Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
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Title: |
MGI Sequence Curation Reference |
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Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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•
•
•
•
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Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
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•
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Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
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Title: |
Nomenclature Committee Use |
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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•
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
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•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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•
|
HT Experiment |
Series Id: |
GSE39253 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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•
•
•
•
•
|
UniProt Feature |
Begin: |
269 |
Description: |
Phosphoserine; by HIPK2 |
Type: |
modified residue |
End: |
269 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
257 |
Description: |
Phosphoserine; by HIPK2 |
Type: |
modified residue |
End: |
257 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
196 |
Description: |
Phosphoserine; by HIPK2 |
Type: |
modified residue |
End: |
196 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
428 |
Description: |
Phosphoserine; by HIPK2 |
Type: |
modified residue |
End: |
428 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
17 |
Description: |
Phosphoserine; by HIPK2 |
Type: |
modified residue |
End: |
17 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
273 |
Description: |
Phosphothreonine; by HIPK2 |
Type: |
modified residue |
End: |
273 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
276 |
Description: |
Phosphoserine; by HIPK2 |
Type: |
modified residue |
End: |
276 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
249 |
Description: |
Phosphoserine; by HIPK2 |
Type: |
modified residue |
End: |
249 |
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•
•
•
•
•
|
UniProt Feature |
Begin: |
953 |
Description: |
Phosphothreonine; by HIPK2 |
Type: |
modified residue |
End: |
953 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
769 |
Description: |
Phosphothreonine; by HIPK2 |
Type: |
modified residue |
End: |
769 |
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•
•
•
•
•
|
UniProt Feature |
Begin: |
771 |
Description: |
Phosphothreonine; by HIPK2 |
Type: |
modified residue |
End: |
771 |
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•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE46077 |
Experiment Type: |
transcription profiling by array |
Study Type: |
Baseline |
Source: |
ArrayExpress |
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•
•
•
•
|
Publication |
First Author: |
Li X |
Year: |
2022 |
Journal: |
Front Pharmacol |
Title: |
SIRT6 overexpression retards renal interstitial fibrosis through targeting HIPK2 in chronic kidney disease. |
Volume: |
13 |
|
Pages: |
1007168 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
33 |
Description: |
Phosphoserine; by GSK3-beta and HIPK2 |
Type: |
modified residue |
End: |
33 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
37 |
Description: |
Phosphoserine; by GSK3-beta and HIPK2 |
Type: |
modified residue |
End: |
37 |
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•
•
•
•
•
|
UniProt Feature |
Begin: |
53 |
Description: |
Phosphothreonine; by HIPK2 and CDC2 |
Type: |
modified residue |
End: |
53 |
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•
•
•
•
•
|
UniProt Feature |
Begin: |
36 |
Description: |
Phosphoserine; by HIPK2 and CDC2 |
Type: |
modified residue |
End: |
36 |
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•
•
•
•
•
|
UniProt Feature |
Begin: |
45 |
Description: |
Phosphoserine; by HIPK2 and MAPK1 |
Type: |
modified residue |
End: |
45 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
47 |
Description: |
Phosphoserine; by HIPK2 and MAPK1 |
Type: |
modified residue |
End: |
47 |
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•
•
•
•
•
|
Allele |
Name: |
homeodomain interacting protein kinase 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
•
•
•
•
|
Publication |
First Author: |
Shima Y |
Year: |
2008 |
Journal: |
Mol Cell Biol |
Title: |
PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation. |
Volume: |
28 |
Issue: |
23 |
Pages: |
7126-38 |
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•
•
•
•
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Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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•
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Interaction Experiment |
Description: |
Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival. |
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•
•
•
•
•
|
Interaction Experiment |
Description: |
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. |
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•
•
•
•
•
|
Interaction Experiment |
Description: |
Functional impairment of the HIPK2 small ubiquitin-like modifier (SUMO)-interacting motif in acute myeloid leukemia. |
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•
•
•
•
•
|
Interaction Experiment |
Description: |
Prolyl isomerase Pin1 and protein kinase HIPK2 cooperate to promote cortical neurogenesis by suppressing Groucho/TLE:Hes1-mediated inhibition of neuronal differentiation. |
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•
•
•
•
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Publication |
First Author: |
Siepi F |
Year: |
2013 |
Journal: |
Biochim Biophys Acta |
Title: |
HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation. |
Volume: |
1833 |
Issue: |
6 |
Pages: |
1443-53 |
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•
•
•
•
•
|
Publication |
First Author: |
Hailemariam K |
Year: |
2010 |
Journal: |
J Cell Sci |
Title: |
Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress. |
Volume: |
123 |
Issue: |
Pt 22 |
Pages: |
3863-71 |
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•
•
•
•
•
|
Publication |
First Author: |
Lee MG |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313. |
Volume: |
111 |
Issue: |
43 |
Pages: |
15532-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sung KS |
Year: |
2019 |
Journal: |
Am J Cancer Res |
Title: |
Functional impairment of the HIPK2 small ubiquitin-like modifier (SUMO)-interacting motif in acute myeloid leukemia. |
Volume: |
9 |
Issue: |
1 |
Pages: |
94-107 |
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•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
F-box only protein 3 (FBXO3) is a substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination of transcription factor coactivators such as HIPK2 and EP300, leading to their rapid degradation by the proteasome []. FBX03 interacts with a nuclear protein PML, which stabilises the transcription factor complex by protecting HIPK2 and p300 from SCFFbx3-induced degradation until transcription is completed []. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation []. |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
140
 |
Fragment?: |
true |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
207
 |
Fragment?: |
true |
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•
•
•
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Publication |
First Author: |
Apaydin T |
Year: |
2023 |
Journal: |
iScience |
Title: |
WIP1 is a novel specific target for growth hormone action. |
Volume: |
26 |
Issue: |
11 |
Pages: |
108117 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
480
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
361
 |
Fragment?: |
false |
|
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•
•
•
•
|
Publication |
First Author: |
Margalit O |
Year: |
2012 |
Journal: |
Int J Cancer |
Title: |
Zinc supplementation augments in vivo antitumor effect of chemotherapy by restoring p53 function. |
Volume: |
131 |
Issue: |
4 |
Pages: |
E562-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song H |
Year: |
2013 |
Journal: |
Cell Death Differ |
Title: |
Critical role of presenilin-dependent γ-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis. |
Volume: |
20 |
Issue: |
4 |
Pages: |
639-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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•
•
•
•
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