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Search results 301 to 396 out of 396 for Ilk

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Type Details Score
Publication
27171814 | J:243708
First Author: Bang ML
Year: 2017
Journal: J Cell Physiol
Title: Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.
Volume: 232
Issue: 1
Pages: 38-52
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Publication
21401944 | J:171452
 
First Author: Holtz ML
Year: 2011
Journal: BMC Dev Biol
Title: Serum response factor is required for cell contact maintenance but dispensable for proliferation in visceral yolk sac endothelium.
Volume: 11
Pages: 18
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Publication
19793892 | J:153959
First Author: Conti FJ
Year: 2009
Journal: Development
Title: Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions.
Volume: 136
Issue: 21
Pages: 3597-606
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Publication
19652092 | J:167114
First Author: Liang X
Year: 2009
Journal: Circulation
Title: Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality.
Volume: 120
Issue: 7
Pages: 568-76
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Publication
26151572 | J:224370
 
First Author: Wu C
Year: 2015
Journal: Nat Commun
Title: Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis.
Volume: 6
Pages: 7531
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Publication
31680851 | J:281878
 
First Author: Yook C
Year: 2019
Journal: Front Mol Neurosci
Title: A TBR1-K228E Mutation Induces Tbr1 Upregulation, Altered Cortical Distribution of Interneurons, Increased Inhibitory Synaptic Transmission, and Autistic-Like Behavioral Deficits in Mice.
Volume: 12
Pages: 241
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Publication
21983115 | J:184432
First Author: Ichikawa-Tomikawa N
Year: 2012
Journal: Matrix Biol
Title: Laminin α1 is essential for mouse cerebellar development.
Volume: 31
Issue: 1
Pages: 17-28
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Publication
15713628 | J:96826
First Author: Di-Poï N
Year: 2005
Journal: Mol Cell Biol
Title: Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development.
Volume: 25
Issue: 5
Pages: 1696-712
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Publication
31062503 | J:288722
First Author: Nilsson D
Year: 2019
Journal: Physiol Rep
Title: Foxc2 is essential for podocyte function.
Volume: 7
Issue: 9
Pages: e14083
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Publication
30651296 | J:272593
 
First Author: Volckaert T
Year: 2019
Journal: Development
Title: Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling.
Volume: 146
Issue: 2
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Publication
14522949 | J:85994
First Author: Aszodi A
Year: 2003
Journal: Genes Dev
Title: Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.
Volume: 17
Issue: 19
Pages: 2465-79
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Publication
31201155 | J:278242
 
First Author: Xia M
Year: 2019
Journal: Development
Title: HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis.
Volume: 146
Issue: 13
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Publication
27434733 | J:238763
First Author: Choo HJ
Year: 2016
Journal: Stem Cells
Title: Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and Survival by Modulating Nuclear Import.
Volume: 34
Issue: 11
Pages: 2784-2797
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Publication
23236519 | J:195548
First Author: Brody MJ
Year: 2012
Journal: PLoS One
Title: Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy.
Volume: 7
Issue: 12
Pages: e51621
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Publication
- | J:46439
     
