Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
158
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
289
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1018
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
803
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Wysocka J |
Year: |
2006 |
Journal: |
Nature |
Title: |
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. |
Volume: |
442 |
Issue: |
7098 |
Pages: |
86-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jordan-Sciutto KL |
Year: |
2000 |
Journal: |
Biochemistry |
Title: |
Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity. |
Volume: |
39 |
Issue: |
12 |
Pages: |
3206-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiao H |
Year: |
2001 |
Journal: |
Mol Cell |
Title: |
Dual functions of largest NURF subunit NURF301 in nucleosome sliding and transcription factor interactions. |
Volume: |
8 |
Issue: |
3 |
Pages: |
531-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Badenhorst P |
Year: |
2002 |
Journal: |
Genes Dev |
Title: |
Biological functions of the ISWI chromatin remodeling complex NURF. |
Volume: |
16 |
Issue: |
24 |
Pages: |
3186-98 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes the nucleosome-remodeling factor subunits BPTF (vertebrates) and NURF301 (Drosophila melanogaster), which are components of the NURF (nucleosome-remodeling factor) complex [, ]. The NURF complex catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin []. The HMGA/HMGI(Y)-like DNA-binding site of NURF301 facilitates nucleosome sliding []. BPTF binds histone H3K4me3 via its PHD zinc finger domain [], and interacts with the myc-associated zinc finger protein MAZ, altering its transcriptional activity, []and the Kelch-like Ech-associated protein KEAP1 []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
467
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang HC |
Year: |
2000 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. |
Volume: |
97 |
Issue: |
23 |
Pages: |
12475-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen T |
Year: |
2004 |
Journal: |
Free Radic Biol Med |
Title: |
The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress. |
Volume: |
37 |
Issue: |
4 |
Pages: |
433-41 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Nuclear factor erythroid 2-related factor 2 (Nrf2) belongs to the CNC-bZIP family, which is a group of transcription factors that are activated in response to cellular stress. It binds to antioxidant response (ARE) elements in the promoter regions of target genes []. It is constitutively and ubiquitously expressed in a number of tissues and cell lines. When exposed to oxidative stress, the expression of Nrf2 increases, further driving the transcriptional activation of genes that control cellular redox homeostasis []. Nrf2 is regulated by the repressor protein Keap1, which acts by directly interacting with Nrf2 and preventing its nuclear accumulation []. Keap1 not only acts to retain Nrf2 in the cytoplasm but also actively promotes its ubiquitylation and subsequent degradation by the proteasome. |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki T |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress. |
Volume: |
292 |
Issue: |
41 |
Pages: |
16817-16824 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carvalho AN |
Year: |
2016 |
Journal: |
FEBS Lett |
Title: |
S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection. |
Volume: |
590 |
Issue: |
10 |
Pages: |
1455-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koike S |
Year: |
2013 |
Journal: |
FEBS Lett |
Title: |
Polysulfide exerts a protective effect against cytotoxicity caused by t-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells. |
Volume: |
587 |
Issue: |
21 |
Pages: |
3548-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sanghvi VR |
Year: |
2019 |
Journal: |
Cell |
Title: |
The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase. |
Volume: |
178 |
Issue: |
4 |
Pages: |
807-819.e21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marzio A |
Year: |
2022 |
Journal: |
Cell |
Title: |
EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion. |
Volume: |
185 |
Issue: |
1 |
Pages: |
169-183.e19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lignitto L |
Year: |
2019 |
Journal: |
Cell |
Title: |
Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1. |
Volume: |
178 |
Issue: |
2 |
Pages: |
316-329.e18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gwinn DM |
Year: |
2018 |
Journal: |
Cancer Cell |
Title: |
Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase. |
Volume: |
33 |
Issue: |
1 |
Pages: |
91-107.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang P |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis. |
Volume: |
10 |
Issue: |
1 |
Pages: |
755 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inami Y |
Year: |
2011 |
Journal: |
J Cell Biol |
Title: |
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. |
Volume: |
193 |
Issue: |
2 |
Pages: |
275-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamada T |
Year: |
2018 |
Journal: |
Cell Metab |
Title: |
Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease. |
Volume: |
28 |
Issue: |
4 |
Pages: |
