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Search results 301 to 400 out of 406 for Lats2

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Type Details Score
Publication
32730753 | J:306079
First Author: Cheung P
Year: 2020
Journal: Cell Stem Cell
Title: Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer.
Volume: 27
Issue: 4
Pages: 590-604.e9
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Publication
34478649 | J:310907
First Author: Nacarino-Palma A
Year: 2021
Journal: Stem Cell Reports
Title: The aryl hydrocarbon receptor promotes differentiation during mouse preimplantational embryo development.
Volume: 16
Issue: 9
Pages: 2351-2363
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Publication
28457749 | J:253651
First Author: Hu JK
Year: 2017
Journal: Cell Stem Cell
Title: An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice.
Volume: 21
Issue: 1
Pages: 91-106.e6
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Publication
30286078 | J:267193
First Author: Sun Z
Year: 2018
Journal: PLoS Genet
Title: FoxO6 regulates Hippo signaling and growth of the craniofacial complex.
Volume: 14
Issue: 10
Pages: e1007675
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Publication
29249622 | J:253963
First Author: Moon KH
Year: 2018
Journal: Dev Cell
Title: Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development.
Volume: 44
Issue: 1
Pages: 13-28.e3
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Publication
27405641 | J:240835
 
First Author: Li CY
Year: 2016
Journal: Nat Commun
Title: αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development.
Volume: 7
Pages: 12133
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Publication
30523785 | J:272393
First Author: Lavado A
Year: 2018
Journal: Dev Cell
Title: The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number.
Volume: 47
Issue: 5
Pages: 576-591.e8
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Publication
21512031 | J:170963
First Author: Heallen T
Year: 2011
Journal: Science
Title: Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size.
Volume: 332
Issue: 6028
Pages: 458-61
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Publication
31980640 | J:283927
First Author: Choi SY
Year: 2020
Journal: Nat Commun
Title: YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells.
Volume: 11
Issue: 1
Pages: 519
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Publication
25912685 | J:224948
First Author: Lin C
Year: 2015
Journal: Dev Biol
Title: A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth.
Volume: 403
Issue: 1
Pages: 101-13
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Publication
30912742 | J:274694
   
First Author: Lodge EJ
Year: 2019
Journal: Elife
Title: Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade.
Volume: 8
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Publication
19786569 | J:155001
First Author: Oh S
Year: 2009
Journal: Mol Cell Biol
Title: Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse.
Volume: 29
Issue: 23
Pages: 6309-20
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Publication
27480037 | J:241275
 
First Author: Reginensi A
Year: 2016
Journal: Nat Commun
Title: A critical role for NF2 and the Hippo pathway in branching morphogenesis.
Volume: 7
Pages: 12309
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Publication
35918150 | J:330505
     
First Author: Drake KA
Year: 2022
Journal: J Am Soc Nephrol
Title: Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney.
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Publication
28943241 | J:245870
First Author: Cotton JL
Year: 2017
Journal: Dev Cell
Title: YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme.
Volume: 43
Issue: 1
Pages: 35-47.e4
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Publication
31323030 | J:279716
First Author: Braitsch CM
Year: 2019
Journal: PLoS Biol
Title: LATS1/2 suppress NFκB and aberrant EMT initiation to permit pancreatic progenitor differentiation.
Volume: 17
Issue: 7
Pages: e3000382
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Publication
35729116 | J:326354
First Author: Allègre N
Year: 2022
Journal: Nat Commun
Title: NANOG initiates epiblast fate through the coordination of pluripotency genes expression.
Volume: 13
Issue: 1
Pages: 3550
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Publication
- | J:101679
     
First Author: Deltagen Inc
Year: 2005
Journal: MGI Direct Data Submission
Title: NIH initiative supporting placement of Deltagen, Inc. mice into public repositories
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Publication
19906978 | J:154739
First Author: Quina LA
Year: 2009
Journal: J Neurosci
Title: Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.
Volume: 29
Issue: 45
Pages: 14309-22
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
18973680 | J:141291
 
First Author: Tamplin OJ
Year: 2008
Journal: BMC Genomics
Title: Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.
Volume: 9
Pages: 511
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:101977
     
