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Search results 301 to 400 out of 683 for Ina

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Type Details Score
Publication
18973680 | J:141291
 
First Author: Tamplin OJ
Year: 2008
Journal: BMC Genomics
Title: Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.
Volume: 9
Pages: 511
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Publication
12477932 | J:82808
First Author: Strausberg RL
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Volume: 99
Issue: 26
Pages: 16899-903
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Atxn3<tm1Isch> | MGI:3833681
Name: ataxin 3; targeted mutation 1, Ina Schmitt
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
16751287 | J:116463
First Author: Guo J
Year: 2006
Journal: Am J Physiol Heart Circ Physiol
Title: Decrease in density of INa is in the common final pathway to heart block in murine hearts overexpressing calcineurin.
Volume: 291
Issue: 6
Pages: H2669-79
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Strain
MGI:3833908 | C57BL/6-Atxn3<tm1Isch>
Attribute String: targeted mutation, coisogenic
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Publication
17764659 | J:145048
First Author: Schmitt I
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination.
Volume: 362
Issue: 3
Pages: 734-9
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Genotype
Genotype
Symbol: Atxn3/Atxn3
Background: C57BL/6-Atxn3
Zygosity: hm
Has Mutant Allele: true
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Publication
18648588 | J:140414
First Author: Sakai K
Year: 2006
Journal: Dose Response
Title: Enhancement of bio-protective functions by low dose/dose-rate radiation.
Volume: 4
Issue: 4
Pages: 327-32
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Publication
9394454 | J:46343
First Author: Takeshita M
Year: 1997
Journal: J Electron Microsc (Tokyo)
Title: Ultrastructural study of capillary and myocytic changes in the masseter and heart of KK-Ay mice.
Volume: 46
Issue: 5
Pages: 413-23
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Publication
33741019 | J:325257
First Author: Sowa AS
Year: 2021
Journal: Mol Brain
Title: Neurodegenerative phosphoprotein signaling landscape in models of SCA3.
Volume: 14
Issue: 1
Pages: 57
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Publication
21060878 | J:166663
First Author: Harris GM
Year: 2010
Journal: PLoS One
Title: Splice isoforms of the polyglutamine disease protein ataxin-3 exhibit similar enzymatic yet different aggregation properties.
Volume: 5
Issue: 10
Pages: e13695
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Publication
14973287 | J:88556
First Author: Oka C
Year: 2004
Journal: Development
Title: HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins.
Volume: 131
Issue: 5
Pages: 1041-53
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Publication
25849081 | J:233414
 
First Author: Izumi K
Year: 2015
Journal: Nat Commun
Title: Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes.
Volume: 6
Pages: 6748
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Publication
19139367 | -
First Author: Ducray F
Year: 2009
Journal: Neurology
Title: alpha-Internexin expression identifies 1p19q codeleted gliomas.
Volume: 72
Issue: 2
Pages: 156-61
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Protein Domain
IPR027703 | Alpha-Inx
Type: Family
Description: Alpha-internexin (INA) is a class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. INA is upregulated in some gliomas, particularly oligodendrogliomas [].
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Publication
31315047 | J:298893
First Author: Li S
Year: 2019
Journal: Cell Rep
Title: Conversion of Astrocytes and Fibroblasts into Functional Noradrenergic Neurons.
Volume: 28
Issue: 3
Pages: 682-697.e7
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Publication
25856240 | -
First Author: Cederholm HM
Year: 2015
Journal: New Phytol
Title: Distinct sensitivities to phosphate deprivation suggest that RGF peptides play disparate roles in Arabidopsis thaliana root development.
Volume: 207
Issue: 3
Pages: 683-91
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Protein Domain
IPR038804 | RGF1/2/3
Type: Family
Description: This entry includes the plant root meristem growth factors 1 /2/3 (RGF1/2/3, also known as GOLVEN 11/5/7) from Arabidopsis. They are signaling peptide that maintains the postembryonic root stem cell niche ina PIN2-traffic dependent manner [, , ]. RGF1 (At5g60810) acts as a peptide hormone recognized by receptors such as RGI1 and RGI2 to trigger signaling events including the regulation of RITF1 expression and leading to the production of reactive oxygen species (ROS) in roots to modulate meristem size [].
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Publication
32383994 | J:293710
First Author: Ebner J
Year: 2020
Journal: Am J Physiol Heart Circ Physiol
Title: Reduced Na+ current in Purkinje fibers explains cardiac conduction defects and arrhythmias in Duchenne muscular dystrophy.
Volume: 318
Issue: 6
Pages: H1436-H1440
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Publication
32198206 | J:290058
First Author: Polina I
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Loss of insulin signaling may contribute to atrial fibrillation and atrial electrical remodeling in type 1 diabetes.
Volume: 117
Issue: 14
Pages: 7990-8000
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Publication
28191886 | J:251095
First Author: Vikram A
Year: 2017
Journal: Nat Med
Title: Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel.
Volume: 23
Issue: 3
Pages: 361-367
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Publication
27364017 | J:254551
First Author: Eichel CA
Year: 2016
Journal: Circ Res
Title: Lateral Membrane-Specific MAGUK CASK Down-Regulates NaV1.5 Channel in Cardiac Myocytes.
Volume: 119
Issue: 4
Pages: 544-56
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Publication
27413200 | J:280604
First Author: Yang L
Year: 2017
Journal: Am J Physiol Renal Physiol
Title: SGK1-dependent ENaC processing and trafficking in mice with high dietary K intake and elevated aldosterone.
Volume: 312
Issue: 1
Pages: F65-F76
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Publication
36821382 | J:353320
 