588-604.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang Y |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response. |
Volume: |
10 |
Issue: |
1 |
Pages: |
3759 |
|
•
•
•
•
•
|
Publication |
First Author: |
Toulis V |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina. |
Volume: |
33 |
Issue: |
6 |
Pages: |
108360 |
|
•
•
•
•
•
|
Publication |
First Author: |
Graham DB |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes. |
Volume: |
24 |
Issue: |
4 |
Pages: |
838-850 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kageyama S |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response. |
Volume: |
12 |
Issue: |
1 |
Pages: |
16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ding H |
Year: |
2021 |
Journal: |
Sci Adv |
Title: |
Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition. |
Volume: |
7 |
Issue: |
47 |
Pages: |
eabk1023 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deng S |
Year: |
2020 |
Journal: |
Redox Biol |
Title: |
Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage. |
Volume: |
32 |
|
Pages: |
101453 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang XW |
Year: |
2022 |
Journal: |
Sci Adv |
Title: |
Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy. |
Volume: |
8 |
Issue: |
32 |
Pages: |
eabo0789 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hashimoto K |
Year: |
2016 |
Journal: |
Antioxid Redox Signal |
Title: |
TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1. |
Volume: |
25 |
Issue: |
17 |
Pages: |
953-964 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alam MM |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2. |
Volume: |
292 |
Issue: |
18 |
Pages: |
7519-7530 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ting KKY |
Year: |
2024 |
Journal: |
Sci Rep |
Title: |
Cholesterol accumulation impairs HIF-1α-dependent immunometabolic reprogramming of LPS-stimulated macrophages by upregulating the NRF2 pathway. |
Volume: |
14 |
Issue: |
1 |
Pages: |
11162 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gorrini C |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway. |
Volume: |
111 |
Issue: |
12 |
Pages: |
4472-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang ZY |
Year: |
2024 |
Journal: |
Nat Commun |
Title: |
Macrophage ILF3 promotes abdominal aortic aneurysm by inducing inflammatory imbalance in male mice. |
Volume: |
15 |
Issue: |
1 |
Pages: |
7249 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kageyama S |
Year: |
2018 |
Journal: |
Mol Cell Biol |
Title: |
Negative regulation of the Keap1-Nrf2 pathway by a p62/Sqstm1 splicing variant. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Pennington SM |
Year: |
2018 |
Journal: |
Redox Biol |
Title: |
Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription. |
Volume: |
16 |
|
Pages: |
401-413 |
|
•
•
•
•
•
|
Publication |
First Author: |
Petriello MC |
Year: |
2014 |
Journal: |
Toxicol Appl Pharmacol |
Title: |
PCB 126 toxicity is modulated by cross-talk between caveolae and Nrf2 signaling. |
Volume: |
277 |
Issue: |
2 |
Pages: |
192-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hou Y |
Year: |
2012 |
Journal: |
Free Radic Biol Med |
Title: |
Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis. |
Volume: |
52 |
Issue: |
2 |
Pages: |
462-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawachi Y |
Year: |
2008 |
Journal: |
J Invest Dermatol |
Title: |
Attenuation of UVB-induced sunburn reaction and oxidative DNA damage with no alterations in UVB-induced skin carcinogenesis in Nrf2 gene-deficient mice. |
Volume: |
128 |
Issue: |
7 |
Pages: |
1773-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo L |
Year: |
2015 |
Journal: |
Toxicol Appl Pharmacol |
Title: |
Butylated hydroxyanisole induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice. |
Volume: |
288 |
Issue: |
3 |
Pages: |
339-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qu C |
Year: |
2015 |
Journal: |
J Ethnopharmacol |
Title: |
Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy. |
Volume: |
168 |
|
Pages: |
326-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang B |
Year: |
2012 |
Journal: |
Free Radic Biol Med |
Title: |
Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage. |
Volume: |
52 |
Issue: |
5 |
Pages: |
928-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reiss LK |
Year: |
2014 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Interplay between nuclear factor erythroid 2-related factor 2 and amphiregulin during mechanical ventilation. |
Volume: |
51 |
Issue: |
5 |
Pages: |
668-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
DeNicola GM |
Year: |
2011 |
Journal: |
Nature |
Title: |
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. |
Volume: |
475 |
Issue: |
7354 |
Pages: |
106-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu P |
Year: |
2021 |
Journal: |
Mol Metab |
Title: |
Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism. |
Volume: |
51 |
|
Pages: |
101243 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pi J |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. |
Volume: |
285 |
Issue: |
12 |
Pages: |
9292-300 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh A |
Year: |
2021 |
Journal: |
Clin Cancer Res |
Title: |
NRF2 Activation Promotes Aggressive Lung Cancer and Associates with Poor Clinical Outcomes. |
