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Search results 301 to 366 out of 366 for Inha

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Type Details Score
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein Domain
IPR012300 | Pept_M6_InhA
Type: Family
Description: Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation which is usually zinc, but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidases, two metal ions are observed in crystal structures ligated by five amino acids, with one amino acid ligating both metal ions. The known metal ligands are His, Glu, Asp or Lys. At least one other residue is required for catalysis, which may play an electrophillic role. Many metalloproteases contain an HEXXH motif, which has been shown in crystallographic studies to form part of the metal-binding site []. The HEXXH motif is relatively common, but can be more stringently defined for metalloproteases as 'abXHEbbHbc', where 'a' is most often valine or threonine and forms part of the S1' subsite in thermolysin and neprilysin, 'b' is an uncharged residue, and 'c' a hydrophobic residue. Proline is never found in this site, possibly because it would break the helical structure adopted by this motif in metalloproteases [].This group of metallopeptidases belong to MEROPS peptidase family M6 (immune inhibitor A family, clan MA(M)). The predicted active site residues for members of this family and thermolysin, the type example for clan MA, occur in the motif HEXXH. InhA (MEROPS identifier M06.001) of Bacillus thuringiensis (an entomopathogenic bacterium) specifically cleaves antibacterial peptides produced by insect hosts []. B. thuringiensis is highly resistant to the insect immune system due to its production of two factors, inhibitor A (InhA or InA) and inhibitor B (InhB or InB), which selectively block the humoral defence system developed by insects against Escherichia coli and Bacillus cereus []. B. thuringiensis is especially resistant to cecropins and attacins, which are the main classes of inducible antibacterial peptides in various lepidopterans and dipterans [], []. InhA has been shown to specifically hydrolyse cecropins and attacins in the immune hemolymph of Hyalophora cecropia in vitro []. However, it has been suggested that the role of InhA in resistance to the humoral defence system is not consistent with the time course of InhA production [].B. thuringiensis has two proteins belonging to this group (InhA and InhA2), and it has been shown that InhA2 (MEROPS identifier M06.004) has a vital role in virulence when the host is infected via the oral route []. The B. cereus member has been found as an exosporium component from endospores []. B. thuringiensis InhA is induced at the onset of sporulation and is regulated by Spo0A and AbrB []. Vibrio cholerae PrtV (MEROPS identifier M06.002) is thought to be encoded in the pathogenicity island []. However, PrtV mutants did not exhibit a reduced virulence phenotype, and thus PrtV is not an indispensable virulence factor [].Annotation note: due to the presence of PKD repeats in some of the members of this group (e.g., V. cholerae VCA0223), spurious similarity hits may appear (involving unrelated proteins), which may lead to the erroneous transfer of functional annotations and protein names. Also, please note that related Bacillus subtilis Bacillopeptidase F (Bpr or Bpf) contains two different protease domains: N-terminal (peptidase S8, subtilase, a subtilisin-like serine protease) and the C-terminal domain (peptidase M6), which may also complicate annotation.
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Publication
9371455 | -
First Author: Ogierman MA
Year: 1997
Journal: J Bacteriol
Title: Characterization of the Vibrio cholerae El Tor lipase operon lipAB and a protease gene downstream of the hly region.
Volume: 179
Issue: 22
Pages: 7072-80
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Publication
6421577 | -
First Author: Dalhammar G
Year: 1984
Journal: Eur J Biochem
Title: Characterization of inhibitor A, a protease from Bacillus thuringiensis which degrades attacins and cecropins, two classes of antibacterial proteins in insects.
Volume: 139
Issue: 2
Pages: 247-52
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Publication
2089225 | -
First Author: Lövgren A
Year: 1990
Journal: Mol Microbiol
Title: Molecular characterization of immune inhibitor A, a secreted virulence protease from Bacillus thuringiensis.
Volume: 4
Issue: 12
Pages: 2137-46
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Publication
992874 | -
First Author: Edlund T
Year: 1976
Journal: Infect Immun
Title: Evidence for two immune inhibitors from Bacillus thuringiensis interfering with the humoral defense system of saturniid pupae.