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
28644436 | J:268162
First Author: Furth N
Year: 2017
Journal: Cell Death Differ
Title: The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway.
Volume: 24
Issue: 9
Pages: 1488-1501
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UniProt Feature
UniProt Feature
Begin: 1
Description: Serine/threonine-protein kinase LATS2
Type: chain
End: 1042
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UniProt Feature
UniProt Feature
Begin: 306
Description: Phosphoserine; by LATS2
Type: modified residue
End: 306
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UniProt Feature
UniProt Feature
Begin: 89
Description: Phosphoserine; by LATS2
Type: modified residue
End: 89
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Publication
31848340 | J:283786
First Author: Tang F
Year: 2019
Journal: Nat Commun
Title: LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function.
Volume: 10
Issue: 1
Pages: 5755
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Protein
G3UXX1
Organism: Mus musculus/domesticus
Length: 12  
Fragment?: true
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Protein
G3UWQ0
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
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Protein
G3UZ29
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Protein
Q8VHE2
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: false
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Protein
Q8VHE1
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: false
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UniProt Feature
UniProt Feature
Begin: 382
Description: Phosphoserine; by LATS1 and LATS2
Type: modified residue
End: 382
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UniProt Feature
UniProt Feature
Begin: 149
Description: Phosphoserine; by LATS1 and LATS2
Type: modified residue
End: 149
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Publication
28775168 | J:245725
First Author: Ye J
Year: 2017
Journal: Cancer Res
Title: JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity.
Volume: 77
Issue: 19
Pages: 5287-5300
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HT Experiment
E-GEOD-68824 | The effect of Lats2 knockout and diet on liver disease in mice
Series Id: GSE68824
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE135855 | Evaluation of the roles of Lats1 and Lats2 in the development of the Mullerian ducts
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Interaction Experiment
Tran THY (2019)
Description: Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.
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Publication
30865227 | -
First Author: Tran THY
Year: 2019
Journal: J Mol Cell Biol
Title: Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.
Volume: 11
Issue: 11
Pages: 1006-1017
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Allele
Lats2<tm1Smoc> | MGI:7290787
Name: large tumor suppressor 2; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
15746036 | -
First Author: Takahashi Y
Year: 2005
Journal: Clin Cancer Res
Title: Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers.
Volume: 11
Issue: 4
Pages: 1380-5
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Allele
Lats2<tm1Raz> | MGI:3056530
 
Name: large tumor suppressor 2; targeted mutation 1, Razqallah Hakem
Allele Type: Targeted
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Strain
MGI:6429098 | C57BL/6JSmoc-Lats2<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Lats2/Lats2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
19878866 | J:153949
First Author: Zhao B
Year: 2009
Journal: Cancer Cell
Title: Mst out and HCC in.
Volume: 16
Issue: 5
Pages: 363-4
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HT Experiment
GSE182721 | Lats1/2 control TGF-beta directed EMT in the dorsal cranial neuroepithelium through YAP regulation
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
12932328 | J:86640
First Author: Weidinger G
Year: 2003
Journal: Curr Biol
Title: dead end, a novel vertebrate germ plasm component, is required for zebrafish primordial germ cell migration and survival.
Volume: 13
Issue: 16
Pages: 1429-34
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Publication
17291453 | J:118625
First Author: Bhattacharya C
Year: 2007
Journal: Biochem Biophys Res Commun
Title: The mouse dead-end gene isoform alpha is necessary for germ cell and embryonic viability.
Volume: 355
Issue: 1
Pages: 194-9
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Publication
18509452 | J:136383
First Author: Bhattacharya C
Year: 2008
Journal: PLoS One
Title: Mouse apolipoprotein B editing complex 3 (APOBEC3) is expressed in germ cells and interacts with dead-end (DND1).
Volume: 3
Issue: 5
Pages: e2315
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Publication
18160032 | -
First Author: Ketting RF
Year: 2007
Journal: Cell
Title: A dead end for microRNAs.
Volume: 131
Issue: 7
Pages: 1226-7
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Protein Domain
IPR034414 | DND1_RRM1
Type: Domain
Description: This entry represents the RNA recognition motif 1 (RRM1) of DND1, an RNA-binding protein that is essential for maintaining viable germ cells in vertebrates [, ]. It interacts with the 3'-untranslated region (3'-UTR) of multiple messenger RNAs (mRNAs) and prevents micro-RNA (miRNA) mediated repression of mRNA [, ]. For instance, DND1 binds cell cycle inhibitor, P27 (p27Kip1, CDKN1B), and cell cycle regulator and tumor suppressor, LATS2 (large tumor suppressor, homologue 2 of Drosophila) []. It helps maintain their protein expression through blocking the inhibitory function of microRNAs (miRNA) from these transcripts. DND1 may also impose another level of translational regulation to modulate expression of critical factors in embryonic stem (ES) cells. DND1 interacts specifically with apolipoprotein B editing complex 3 (APOBEC3), a multi-functional protein inhibiting retroviral replication. The DND1-APOBEC3 interaction may play a role in maintaining viability of germ cells and for preventing germ cell tumor development []. DND1 contains two conserved RNA recognition motifs (RRMs).
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Publication
18155131 | -
First Author: Kedde M
Year: 2007
Journal: Cell
Title: RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.
Volume: 131
Issue: 7
Pages: 1273-86
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Publication
21851623 | -
 
