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Search results 301 to 400 out of 1374 for Lox

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Type Details Score
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Strain
MGI:5905288 | B6.129-P2ry14<tm1Gac>/Orl
Attribute String: congenic, mutant strain, targeted mutation
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Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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Publication
28801621 | J:287496
First Author: Horii T
Year: 2017
Journal: Sci Rep
Title: Efficient generation of conditional knockout mice via sequential introduction of lox sites.
Volume: 7
Issue: 1
Pages: 7891
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Publication
10471751 | J:137342
First Author: Soukharev S
Year: 1999
Journal: Nucleic Acids Res
Title: Segmental genomic replacement in embryonic stem cells by double lox targeting.
Volume: 27
Issue: 18
Pages: e21
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Publication
12364620 | J:243719
First Author: Araki K
Year: 2002
Journal: Nucleic Acids Res
Title: Site-directed integration of the cre gene mediated by Cre recombinase using a combination of mutant lox sites.
Volume: 30
Issue: 19
Pages: e103
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Allele
Slc6a9<tm1.1Caz> | MGI:5085299
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 9; targeted mutation 1.1, Chiara Cazzin
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Chrna4<tm1.1Tmcg> | MGI:5285618
Name: cholinergic receptor, nicotinic, alpha polypeptide 4; targeted mutation 1.1, Tresa M McGranahan
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Cept1<tm1.1Sem> | MGI:6117770
Name: choline/ethanolaminephosphotransferase 1; targeted mutation 1.1, Clay F Semenkovich
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Flrt2<tm1c(EUCOMM)Wtsi> | MGI:6119416
Name: fibronectin leucine rich transmembrane protein 2; targeted mutation 1c, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready
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Publication
27877081 | J:286950
First Author: Qi C
Year: 2016
Journal: Int J Biol Sci
Title: P-selectin-mediated LOX expression promotes insulinoma growth in Rip1-Tag2 mice by increasing tissue stiffness.
Volume: 12
Issue: 11
Pages: 1289-1297
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Publication
28720379 | J:249754
 
First Author: Choudhary R
Year: 2017
Journal: Neuroscience
Title: Inhibition of 12/15 LOX ameliorates cognitive and cholinergic dysfunction in mouse model of hypobaric hypoxia via. attenuation of oxidative/nitrosative stress.
Volume: 359
Pages: 308-324
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Allele
Lox<em1Mech> | MGI:6406219
Name: lysyl oxidase; endonuclease-mediated mutation 1, Robert P Mecham
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Dhx33<em1Yazh> | MGI:6502108
Name: DEAH-box helicase 33; endonuclease-mediated mutation 1, Yandong Zhang
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready
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Allele
Mtr<tm1.1Ics> | MGI:7751203
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase; targeted mutation 1.1, Mouse Clinical Institute
Allele Type: Targeted
Attribute String: Conditional ready
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Publication
26077591 | J:233548
First Author: Miller BW
Year: 2015
Journal: EMBO Mol Med
Title: Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.
Volume: 7
Issue: 8
Pages: 1063-76
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Allele
Cdkn2a<tm4Rdp> | MGI:2687203
Name: cyclin dependent kinase inhibitor 2A; targeted mutation 4, Ronald DePinho
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Gabbr1<tm2Bet> | MGI:3512742
Name: gamma-aminobutyric acid type B receptor subunit 1; targeted mutation 2, Bernhard Bettler
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Ctnnb1<tm4Wbm> | MGI:2148594
Name: catenin beta 1; targeted mutation 4, Walter Birchmeier
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Slc2a4<tm1Abel> | MGI:2182083
Name: solute carrier family 2 (facilitated glucose transporter), member 4; targeted mutation 1, E Dale Abel
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
9664079 | J:115147
First Author: Holvoet P
Year: 1998
Journal: J Clin Invest
Title: Substitution of the carboxyl-terminal domain of apo AI with apo AII sequences restores the potential of HDL to reduce the progression of atherosclerosis in apo E knockout mice.
Volume: 102
Issue: 2
Pages: 379-85
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Publication
10669644 | J:130702
First Author: Holvoet P
Year: 2000
Journal: Arterioscler Thromb Vasc Biol
Title: The Arg123-Tyr166 central domain of human ApoAI is critical for lecithin:cholesterol acyltransferase-induced hyperalphalipoproteinemia and HDL remodeling in transgenic mice.
Volume: 20
Issue: 2
Pages: 459-66
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Publication
32210087 | J:304666
 