Volume: 14
Issue: 4
Pages: 934-41
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Publication
12029046 | -
First Author: Fedhila S
Year: 2002
Journal: J Bacteriol
Title: The InhA2 metalloprotease of Bacillus thuringiensis strain 407 is required for pathogenicity in insects infected via the oral route.
Volume: 184
Issue: 12
Pages: 3296-304
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Publication
10475957 | -
First Author: Charlton S
Year: 1999
Journal: J Appl Microbiol
Title: Characterization of the exosporium of Bacillus cereus.
Volume: 87
Issue: 2
Pages: 241-5
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Publication
7140755 | -
First Author: Hultmark D
Year: 1982
Journal: Eur J Biochem
Title: Insect immunity: isolation and structure of cecropin D and four minor antibacterial components from Cecropia pupae.
Volume: 127
Issue: 1
Pages: 207-17
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HT Experiment
GSE236488 | Whole transcriptome RNAseq analysis of adult Inha WT and KO normal testis (N), tumour associated tubules (TAT) and tumour regions (TM).
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE236618 | Whole transcriptome RNAseq analysis of E13.5, E15.5 and PND 0 Inha WT and KO testes
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
3318666 | -
 
First Author: Boman HG
Year: 1987
Journal: Annu Rev Microbiol
Title: Cell-free immunity in insects.
Volume: 41
Pages: 103-26
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HT Experiment
GSE201520 | Whole transcriptome RNAseq analysis of germ cells in Inhba and Inha fetal testis
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Inha<em1Smoc> | MGI:7290547
Name: inhibin alpha; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6475599 | C57BL/6JSmoc-Inha<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Inha<tm1Bay> | MGI:1857202
Name: inhibin alpha; targeted mutation 1, Baylor College of Medicine
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Tg(IT2)4Kka | MGI:2446096
Name: transgene insertion 4, Kirsi Kananen
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Inha/Inha
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Inha/Inha
Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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Protein Domain
IPR012045 | Pept_M6_InhA-rel
Type: Family
Description: This group of proteins are related to the secreted virulence peptidase InhA () and along with InhA belong to MEROPS peptidase family M6 (immune inhibitor A, clan MA). On the basis of sequence similarity, and a conserved HEXXHXXGXXD motif, where the two histidines and the aspartate are zinc ligands and the glutamate is the catalytic residue it can be predicted that all members are peptidases. Annotation note: due to the presence of PKD repeats in some of the members of this group, spurious similarity hits may appear (involving unrelated proteins), which may lead to the erroneous transfer of functional annotations and protein names.
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Allele
Tg(IT6)5Kka | MGI:2446091
Name: transgene insertion 5, Kirsi Kananen
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
14639657 | J:87014
First Author: Segretain D
Year: 2003
Journal: Mol Carcinog
Title: Sequestration of connexin43 in the early endosomes: an early event of Leydig cell tumor progression.
Volume: 38
Issue: 4
Pages: 179-87
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Publication
15967102 | J:100161
First Author: Bodek G
Year: 2005
Journal: Neoplasia
Title: A novel targeted therapy of Leydig and granulosa cell tumors through the luteinizing hormone receptor using a hecate-chorionic gonadotropin beta conjugate in transgenic mice.
Volume: 7
Issue: 5
Pages: 497-508
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Publication
11259258 | J:68195
First Author: Rahman NA
Year: 2001
Journal: Biol Reprod
Title: Ovarian tumorigenesis in mice transgenic for murine inhibin alpha subunit promoter-driven Simian Virus 40 T-antigen: ontogeny, functional characteristics, and endocrine effects.
