Type |
Details |
Score |
Publication |
First Author: |
Kasahara DI |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Role of the adiponectin binding protein, T-cadherin (cdh13), in pulmonary responses to subacute ozone. |
Volume: |
8 |
Issue: |
6 |
Pages: |
e65829 |
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•
•
•
•
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Publication |
First Author: |
Guler ML |
Year: |
1999 |
Journal: |
J Immunol |
Title: |
Tpm1, a locus controlling IL-12 responsiveness, acts by a cell-autonomous mechanism. |
Volume: |
162 |
Issue: |
3 |
Pages: |
1339-47 |
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•
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Publication |
First Author: |
Csóka B |
Year: |
2018 |
Journal: |
FASEB J |
Title: |
Adenosine receptors differentially regulate type 2 cytokine production by IL-33-activated bone marrow cells, ILC2s, and macrophages. |
Volume: |
32 |
Issue: |
2 |
Pages: |
829-837 |
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Publication |
First Author: |
Hayakawa H |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. |
Volume: |
282 |
Issue: |
36 |
Pages: |
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•
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Publication |
First Author: |
Yan H |
Year: |
1993 |
Journal: |
J Biol Chem |
Title: |
A novel receptor tyrosine phosphatase-sigma that is highly expressed in the nervous system. |
Volume: |
268 |
Issue: |
33 |
Pages: |
24880-6 |
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•
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Publication |
First Author: |
Rooney JW |
Year: |
1994 |
Journal: |
EMBO J |
Title: |
A common factor regulates both Th1- and Th2-specific cytokine gene expression. |
Volume: |
13 |
Issue: |
3 |
Pages: |
625-33 |
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•
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Publication |
First Author: |
Mock BA |
Year: |
1994 |
Journal: |
Eur J Immunogenet |
Title: |
The inducible form of nitric oxide synthase (NOS2) isolated from murine macrophages maps near the nude mutation on mouse chromosome 11. |
Volume: |
21 |
Issue: |
4 |
Pages: |
231-8 |
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•
•
•
•
•
|
Publication |
First Author: |
Zhu W |
Year: |
2009 |
Journal: |
Immunogenetics |
Title: |
Comparison of allergic lung disease in three mouse strains after systemic or mucosal sensitization with ovalbumin antigen. |
Volume: |
61 |
Issue: |
3 |
Pages: |
199-207 |
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•
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•
•
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Publication |
First Author: |
Buckwalter MS |
Year: |
1993 |
Journal: |
Genomics |
Title: |
Genetic mapping and evaluation of candidate genes for spasmodic, a neurological mouse mutation with abnormal startle response. |
Volume: |
17 |
Issue: |
2 |
Pages: |
279-86 |
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Publication |
First Author: |
Newland SA |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
Type-2 innate lymphoid cells control the development of atherosclerosis in mice. |
Volume: |
8 |
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Pages: |
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Publication |
First Author: |
Saluzzo S |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment. |
Volume: |
18 |
Issue: |
8 |
Pages: |
1893-1905 |
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Publication |
First Author: |
Hiraishi Y |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation. |
Volume: |
8 |
Issue: |
1 |
Pages: |
18052 |
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Publication |
First Author: |
Hara K |
Year: |
2014 |
Journal: |
J Immunol |
Title: |
Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa. |
Volume: |
192 |
Issue: |
9 |
Pages: |
4032-42 |
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Publication |
First Author: |
Sokulsky LA |
Year: |
2016 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
TRAIL deficiency and PP2A activation with salmeterol ameliorates egg allergen-driven eosinophilic esophagitis. |
Volume: |
311 |
Issue: |
6 |
Pages: |
G998-G1008 |
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Publication |
First Author: |
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Year: |
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Journal: |
Adv Immunol |
Title: |
Interleukin-1 and its biologically related cytokines. |
Volume: |
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Pages: |
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Publication |
First Author: |
Wilson SD |
Year: |
1990 |
Journal: |
J Exp Med |
Title: |
Clustering of cytokine genes on mouse chromosome 11. |
Volume: |
171 |
Issue: |
4 |
Pages: |
1301-14 |
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Publication |
First Author: |
Kaupmann K |
Year: |
1992 |
Journal: |
Genomics |
Title: |
Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11. |
Volume: |
13 |
Issue: |
1 |
Pages: |
39-43 |
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•
•
•
•
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Publication |
First Author: |
Dietrich W |
Year: |
1992 |
Journal: |
Genetics |
Title: |
A genetic map of the mouse suitable for typing intraspecific crosses. |
Volume: |
131 |
Issue: |
2 |
Pages: |
423-47 |
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Publication |
First Author: |
Buckwalter MS |
Year: |
1992 |
Journal: |
Mamm Genome |
Title: |