First Author: Zhu R
Year: 2011
Journal: BMC Mol Biol
Title: Transcripts that associate with the RNA binding protein, DEAD-END (DND1), in embryonic stem (ES) cells.
Volume: 12
Pages: 37
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Publication
23791728 | J:199463
First Author: Cockburn K
Year: 2013
Journal: Curr Biol
Title: The Hippo pathway member Nf2 is required for inner cell mass specification.
Volume: 23
Issue: 13
Pages: 1195-201
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Publication
23890083 | J:335287
 
First Author: Ali S
Year: 2013
Journal: BMC Mol Biol
Title: APOBEC3 inhibits DEAD-END function to regulate microRNA activity.
Volume: 14
Pages: 16
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Publication
22286172 | J:327189
First Author: Qin H
Year: 2012
Journal: Hum Mol Genet
Title: Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming.
Volume: 21
Issue: 9
Pages: 2054-67
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Publication
29229597 | J:257853
First Author: Zhang Y
Year: 2018
Journal: Cancer Res
Title: Nkx2-2as Suppression Contributes to the Pathogenesis of Sonic Hedgehog Medulloblastoma.
Volume: 78
Issue: 4
Pages: 962-973
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Publication
27218122 | J:290419
 
First Author: Nakamura M
Year: 2016
Journal: JCI Insight
Title: Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury.
Volume: 1
Issue: 5
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Publication
21911408 | J:176882
First Author: Zheng GX
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Genome-wide impact of a recently expanded microRNA cluster in mouse.
Volume: 108
Issue: 38
Pages: 15804-9
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Publication
21278236 | J:170110
First Author: Li W
Year: 2011
Journal: Cancer Res
Title: Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers.
Volume: 71
Issue: 6
Pages: 2162-71
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Publication
22037235 | J:179215
First Author: Zhang H
Year: 2012
Journal: Dev Biol
Title: Negative regulation of Yap during neuronal differentiation.
Volume: 361
Issue: 1
Pages: 103-15
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Publication
26109050 | J:225729
First Author: Moroishi T
Year: 2015
Journal: Genes Dev
Title: A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis.
Volume: 29
Issue: 12
Pages: 1271-84
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Publication
29378174 | J:261115
First Author: Zhang S
Year: 2018
Journal: Am J Pathol
Title: Hippo Cascade Controls Lineage Commitment of Liver Tumors in Mice and Humans.
Volume: 188
Issue: 4
Pages: 995-1006
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Publication
30135582 | J:265296
First Author: Meng Z
Year: 2018
Journal: Nature
Title: RAP2 mediates mechanoresponses of the Hippo pathway.
Volume: 560
Issue: 7720
Pages: 655-660
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Publication
26530630 | J:269058
 
First Author: Mukai S
Year: 2015
Journal: Sci Rep
Title: Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B.
Volume: 5
Pages: 16173
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