First Author: Benn A
Year: 2020
Journal: Biomolecules
Title: BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development.
Volume: 10
Issue: 3
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Publication
11023987 | J:119589
First Author: Theilmeier G
Year: 2000
Journal: FASEB J
Title: HDL-associated PAF-AH reduces endothelial adhesiveness in apoE-/- mice.
Volume: 14
Issue: 13
Pages: 2032-9
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Publication
27614188 | J:237835
 
First Author: Criel M
Year: 2016
Journal: Thromb Res
Title: Absence of Pear1 does not affect murine platelet function in vivo.
Volume: 146
Pages: 76-83
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Allele
Chuk<tm1Mpa> | MGI:3714160
Name: conserved helix-loop-helix ubiquitous kinase; targeted mutation 1, Manolis Pasparakis
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
33909875 | J:337232
First Author: de Haan W
Year: 2022
Journal: Cardiovasc Res
Title: Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis.
Volume: 118
Issue: 5
Pages: 1262-1275
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Allele
Slc17a6<tm1Lowl> | MGI:3771177
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; targeted mutation 1, Bradford B Lowell
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Crb2<tm1Vlcg> | MGI:5296808
Name: crumbs family member 2; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Nos1<tm3Plh> | MGI:5516456
Name: nitric oxide synthase 1, neuronal; targeted mutation 3, Paul L Huang
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Nkiras1<tm1Gho> | MGI:6342807
Name: NFKB inhibitor interacting Ras-like protein 1; targeted mutation 1, Sankar Ghosh
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Nkiras2<tm1Gho> | MGI:6342811
Name: NFKB inhibitor interacting Ras-like protein 2; targeted mutation 1, Sankar Ghosh
Allele Type: Targeted
Attribute String: Conditional ready
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Publication
22072575 | J:177837
First Author: Xiao Z
Year: 2011
Journal: Dev Dyn
Title: Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice.
Volume: 240
Issue: 12
Pages: 2646-56
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Allele
Pot1b<tm1Schg> | MGI:3831880
Name: protection of telomeres 1B; targeted mutation 1, Sandy Chang
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Aplnr<tm1.1Tq> | MGI:4367882
Name: apelin receptor; targeted mutation 1.1, Thomas Quertermous
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Lims2<tm1Chen> | MGI:4867245
Name: LIM and senescent cell antigen like domains 2; targeted mutation 1, Ju Chen
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Nkx2-2<tm1Suss> | MGI:5297809
Name: NK2 homeobox 2; targeted mutation 1, Lori Sussel
Allele Type: Targeted
Attribute String: Null/knockout, RMCE-ready
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Strain
MGI:5297068 | B6.Cg-Crb2<tm1Vlcg>
Attribute String: targeted mutation, mutant strain, congenic
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Allele
Sufu<tm1Zyzh> | MGI:5825362
Name: SUFU negative regulator of hedgehog signaling; targeted mutation 1, Zunyi Zhang
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Nkiras1<tm1.1Gho> | MGI:6342804
Name: NFKB inhibitor interacting Ras-like protein 1; targeted mutation 1.1, Sankar Ghosh
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Nkiras2<tm1.1Gho> | MGI:6342810
Name: NFKB inhibitor interacting Ras-like protein 2; targeted mutation 1.1, Sankar Ghosh
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Aplnr<tm1.2Tq> | MGI:6391402
Name: apelin receptor; targeted mutation 1.2, Thomas Quertermous
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Spata19<tm1Lij> | MGI:6510019
Name: spermatogenesis associated 19; targeted mutation 1, Jian Li
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Nrip1<tm1.1Ry> | MGI:6830912
Name: nuclear receptor interacting protein 1; targeted mutation 1.1, Rong Yuan
Allele Type: Targeted
Attribute String: Conditional ready
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Genotype
Genotype
Symbol: Crb2/Crb2
Background: B6.Cg-Crb2
Zygosity: hm
Has Mutant Allele: true
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Allele
C5ar1<tm1Raw> | MGI:3028524
Name: complement component 5a receptor 1; targeted mutation 1, Rick A Wetsel
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Npy1r<tm1Wpg> | MGI:3053795
Name: neuropeptide Y receptor Y1; targeted mutation 1, William P Gray
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Pik3ca<tm1Jjz> | MGI:3691486
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1, Jean J Zhao
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Strain
MGI:4452353 | STOCK Slc17a6<tm1Lowl>/J
Attribute String: targeted mutation, mutant stock
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Strain
MGI:6303611 | B6J.129S6(129S4)-Slc17a6<tm1Lowl>/RujfJ
Attribute String: targeted mutation, mutant strain, congenic
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Publication
28823729 | J:256028
First Author: Aguilar JI
Year: 2017
Journal: Neuron
Title: Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT.
Volume: 95
Issue: 5
Pages: 1074-1088.e7
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Allele
Sparc<tm1Anjm> | MGI:4421677
Name: secreted acidic cysteine rich glycoprotein; targeted mutation 1, Andrew N J McKenzie
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Ppib<tm1Rjb> | MGI:4462801
Name: peptidylprolyl isomerase B; targeted mutation 1, Richard J Bram