Volume: |
27 |
Issue: |
3 |
Pages: |
877-888 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ikeda R |
Year: |
2023 |
Journal: |
EMBO J |
Title: |
Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response. |
Volume: |
42 |
Issue: |
14 |
Pages: |
e113349 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rada P |
Year: |
2012 |
Journal: |
Mol Cell Biol |
Title: |
Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis. |
Volume: |
32 |
Issue: |
17 |
Pages: |
3486-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tapias V |
Year: |
2018 |
Journal: |
Hum Mol Genet |
Title: |
Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy. |
Volume: |
27 |
Issue: |
16 |
Pages: |
2874-2892 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang F |
Year: |
2021 |
Journal: |
Cell Mol Gastroenterol Hepatol |
Title: |
The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway. |
Volume: |
11 |
Issue: |
5 |
Pages: |
1369-1385 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rajasekaran NS |
Year: |
2011 |
Journal: |
Antioxid Redox Signal |
Title: |
Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice. |
Volume: |
14 |
Issue: |
6 |
Pages: |
957-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kong C |
Year: |
2021 |
Journal: |
Cancer Res |
Title: |
Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling. |
Volume: |
81 |
Issue: |
17 |
Pages: |
4485-4498 |
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•
•
•
•
•
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Publication |
First Author: |
Vomhof-DeKrey EE |
Year: |
2012 |
Journal: |
Free Radic Biol Med |
Title: |
NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes. |
Volume: |
53 |
Issue: |
4 |
Pages: |
690-700 |
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•
•
•
•
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Publication |
First Author: |
Holmström KM |
Year: |
2013 |
Journal: |
Biol Open |
Title: |
Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration. |
Volume: |
2 |
Issue: |
8 |
Pages: |
761-70 |
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•
•
•
•
•
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Publication |
First Author: |
Baird L |
Year: |
2013 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells. |
Volume: |
433 |
Issue: |
1 |
Pages: |
58-65 |
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•
•
•
•
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Publication |
First Author: |
Sachdeva MM |
Year: |
2014 |
Journal: |
Exp Eye Res |
Title: |
Nrf2 signaling is impaired in the aging RPE given an oxidative insult. |
Volume: |
119 |
|
Pages: |
111-4 |
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•
•
•
•
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Publication |
First Author: |
Duru N |
Year: |
2015 |
Journal: |
Cancer Lett |
Title: |
NRF2/miR-140 signaling confers radioprotection to human lung fibroblasts. |
Volume: |
369 |
Issue: |
1 |
Pages: |
184-91 |
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•
•
•
•
•
|
Publication |
First Author: |
Gonzalez-Donquiles C |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review. |
Volume: |
12 |
Issue: |
5 |
Pages: |
e0177549 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bollong MJ |
Year: |
2018 |
Journal: |
Nature |
Title: |
A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. |
Volume: |
562 |
Issue: |
7728 |
Pages: |
600-604 |
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•
•
•
•
•
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Publication |
First Author: |
Hu X |
Year: |
2019 |
Journal: |
Oxid Med Cell Longev |
Title: |
miR-200a Attenuated Doxorubicin-Induced Cardiotoxicity through Upregulation of Nrf2 in Mice. |
Volume: |
2019 |
|
Pages: |
1512326 |
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•
•
•
•
•
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Publication |
First Author: |
Ren X |
Year: |
2020 |
Journal: |
Exp Cell Res |
Title: |
TRIM16 protects from OGD/R-induced oxidative stress in cultured hippocampal neurons by enhancing Nrf2/ARE antioxidant signaling via downregulation of Keap1. |
Volume: |
391 |
Issue: |
1 |
Pages: |
111988 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hayashi M |
Year: |
2020 |
Journal: |
Cancer Res |
Title: |
Microenvironmental Activation of Nrf2 Restricts the Progression of Nrf2-Activated Malignant Tumors. |
Volume: |
80 |
Issue: |
16 |
Pages: |
3331-3344 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hamada S |
Year: |
2021 |
Journal: |
Int J Mol Sci |
Title: |
Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition. |
Volume: |
22 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Foggetti G |
Year: |
2021 |
Journal: |
Cancer Discov |
Title: |
Genetic Determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo. |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Hayashi R |
Year: |
2013 |
Journal: |
Free Radic Biol Med |
Title: |
The role of the Nrf2-mediated defense system in corneal epithelial wound healing. |
Volume: |
61 |
|
Pages: |
333-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okada K |
Year: |
2012 |
Journal: |
J Gastroenterol |
Title: |
Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis. |
Volume: |
47 |
Issue: |
8 |
Pages: |
924-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wan Y |
