume: 187
Issue: 4
Pages: 781-797
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Interaction Experiment
Li J (2012)
Description: Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia.
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Interaction Experiment
Federspiel JD (2019)
Description: Hdac4 Interactions in Huntingtons Disease Viewed Through the Prism of Multiomics.
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Publication
26074448 | -
 
First Author: Fitzsimons HL
Year: 2015
Journal: Neurobiol Learn Mem
Title: The Class IIa histone deacetylase HDAC4 and neuronal function: Nuclear nuisance and cytoplasmic stalwart?
Volume: 123
Pages: 149-58
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Allele
Hdac4<tm2.1Eno> | MGI:4418117
Name: histone deacetylase 4; targeted mutation 1, Eric N Olson
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
12032081 | -
First Author: Kirsh O
Year: 2002
Journal: EMBO J
Title: The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.
Volume: 21
Issue: 11
Pages: 2682-91
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Strain
MGI:6284844 | B6.129S(Cg)-Hdac4<tm2.1Eno>
Attribute String: congenic
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Genotype
Genotype
Symbol: Hdac4/Hdac4
Background: involves: 129S/SvEv
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hdac4/Hdac4
Background: B6.129S(Cg)-Hdac4
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
E-GEOD-38219 | Gene expression data from cortex of 15 week old wild type, R6/2, HDAC4het and R6/2::HDAC4het mice
Series Id: GSE38219
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-38218 | Gene expression data from cortex of 9 week old wild type, R6/2, HDAC4het and R6/2::HDAC4het mice
Series Id: GSE38218
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Tg(Col2a1-Hdac4)1Eno | MGI:3525223
Name: transgene insertion 1, Eric N Olson
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Hdac4/Hdac4 Tg(Myog-cre)1Eno/?
Background: involves: 129S/SvEv
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Col2a1-Hdac4)1Eno/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Strain
MGI:6284846 | B6.129(Cg)-Hdac4<tm2.1Eno> Scn10a<tm2(cre)Jnw>
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Hdac4/Hdac4 Scn10a/Scn10a<+>
Background: B6.129(Cg)-Hdac4 Scn10a
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hdac4/Hdac4 Hdac5/Hdac5 Tg(Myog-cre)1Eno/?
Background: involves: 129 * 129S/SvEv * 129S2/SvPas
Zygosity: cn
Has Mutant Allele: true
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Publication
24579951 | -
First Author: Wang Z
Year: 2014
Journal: Epigenomics
Title: HDAC4: mechanism of regulation and biological functions.
Volume: 6
Issue: 1
Pages: 139-50
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Publication
25967576 | -
First Author: Kassis H
Year: 2015
Journal: Stroke
Title: Stroke Induces Nuclear Shuttling of Histone Deacetylase 4.
Volume: 46
Issue: 7
Pages: 1909-15
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Publication
25244360 | J:242819
First Author: Parra M
Year: 2015
Journal: FEBS J
Title: Class IIa HDACs - new insights into their functions in physiology and pathology.
Volume: 282
Issue: 9
Pages: 1736-44
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Publication
16289629 | -
 