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Sufu<tm1.1Zyzh> | MGI:5825364
Name: SUFU negative regulator of hedgehog signaling; targeted mutation 1.1, Zunyi Zhang
Allele Type: Targeted
Attribute String: Not Specified
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Allele
Tuba8<tm1.1Ctpd> | MGI:6094270
Name: tubulin, alpha 8; targeted mutation 1.1, Christine P Diggle
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Gcgr<tm1.1Rdi> | MGI:6117294
Name: glucagon receptor; targeted mutation 1.1, Richard DiMarchi
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Tspyl2<tm1.1Yph> | MGI:6852744
Name: TSPY-like 2; targeted mutation 1.1, Yi-Ping Hsueh
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Tspyl2<tm1.2Yph> | MGI:6852745
Name: TSPY-like 2; targeted mutation 1.2, Yi-Ping Hsueh
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Nrip1<tm1.2Ry> | MGI:6830913
Name: nuclear receptor interacting protein 1; targeted mutation 1.2, Rong Yuan
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
H2-K1<b-em1Tyj> | MGI:7382781
Name: histocompatibility 2, K1, K region; endonuclease-mediated mutation 1, Tyler Jacks
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready
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Protein
Q8BP04
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
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Publication
1352776 | -
First Author: Svinarich DM
Year: 1992
Journal: J Biol Chem
Title: Characterization of the human lysyl oxidase gene locus.
Volume: 267
Issue: 20
Pages: 14382-7
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Protein Domain
IPR001246 | LipOase_plant
Type: Family
Description: Lipoxygenases ([intenz:1.13.11.-]) are a class of iron-containing dioxygenases which catalyses the hydroperoxidation of lipids, containing a cis,cis-1,4-pentadiene structure. They are common in plants where they may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Lipoxygenases can be classified as 9- and 13-lipoxygenases, according to the position of oxygen incorporation in linoleic acid and linolenic acid, the most important substrates for LOX catalysis in plants. There are six A. thaliana lipoxygenases identified: AtLOX1-6, among which AtLOX-1 and AtLOX-5 are 9S-lipoxygenases, and AtLOX-2, AtLOX-3, AtLOX-4 and AtLOX-6 are 13S-lipoxygenases [].
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Protein Domain
IPR001695 | Lysyl_oxidase
Type: Family
Description: Lysyl oxidase () (LOX) []is an extracellular copper-dependent enzyme that catalyses the oxidative deamination of peptidyl lysine residues in precursors of various collagens and elastins, yielding alpha-aminoadipic-delta-semialdehyde. The deaminated lysines are then able to form semialdehyde cross-links, resulting in the formation of insoluble collagen and elastin fibres in the extracellular matrix [].The active site of LOX resides towards the C terminus: this region also binds a single copper atom in an octahedral coordination complex involving at least 3 His residues []. Four histidine residues are clustered in a central region of the enzyme. This region is thought to be involved in cooper-binding and is called the 'copper-talon' [].
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Allele
Il2rg<tm1Cgn> | MGI:1861947
Name: interleukin 2 receptor, gamma chain; targeted mutation 1, University of Cologne
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Fgf8<tm2Mrc> | MGI:2150351
Name: fibroblast growth factor 8; targeted mutation 2, Mario R Capecchi
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Tg(GFP/KRAS2/ALPP)1Brn | MGI:2182853
Name: transgene insertion 1, Anton Berns
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Reporter
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Allele
Neurog3<tm1(EGFP)Khk> | MGI:2651394
Name: neurogenin 3; targeted mutation 1, Klaus H Kaestner
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:3811797 | B6.Cg-C5ar1<tm1Raw>
Attribute String: targeted mutation, congenic
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Publication
36434087 | J:334788
First Author: Coughlan MT
Year: 2022
Journal: Sci Rep
Title: Valproic acid attenuates cellular senescence in diabetic kidney disease through the inhibition of complement C5a receptors.
Volume: 12
Issue: 1
Pages: 20278
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Publication
18455242 | J:139786
First Author: Qi H
Year: 2008
Journal: J Neuroimmunol
Title: C5a is not involved in experimental autoimmune myasthenia gravis pathogenesis.
Volume: 196
Issue: 1-2
Pages: 101-6
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Publication
16997854 | J:117272
First Author: Connelly MA
Year: 2007
Journal: J Leukoc Biol
Title: Mycobacteria-primed macrophages and dendritic cells induce an up-regulation of complement C5a anaphylatoxin receptor (CD88) in CD3+ murine T cells.
Volume: 81
Issue: 1
Pages: 212-20
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Publication
22651932 | J:187444
First Author: Pavlovski D
Year: 2012
Journal: FASEB J
Title: Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis.
Volume: 26
Issue: 9
Pages: 3680-90
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Publication
23420882 | J:194466
First Author: Denny KJ
Year: 2013
Journal: J Immunol
Title: C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice.
Volume: 190
Issue: 7
Pages: 3493-9
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Publication
25681535 | J:259398
 
