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Search results 301 to 400 out of 538 for Jak1

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Type Details Score
Publication
32814877 | J:319816
First Author: Guo X
Year: 2021
Journal: Cell Death Differ
Title: RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense.
Volume: 28
Issue: 2
Pages: 640-656
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Publication
28723893 | J:351452
First Author: Manguso RT
Year: 2017
Journal: Nature
Title: In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.
Volume: 547
Issue: 7664
Pages: 413-418
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Publication
29692363 | J:282708
 
First Author: Babaei R
Year: 2018
Journal: Sci Signal
Title: Jak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis.
Volume: 11
Issue: 527
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Publication
28278176 | J:242064
First Author: Mapes J
Year: 2017
Journal: PLoS Genet
Title: CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy.
Volume: 13
Issue: 3
Pages: e1006654
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Publication
7539296 | J:25660
First Author: Larner AC
Year: 1995
Journal: Biochim Biophys Acta
Title: Protein tyrosine phosphorylation as a mechanism which regulates cytokine activation of early response genes.
Volume: 1266
Issue: 3
Pages: 278-87
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Publication
8662243 | J:33549
First Author: Kono DH
Year: 1996
Journal: Mamm Genome
Title: Jak3 maps to chromosome 8.
Volume: 7
Issue: 6
Pages: 476-7
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Publication
9360952 | J:44063
First Author: Hanisch UK
Year: 1997
Journal: J Biol Chem
Title: Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity.
Volume: 272
Issue: 46
Pages: 28853-60
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Publication
9548458 | J:44275
First Author: Yu CL
Year: 1997
Journal: J Immunol
Title: Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase.
Volume: 159
Issue: 11
Pages: 5206-10
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Publication
10526570 | J:58302
First Author: Yeh TC
Year: 1999
Journal: Cell Mol Life Sci
Title: The Janus kinase family of protein tyrosine kinases and their role in signaling.
Volume: 55
Issue: 12
Pages: 1523-34
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Publication
22972935 | J:187745
First Author: Doles J
Year: 2012
Journal: Genes Dev
Title: Age-associated inflammation inhibits epidermal stem cell function.
Volume: 26
Issue: 19
Pages: 2144-53
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Publication
9524251 | J:40252
First Author: Inman MV
Year: 1998
Journal: Gene
Title: Gene organization and chromosome location of the neural-specific RNA binding protein Elavl4.
Volume: 208
Issue: 2
Pages: 139-45
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Publication
17855365 | J:128382
First Author: Li YF
Year: 2007
Journal: J Biol Chem
Title: FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis.
Volume: 282
Issue: 47
Pages: 34104-19
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Publication
8022486 | J:19201
First Author: Witthuhn BA
Year: 1994
Journal: Nature
Title: Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells.
Volume: 370
Issue: 6485
Pages: 153-7
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Publication
9889194 | J:52380
First Author: Nicholson SE
Year: 1999
Journal: EMBO J
Title: Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.
Volume: 18
Issue: 2
Pages: 375-85
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Publication
11390995 | J:81243
First Author: Gil MP
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Biologic consequences of Stat1-independent IFN signaling.
Volume: 98
Issue: 12
Pages: 6680-5
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Publication
24398427 | J:320713
First Author: Stuart E
Year: 2014
Journal: Mol Cancer Ther
Title: Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice.
Volume: 13
Issue: 2
Pages: 468-74
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Publication
39521937 | J:359563
First Author: Strobl K
Year: 2024
Journal: EMBO Mol Med
Title: JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia.
Volume: 16
Issue: 12
Pages: 3142-3168
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Publication
28191885 | J:251092
First Author: Chuang CH
Year: 2017
Journal: Nat Med
Title: Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis.
Volume: 23
Issue: 3
Pages: 291-300
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Publication
8593242 | J:33063
First Author: Finbloom DS
Year: 1995
Journal: Cell Signal
Title: Regulation of the Jak/STAT signalling pathway.
Volume: 7
Issue: 8
Pages: 739-45
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Publication
8918879 | J:36745
First Author: Liu ZG
Year: 1996
Journal: Nature
Title: Three distinct signalling responses by murine fibroblasts to genotoxic stress.
Volume: 384
Issue: 6606
Pages: 273-6
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Publication
15677447 | J:98567
First Author: Novotny-Diermayr V
Year: 2005
Journal: J Biol Chem
Title: Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction.
Volume: 280
Issue: 13
Pages: 12747-57
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Publication
19361784 | J:149493
First Author: Hirata N
Year: 2009
Journal: Cell Immunol
Title: Selective regulation of interleukin-10 production via Janus kinase pathway in murine conventional dendritic cells.
Volume: 258
Issue: 1
Pages: 9-17
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Publication
20846526 | J:164659
First Author: Cha Y
Year: 2010
Journal: FEBS Lett
Title: SHP2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells.
Volume: 584
Issue: 19
Pages: 4241-6
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Publication
25057888 | J:215673
First Author: Babon JJ
Year: 2014
Journal: Biochem J
Title: The molecular regulation of Janus kinase (JAK) activation.
Volume: 462
Issue: 1
Pages: 1-13
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Publication
33042133 | J:298970
 
