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Search results 301 to 398 out of 398 for Keap1

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0.716s
Type Details Score
Protein
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1018  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 803  
Fragment?: true
Publication
First Author: Wysocka J
Year: 2006
Journal: Nature
Title: A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.
Volume: 442
Issue: 7098
Pages: 86-90
Publication
First Author: Jordan-Sciutto KL
Year: 2000
Journal: Biochemistry
Title: Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity.
Volume: 39
Issue: 12
Pages: 3206-15
Publication
First Author: Xiao H
Year: 2001
Journal: Mol Cell
Title: Dual functions of largest NURF subunit NURF301 in nucleosome sliding and transcription factor interactions.
Volume: 8
Issue: 3
Pages: 531-43
Publication
First Author: Badenhorst P
Year: 2002
Journal: Genes Dev
Title: Biological functions of the ISWI chromatin remodeling complex NURF.
Volume: 16
Issue: 24
Pages: 3186-98
Protein Domain
Type: Family
Description: This entry includes the nucleosome-remodeling factor subunits BPTF (vertebrates) and NURF301 (Drosophila melanogaster), which are components of the NURF (nucleosome-remodeling factor) complex [, ]. The NURF complex catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin []. The HMGA/HMGI(Y)-like DNA-binding site of NURF301 facilitates nucleosome sliding []. BPTF binds histone H3K4me3 via its PHD zinc finger domain [], and interacts with the myc-associated zinc finger protein MAZ, altering its transcriptional activity, []and the Kelch-like Ech-associated protein KEAP1 [].
Protein
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: true
Publication
First Author: Huang HC
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2.
Volume: 97
Issue: 23
Pages: 12475-80
Publication
First Author: Nguyen T
Year: 2004
Journal: Free Radic Biol Med
Title: The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress.
Volume: 37
Issue: 4
Pages: 433-41
Protein Domain
Type: Family
Description: Nuclear factor erythroid 2-related factor 2 (Nrf2) belongs to the CNC-bZIP family, which is a group of transcription factors that are activated in response to cellular stress. It binds to antioxidant response (ARE) elements in the promoter regions of target genes []. It is constitutively and ubiquitously expressed in a number of tissues and cell lines. When exposed to oxidative stress, the expression of Nrf2 increases, further driving the transcriptional activation of genes that control cellular redox homeostasis []. Nrf2 is regulated by the repressor protein Keap1, which acts by directly interacting with Nrf2 and preventing its nuclear accumulation []. Keap1 not only acts to retain Nrf2 in the cytoplasm but also actively promotes its ubiquitylation and subsequent degradation by the proteasome.
Publication
First Author: Suzuki T
Year: 2017
Journal: J Biol Chem
Title: Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress.
Volume: 292
Issue: 41
Pages: 16817-16824
Publication
First Author: Carvalho AN
Year: 2016
Journal: FEBS Lett
Title: S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection.
Volume: 590
Issue: 10
Pages: 1455-66
Publication
First Author: Koike S
Year: 2013
Journal: FEBS Lett
Title: Polysulfide exerts a protective effect against cytotoxicity caused by t-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells.
Volume: 587
Issue: 21
Pages: 3548-55
Publication
First Author: Sanghvi VR
Year: 2019
Journal: Cell
Title: The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase.
Volume: 178
Issue: 4
Pages: 807-819.e21
Publication
First Author: Marzio A
Year: 2022
Journal: Cell
Title: EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion.
Volume: 185
Issue: 1
Pages: 169-183.e19
Publication
First Author: Lignitto L
Year: 2019
Journal: Cell
Title: Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.
Volume: 178
Issue: 2
Pages: 316-329.e18
Publication
First Author: Gwinn DM
Year: 2018
Journal: Cancer Cell
Title: Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase.
Volume: 33
Issue: 1
Pages: 91-107.e6
Publication
First Author: Wang P
Year: 2019
Journal: Nat Commun
Title: Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis.
Volume: 10
Issue: 1
Pages: 755
Publication
First Author: Inami Y
Year: 2011
Journal: J Cell Biol
Title: Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.
Volume: 193
Issue: 2
Pages: 275-84
Publication
First Author: Yamada T
Year: 2018
Journal: Cell Metab
Title: Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease.