First Author: Tarasov M
Year: 2023
Journal: J Clin Invest
Title: NaV1.6 dysregulation within myocardial T-tubules by D96V calmodulin enhances proarrhythmic sodium and calcium mishandling.
Volume: 133
Issue: 7
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Publication
27498076 | J:319201
First Author: Markandeya YS
Year: 2016
Journal: Heart Rhythm
Title: Inhibition of late sodium current attenuates ionic arrhythmia mechanism in ventricular myocytes expressing LaminA-N195K mutation.
Volume: 13
Issue: 11
Pages: 2228-2236
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Publication
28888949 | J:252637
 
First Author: Wang P
Year: 2017
Journal: Biochem Pharmacol
Title: Deficiency of N-acetyltransferase increases the interactions of isoniazid with endobiotics in mouse liver.
Volume: 145
Pages: 218-225
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Publication
32041188 | J:297757
 
First Author: D'Angelo V
Year: 2020
Journal: Int J Mol Sci
Title: Dystonia: Sparse Synapses for D2 Receptors in Striatum of a DYT1 Knock-out Mouse Model.
Volume: 21
Issue: 3
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Publication
31125670 | J:333144
First Author: Daniel LL
Year: 2019
Journal: Heart Rhythm
Title: SCN5A variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells.
Volume: 16
Issue: 11
Pages: 1676-1685
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Publication
23723061 | J:218654
First Author: King JH
Year: 2013
Journal: Cardiovasc Res
Title: Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation.
Volume: 99
Issue: 4
Pages: 751-9
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Publication
28430892 | J:263303
First Author: Portero V
Year: 2017
Journal: Cardiovasc Res
Title: Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes.
Volume: 113
Issue: 7
Pages: 829-838
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Publication
31614475 | J:290393
 
First Author: Casini S
Year: 2019
Journal: Int J Mol Sci
Title: Functional Consequences of the SCN5A-p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice.
Volume: 20
Issue: 20
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Publication
31822608 | J:285899
     