First Author: Meissl K
Year: 2020
Journal: Front Immunol
Title: STAT1 Isoforms Differentially Regulate NK Cell Maturation and Anti-tumor Activity.
Volume: 11
Pages: 2189
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Publication
29242197 | J:257563
 
First Author: Huang K
Year: 2018
Journal: Biol Open
Title: JAK signaling regulates germline cyst breakdown and primordial follicle formation in mice.
Volume: 7
Issue: 1
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Publication
9229117 | J:41474
First Author: Naggert J
Year: 1997
Journal: Curr Opin Genet Dev
Title: The genetics of obesity.
Volume: 7
Issue: 3
Pages: 398-404
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Publication
9342212 | J:43723
First Author: Pellegrini S
Year: 1997
Journal: Eur J Biochem
Title: The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs).
Volume: 248
Issue: 3
Pages: 615-33
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Publication
9638363 | J:48063
First Author: Liu KD
Year: 1998
Journal: Curr Opin Immunol
Title: JAK/STAT signaling by cytokine receptors.
Volume: 10
Issue: 3
Pages: 271-8
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Publication
19103753 | J:145722
First Author: Proietti CJ
Year: 2009
Journal: Mol Cell Biol
Title: Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth.
Volume: 29
Issue: 5
Pages: 1249-65
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Publication
28784777 | J:244072
First Author: Li S
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis.
Volume: 114
Issue: 34
Pages: E7111-E7120
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Publication
10872802 | J:62510
First Author: Iseki M
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.
Volume: 272
Issue: 1
Pages: 45-54
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Publication
8535092 | J:28731
First Author: Reith AD
Year: 1995
Journal: Mamm Genome
Title: Isolation and chromosomal location of Nsk1, a novel murine putative receptor tyrosine kinase.
Volume: 6
Issue: 9
Pages: 689
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Publication
17114464 | J:116666
First Author: Johansson MH
Year: 2006
Journal: J Immunol
Title: Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice.
Volume: 177
Issue: 11
Pages: 7923-9
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Publication
22284677 | J:232386
First Author: Van Nguyen T
Year: 2012
Journal: Mol Cell
Title: SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation.
Volume: 45
Issue: 2
Pages: 210-21
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Publication
22527485 | J:183993
First Author: Sabrautzki S
Year: 2012
Journal: Mamm Genome
Title: New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis.
Volume: 23
Issue: 7-8
Pages: 416-30
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Publication
10781830 | J:62318
First Author: Imada K
Year: 2000
Journal: Mol Immunol
Title: The Jak-STAT pathway.
Volume: 37
Issue: 1-2
Pages: 1-11
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Publication
10200816 | J:53840
First Author: Brown MP
Year: 1999
Journal: Aust N Z J Med
Title: Cytokines, Jaks, Stats, health and disease.
Volume: 29
Issue: 1
Pages: 73-8
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Publication
11437454 | J:70363
First Author: Brunskill EW
Year: 2001
Journal: Dev Biol
Title: Novel cell lines promote the discovery of genes involved in early heart development.
Volume: 235
Issue: 2
Pages: 507-20
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Publication
31346084 | J:279163
First Author: Orvedahl A
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock.
Volume: 116
Issue: 33
Pages: 16497-16506
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Publication
29581031 | J:260356
 
First Author: Aiello FB
Year: 2018
Journal: Cell Signal
Title: IL-7-induced phosphorylation of the adaptor Crk-like and other targets.
Volume: 47
Pages: 131-141
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Publication
7893599 | J:22208
First Author: Ruiz JC
Year: 1994
Journal: Mech Dev
Title: Identification of novel protein kinases expressed in the myocardium of the developing mouse heart.
Volume: 48
Issue: 3
Pages: 153-64
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Publication
10932192 | J:68708
First Author: Hrabé de Angelis MH
Year: 2000
Journal: Nat Genet
Title: Genome-wide, large-scale production of mutant mice by ENU mutagenesis.
Volume: 25
Issue: 4
Pages: 444-7
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Publication
15254900 | J:91730
First Author: Verma-Kurvari S
Year: 2004
Journal: Dev Dyn
Title: Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.
Volume: 230
Issue: 4
Pages: 660-5
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Publication
7542761 | J:27414
First Author: Sommers CL
Year: 1995
Journal: Oncogene
Title: Murine txk: a protein tyrosine kinase gene regulated by T cell activation.
Volume: 11
Issue: 2
Pages: 245-51
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Publication
27318131 | J:239041
 
