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Search results 301 to 313 out of 313 for Ing4

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0.012s

Type

Details

Score

Publication

14973063 | -

First Author:	Zhou MI
Year:	2004
Journal:	Cancer Res
Title:	Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent.
Volume:	64
Issue:	4
Pages:	1278-86

•

Publication

23001567 | J:191148

First Author:	Foy RL
Year:	2012
Journal:	Hum Mol Genet
Title:	Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1.
Volume:	21
Issue:	26
Pages:	5456-71

•

Protein Domain

IPR039546 | Jade-1_PHD

Type:

Domain

Description:

Jade-1 is a novel binding partner of von Hippel-Lindau (VHL) tumour suppressor Pvhl, a key regulator of the cellular oxygen sensing pathway []. It is highly expressed in renal proximal tubules. Jade-1 functions as an essential regulator of multiple cell signaling pathways. It may be involved in the serine/threonine kinase AKT/AKT1 pathway during renal cancer pathogenesis and normally prevents renal epithelial cell proliferation and transformation []. It also acts as a pro-apoptotic and growth suppressive ubiquitin ligase to inhibit canonical Wnt downstream effector beta-catenin for proteasomal degradation [, ], and as a transcription factor associated with histone acetyltransferase activity and with increased abundance of cyclin-dependent kinase inhibitor p21 []. Moreover, Jade-1 is required for ING4 and ING5 to associate with histone acetyltransferase (HAT) HBO1 and Eaf6 to form a HBO1 complex, and plays a role in epithelial cell regeneration []. It has also been identified as a novel component of the nephrocystin protein (NPHP) complex and interacts with the ciliary protein nephrocystin-4 (NPHP4) []. Jade-1 contains a canonical Cys4HisCys3 PHD ("plant homeodomain") finger followed by a non-canonical extended PHD (ePHD) finger, Cys2HisCys5HisCys2His, both of which are zinc-binding motifs. This model corresponds to the canonical Cys4HisCys3 PHD finger [].

•

Publication

22654112 | -

First Author:	Borgal L
Year:	2012
Journal:	J Biol Chem
Title:	The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling.
Volume:	287
Issue:	30
Pages:	25370-80

•

Publication

22820306 | -

First Author:	Liu L
Year:	2012
Journal:	J Struct Biol
Title:	Solution structure of an atypical PHD finger in BRPF2 and its interaction with DNA.
Volume:	180
Issue:	1
Pages:	165-73

•

Publication

18794358 | -

First Author:	Ullah M
Year:	2008
Journal:	Mol Cell Biol
Title:	Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.
Volume:	28
Issue:	22
Pages:	6828-43

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Protein

Q6ZQF7

Organism:	Mus musculus/domesticus
Length:	829
Fragment?:	false

•

Protein

G5E8P1

Organism:	Mus musculus/domesticus
Length:	1058
Fragment?:	false

•

Protein

Q3UE68

Organism:	Mus musculus/domesticus
Length:	867
Fragment?:	false

•

Protein

Q6ZPI0

Organism:	Mus musculus/domesticus
Length:	834
Fragment?:	false

•

Protein

Q6IE82

Organism:	Mus musculus/domesticus
Length:	823
Fragment?:	false

•

Protein

A0A140T8R5

Organism:	Mus musculus/domesticus
Length:	824
Fragment?:	false

•

Protein

A2AA59

Organism:	Mus musculus/domesticus
Length:	576
Fragment?:	false

•

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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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