First Author: Benson MJ
Year: 2015
Journal: Neurobiol Dis
Title: A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models.
Volume: 76
Pages: 87-97
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Allele
Prkar1a<tm1.2Lsk> | MGI:3512112
Name: protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1.2, Lawrence Kirschner
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
30072881 | J:277165
 
First Author: Roccaro-Waldmeyer DM
Year: 2018
Journal: Front Behav Neurosci
Title: Eliminating the VGlut2-Dependent Glutamatergic Transmission of Parvalbumin-Expressing Neurons Leads to Deficits in Locomotion and Vocalization, Decreased Pain Sensitivity, and Increased Dominance.
Volume: 12
Pages: 146
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Allele
Akr1b7<tm1Fth> | MGI:3629296
Name: aldo-keto reductase family 1, member B7; targeted mutation 1, Franz Theuring
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Strain
MGI:5299922 | B6N.129-Pik3ca<tm1Jjz>/J
Attribute String: congenic, mutant strain, targeted mutation
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Allele
St6gal1<tm2Jxm> | MGI:3699718
Name: beta galactoside alpha 2,6 sialyltransferase 1; targeted mutation 2, Jamey Marth
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Inhba<tm3Zuk> | MGI:3758877
Name: inhibin beta-A; targeted mutation 3, Martin M Matzuk
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Pyy<tm1Batt> | MGI:3771166
Name: peptide YY; targeted mutation 1, Rachel L Batterham
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Pkp3<tm1Fvr> | MGI:3798859
Name: plakophilin 3; targeted mutation 1, Frans van Roy
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Mcl1<tm1Ywh> | MGI:3800294
Name: myeloid cell leukemia sequence 1; targeted mutation 1, You-Wen He
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Strain
MGI:4367998 | C57BL/6-Aplnr<tm1.1Tq>
Attribute String: coisogenic, mutant strain, targeted mutation
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Publication
23603510 | J:213291
First Author: Kang Y
Year: 2013
Journal: Circ Res
Title: Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
Volume: 113
Issue: 1
Pages: 22-31
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Publication
23681476 | J:204019
First Author: Han S
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Pancreatitis activates pancreatic apelin-APJ axis in mice.
Volume: 305
Issue: 2
Pages: G139-50
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Allele
Hbegf<tm1Hhar> | MGI:4398735
Name: heparin-binding EGF-like growth factor; targeted mutation 1, Hideaki Hara
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Tardbp<tm1.1Ckjs> | MGI:4418700
Name: TAR DNA binding protein; targeted mutation 1.1, C K James Shen
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Cttn<tm1.1Okab> | MGI:4418948
Name: cortactin; targeted mutation 1.1, Shigeo Okabe
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Casp6<tm1.1Xen> | MGI:5426935
Name: caspase 6; targeted mutation 1.1, Taconic Biosciences
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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•
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Allele
Hdac3<tm1.1Xen> | MGI:5426944
Name: histone deacetylase 3; targeted mutation 1.1, Taconic Biosciences
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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•
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Allele
Spo11<tm1Bdm> | MGI:5432496
 
Name: SPO11 initiator of meiotic double stranded breaks; targeted mutation 1, Bernard de Massy
Allele Type: Targeted
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•
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Allele
Eif2ak2<tm1Ajs> | MGI:5438001
 
Name: eukaryotic translation initiation factor 2-alpha kinase 2; targeted mutation 1, Anthony J Sadler
Allele Type: Targeted
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•
•
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Allele
Ddx5<tm1.1Arte> | MGI:5463981
Name: DEAD box helicase 5; targeted mutation 1.1, TaconicArtemis
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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