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Search results 301 to 365 out of 365 for Hfe

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Type Details Score
Genotype
Genotype
Symbol: Hfe/? Hfem4/Hfem4
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Allele
Hfe<tm1Gfn> | MGI:1934013
Name: homeostatic iron regulator; targeted mutation 1, Susan Gilfillan
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Hfe<tm1Sly> | MGI:2181388
Name: homeostatic iron regulator; targeted mutation 1, William S Sly
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Hfe<tm1.1Nca> | MGI:2385350
Name: homeostatic iron regulator; targeted mutation 1.1, Nancy C Andrews
Allele Type: Targeted
Attribute String: Humanized sequence, Hypomorph
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Allele
Hfe<tm2Nca> | MGI:2385353
Name: homeostatic iron regulator; targeted mutation 2, Nancy C Andrews
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Hfe<tm2Sly> | MGI:3033459
Name: homeostatic iron regulator; targeted mutation 2, William S Sly
Allele Type: Targeted
Attribute String: Humanized sequence
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Allele
Hfe<tm3Sly> | MGI:3033462
Name: homeostatic iron regulator; targeted mutation 3, William S Sly
Allele Type: Targeted
Attribute String: Humanized sequence
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Allele
Hfe<tm1Wsr> | MGI:3775647
Name: homeostatic iron regulator; targeted mutation 1, Wolfgang Stremmel
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Hfe<tm1.1Wsr> | MGI:3775648
Name: homeostatic iron regulator; targeted mutation 1.1, Wolfgang Stremmel
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Hfe<tm1.1Gfn> | MGI:4821356
Name: homeostatic iron regulator; targeted mutation 1.1, Susan Gilfillan
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Hfe/Hfe
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hfe/Hfe
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hfe/Hfe
Background: involves: 129S6/SvEvTac * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hfe/Hfe
Background: involves: 129S6/SvEvTac * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hfe/Hfe
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hfe/Hfe
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hfe/Hfe
Background: involves: 129X1/SvJ * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hfe/Hfe
Background: involves: 129X1/SvJ * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hfe/Hfe
Background: involves: 129X1/SvJ * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hfe/Hfe
Background: involves: 129X1/SvJ * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hfe/Hfe
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hfe/Hfe Tg(Vil1-cre)997Gum/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hfe/Hfe
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hfe/Hfe
Background: B6.129P2-Hfe
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0111029 | hemochromatosis type 1
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Allele
Tg(Ttr-Hfe)1Nca | MGI:3778909
Name: transgene insertion 1, Nancy C Andrews
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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HT Experiment
E-GEOD-7357 | Transcription profiling of Hfe-deficient liver and duodenum in mouse strains with differing susceptibilities to iron loading
Series Id: GSE7357
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Strain
MGI:4453185 | C57BL/6J-Tg(Ttr-Hfe)1Nca/Mmnc
Attribute String: transgenic, mutant strain, coisogenic
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GO Term
GO:1990712 | HFE-transferrin receptor complex
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Allele
Tfrc<tm2Nca> | MGI:3778906
 
Name: transferrin receptor; targeted mutation 2, Nancy C Andrews
Allele Type: Targeted
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Publication
38117649 | J:349490
First Author: Pritchard JE
Year: 2024
Journal: Cell Rep
Title: Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms.
Volume: 43
Issue: 1
Pages: 113608
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Publication
33301706 | J:350603
First Author: Leimkühler NB
Year: 2021
Journal: Cell Stem Cell
Title: Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis.
Volume: 28
Issue: 4
Pages: 637-652.e8
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Strain
MGI:4453181 | 129S-Tfrc<tm2Nca>/Mmnc
Attribute String: coisogenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Tfrc/Tfrc
Background: involves: 129S4/SvJae * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hfe/Hfe Tg(Ttr-Hfe)1Nca/?
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
16604073 | J:109016
First Author: Babitt JL
Year: 2006
Journal: Nat Genet
Title: Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.
Volume: 38
Issue: 5
Pages: 531-9
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Publication
14647275 | -
First Author: Papanikolaou G
Year: 2004
Journal: Nat Genet
Title: Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis.
Volume: 36
Issue: 1
Pages: 77-82
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Publication
22728873 | -
First Author: D'Alessio F
Year: 2012
Journal: J Hepatol
Title: The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation.
Volume: 57
Issue: 5
Pages: 1052-60
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Protein Domain
IPR033606 | Hemojuvelin
Type: Family
Description: Hemojuvelin, also called repulsive guidance molecule C or Hfe2, is a GPI-linked membrane protein essential for iron homeostasis []. Hemojuvelin is a bone morphogenetic protein (BMP) coreceptor; it regulates iron homeostasis by interacting with BMP ligands to induce hepcidin expression []. It forms a membrane-associated protein complex with HFE and the transferrin receptor 2 for hepcidin regulation [].
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Gene
650 | BMP2
Type: gene
Organism: human
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Publication
10047540 | J:53145
First Author: Braud VM
Year: 1999
Journal: Curr Opin Immunol
Title: Functions of nonclassical MHC and non-MHC-encoded class I molecules.
Volume: 11
Issue: 1
Pages: 100-8
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Publication
- | J:46866
     
