Type |
Details |
Score |
Allele |
Name: |
transgene insertion 12403/1, Curt Sigmund |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Atg5/Atg5 Tg(Kap-cre)1Isa/? |
Background: |
involves: 129S/SvEv * C57BL/6 * DBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 29066/2, Curt Sigmund |
Allele Type: |
Transgenic |
Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
Publication |
First Author: |
Mori K |
Year: |
1997 |
Journal: |
FEBS Lett |
Title: |
Molecular cloning of a novel mouse aspartic protease-like protein that is expressed abundantly in the kidney. |
Volume: |
401 |
Issue: |
2-3 |
Pages: |
218-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Iriuchijima N |
Year: |
2005 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Reduced expression of kinase-associated phosphatase in cortical dendrites of MAP2-deficient mice. |
Volume: |
338 |
Issue: |
2 |
Pages: |
1216-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kutok JL |
Year: |
2005 |
Journal: |
J Mol Histol |
Title: |
The cell cycle associated protein, HTm4, is expressed in differentiating cells of the hematopoietic and central nervous system in mice. |
Volume: |
36 |
Issue: |
1-2 |
Pages: |
77-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jia P |
Year: |
2022 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Chemokine CCL2 from proximal tubular epithelial cells contributes to sepsis-induced acute kidney injury. |
Volume: |
323 |
Issue: |
2 |
Pages: |
F107-F119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsusaka T |
Year: |
2012 |
Journal: |
J Am Soc Nephrol |
Title: |
Liver angiotensinogen is the primary source of renal angiotensin II. |
Volume: |
23 |
Issue: |
7 |
Pages: |
1181-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki C |
Year: |
2019 |
Journal: |
Int J Mol Sci |
Title: |
Autophagy Deficiency in Renal Proximal Tubular Cells Leads to an Increase in Cellular Injury and Apoptosis under Normal Fed Conditions. |
Volume: |
21 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Li H |
Year: |
2016 |
Journal: |
Autophagy |
Title: |
Atg5-mediated autophagy deficiency in proximal tubules promotes cell cycle G2/M arrest and renal fibrosis. |
Volume: |
12 |
Issue: |
9 |
Pages: |
1472-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peng X |
Year: |
2019 |
Journal: |
Cell Death Dis |
Title: |
ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury. |
Volume: |
10 |
Issue: |
4 |
Pages: |
253 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu M |
Year: |
2023 |
Journal: |
Adv Sci (Weinh) |
Title: |
TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5. |
Volume: |
10 |
Issue: |
25 |
Pages: |
e2301753 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gall JM |
Year: |
2015 |
Journal: |
J Am Soc Nephrol |
Title: |
Conditional knockout of proximal tubule mitofusin 2 accelerates recovery and improves survival after renal ischemia. |
Volume: |
26 |
Issue: |
5 |
Pages: |
1092-102 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, congenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Li H |
Year: |
2011 |
Journal: |
Am J Physiol Regul Integr Comp Physiol |
Title: |
Renal proximal tubule angiotensin AT1A receptors regulate blood pressure. |
Volume: |
301 |
Issue: |
4 |
Pages: |
R1067-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gjorgjieva M |
Year: |
2016 |
Journal: |
Hum Mol Genet |
Title: |
Progressive development of renal cysts in glycogen storage disease type I. |
Volume: |
25 |
Issue: |
17 |
Pages: |
3784-3797 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bai M |
Year: |
2023 |
Journal: |
EMBO Mol Med |
Title: |
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease. |
Volume: |
15 |
Issue: |
2 |
Pages: |
e16581 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang W |
Year: |
2024 |
Journal: |
Int Immunopharmacol |
Title: |
Ulinastatin attenuates renal ischemia-reperfusion injury by inhibiting NLRP3 inflammasome-triggered pyroptosis. |
Volume: |
143 |
Issue: |
Pt 1 |
Pages: |
113306 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Atg5/Atg5 Tg(Kap-icre)29066/2Sig/? |
Background: |
involves: 129S/SvEv * C57BL/6J * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(CAG-cat,-lacZ)11Miya/? Tg(Kap-cre)1Isa/? |
Background: |
involves: C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Tkatchenko AV |
Year: |
2001 |
Journal: |
Development |
Title: |
Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia. |
Volume: |
128 |
Issue: |
9 |
Pages: |
1547-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pruett ND |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Krtap16, characterization of a new hair keratin-associated protein (KAP) gene complex on mouse chromosome 16 and evidence for regulation by Hoxc13. |
Volume: |
279 |
Issue: |
49 |
Pages: |
51524-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bayer KU |
Year: |
1996 |
Journal: |
Mol Cell Biol |
Title: |
An alternative, nonkinase product of the brain-specifically expressed Ca2+/calmodulin-dependent kinase II alpha isoform gene in skeletal muscle. |
Volume: |
16 |
Issue: |
1 |
Pages: |
29-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Melià MJ |
Year: |
1998 |
Journal: |
Endocrinology |
Title: |
Identification of androgen-regulated genes in mouse kidney by representational difference analysis and random arbitrarily primed polymerase chain reaction. |
Volume: |
139 |
Issue: |
2 |
Pages: |
688-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cole SE |
Year: |
1998 |
Journal: |
Genomics |
Title: |
A cluster of keratin-associated proteins on mouse chromosome 10 in the region of conserved linkage with human chromosome 21. |
Volume: |
54 |
Issue: |
3 |
Pages: |
437-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tzortzaki EG |
Year: |
2002 |
Journal: |
J Histochem Cytochem |
Title: |
