| Type |
Details |
Score |
| Publication |
| First Author: |
GOA curators, MGI curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology annotation based on Enzyme Commission mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Thompson CL |
| Year: |
2014 |
| Journal: |
Neuron |
| Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
| Volume: |
83 |
| Issue: |
2 |
| Pages: |
309-323 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bedogni F |
| Year: |
2021 |
| Journal: |
Front Mol Neurosci |
| Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
| Volume: |
14 |
|
| Pages: |
686034 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lennon G |
| Year: |
1999 |
| Journal: |
Database Download |
| Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
1670-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2014 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Magdaleno S |
| Year: |
2006 |
| Journal: |
PLoS Biol |
| Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
e86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
|
| Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hashikawa-Hobara N |
| Year: |
2021 |
| Journal: |
Sci Rep |
| Title: |
Npas4 impairs fear memory via phosphorylated HDAC5 induced by CGRP administration in mice. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
7006 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Seo HW |
| Year: |
2009 |
| Journal: |
FEBS Lett |
| Title: |
Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1. |
| Volume: |
583 |
| Issue: |
1 |
| Pages: |
55-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Angiolilli C |
| Year: |
2016 |
| Journal: |
Ann Rheum Dis |
| Title: |
Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression. |
| Volume: |
75 |
| Issue: |
2 |
| Pages: |
430-8 |
|
•
•
•
•
•
|
| Allele |
| Name: |
histone deacetylase 5; targeted mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Eric N Olson |
| Allele Type: |
Transgenic |
| Attribute String: |
Dominant negative, Inducible, Inserted expressed sequence |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wei JY |
| Year: |
2015 |
| Journal: |
Brain Res |
| Title: |
Intracellular translocation of histone deacetylase 5 regulates neuronal cell apoptosis. |
| Volume: |
1604 |
|
| Pages: |
15-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Duarte JH |
| Year: |
2015 |
| Journal: |
Nat Rev Rheumatol |
| Title: |
Rheumatoid arthritis: Inflammation feeds inflammation-HDAC5 downregulation leads to activation of fibroblast-like synoviocytes in RA. |
| Volume: |
11 |
| Issue: |
2 |
| Pages: |
64 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Histone deacetylases (HDACs) modulate the acetylation level of histone and non-histone proteins to regulate chromatin structure and gene expression. Histone deacetylase 5 (HDAC5) undergoes signal-dependent translocation between the nucleus and cytoplasm, which is regulated in part by calcium/calmodulin-dependent kinase (CaMK)-mediatedphosphorylation. HDAC5 and its intracellular translocation are key effectors of multiple pathways that regulate neuronal cell apoptosis []. HDAC5 has been identified as a inflammatory mediator in rheumatoid arthritis, as its expression is suppressed by inflammatory cytokines which leads to activation of fibroblast-like synoviocytes [, ]. |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Myog-tTA)1Eno/? Tg(tetO-HDAC5*)1Eno/? |
| Background: |
involves: C3H * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Myh6-tTA)6Smbf/? Tg(tetO-HDAC5*)1Eno/? |
| Background: |
involves: C3H * C57BL/6 * CBA |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
158
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
175
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meng ZX |
| Year: |
2017 |
| Journal: |
Mol Cell |
| Title: |
Glucose Sensing by Skeletal Myocytes Couples Nutrient Signaling to Systemic Homeostasis. |
| Volume: |
66 |
| Issue: |
3 |
| Pages: |
332-344.e4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Au NPB |
| Year: |
2023 |
| Journal: |
Neuron |
| Title: |
Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair. |
| Volume: |
111 |
| Issue: |
24 |
| Pages: |
3970-3987.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim MS |
| Year: |
2012 |
| Journal: |
J Neurosci |
| Title: |
An essential role for histone deacetylase 4 in synaptic plasticity and memory formation. |
| Volume: |
32 |
| Issue: |
32 |
| Pages: |
10879-86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sasaki S |
| Year: |
2023 |
| Journal: |
iScience |
| Title: |
Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5. |
| Volume: |
26 |
| Issue: |
8 |
| Pages: |
107311 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ling H |
| Year: |
2009 |
| Journal: |
J Clin Invest |
| Title: |
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. |