First Author: Norden DM
Year: 2016
Journal: Neurobiol Aging
Title: Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain.
Volume: 44
Pages: 22-41
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Publication
35493520 | J:324243
 
First Author: Lei Z
Year: 2022
Journal: Front Immunol
Title: EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice.
Volume: 13
Pages: 843378
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Publication
26764350 | J:232444
First Author: Li S
Year: 2016
Journal: Biol Reprod
Title: Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation.
Volume: 94
Issue: 2
Pages: 41
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Publication
24859004 | J:219394
First Author: Boroviak T
Year: 2014
Journal: Nat Cell Biol
Title: The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.
Volume: 16
Issue: 6
Pages: 516-28
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Publication
11114734 | J:66153
First Author: Robinson DR
Year: 2000
Journal: Oncogene
Title: The protein tyrosine kinase family of the human genome.
Volume: 19
Issue: 49
Pages: 5548-57
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Publication
27480124 | J:237787
First Author: Liu X
Year: 2016
Journal: BMC Immunol
Title: Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Volume: 17
Issue: 1
Pages: 25
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Publication
- | J:165963
     
First Author: Centre for Modeling Human Disease
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto
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Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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Publication
- | J:46439
     
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
11909529 | J:115366
First Author: Simoncic PD
Year: 2002
Journal: Curr Biol
Title: The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.
Volume: 12
Issue: 6
Pages: 446-53
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Publication
12133952 | -
First Author: Usacheva A
Year: 2002
Journal: J Immunol
Title: Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors.
Volume: 169
Issue: 3
Pages: 1302-8
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Protein Domain
IPR020776 | Tyr_kinase_non-rcpt_Jak1
Type: Family
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].Janus kinases (JAKs) are tyrosine kinases that function in membrane-proximal signalling events initiated by a variety of extracellular factors binding to cell surface receptors []. Many type I and II cytokine receptors lack a protein tyrosine kinase domain and rely on JAKs to initiate the cytoplasmic signal transduction cascade. Ligand binding induces oligomerisation of the receptors, which then activates the cytoplasmic receptor-associated JAKs. These subsequently phosphorylate tyrosine residues along the receptor chains with which they are associated. The phosphotyrosine residues are a target for a variety of SH2 domain-containing transducer proteins. Amongst these are the signal transducers and activators of transcription (STAT) proteins, which, after binding to the receptor chains, are phosphorylated by the JAK proteins. Phosphorylation enables the STAT proteins to dimerise and translocate into the nucleus, where they alter the expression of cytokine-regulated genes. This system is known as the JAK-STAT pathway.Four mammalian JAK family members have been identified: JAK1, JAK2, JAK3, and TYK2. They are relatively large kinases of approximately 1150 amino acids, with molecular weights of ~120-130kDa. Their amino acid sequences are characterised by the presence of 7 highly conserved domains, termed JAK homology (JH) domains. The C-terminal domain (JH1) is responsible for the tyrosine kinase function. The next domain in the sequence (JH2) is known as the tyrosine kinase-like domain, as its sequence shows high similarity to functional kinases but does not possess any catalytic activity. Although the function of this domain is not well established, there is some evidence for a regulatory role on the JH1 domain, thus modulating catalytic activity. The N-terminal portion of the JAKs (spanning JH7 to JH3) is important for receptor association and non-catalytic activity, and consists of JH3-JH4, which is homologous to the SH2 domain, and lastly JH5-JH7, which is a FERM domain.This represents the non-receptor tyrosine kinase JAK1, which is involved in the IFN-alpha/beta/gamma signal pathway. Jak1 acts as the kinase partner for the interleukin (IL)-2 receptor []and interleukin (IL)-10 receptor []. It directly phosphorylates STAT but also activates STAT signalling through the transactivation of other JAK kinases associated with signalling receptors [, ].JAK1 was initially cloned using a PCR-based strategy utilising degenerateprimers corresponding to conserved motifs within the catalytic domain of protein-tyrosine kinases []. In common with JAK2 and TYK2, and by contrastwith JAK3, JAK1 appears to be ubiquitously expressed.
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Protein
B1ASP3
Organism: Mus musculus/domesticus
Length: 18  
Fragment?: true
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Publication
33207208 | J:300601
First Author: Tuttle KD
Year: 2020
Journal: Cell Rep
Title: JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome.
Volume: 33
Issue: 7
Pages: 108407
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Interaction Experiment
Danial NN (1998)
Description: Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation.
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Interaction Experiment
Su Q (2007)
Description: Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2.
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Interaction Experiment
Huang HM (2005)
Description: Simultaneous activation of JAK1 and JAK2 confers IL-3 independent growth on Ba/F3 pro-B cells.
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Interaction Experiment
Linossi EM (2013)
Description: Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.
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