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Gene
446725 | ilkap.L
Type: gene
Organism: frog, African clawed
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Publication
33785768 | J:304964
First Author: Qu X
Year: 2021
Journal: Sci Rep
Title: Micro-RNA miR-542-3p suppresses decidualization by targeting ILK pathways in human endometrial stromal cells.
Volume: 11
Issue: 1
Pages: 7186
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Publication
20005845 | -
First Author: Fukuda K
Year: 2009
Journal: Mol Cell
Title: The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions.
Volume: 36
Issue: 5
Pages: 819-30
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Allele
Ilk<tm2Star> | MGI:5499793
Name: integrin linked kinase; targeted mutation 2, Rene St-Arnaud
Allele Type: Targeted
Attribute String: Null/knockout
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HT Experiment
E-GEOD-35129 | Expression data from Integrin-linked kinase (ILK)-deficient epidermis
Series Id: GSE35129
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE41179 | Expression data from the neural crest cells isolated from mouse cardiac outflow tract at E10.5
Series Id: E-GEOD-41179
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Publication
20033063 | -
First Author: Wickström SA
Year: 2010
Journal: EMBO J
Title: The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!
Volume: 29
Issue: 2
Pages: 281-91
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Publication
19153670 | -
First Author: Fielding AB
Year: 2009
Journal: Cancer Metastasis Rev
Title: The mitotic functions of integrin-linked kinase.
Volume: 28
Issue: 1-2
Pages: 99-111
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Publication
16546570 | -
First Author: Boulter E
Year: 2006
Journal: Eur J Cell Biol
Title: Integrin-linked kinase and its partners: a modular platform regulating cell-matrix adhesion dynamics and cytoskeletal organization.
Volume: 85
Issue: 3-4
Pages: 255-63
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Protein Domain
IPR035692 | PK_ILK
Type: Domain
Description: The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. Integrin linked kinase (ILK) contains N-terminal ankyrin repeats, a Pleckstrin Homology (PH) domain, and a C-terminal pseudokinase domain. It is a component of the IPP (ILK/PINCH/Parvin) complex that couples beta integrins to the actin cytoskeleton, and plays important roles in cell adhesion, spreading, invasion, and migration []. ILK was initially thought to be an active kinase despite the lack of key conserved residues because of in vitro studies showing that it can phosphorylate certain protein substrates. However, in vivo experiments in Caenorhabditis elegans, Drosophila melanogaster, and mice (ILK-null and knock-in) proved that ILK is not an active kinase []. In addition to actin cytoskeleton regulation, ILK also influences the microtubule network and mitotic spindle orientation [, ]. The pseudokinase domain of ILK binds several adaptor proteins including the parvins and paxillin [, ].
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Genotype
Genotype
Symbol: Ilk/Ilk Tg(Acp5-cre)1Star/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ilk/Ilk<+> Itgb3/Itgb3<+>
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
24590809 | -
First Author: Peng H
Year: 2014
Journal: Cancer Res
Title: LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase.
Volume: 74
Issue: 5
Pages: 1390-1403
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Publication
23303138 | J:193503
First Author: Matthews JM
Year: 2013
Journal: Nat Rev Cancer
Title: LIM-domain-only proteins in cancer.
Volume: 13
Issue: 2
Pages: 111-22
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Protein Domain
IPR044115 | LIM_LIMD2
Type: Domain
Description: In general, LIM domains coordinate one or more zinc atoms, and are named after the three proteins (LIN-11, Isl1 and MEC-3) in which they were first found. They consist of two zinc-binding motifs that resemble GATA-like Znf's, however the residues holding the zinc atom(s) are variable, involving Cys, His, Asp or Glu residues. LIM domain-containing proteins have diverse cellular roles such as regulators of gene expression, cyto-architecture, cell adhesion, cell motility, and signal transduction. LIM domain-containing proteins have been shown to be key molecules in a wide variety of human cancers [].LIMD2 binds directly to the kinase domain of integrin-linked kinase (ILK) near the active site and strongly activated ILK kinase activity. Its LIM-domain structure is highly related to LIM1 of PINCH1, a core component of the integrin-linked kinase-parvin-pinch complex [].
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Publication
16876785 | J:114381
First Author: Ussar S
Year: 2006
Journal: Exp Cell Res
Title: The Kindlins: subcellular localization and expression during murine development.
Volume: 312
Issue: 16
Pages: 3142-51
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Publication
24213576 | J:216271
First Author: Zhu B
Year: 2014
Journal: Oncogene
Title: PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling.
Volume: 33
Issue: 46
Pages: 5348-59
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Publication
35294882 | J:324903
First Author: Yang W
Year: 2022
Journal: Cell Rep
Title: Delicate regulation of IL-1β-mediated inflammation by cyclophilin A.
Volume: 38
Issue: 11
Pages: 110513
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Publication
22345562 | J:182147
First Author: Holmes KM
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF-κB network.
Volume: 109
Issue: 9
Pages: 3475-80
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Protein
O55222
Organism: Mus musculus/domesticus
Length: 452  
Fragment?: false
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Publication
21216283 | J:170661
First Author: Boppart MD
Year: 2011
Journal: Biochim Biophys Acta
Title: Activation of AKT signaling promotes cell growth and survival in α7β1 integrin-mediated alleviation of muscular dystrophy.
Volume: 1812
Issue: 4
Pages: 439-46
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Publication
15472100 | J:134752
First Author: Saito A
Year: 2004
Journal: Stroke
Title: Oxidative stress affects the integrin-linked kinase signaling pathway after transient focal cerebral ischemia.
Volume: 35
Issue: 11
Pages: 2560-5
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Publication
27182643 | J:234014
First Author: Zheng G
Year: 2016
Journal: Am J Pathol
Title: α3 Integrin of Cell-Cell Contact Mediates Kidney Fibrosis by Integrin-Linked Kinase in Proximal Tubular E-Cadherin Deficient Mice.
Volume: 186
Issue: 7
Pages: 1847-60
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Publication
15976450 | J:99800
First Author: Li S
Year: 2005
Journal: J Cell Sci
Title: PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage.
Volume: 118
Issue: Pt 13
Pages: 2913-21
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Publication
25609703 | J:223845
First Author: Karaköse E
Year: 2015
Journal: J Cell Sci
Title: The focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites.
Volume: 128
Issue: 5
Pages: 1023-33
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Publication
11791176 | J:74388
First Author: Segrelles C
Year: 2002
Journal: Oncogene
Title: Functional roles of Akt signaling in mouse skin tumorigenesis.
Volume: 21
Issue: 1
Pages: 53-64
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Publication
17088456 | J:127581
First Author: Lu H
Year: 2006
Journal: Circulation
Title: Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice.
Volume: 114
Issue: 21
Pages: 2271-9
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Publication
18436206 | J:136686
First Author: Postel R
Year: 2008
Journal: Dev Biol
Title: Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex.
Volume: 318
Issue: 1
Pages: 92-101
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Publication
18550647 | J:139207
First Author: Ardura JA
Year: 2008
Journal: Am J Physiol Renal Physiol
Title: Parathyroid hormone-related protein interacts with vascular endothelial growth factor to promote fibrogenesis in the obstructed mouse kidney.
Volume: 295
Issue: 2
Pages: F415-25
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Publication
20493167 | J:162427
First Author: Bettink SI
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Integrin-linked kinase is a central mediator in angiotensin II type 1- and chemokine receptor CXCR4 signaling in myocardial hypertrophy.
Volume: 397
Issue: 2
Pages: 208-13
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Publication
28794235 | J:254731
     