First Author: Hasan R
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: SUMO1 modification of PKD2 channels regulates arterial contractility.
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Publication
24812278 | J:229843
First Author: Dybkova N
Year: 2014
Journal: Cardiovasc Res
Title: Tubulin polymerization disrupts cardiac β-adrenergic regulation of late INa.
Volume: 103
Issue: 1
Pages: 168-77
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Publication
25139742 | J:230223
First Author: Agullo-Pascual E
Year: 2014
Journal: Cardiovasc Res
Title: Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc.
Volume: 104
Issue: 2
Pages: 371-81
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Publication
28193882 | J:264804
First Author: Lopez-Santiago LF
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy.
Volume: 114
Issue: 9
Pages: 2383-2388
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Publication
25995484 | J:220881
First Author: Lu VB
Year: 2015
Journal: J Neurosci
Title: A 3.7 kb fragment of the mouse Scn10a gene promoter directs neural crest but not placodal lineage EGFP expression in a transgenic animal.
Volume: 35
Issue: 20
Pages: 8021-34
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Publication
26392562 | J:227075
First Author: Musa H
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia.
Volume: 112
Issue: 40
Pages: 12528-33
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Publication
24895455 | J:224433
First Author: Shy D
Year: 2014
Journal: Circulation
Title: PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function.
Volume: 130
Issue: 2
Pages: 147-60
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Publication
26187182 | J:239053
First Author: Glynn P
Year: 2015
Journal: Circulation
Title: Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo.
Volume: 132
Issue: 7
Pages: 567-77
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Publication
25239140 | J:251320
First Author: Makara MA
Year: 2014
Journal: Circ Res
Title: Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo.
Volume: 115
Issue: 11
Pages: 929-38
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Publication
12730095 | J:313302
First Author: Thomas SP
Year: 2003
Journal: Circ Res
Title: Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43.
Volume: 92
Issue: 11
Pages: 1209-16
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Publication
8021246 | J:47387
First Author: Li Z
Year: 1994
Journal: J Biol Chem
Title: Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger.
Volume: 269
Issue: 26
Pages: 17434-9
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Protein Domain
IPR004836 | Na_Ca_Ex
Type: Family
Description: Na+/Ca2+exchange proteins are involved in maintaining Ca2+homeostasis ina wide variety of cell types. They are found in both the plasma membraneand intracellular organellar membranes, where they exchange Na+for Ca2+inan electrogenic manner. When located in the plasma membrane, they generallyutilise the transmembrane (TM) Na+concentration gradient in order toextrude Ca2+from cells. Three mammalian isoforms have been cloned to date(NCX1-3), which consist of 920-970 amino acid residues that are predictedto possess 11 or 12 TM domains. Interestingly, they possess a short motif(~30 residues) that is similar to the Na+/K+-ATPase, although its functionis unknown [, ].NCX1 has been found to be predominantly expressed in the heart, where itplays an important role in excitation-contraction coupling, but it is alsoabundant in a variety of other tissues []. NCX2 and NCX3 transcripts havebeen detected in the brain and skeletal muscle [, ]. Homologous Na+/Ca2+exchange proteins have also been found in Caenorhabditis elegans, Drosophila melanogaster andLoligo opalescens (California market squid).
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Publication
35628543 | J:325694
 
First Author: Cheng H
Year: 2022
Journal: Int J Mol Sci
Title: Delayed Ventricular Repolarization and Sodium Channel Current Modification in a Mouse Model of Rett Syndrome.
Volume: 23
Issue: 10
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Publication
27670841 | J:303007
First Author: Oginsky MF
Year: 2017
Journal: J Cell Physiol
Title: Hyperexcitability of Mesencephalic Trigeminal Neurons and Reorganization of Ion Channel Expression in a Rett Syndrome Model.
Volume: 232
Issue: 5
Pages: 1151-1164
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Publication
12684224 | J:113595
First Author: Dahlmann A
Year: 2003
Journal: Am J Physiol Renal Physiol
Title: Mineralocorticoid regulation of epithelial Na+ channels is maintained in a mouse model of Liddle's syndrome.
Volume: 285
Issue: 2
Pages: F310-8
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Publication
24352520 | J:219313
First Author: Cerrone M
Year: 2014
Journal: Circulation
Title: Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype.
Volume: 129
Issue: 10
Pages: 1092-103
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Publication
30499712 | J:272751
First Author: Pan Z
Year: 2019
Journal: Am J Physiol Heart Circ Physiol
Title: Atrial fibrillation and electrophysiology in transgenic mice with cardiac-restricted overexpression of FKBP12.
Volume: 316
Issue: 2
Pages: H371-H379
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Publication
24434335 | J:205479
 
First Author: Mistry AM
Year: 2014
Journal: Neurobiol Dis
Title: Strain- and age-dependent hippocampal neuron sodium currents correlate with epilepsy severity in Dravet syndrome mice.
Volume: 65
Pages: 1-11
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Publication
31333492 | J:286963
 