Localization of the human chromosome 5q genes Gabra-1, Gabrg-2, Il-4, Il-5, and Irf-1 on mouse chromosome 11. |
Volume: |
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Issue: |
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Pages: |
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Publication |
First Author: |
Iseki M |
Year: |
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Journal: |
Biochem Biophys Res Commun |
Title: |
Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. |
Volume: |
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Issue: |
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Publication |
First Author: |
McKee AS |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. |
Volume: |
183 |
Issue: |
7 |
Pages: |
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•
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Publication |
First Author: |
Chang Y |
Year: |
1994 |
Journal: |
J Neuroimmunol |
Title: |
Cytokines in the central nervous system: expression of macrophage colony stimulating factor and its receptor during development. |
Volume: |
52 |
Issue: |
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Pages: |
9-17 |
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First Author: |
Borrego A |
Year: |
2006 |
Journal: |
Microbes Infect |
Title: |
Genetic determinants of acute inflammation regulate Salmonella infection and modulate Slc11a1 gene (formerly Nramp1) effects in selected mouse lines. |
Volume: |
8 |
Issue: |
12-13 |
Pages: |
2766-71 |
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Publication |
First Author: |
Lin W |
Year: |
2005 |
Journal: |
J Allergy Clin Immunol |
Title: |
Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. |
Volume: |
116 |
Issue: |
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Pages: |
1106-15 |
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First Author: |
Ogasawara T |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Development of chronic allergic responses by dampening Bcl6-mediated suppressor activity in memory T helper 2 cells. |
Volume: |
114 |
Issue: |
5 |
Pages: |
E741-E750 |
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First Author: |
Zhu Y |
Year: |
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Journal: |
Proc Natl Acad Sci U S A |
Title: |
Genomic interval engineering of mice identifies a novel modulator of triglyceride production. |
Volume: |
97 |
Issue: |
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Pages: |
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First Author: |
Montgomery RA |
Year: |
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Journal: |
J Immunol |
Title: |
Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction. |
Volume: |
147 |
Issue: |
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Pages: |
554-60 |
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First Author: |
Montagutelli X |
Year: |
1991 |
Journal: |
Mamm Genome |
Title: |
PCR-analyzed microsatellites: data concerning laboratory and wild-derived mouse inbred strains. |
Volume: |
1 |
Issue: |
4 |
Pages: |
255-9 |
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Publication |
First Author: |
Jacob CO |
Year: |
1993 |
Journal: |
Immunogenetics |
Title: |
DNA polymorphism in cytokine genes based on length variation in simple-sequence tandem repeats. |
Volume: |
38 |
Issue: |
4 |
Pages: |
251-7 |
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First Author: |
Gerwin N |
Year: |
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Journal: |
Dev Immunol |
Title: |
Interleukin gene expression in mouse preimplantation development. |
Volume: |
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Hemmerle T |
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Proc Natl Acad Sci U S A |
Title: |
Antibody-based delivery of IL4 to the neovasculature cures mice with arthritis. |
Volume: |
111 |
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33 |
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12008-12 |
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First Author: |
Wenderfer SE |
Year: |
2000 |
Journal: |
Genomics |
Title: |
Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11. |
Volume: |
63 |
Issue: |
3 |
Pages: |
354-73 |
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First Author: |
Sornson MW |
Year: |
1996 |
Journal: |
Nature |
Title: |
Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. |
Volume: |
384 |
Issue: |
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First Author: |
McKee AS |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. |
Volume: |
173 |
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First Author: |
Dardalhon V |
Year: |
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Journal: |
Nat Immunol |
Title: |
IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. |
Volume: |
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Pages: |
1347-55 |
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First Author: |
Krulová M |
Year: |
1997 |
Journal: |
Genomics |
Title: |
IL-2-induced proliferative response is controlled by loci Cinda1 and Cinda2 on mouse chromosomes 11 and 12: a distinct control of the response induced by different IL-2 concentrations. |
Volume: |
42 |
Issue: |
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Pages: |
11-5 |
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First Author: |
Montgomery RA |
Year: |
1997 |
Journal: |
Cytokine |
Title: |
Semi-quantitative polymerase chain reaction analysis of cytokine and cytokine receptor gene expression during thymic ontogeny. |
Volume: |