Gender- and age-dependent changes in kidney androgen protein mRNA expression in a knockout mouse model for nephrolithiasis. |
Volume: |
50 |
Issue: |
12 |
Pages: |
1663-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chau BN |
Year: |
2012 |
Journal: |
Sci Transl Med |
Title: |
MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. |
Volume: |
4 |
Issue: |
121 |
Pages: |
121ra18 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Li H |
Year: |
2008 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
An androgen-inducible proximal tubule-specific Cre recombinase transgenic model. |
Volume: |
294 |
Issue: |
6 |
Pages: |
F1481-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takagi A |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation. |
Volume: |
6 |
|
Pages: |
18944 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2024 |
Journal: |
FASEB J |
Title: |
MiR-21 suppression in macrophages promotes M2-like polarization and attenuates kidney ischemia-reperfusion injury. |
Volume: |
38 |
Issue: |
23 |
Pages: |
e70251 |
|
•
•
•
•
•
|
Publication |
First Author: |
Davisson RL |
Year: |
1999 |
Journal: |
Physiol Genomics |
Title: |
Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. |
Volume: |
1 |
Issue: |
1 |
Pages: |
3-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu S |
Year: |
2013 |
Journal: |
Toxicol Appl Pharmacol |
Title: |
The role of renal proximal tubule P450 enzymes in chloroform-induced nephrotoxicity: utility of renal specific P450 reductase knockout mouse models. |
Volume: |
272 |
Issue: |
1 |
Pages: |
230-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Casemayou A |
Year: |
2023 |
Journal: |
Sci Rep |
Title: |
Abcc6 deficiency prevents rhabdomyolysis-induced acute kidney injury. |
Volume: |
13 |
Issue: |
1 |
Pages: |
21513 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahashi A |
Year: |
2012 |
Journal: |
Am J Pathol |
Title: |
Autophagy guards against cisplatin-induced acute kidney injury. |
Volume: |
180 |
Issue: |
2 |
Pages: |
517-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakamura S |
Year: |
2020 |
Journal: |
Nat Cell Biol |
Title: |
LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury. |
Volume: |
22 |
Issue: |
10 |
Pages: |
1252-1263 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Kap-icre)29066/2Sig/? |
Background: |
involves: 129S4/SvJaeSor * C57BL/6 * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Kap-icre)29066/2Sig/? |
Background: |
B6.Cg-Gt(ROSA)26Sor Tg(Kap-icre)29066/2Sig |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
213
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
168
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
213
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
213
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Sakai S |
Year: |
2019 |
Journal: |
J Am Soc Nephrol |
Title: |
Proximal Tubule Autophagy Differs in Type 1 and 2 Diabetes. |
Volume: |
30 |
Issue: |
6 |
Pages: |
929-945 |
|
•
•
•
•
•
|
Publication |
First Author: |
Johansson E |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Simultaneous targeted activation of Notch1 and Vhl-disruption in the kidney proximal epithelial tubular cells in mice. |
Volume: |
6 |
|
Pages: |
30739 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kimura T |
Year: |
2011 |
Journal: |
J Am Soc Nephrol |
Title: |
Autophagy protects the proximal tubule from degeneration and acute ischemic injury. |
Volume: |
22 |
Issue: |
5 |
Pages: |
902-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liang L |
Year: |
2014 |
Journal: |
Mol Endocrinol |
Title: |
Androgen receptor enhances kidney stone-CaOx crystal formation via modulation of oxalate biosynthesis & oxidative stress. |
Volume: |
28 |
Issue: |
8 |
Pages: |
1291-303 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamoto T |
Year: |
2016 |
Journal: |
Autophagy |
Title: |
Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule. |
Volume: |
12 |
Issue: |
5 |
Pages: |
801-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamoto T |
Year: |
2017 |
Journal: |
J Am Soc Nephrol |
Title: |
High-Fat Diet-Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney. |
Volume: |
28 |
Issue: |
5 |
Pages: |
1534-1551 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ide N |
Year: |
2016 |
Journal: |
Kidney Int |
Title: |
In vivo evidence for a limited role of proximal tubular Klotho in renal phosphate handling. |
Volume: |
90 |
Issue: |
2 |
Pages: |
348-362 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakamura J |
Year: |
2023 |
Journal: |
JCI Insight |
Title: |
TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney. |
Volume: |
8 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lavoie JL |
Year: |
2004 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule. |
Volume: |
286 |
Issue: |
5 |
Pages: |
F965-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Genetic Resource Science at The Jackson Laboratory |
Year: |
2014 |
Journal: |
Direct Data Submission from Genetic Resource Science |
Title: |
Expression/Specificity Patterns of Cre Alleles, 2014 |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Function or Process or Component Unknown following Literature Review |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1617-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
1999 |
Journal: |
Methods Enzymol |
Title: |
High-efficiency full-length cDNA cloning. |
Volume: |
303 |
|
Pages: |
19-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata K |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1757-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katayama S |
Year: |
2005 |
Journal: |
Science |
Title: |
Antisense transcription in the mammalian transcriptome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1564-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|