First Author: Rougier JS
Year: 2019
Journal: Front Physiol
Title: A Distinct Pool of Nav1.5 Channels at the Lateral Membrane of Murine Ventricular Cardiomyocytes.
Volume: 10
Pages: 834
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Publication
33035439 | J:299682
First Author: Trum M
Year: 2020
Journal: Am J Physiol Heart Circ Physiol
Title: Inhibition of cardiac potassium currents by oxidation-activated protein kinase A contributes to early afterdepolarizations in the heart.
Volume: 319
Issue: 6
Pages: H1347-H1357
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Publication
14736542 | J:134567
First Author: Tian XL
Year: 2004
Journal: Cardiovasc Res
Title: Mechanisms by which SCN5A mutation N1325S causes cardiac arrhythmias and sudden death in vivo.
Volume: 61
Issue: 2
Pages: 256-67
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Publication
8798769 | J:35796
First Author: Nicoll DA
Year: 1996
Journal: J Biol Chem
Title: Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3.
Volume: 271
Issue: 40
Pages: 24914-21
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Publication
1700476 | J:47389
First Author: Nicoll DA
Year: 1990
Journal: Science
Title: Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger.
Volume: 250
Issue: 4980
Pages: 562-5
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Publication
25772295 | J:302071
First Author: Lin X
Year: 2015
Journal: J Physiol
Title: Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts.
Volume: 593
Issue: 6
Pages: 1389-407
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Protein
Q9CVC3
Organism: Mus musculus/domesticus
Length: 73  
Fragment?: true
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Protein
Q91ZQ6
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: true
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Publication
31801996 | -
First Author: Yamada M
Year: 2020
Journal: Nature
Title: RGF1 controls root meristem size through ROS signalling.
Volume: 577
Issue: 7788
Pages: 85-88
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Publication
20798316 | -
First Author: Matsuzaki Y
Year: 2010
Journal: Science
Title: Secreted peptide signals required for maintenance of root stem cell niche in Arabidopsis.
Volume: 329
Issue: 5995
Pages: 1065-7
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Publication
23370719 | -
First Author: Fernandez A
Year: 2013
Journal: Plant Physiol
Title: Transcriptional and functional classification of the GOLVEN/ROOT GROWTH FACTOR/CLE-like signaling peptides reveals their role in lateral root and hair formation.
Volume: 161
Issue: 2
Pages: 954-70
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Protein Domain
IPR002987 | NaCa_exhngr1
Type: Family
Description: Na+/Ca2+exchange proteins are involved in maintaining Ca2+homeostasis ina wide variety of cell types. They are found in both the plasma membraneand intracellular organellar membranes, where they exchange Na+for Ca2+inan electrogenic manner. When located in the plasma membrane, they generallyutilise the transmembrane (TM) Na+concentration gradient in order toextrude Ca2+from cells. Three mammalian isoforms have been cloned to date(NCX1-3), which consist of 920-970 amino acid residues that are predictedto possess 11 or 12 TM domains. Interestingly, they possess a short motif(~30 residues) that is similar to the Na+/K+-ATPase, although its functionis unknown [, ].NCX1 is the principal Na+/Ca2+exchanger of cardiac myocytes, where it isthought to play an important role in excitation-contraction coupling. It isalso found in a variety of other tissues, suggesting it serves as ahousekeeping protein, maintaining low cytosolic Ca2+concentration. Alternativelyspliced variants of NCX1 have been identified, expression of which is celltype-specific. Sequence analysis reveals two sets of tandem repeats arefound within the NCX1 protein sequence, which are usually referred to asalpha and beta. The alpha repeats are thought to be involved in the ionbinding and translocation reactions of the exchanger, and the first betarepeat may be part of a regulatory site that responds to Ca2+concentration.
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Protein Domain
IPR036430 | RNase_T2-like_sf
Type: Homologous_superfamily
Description: Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases) [, , , , ]. Plant T2 RNases are expressed during leaf senescence in order to scavenge phosphate from ribonucleotides. They are also expressed in response to wounding or pathogen invasion. S-RNases are thought to prevent self-fertilization by acting as selective cytotoxins of "self"pollen. Generally, RNases have two distinct binding sites: the primary site (B1 site) and the subsite (B2 site), for nucleotides located at the 5'- and 3'- terminal ends of the sissile bond, respectively.The fungal ribonucleases T2 from Aspergillus oryzae, M from Aspergillus saitoi and Rh from Rhizopus niveus are structurally and functionally related 30 Kd glycoproteins []that cleave the 3'-5' internucleotide linkage of RNA via a nucleotide 2',3'-cyclic phosphate intermediate (). Two histidines residues have been shown [, ]to be involved in the catalytic mechanism of RNase T2 and Rh. These residues and the region around them are highly conserved ina number of other RNAses that have been found to be evolutionary related to these fungal enzymes.The structure of ribonuclease T2 is composed of an alpha+beta fold.