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First Author: |
Fukuda K |
Year: |
2003 |
Journal: |
Dev Biol |
Title: |
Mesenchymal expression of Foxl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs. |
Volume: |
255 |
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Excess neuropeptides in lung signal through endothelial cells to impair gas exchange. |
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First Author: |
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Nat Immunol |
Title: |
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. |
Volume: |
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First Author: |
Brenner O |
Year: |
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Journal: |
Proc Natl Acad Sci U S A |
Title: |
Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia. |
Volume: |
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First Author: |
McClanahan T |
Year: |
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Journal: |
Blood |
Title: |
Hematopoietic growth factor receptor genes as markers of lineage commitment during in vitro development of hematopoietic cells. |
Volume: |
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First Author: |
Taverne J |
Year: |
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Journal: |
Int J Exp Pathol |
Title: |
Transgenic mice in the study of cytokine function. |
Volume: |
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Pages: |
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First Author: |
Spicer AP |
Year: |
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Journal: |
Genomics |
Title: |
The human and mouse receptors for hyaluronan-mediated motility, RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse chromosome 11. |
Volume: |
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First Author: |
Watkins-Chow DE |
Year: |
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Journal: |
Genomics |
Title: |
Genetic mapping of 21 genes on mouse chromosome 11 reveals disruptions in linkage conservation with human chromosome 5. |
Volume: |
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First Author: |
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Year: |
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Journal: |
Mamm Genome |
Title: |
Additional microsatellite markers for mouse genome mapping. |
Volume: |
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First Author: |
Shanghai Model Organisms Center |
Year: |
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Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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First Author: |
International Committee on Standardized Genetic Nomenclature for Mice |
Year: |
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Title: |
Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols |
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First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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First Author: |
The Gene Ontology Consortium |
Year: |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
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Gene Ontology annotation through association of InterPro records with GO terms |
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First Author: |
UniProt-GOA |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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First Author: |
GOA curators |
Year: |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
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2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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The Gene Ontology Consortium |
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PLoS Biol |
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Mouse Genome Informatics Scientific Curators |
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MGI Genome Annotation Group and UniGene Staff |
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Database Download |
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MGI-UniGene Interconnection Effort |
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Year: |
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Title: |
Annotation inferences using phylogenetic trees |
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Mouse Genome Database and National Center for Biotechnology Information |
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Database Release |
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Entrez Gene Load |
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Allen Institute for Brain Science |
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Allen Institute |
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Allen Brain Atlas: mouse riboprobes |
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Mouse Genome Informatics Scientific Curators |
Year: |
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Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
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Journal: |
Database Download |
Title: |
Consensus CDS project |
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Mouse Genome Informatics Group |
Year: |
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Journal: |
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Automatic Encodes (AutoE) Reference |
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Mouse Genome Informatics Scientific Curators |
Year: |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Mouse Genome Informatics |
Year: |