Volume: 64
Issue: 4
Pages: 1122-30
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Allele
Tg(Inha-cre)1Zuk | MGI:3641115
Name: transgene insertion 1, Martin M Matzuk
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Inha-cre)2Zuk | MGI:3641116
Name: transgene insertion 2, Martin M Matzuk
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Inha-cre)3Zuk | MGI:3641118
Name: transgene insertion 3, Martin M Matzuk
Allele Type: Transgenic
Attribute String: Recombinase
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Genotype
Genotype
Symbol: Amhr2/Amhr2 Inha/Inha<+>
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Amhr2/Amhr2 Inha/Inha
Background: involves: 129S7/SvEvBrd
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gnrh1/Gnrh1 Inha/Inha
Background: involves: 129S7/SvEvBrd * C57BL/6 * HPG/Bm
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Esr2/Esr2 Inha/Inha
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd
Zygosity: cx
Has Mutant Allele: true
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Protein Domain
IPR008757 | Peptidase_M6-like_domain
Type: Domain
Description: Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation which is usually zinc, but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidases, two metal ions are observed in crystal structures ligated by five amino acids, with one amino acid ligating both metal ions. The known metal ligands are His, Glu, Asp or Lys. At least one other residue is required for catalysis, which may play an electrophillic role. Many metalloproteases contain an HEXXH motif, which has been shown in crystallographic studies to form part of the metal-binding site []. The HEXXH motif is relatively common, but can be more stringently defined for metalloproteases as 'abXHEbbHbc', where 'a' is most often valine or threonine and forms part of the S1' subsite in thermolysin and neprilysin, 'b' is an uncharged residue, and 'c' a hydrophobic residue. Proline is never found in this site, possibly because it would break the helical structure adopted by this motif in metalloproteases [].This group of metallopeptidases belong to MEROPS peptidase family M6 (immune inhibitor A family, clan MA(M)). The predicted active site residues for members of this family and thermolysin, the type example for clan MA, occur in the motif HEXXH. InhA of Bacillus thuringiensis (an entomopathogenic bacterium) specifically cleaves antibacterial peptides produced by insect hosts []. B. thuringiensis is highly resistant to the insect immune system due to its production of two factors, inhibitor A (InhA or InA) and inhibitor B (InhB or InB), which selectively block the humoral defence system developed by insects against Escherichia coli and Bacillus cereus []. B. thuringiensis is especially resistant to cecropins and attacins, which are the main classes of inducible antibacterial peptides in various lepidopterans and dipterans [], []. InhA has been shown to specifically hydrolyze cecropins and attacins in the immune hemolymph of Hyalophora cecropia (Cecropia moth) in vitro []. However, it has been suggested that the role of InhA in resistance to the humoral defence system is not consistent with the time course of InhA production [].B. thuringiensis has two proteins belonging to this group (InhA and InhA2), and it has been shown that InhA2 has a vital role in virulence when the host is infected via the oral route []. The B. cereus member has been found as an exosporium component from endospores []. B. thuringiensis InhA is induced at the onset of sporulation and is regulated by Spo0A and AbrB []. Vibrio cholerae PrtV is thought to be encoded in the pathogenicity island []. However, PrtV mutants did not exhibit a reduced virulence phenotype, and thus PrtV is not an indispensable virulence factor [].Annotation note: due to the presence of PKD repeats in some of the members of this group (e.g., V. cholerae VCA0223), spurious similarity hits may appear (involving unrelated proteins), which may lead to the erroneous transfer of functional annotations and protein names. Also, please note that related Bacillus subtilis Bacillopeptidase F (Bpr or Bpf) contains two different protease domains: N-terminal (peptidase S8, subtilase, a subtilisin-like serine protease) and thisC-terminal domain (peptidase M6), which may also complicate annotation.
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Publication
9231807 | J:42412
First Author: Kananen K
Year: 1997
Journal: Endocrinology
Title: Suppression of gonadotropins inhibits gonadal tumorigenesis in mice transgenic for the mouse inhibin alpha-subunit promoter/simian virus 40 T-antigen fusion gene.
Volume: 138
Issue: 8
Pages: 3521-31
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Publication
11431140 | J:70360
First Author: Mikola MK
Year: 2001
Journal: J Endocrinol
Title: Gonadal tumors of mice double transgenic for inhibin-alpha promoter-driven simian virus 40 T-antigen and herpes simplex virus thymidine kinase are sensitive to ganciclovir treatment.