Volume: 28
Issue: 4
Pages: 588-604.e5
Publication
First Author: Yang Y
Year: 2019
Journal: Nat Commun
Title: Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response.
Volume: 10
Issue: 1
Pages: 3759
Publication
First Author: Toulis V
Year: 2020
Journal: Cell Rep
Title: The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina.
Volume: 33
Issue: 6
Pages: 108360
Publication
First Author: Graham DB
Year: 2018
Journal: Cell Rep
Title: Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes.
Volume: 24
Issue: 4
Pages: 838-850
Publication
First Author: Kageyama S
Year: 2021
Journal: Nat Commun
Title: p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response.
Volume: 12
Issue: 1
Pages: 16
Publication
First Author: Ding H
Year: 2021
Journal: Sci Adv
Title: Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition.
Volume: 7
Issue: 47
Pages: eabk1023
Publication  
First Author: Deng S
Year: 2020
Journal: Redox Biol
Title: Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage.
Volume: 32
Pages: 101453
Publication
First Author: Zhang XW
Year: 2022
Journal: Sci Adv
Title: Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy.
Volume: 8
Issue: 32
Pages: eabo0789
Publication
First Author: Hashimoto K
Year: 2016
Journal: Antioxid Redox Signal
Title: TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1.
Volume: 25
Issue: 17
Pages: 953-964
Publication
First Author: Alam MM
Year: 2017
Journal: J Biol Chem
Title: Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2.
Volume: 292
Issue: 18
Pages: 7519-7530
Publication
First Author: Ting KKY
Year: 2024
Journal: Sci Rep
Title: Cholesterol accumulation impairs HIF-1α-dependent immunometabolic reprogramming of LPS-stimulated macrophages by upregulating the NRF2 pathway.
Volume: 14
Issue: 1
Pages: 11162
Publication
First Author: Gorrini C
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway.
Volume: 111
Issue: 12
Pages: 4472-7
Publication
First Author: Wang ZY
Year: 2024
Journal: Nat Commun
Title: Macrophage ILF3 promotes abdominal aortic aneurysm by inducing inflammatory imbalance in male mice.
Volume: 15
Issue: 1
Pages: 7249
Publication      
First Author: Kageyama S
Year: 2018
Journal: Mol Cell Biol
Title: Negative regulation of the Keap1-Nrf2 pathway by a p62/Sqstm1 splicing variant.
Publication  
First Author: Pennington SM
Year: 2018
Journal: Redox Biol
Title: Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription.
Volume: 16
Pages: 401-413
Publication
First Author: Petriello MC
Year: 2014
Journal: Toxicol Appl Pharmacol
Title: PCB 126 toxicity is modulated by cross-talk between caveolae and Nrf2 signaling.
Volume: 277
Issue: 2
Pages: 192-9
Publication
First Author: Hou Y
Year: 2012
Journal: Free Radic Biol Med
Title: Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis.
Volume: 52
Issue: 2
Pages: 462-72
Publication
First Author: Kawachi Y
Year: 2008
Journal: J Invest Dermatol
Title: Attenuation of UVB-induced sunburn reaction and oxidative DNA damage with no alterations in UVB-induced skin carcinogenesis in Nrf2 gene-deficient mice.
Volume: 128
Issue: 7
Pages: 1773-9
Publication
First Author: Luo L
Year: 2015
Journal: Toxicol Appl Pharmacol
Title: Butylated hydroxyanisole induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice.
Volume: 288
Issue: 3
Pages: 339-48
Publication  
First Author: Qu C
Year: 2015
Journal: J Ethnopharmacol
Title: Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy.
Volume: 168
Pages: 326-36
Publication
First Author: Wang B
Year: 2012
Journal: Free Radic Biol Med
Title: Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage.
Volume: 52
Issue: 5
Pages: 928-36
Publication
First Author: Reiss LK
Year: 2014
Journal: Am J Respir Cell Mol Biol
Title: Interplay between nuclear factor erythroid 2-related factor 2 and amphiregulin during mechanical ventilation.
Volume: 51
Issue: 5
Pages: 668-77
Publication
First Author: DeNicola GM
Year: 2011
Journal: Nature
Title: Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.
Volume: 475
Issue: 7354
Pages: 106-9
Publication  
First Author: Liu P
Year: 2021
Journal: Mol Metab
Title: Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism.