First Author: Levy JE
Year: 1998
Journal: MGI Direct Data Submission
Title: The Transferrin Receptor (Trfr) maps to mouse Chromosome 16
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Publication
11447267 | J:70464
First Author: Nicolas G
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice.
Volume: 98
Issue: 15
Pages: 8780-5
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Publication
9780177 | J:50232
First Author: Riegert P
Year: 1998
Journal: J Immunol
Title: Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene.
Volume: 161
Issue: 8
Pages: 4066-77
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Publication
17065470 | J:123093
First Author: Dunaief JL
Year: 2006
Journal: Invest Ophthalmol Vis Sci
Title: Iron induced oxidative damage as a potential factor in age-related macular degeneration: the Cogan Lecture.
Volume: 47
Issue: 11
Pages: 4660-4
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Publication
11106561 | J:66131
First Author: Santos MM
Year: 2000
Journal: Am J Pathol
Title: Iron overload and heart fibrosis in mice deficient for both beta2-microglobulin and Rag1.
Volume: 157
Issue: 6
Pages: 1883-92
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Publication
11309500 | J:68985
First Author: Sproule TJ
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Naturally variant autosomal and sex-linked loci determine the severity of iron overload in beta 2-microglobulin-deficient mice.
Volume: 98
Issue: 9
Pages: 5170-4
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Publication
21292994 | J:171145
First Author: McDonald CJ
Year: 2011
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Iron loading and oxidative stress in the Atm-/- mouse liver.
Volume: 300
Issue: 4
Pages: G554-60
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Publication
12134060 | J:78360
First Author: Fleming RE
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis.
Volume: 99
Issue: 16
Pages: 10653-8
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Publication
15951546 | J:114330
First Author: Wallace DF
Year: 2005
Journal: Gut
Title: First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin.
Volume: 54
Issue: 7
Pages: 980-6
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Publication
8781118 | J:35547
First Author: Giffon T
Year: 1996
Journal: Immunogenetics
Title: Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region.
Volume: 44
Issue: 5
Pages: 331-9
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Publication
12547217 | J:108469
First Author: Meyer PN
Year: 2002
Journal: Blood Cells Mol Dis
Title: Hemochromatosis protein (HFE) and tumor necrosis factor receptor 2 (TNFR2) influence tissue iron levels: elements of a common gut pathway?
Volume: 29
Issue: 3
Pages: 274-85
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Publication
32766721 | J:305757
 
First Author: Rishi G
Year: 2020
Journal: Biosci Rep
Title: Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression.
Volume: 40
Issue: 8
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Protein
Q7TQ32
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
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Protein Coding Gene
MGI:1916835 | Hjv
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1354956 | Tfr2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
9531620 | J:47457
First Author: Santos M
Year: 1998
Journal: Blood
Title: Adaptive response of iron absorption to anemia, increased erythropoiesis, iron deficiency, and iron loading in beta2-microglobulin knockout mice.
Volume: 91
Issue: 8
Pages: 3059-65
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Publication
31800957 | J:335613
First Author: Wang CY
Year: 2020
Journal: Blood
Title: Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3.
Volume: 135
Issue: 6
Pages: 453-456
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Publication
23874600 | J:204407
First Author: Josson S
Year: 2013
Journal: PLoS One
Title: Inhibition of β2-microglobulin/hemochromatosis enhances radiation sensitivity by induction of iron overload in prostate cancer cells.
Volume: 8
Issue: 7
Pages: e68366
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Publication
21943374 | J:179221
First Author: Gnana-Prakasam JP
Year: 2012
Journal: Biochem J
Title: Iron-mediated retinal degeneration in haemojuvelin-knockout mice.
Volume: 441
Issue: 2
Pages: 599-608
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Publication
24121729 | J:237471
First Author: Delaby C
Year: 2013
Journal: Mamm Genome
Title: Epistasis in iron metabolism: complex interactions between Cp, Mon1a, and Slc40a1 loci and tissue iron in mice.
Volume: 24
Issue: 11-12
Pages: 427-38
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Protein Coding Gene
MGI:98821 | Trf
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
9642100 | J:51452
First Author: Lee PL
Year: 1998
Journal: Blood Cells Mol Dis
Title: The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms.
Volume: 24
Issue: 2
Pages: 199-215
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Protein Coding Gene
MGI:98822 | Tfrc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88127 | B2m
Type: protein_coding_gene
Organism: mouse, laboratory
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