First Author: Ahmed AU
Year: 2017
Journal: J Immunol
Title: Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis.
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Publication
29930281 | J:262935
First Author: Fang CC
Year: 2018
Journal: Sci Rep
Title: The Small Molecule Inhibitor QLT-0267 Decreases the Production of Fibrin-Induced Inflammatory Cytokines and Prevents Post-Surgical Peritoneal Adhesions.
Volume: 8
Issue: 1
Pages: 9481
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Publication
29588395 | J:261447
 
First Author: Han S
Year: 2018
Journal: J Cell Sci
Title: Substratum stiffness tunes proliferation downstream of Wnt3a in part by regulating integrin-linked kinase and frizzled-1.
Volume: 131
Issue: 8
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Publication
28630423 | J:280114
First Author: Kim J
Year: 2017
Journal: Sci Rep
Title: Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling.
Volume: 7
Issue: 1
Pages: 3815
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Publication
32439895 | J:295368
First Author: Kumar R
Year: 2020
Journal: Leukemia
Title: Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia.
Volume: 34
Issue: 8
Pages: 2087-2101
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Publication
35616334 | J:330429
 
First Author: Paes de Faria J
Year: 2022
Journal: Development
Title: Pinch2 regulates myelination in the mouse central nervous system.
Volume: 149
Issue: 13
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Protein
Q8BGB5
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Publication
16221682 | J:104099
First Author: Hresko RC
Year: 2005
Journal: J Biol Chem
Title: mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.
Volume: 280
Issue: 49
Pages: 40406-16
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Publication
31815595 | J:336579
First Author: Yue Y
Year: 2020
Journal: Circ Res
Title: Interleukin-10 Deficiency Alters Endothelial Progenitor Cell-Derived Exosome Reparative Effect on Myocardial Repair via Integrin-Linked Kinase Enrichment.
Volume: 126
Issue: 3
Pages: 315-329
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Publication
30582451 | J:292305
First Author: Miyagawa K
Year: 2019
Journal: Circ Res
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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