Volume: 51
Pages: 101243
Publication
First Author: Pi J
Year: 2010
Journal: J Biol Chem
Title: Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity.
Volume: 285
Issue: 12
Pages: 9292-300
Publication
First Author: Singh A
Year: 2021
Journal: Clin Cancer Res
Title: NRF2 Activation Promotes Aggressive Lung Cancer and Associates with Poor Clinical Outcomes.
Volume: 27
Issue: 3
Pages: 877-888
Publication
First Author: Ikeda R
Year: 2023
Journal: EMBO J
Title: Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response.
Volume: 42
Issue: 14
Pages: e113349
Publication
First Author: Rada P
Year: 2012
Journal: Mol Cell Biol
Title: Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis.
Volume: 32
Issue: 17
Pages: 3486-99
Publication
First Author: Tapias V
Year: 2018
Journal: Hum Mol Genet
Title: Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy.
Volume: 27
Issue: 16
Pages: 2874-2892
Publication
First Author: Wang F
Year: 2021
Journal: Cell Mol Gastroenterol Hepatol
Title: The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.
Volume: 11
Issue: 5
Pages: 1369-1385
Publication
First Author: Rajasekaran NS
Year: 2011
Journal: Antioxid Redox Signal
Title: Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice.
Volume: 14
Issue: 6
Pages: 957-71
Publication
First Author: Kong C
Year: 2021
Journal: Cancer Res
Title: Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling.
Volume: 81
Issue: 17
Pages: 4485-4498
Publication
First Author: Vomhof-DeKrey EE
Year: 2012
Journal: Free Radic Biol Med
Title: NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes.
Volume: 53
Issue: 4
Pages: 690-700
Publication
First Author: Holmström KM
Year: 2013
Journal: Biol Open
Title: Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration.
Volume: 2
Issue: 8
Pages: 761-70
Publication
First Author: Baird L
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells.
Volume: 433
Issue: 1
Pages: 58-65
Publication  
First Author: Sachdeva MM
Year: 2014
Journal: Exp Eye Res
Title: Nrf2 signaling is impaired in the aging RPE given an oxidative insult.
Volume: 119
Pages: 111-4
Publication
First Author: Duru N
Year: 2015
Journal: Cancer Lett
Title: NRF2/miR-140 signaling confers radioprotection to human lung fibroblasts.
Volume: 369
Issue: 1
Pages: 184-91
Publication
First Author: Gonzalez-Donquiles C
Year: 2017
Journal: PLoS One
Title: The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review.
Volume: 12
Issue: 5
Pages: e0177549
Publication
First Author: Bollong MJ
Year: 2018
Journal: Nature
Title: A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling.
Volume: 562
Issue: 7728
Pages: 600-604
Publication  
First Author: Hu X
Year: 2019
Journal: Oxid Med Cell Longev
Title: miR-200a Attenuated Doxorubicin-Induced Cardiotoxicity through Upregulation of Nrf2 in Mice.
Volume: 2019
Pages: 1512326
Publication
First Author: Ren X
Year: 2020
Journal: Exp Cell Res
Title: TRIM16 protects from OGD/R-induced oxidative stress in cultured hippocampal neurons by enhancing Nrf2/ARE antioxidant signaling via downregulation of Keap1.
Volume: 391
Issue: 1
Pages: 111988
Publication
First Author: Hayashi M
Year: 2020
Journal: Cancer Res
Title: Microenvironmental Activation of Nrf2 Restricts the Progression of Nrf2-Activated Malignant Tumors.
Volume: 80
Issue: 16
Pages: 3331-3344
Publication  
First Author: Hamada S
Year: 2021
Journal: Int J Mol Sci
Title: Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition.
Volume: 22
Issue: 4
Publication      
First Author: Foggetti G
Year: 2021
Journal: Cancer Discov
Title: Genetic Determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo.
Publication  
First Author: Hayashi R
Year: 2013
Journal: Free Radic Biol Med
Title: The role of the Nrf2-mediated defense system in corneal epithelial wound healing.
Volume: 61
Pages: 333-42
Publication
First Author: Okada K
Year: 2012
Journal: J Gastroenterol
Title: Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis.