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Protein Domain
IPR021165 | Saposin_chordata
Type: Family
Description: Sphingolipids are bioactive compounds found in lower and higher eukaryotes.They are involved in the regulation of various cellular functions, such asgrowth, differentiation and apoptosis, and are believed to be essential ina healthy diet. Sphigolipids are degraded in the lysosome, and theproducts from their hydrolysis are used in other biosynthetic and regulatorypathways in the host.There are a number of lysosomal enzymes involved in the breakdown ofsphinogolipids, and these act in sequence to degrade the moieties []. These enzymes require co-proteins called sphingolipid activator proteins, (SAPs or saposins), to stabilise and activate them as necessary. SAPs are non-enzymatic and usually have a low molecular weight. They are conserved across a wide range of eukaryotes and contain specific saposin domains that aid in the activation of hydrolase enzymes. There have been four human saposins described so far, sharing significant similarity with each otherand with other eukaryotic SAP proteins.Mutations in SAP genes have been linked to a number of conditions. A defectin the saposin B region leads to metachromatic leucodystrophy (MLD), whilea single nucleotide polymorphism in the SAP-C region may give rise toGaucher disease []. More recently, an opportunistic protozoan parasite protein has shown similarity both to the higher and lower eukaryotic saposins. The pore-forming protein isolated from virulent Naegleria fowleri (Brain eating amoeba) has been dubbed Naegleriapore A. It also shares structural similarity with cytolytic bacterial peptides, although this similarity does not extend to the sequence level.This entry represents a group of saposins found specifically in chordates.
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Protein Domain
IPR008373 | Saposin
Type: Family
Description: Sphingolipids are bioactive compounds found in lower and higher eukaryotes.They are involved in the regulation of various cellular functions, such asgrowth, differentiation and apoptosis, and are believed to be essential ina healthy diet. Sphigolipids are degraded in the lysosome, and theproducts from their hydrolysis are used in other biosynthetic and regulatorypathways in the host.There are a number of lysosomal enzymes involved in the breakdown ofsphinogolipids, and these act in sequence to degrade the moieties []. These enzymes require co-proteins called sphingolipid activator proteins, (SAPs or saposins), to stabilise and activate them as necessary. SAPs are non-enzymatic and usually have a low molecular weight. They are conserved across a wide range of eukaryotes and contain specific saposin domains that aid in the activation of hydrolase enzymes. There have been four human saposins described so far, sharing significant similarity with each otherand with other eukaryotic SAP proteins.Mutations in SAP genes have been linked to a number of conditions. A defectin the saposin B region leads to metachromatic leucodystrophy (MLD), whilea single nucleotide polymorphism in the SAP-C region may give rise toGaucher disease []. More recently, an opportunistic protozoan parasite protein has shown similarity both to the higher and lower eukaryotic saposins. The pore-forming protein isolated from virulent Naegleria fowleri (Brain eating amoeba) has been dubbed Naegleriapore A. It also shares structural similarity with cytolytic bacterial peptides, although this similarity does not extend to the sequence level.
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Protein
Q0ZCJ7
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
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Protein
Q9D1J3
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
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Protein
B2RXM7
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
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Protein
A0A1W2P6N2
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: false
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Protein
A0A1B0GSW4
Organism: Mus musculus/domesticus
Length: 50  
Fragment?: true
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Protein
Q3UZ28
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: false
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Protein
Q8BIQ7
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: false
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Protein
B7ZWI2
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Protein
Q8CBF9
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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