| Volume: |
119 |
| Issue: |
5 |
| Pages: |
1230-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Backs J |
| Year: |
2009 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. |
| Volume: |
106 |
| Issue: |
7 |
| Pages: |
2342-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jama A |
| Year: |
2019 |
| Journal: |
J Physiol |
| Title: |
Lipin1 is required for skeletal muscle development by regulating MEF2c and MyoD expression. |
| Volume: |
597 |
| Issue: |
3 |
| Pages: |
889-901 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gold JI |
| Year: |
2012 |
| Journal: |
Circ Res |
| Title: |
Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication. |
| Volume: |
111 |
| Issue: |
8 |
| Pages: |
1048-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Penrod RD |
| Year: |
2018 |
| Journal: |
Addict Biol |
| Title: |
Novel role and regulation of HDAC4 in cocaine-related behaviors. |
| Volume: |
23 |
| Issue: |
2 |
| Pages: |
653-664 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rogge GA |
| Year: |
2013 |
| Journal: |
J Neurosci |
| Title: |
HDAC3 is a negative regulator of cocaine-context-associated memory formation. |
| Volume: |
33 |
| Issue: |
15 |
| Pages: |
6623-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
He K |
| Year: |
2017 |
| Journal: |
J Biol Chem |
| Title: |
Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator of Skeletal Muscle Differentiation. |
| Volume: |
292 |
| Issue: |
1 |
| Pages: |
351-360 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lahm A |
| Year: |
2007 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. |
| Volume: |
104 |
| Issue: |
44 |
| Pages: |
17335-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang CL |
| Year: |
2002 |
| Journal: |
Mol Cell Biol |
| Title: |
Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation. |
| Volume: |
22 |
| Issue: |
20 |
| Pages: |
7302-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lemercier C |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor. |
| Volume: |
277 |
| Issue: |
24 |
| Pages: |
22045-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Harrison BC |
| Year: |
2006 |
| Journal: |
Mol Cell Biol |
| Title: |
Regulation of cardiac stress signaling by protein kinase d1. |
| Volume: |
26 |
| Issue: |
10 |
| Pages: |
3875-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li B |
| Year: |
2006 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Nuclear Ca2+/calmodulin-dependent protein kinase II in the murine heart. |
| Volume: |
1763 |
| Issue: |
11 |
| Pages: |
1275-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dahl EF |
| Year: |
2018 |
| Journal: |
J Biol Chem |
| Title: |
Subcellular compartmentalization of proximal Gαq-receptor signaling produces unique hypertrophic phenotypes in adult cardiac myocytes. |
| Volume: |
293 |
| Issue: |
23 |
| Pages: |
8734-8749 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun N |
| Year: |
2019 |
| Journal: |
J Biol Chem |
| Title: |
Effects of histone deacetylase inhibitor Scriptaid and parathyroid hormone on osteocyte functions and metabolism. |
| Volume: |
294 |
| Issue: |
25 |
| Pages: |
9722-9733 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nishimori S |
| Year: |
2021 |
| Journal: |
Bone |
| Title: |
PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate. |
| Volume: |
142 |
|
| Pages: |
115709 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
CosÃn-Tomás M |
| Year: |
2014 |
| Journal: |
Front Aging Neurosci |
| Title: |
Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise. |
| Volume: |
6 |
|
| Pages: |
51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sinnett-Smith J |
| Year: |
2014 |
| Journal: |
Am J Physiol Cell Physiol |
| Title: |
Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. |
| Volume: |
306 |
| Issue: |
10 |
| Pages: |
C961-71 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1113
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1115
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1121
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1030
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1115
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1114
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
917
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1102
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Federspiel JD |
| Year: |
2019 |
| Journal: |
Mol Cell Proteomics |
| Title: |
Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. |
| Volume: |
18 |
| Issue: |
8 suppl 1 |
| Pages: |
S92-S113 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pierno S |
| Year: |
2014 |
| Journal: |
PLoS One |
| Title: |
Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice. |
| Volume: |
8 |
| Issue: |
6 |
| Pages: |
e65167 |
|
•
•
•
•
•
|