Year: |
2023 |
Journal: |
Free Radic Biol Med |
Title: |
Baicalein limits osteoarthritis development by inhibiting chondrocyte ferroptosis. |
Volume: |
196 |
|
Pages: |
108-120 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hirose W |
Year: |
2022 |
Journal: |
Cancers (Basel) |
Title: |
The KEAP1-NRF2 System and Esophageal Cancer. |
Volume: |
14 |
Issue: |
19 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Liu B |
Year: |
2023 |
Journal: |
Int Immunopharmacol |
Title: |
Tripartite motif containing 59 mediates protective anti-oxidative effects in intestinal injury through Nrf2 signaling. |
Volume: |
124 |
Issue: |
Pt B |
Pages: |
110896 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mukhopadhyay S |
Year: |
2023 |
Journal: |
Cancer Res |
Title: |
Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy. |
Volume: |
83 |
Issue: |
24 |
Pages: |
4095-4111 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
99
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu Y |
Year: |
2019 |
Journal: |
Atherosclerosis |
Title: |
Z-Ligustilide protects vascular endothelial cells from oxidative stress and rescues high fat diet-induced atherosclerosis by activating multiple NRF2 downstream genes. |
Volume: |
284 |
|
Pages: |
110-120 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liao K |
Year: |
2021 |
Journal: |
Biomed Pharmacother |
Title: |
Sinomenine protects bone from destruction to ameliorate arthritis via activating p62Thr269/Ser272-Keap1-Nrf2 feedback loop. |
Volume: |
135 |
|
Pages: |
111195 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lou Y |
Year: |
2021 |
Journal: |
Oxid Med Cell Longev |
Title: |
Inhibition of the Keap1/Nrf2 Signaling Pathway Significantly Promotes the Progression of Type 1 Diabetes Mellitus. |
Volume: |
2021 |
|
Pages: |
7866720 |
|
•
•
•
•
•
|
Publication |
First Author: |
Su X |
Year: |
2018 |
Journal: |
Free Radic Biol Med |
Title: |
Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349. |
Volume: |
115 |
|
Pages: |
471-483 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kombairaju P |
Year: |
2012 |
Journal: |
J Carcinog |
Title: |
Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer. |
Volume: |
11 |
|
Pages: |
8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bowman BM |
Year: |
2020 |
Journal: |
J Pathol |
Title: |
A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue. |
Volume: |
252 |
Issue: |
2 |
Pages: |
125-137 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang J |
Year: |
2015 |
Journal: |
Free Radic Biol Med |
Title: |
Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger. |
Volume: |
86 |
|
Pages: |
25-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang J |
Year: |
2018 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
HDAC3 inhibition in diabetic mice may activate Nrf2 preventing diabetes-induced liver damage and FGF21 synthesis and secretion leading to aortic protection. |
Volume: |
315 |
Issue: |
2 |
Pages: |
E150-E162 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hou K |
Year: |
2021 |
Journal: |
EBioMedicine |
Title: |
Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin. |
Volume: |
69 |
|
Pages: |
103456 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sanz-Alcázar A |
Year: |
2024 |
Journal: |
Redox Biol |
Title: |
Deciphering the ferroptosis pathways in dorsal root ganglia of Friedreich ataxia models. The role of LKB1/AMPK, KEAP1, and GSK3β in the impairment of the NRF2 response. |
Volume: |
76 |
|
Pages: |
103339 |
|
•
•
•
•
•
|
Publication |
First Author: |
Osburn WO |
Year: |
2008 |
Journal: |
Mutat Res |
Title: |
Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. |
Volume: |
659 |
Issue: |
1-2 |
Pages: |
31-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rooney J |
Year: |
2018 |
Journal: |
PLoS One |
Title: |
Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor. |
Volume: |
13 |
Issue: |
8 |
Pages: |
e0200004 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanmugam G |
Year: |
2017 |
Journal: |
Redox Biol |
Title: |
Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium. |
Volume: |
12 |
|
Pages: |
937-945 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cong P |
Year: |
2019 |
Journal: |
Oxid Med Cell Longev |
Title: |
CD28 Deficiency Ameliorates Thoracic Blast Exposure-Induced Oxidative Stress and Apoptosis in the Brain through the PI3K/Nrf2/Keap1 Signaling Pathway. |
Volume: |
2019 |
|
Pages: |
8460290 |
|
•
•
•
•
•
|
Publication |
First Author: |
He F |
Year: |
2020 |
Journal: |
J Hepatol |
Title: |
NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly. |
Volume: |
72 |
Issue: |
6 |
Pages: |
1182-1195 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
597
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2973
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
826
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
645
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1114
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
3036
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
669
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2640
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
329
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2921
 |
Fragment?: |
false |
|
•
•
•
•
•
|