First Author: Glozak MA
Year: 2005
Journal: Gene
Title: Acetylation and deacetylation of non-histone proteins.
Volume: 363
Pages: 15-23
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Publication
26791815 | -
First Author: Di Giorgio E
Year: 2016
Journal: Epigenomics
Title: Regulation of class IIa HDAC activities: it is not only matter of subcellular localization.
Volume: 8
Issue: 2
Pages: 251-69
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Publication
17470548 | J:123639
First Author: Kasler HG
Year: 2007
Journal: Mol Cell Biol
Title: Histone deacetylase 7 functions as a key regulator of genes involved in both positive and negative selection of thymocytes.
Volume: 27
Issue: 14
Pages: 5184-200
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Publication
25616866 | -
First Author: Mathias RA
Year: 2015
Journal: Mol Cell Proteomics
Title: Post-translational modifications regulate class IIa histone deacetylase (HDAC) function in health and disease.
Volume: 14
Issue: 3
Pages: 456-70
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Protein Domain
IPR033660 | HDAC4/7
Type: Family
Description: Histone deacetylases (HDACs) modulate the acetylation level of histones to regulate chromatin structure and gene expression. They are considered to be crucial regulators of specific developmental and differentiation processes. Whilst they are primarily involved in the deacetylation of histones, they have also been shown to regulate the acetylation levels of non-histone proteins [].Class IIa histone deacetylases (HDACs4, -5, -6, -7, -9 and -10) modulate the physiology of the human cardiovascular, musculoskeletal, nervous, and immune systems [, [].HDAC4 performs a wide variety of functions, including the regulation of cell growth, survival and proliferation, and the regulation of gene transcription. It has been closely associated with the development of tumours in various tissues. It also induces demethylation of histone proteins, and has been shown to be subject to post-transcriptional modification by multiple methods []. HDAC4 has been reported to regulate chondrocyte hypertrophy and endochondral bone formation, muscle development, and cardiovascular diseases [].HDAC4 is localized to both the nucleus and cytoplasm, and undergoes subcellular shuttling in response to synaptic activity and environmental signals [, ]. It is important for neuronal development and function, and has been implicated in a number of neuronal diseases including brachydactyly mental retardation (BDMR) syndrome, ataxia telangiectasia, and Huntington's disease [].Histone deacetylase 7 (HDAC7) is highly expressed in double-positive thymocytes, suggesting a possible role in thymic T-cell development [, ].
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Publication
19276356 | J:147076
First Author: Liu R
Year: 2009
Journal: Cancer Res
Title: FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus.
Volume: 69
Issue: 6
Pages: 2252-9
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Publication
28352664 | J:290770
First Author: Pardo M
Year: 2017
Journal: JCI Insight
Title: Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice.
Volume: 2
Issue: 6
Pages: e91782
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Publication
34348664 | J:310973
First Author: Dimitrakopoulos C
Year: 2021
Journal: BMC Genomics
Title: Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma.
Volume: 22
Issue: 1
Pages: 592
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Publication
31320633 | J:279499
First Author: Castets P
Year: 2019
Journal: Nat Commun
Title: mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4.
Volume: 10
Issue: 1
Pages: 3187
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Publication
30962442 | J:273328
First Author: Li J
Year: 2019
Journal: Nat Commun
Title: TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling.
Volume: 10
Issue: 1
Pages: 1589
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Publication
23431031 | J:193960
First Author: Han K
Year: 2013
Journal: Genes Dev
Title: Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p.
Volume: 27
Issue: 5
Pages: 485-90
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Publication
27484840 | J:241273
 
First Author: Moretti I
Year: 2016
Journal: Nat Commun
Title: MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity.
Volume: 7
Pages: 12397
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Protein
A0A087WSF0
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: true
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Publication
19179290 | J:146285
First Author: Backs J
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload.
Volume: 106
Issue: 7
Pages: 2342-7
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Publication
11390982 | J:70040
First Author: Zhang CL
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: The transcriptional corepressor MITR is a signal-responsive inhibitor of myogenesis.
Volume: 98
Issue: 13
Pages: 7354-9
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Publication
16221865 | J:123044
First Author: Bolger TA
Year: 2005
Journal: J Neurosci
Title: Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death.
Volume: 25
Issue: 41
Pages: 9544-53
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Publication
24465754 | J:212336
First Author: Yang Y
Year: 2014
Journal: PLoS One
Title: The interaction of the atm genotype with inflammation and oxidative stress.
Volume: 9
Issue: 1
Pages: e85863
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Publication
27538496 | J:356029
First Author: Chen J
Year: 2016
Journal: Mol Neurodegener
Title: The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment.
Volume: 11
Issue: 1
Pages: 60
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Publication
27711113 | J:236238
First Author: Lin X
Year: 2016
Journal: PLoS Genet
Title: MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice.
Volume: 12
Issue: 10
Pages: e1006308
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Publication
23524588 | J:213308
First Author: Huang ZP
Year: 2013
Journal: Circ Res
Title: MicroRNA-22 regulates cardiac hypertrophy and remodeling in response to stress.
Volume: 112
Issue: 9
Pages: 1234-43
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Publication
28234968 | J:248314
First Author: Li LF
Year: 2017
Journal: PLoS One
Title: Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway.
Volume: 12
Issue: 2
Pages: e0172571
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Publication
25042397 | J:346368
First Author: Ferry A
Year: 2014
Journal: Neuromuscul Disord
Title: Advances in the understanding of skeletal muscle weakness in murine models of diseases affecting nerve-evoked muscle activity, motor neurons, synapses and myofibers.
Volume: 24
Issue: 11
Pages: 960-72
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