Volume: 170
Issue: 1
Pages: 79-90
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Genotype
Genotype
Symbol: Inha/Inha Smad3/Smad3
Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/Sv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Inha/Inha Smad3/Smad3<+>
Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/Sv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Inha/Inha Tg(Pou5f1-EGFP)2Mnn/?
Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA/CaJ
Zygosity: cx
Has Mutant Allele: true
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Publication
7661397 | J:28624
First Author: Montgomery GW
Year: 1995
Journal: Anim Genet
Title: Sheep linkage mapping: RFLP markers for comparative mapping studies.
Volume: 26
Issue: 4
Pages: 249-59
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Publication
12761497 | J:83778
First Author: Mikola M
Year: 2003
Journal: Oncogene
Title: High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-alpha-subunit promoter/Simian virus 40 T-antigen fusion gene.
Volume: 22
Issue: 21
Pages: 3269-78
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Genotype
Genotype
Symbol: Esr1/Esr1 Inha/Inha
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptpn11/Ptpn11 Tg(Inha-cre)3Zuk/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
7674922 | -
 
First Author: Rawlings ND
Year: 1995
Journal: Methods Enzymol
Title: Evolutionary families of metallopeptidases.
Volume: 248
Pages: 183-228
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Publication
9626655 | J:80664
First Author: Rilianawati
Year: 1998
Journal: Mol Endocrinol
Title: Direct luteinizing hormone action triggers adrenocortical tumorigenesis in castrated mice transgenic for the murine inhibin alpha-subunit promoter/simian virus 40 T-antigen fusion gene.
Volume: 12
Issue: 6
Pages: 801-9
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Publication
26265072 | J:250152
 
First Author: Hu X
Year: 2015
Journal: Sci Rep
Title: Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice.
Volume: 5
Pages: 12982
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Genotype
Genotype
Symbol: Esr1/Esr1 Esr2/Esr2 Inha/Inha
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Esr1/Esr1 Esr2/Esr2 Inha/Inha<+>
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Inha-cre)1Zuk/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Inha-cre)2Zuk/?
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Inha-cre)3Zuk/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
11971979 | J:76247
First Author: Lopez P
Year: 2002
Journal: Mol Cell Biol
Title: Gene control in germinal differentiation: RNF6, a transcription regulatory protein in the mouse sertoli cell.
Volume: 22
Issue: 10
Pages: 3488-96
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Publication
10341086 | J:55081
First Author: Robic A
Year: 1999
Journal: Mamm Genome
Title: A radiation hybrid map of the RN region in pigs demonstrates conserved gene order compared with the human and mouse genomes.
Volume: 10
Issue: 6
Pages: 565-8
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Publication
30598510 | J:276299
First Author: Henen MA
Year: 2019
Journal: J Biol Chem
Title: TGF-β2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-β and inhibin-α.
Volume: 294
Issue: 9
Pages: 3065-3080
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Publication
19553606 | J:154524
First Author: Kim H
Year: 2009
Journal: Biol Reprod
Title: Effects of diethylstilbestrol on programmed oocyte death and induction of polyovular follicles in neonatal mouse ovaries.
Volume: 81
Issue: 5
Pages: 1002-9
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Publication
26061565 | J:232961
First Author: Liu Z
Year: 2015
Journal: Mol Endocrinol
Title: FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development.
Volume: 29
Issue: 7
Pages: 1006-24
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Publication
16604527 | J:110150
First Author: Jorgez CJ
Year: 2006
Journal: Genesis
Title: Inhibin alpha-iCre mice: Cre deleter lines for the gonads, pituitary, and adrenal.
Volume: 44
Issue: 4
Pages: 183-8
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Publication
- | J:4884
 
First Author: Barton DE
Year: 1987
Journal: Cytogenet Cell Genet
Title: INHA, INHBA, and INHBB, the loci for the three subunits of inhibin, mapped in mouse and man.
Volume: 46
Pages: 578 (Abstr.)
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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