Volume: 47
Issue: 8
Pages: 924-35
Publication  
First Author: Wan Y
Year: 2023
Journal: Free Radic Biol Med
Title: Baicalein limits osteoarthritis development by inhibiting chondrocyte ferroptosis.
Volume: 196
Pages: 108-120
Publication  
First Author: Hirose W
Year: 2022
Journal: Cancers (Basel)
Title: The KEAP1-NRF2 System and Esophageal Cancer.
Volume: 14
Issue: 19
Publication
First Author: Liu B
Year: 2023
Journal: Int Immunopharmacol
Title: Tripartite motif containing 59 mediates protective anti-oxidative effects in intestinal injury through Nrf2 signaling.
Volume: 124
Issue: Pt B
Pages: 110896
Publication
First Author: Mukhopadhyay S
Year: 2023
Journal: Cancer Res
Title: Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy.
Volume: 83
Issue: 24
Pages: 4095-4111
Protein
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: false
Publication  
First Author: Zhu Y
Year: 2019
Journal: Atherosclerosis
Title: Z-Ligustilide protects vascular endothelial cells from oxidative stress and rescues high fat diet-induced atherosclerosis by activating multiple NRF2 downstream genes.
Volume: 284
Pages: 110-120
Publication  
First Author: Liao K
Year: 2021
Journal: Biomed Pharmacother
Title: Sinomenine protects bone from destruction to ameliorate arthritis via activating p62Thr269/Ser272-Keap1-Nrf2 feedback loop.
Volume: 135
Pages: 111195
Publication  
First Author: Lou Y
Year: 2021
Journal: Oxid Med Cell Longev
Title: Inhibition of the Keap1/Nrf2 Signaling Pathway Significantly Promotes the Progression of Type 1 Diabetes Mellitus.
Volume: 2021
Pages: 7866720
Publication  
First Author: Su X
Year: 2018
Journal: Free Radic Biol Med
Title: Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349.
Volume: 115
Pages: 471-483
Publication  
First Author: Kombairaju P
Year: 2012
Journal: J Carcinog
Title: Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer.
Volume: 11
Pages: 8
Publication
First Author: Bowman BM
Year: 2020
Journal: J Pathol
Title: A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue.
Volume: 252
Issue: 2
Pages: 125-137
Publication  
First Author: Wang J
Year: 2015
Journal: Free Radic Biol Med
Title: Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger.
Volume: 86
Pages: 25-36
Publication
First Author: Zhang J
Year: 2018
Journal: Am J Physiol Endocrinol Metab
Title: HDAC3 inhibition in diabetic mice may activate Nrf2 preventing diabetes-induced liver damage and FGF21 synthesis and secretion leading to aortic protection.
Volume: 315
Issue: 2
Pages: E150-E162
Publication  
First Author: Hou K
Year: 2021
Journal: EBioMedicine
Title: Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin.
Volume: 69
Pages: 103456
Publication  
First Author: Sanz-Alcázar A
Year: 2024
Journal: Redox Biol
Title: Deciphering the ferroptosis pathways in dorsal root ganglia of Friedreich ataxia models. The role of LKB1/AMPK, KEAP1, and GSK3β in the impairment of the NRF2 response.
Volume: 76
Pages: 103339
Publication
First Author: Osburn WO
Year: 2008
Journal: Mutat Res
Title: Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults.
Volume: 659
Issue: 1-2
Pages: 31-9
Publication
First Author: Rooney J
Year: 2018
Journal: PLoS One
Title: Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor.
Volume: 13
Issue: 8
Pages: e0200004
Publication  
First Author: Shanmugam G
Year: 2017
Journal: Redox Biol
Title: Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium.
Volume: 12
Pages: 937-945
Publication  
First Author: Cong P
Year: 2019
Journal: Oxid Med Cell Longev
Title: CD28 Deficiency Ameliorates Thoracic Blast Exposure-Induced Oxidative Stress and Apoptosis in the Brain through the PI3K/Nrf2/Keap1 Signaling Pathway.
Volume: 2019
Pages: 8460290
Publication
First Author: He F
Year: 2020
Journal: J Hepatol
Title: NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly.
Volume: 72
Issue: 6
Pages: 1182-1195
Protein
Organism: Mus musculus/domesticus
Length: 597  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2973  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 826  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 645  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1114  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 3036  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 669  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 2640  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 2921  
Fragment?: false