2010 |
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Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
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Mouse Genome Informatics Scientific Curators |
Year: |
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Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
133
 |
Fragment?: |
false |
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•
•
•
•
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Publication |
First Author: |
Marrugo J |
Year: |
1996 |
Journal: |
Mol Immunol |
Title: |
The conserved lymphokine element-0 in the IL5 promoter binds to a high mobility group-1 protein. |
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Pages: |
1119-25 |
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HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Allele |
Name: |
interleukin 5; endonuclease-mediated mutation 4, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
•
•
•
•
|
MP Term |
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•
•
•
•
|
MP Term |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 6, Akira Tominaga |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
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Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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MP Term |
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MP Term |
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Allele |
Name: |
regulatory region 250409; endonuclease-mediated mutation 1, Keji Zhao |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Modified regulatory region |
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Allele |
Name: |
interleukin 5; targeted mutation 3, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
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Publication |
First Author: |
Pattaradilokrat S |
Year: |
2014 |
Journal: |
Genes Immun |
Title: |
Plasmodium genetic loci linked to host cytokine and chemokine responses. |
Volume: |
15 |
Issue: |
3 |
Pages: |
145-52 |
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MP Term |
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Allele |
Name: |
transgene insertion 5C2, Lindsay A Dent |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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Strain |
Attribute String: |
congenic, mutant strain, transgenic |
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Strain |
Attribute String: |
congenic, mutant strain, transgenic |
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Strain |
Attribute String: |
mutant strain, congenic, transgenic |
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Publication |
First Author: |
Watanabe Y |
Year: |
2004 |
Journal: |
DNA Cell Biol |
Title: |
IL-5-Induced Eosinophils Suppress the Growth of Leishmania amazonensis In Vivo and Kill Promastigotes In Vitro in Response to Either IL-4 or IFN-gamma. |
Volume: |
23 |
Issue: |
7 |
Pages: |
412-8 |
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Publication |
First Author: |
Sugita K |
Year: |
2010 |
Journal: |
Am J Pathol |
Title: |
FTY720 regulates bone marrow egress of eosinophils and modulates late-phase skin reaction in mice. |
Volume: |
177 |
Issue: |
4 |
Pages: |
1881-7 |
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Publication |
First Author: |
Wen X |
Year: |
2004 |
Journal: |
Eur J Immunol |
Title: |
Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus. |
Volume: |
34 |
Issue: |
10 |
Pages: |
2740-9 |
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Allele |
Name: |
interleukin 5; targeted mutation 1, Andrew NJ McKenzie |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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Strain |
Attribute String: |
coisogenic, targeted mutation, mutant strain |
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Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
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Publication |
First Author: |
Proudfoot AE |
Year: |
1991 |
Journal: |
FEBS Lett |
Title: |
Human interleukin-5 expressed in Escherichia coli: assignment of the disulfide bridges of the purified unglycosylated protein. |
Volume: |
283 |
Issue: |
1 |
Pages: |
61-4 |
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Publication |
First Author: |
Milburn MV |
Year: |
1993 |
Journal: |
Nature |
Title: |
A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. |
Volume: |
363 |
Issue: |
6425 |
Pages: |
172-6 |
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Publication |
First Author: |
Campbell HD |
Year: |
1987 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5). |
Volume: |
84 |
Issue: |
19 |
Pages: |
6629-33 |
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Protein Domain |
Type: |
Family |
Description: |
This entry represents interleukin-5 (IL5), also known as eosinophil differentiation factor (EDF),is a lineage-specific cytokine for eosinophilpoiesis [, ]. It regulates eosinophil growth and activation [], and thus plays an important role indiseases associated with increased levels of eosinophils, including asthma[]. IL5 has a similar overall fold to other cytokines (e.g., IL2, IL4 and GCSF)[], but while these exist as monomeric structures, IL5 is a homodimer. Thefold contains an anti-parallel 4-α-helix bundle with a left handed twist,connected by a 2-stranded anti-parallel β-sheet [, ]. The monomers areheld together by 2 interchain disulphide bonds []. |
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MP Term |
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