Type |
Details |
Score |
Publication |
First Author: |
Watanabe T |
Year: |
2002 |
Journal: |
Dev Biol |
Title: |
SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis. |
Volume: |
250 |
Issue: |
2 |
Pages: |
332-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Welsbie DS |
Year: |
2017 |
Journal: |
Neuron |
Title: |
Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. |
Volume: |
94 |
Issue: |
6 |
Pages: |
1142-1154.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang Z |
Year: |
1997 |
Journal: |
Genomics |
Title: |
Identification, partial characterization, and genetic mapping of kinesin-like protein genes in mouse. |
Volume: |
45 |
Issue: |
1 |
Pages: |
123-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bogani D |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. |
Volume: |
7 |
Issue: |
9 |
Pages: |
e1000196 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sugiyama D |
Year: |
2011 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Hepatoblasts comprise a niche for fetal liver erythropoiesis through cytokine production. |
Volume: |
410 |
Issue: |
2 |
Pages: |
301-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamasaki T |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex. |
Volume: |
31 |
Issue: |
46 |
Pages: |
16872-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goodwani S |
Year: |
2020 |
Journal: |
Int J Mol Sci |
Title: |
Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions. |
Volume: |
21 |
Issue: |
14 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2007 |
Journal: |
Mol Cell Biol |
Title: |
Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death. |
Volume: |
27 |
Issue: |
22 |
Pages: |
7935-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sugiyama D |
Year: |
2013 |
Journal: |
Mech Dev |
Title: |
TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts. |
Volume: |
130 |
Issue: |
2-3 |
Pages: |
195-206 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kelkar N |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). |
Volume: |
100 |
Issue: |
17 |
Pages: |
9843-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Breitwieser W |
Year: |
2007 |
Journal: |
Genes Dev |
Title: |
Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. |
Volume: |
21 |
Issue: |
16 |
Pages: |
2069-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goodwin N |
Year: |
1998 |
Journal: |
MGI Direct Data Submission |
Title: |
An embryonic stem cell bank for producing deletion complexes in mice |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GO Central curators, GOA curators, Rhea curators |
Year: |
2020 |
|
Title: |
Automatic Gene Ontology annotation based on Rhea mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators, MGI curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation based on Enzyme Commission mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
185 |
Description: |
Phosphotyrosine; by MAP2K4 |
Type: |
modified residue |
End: |
185 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
223 |
Description: |
Phosphotyrosine; by MAP2K4 |
Type: |
modified residue |
End: |
223 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
185 |
Description: |
Phosphotyrosine; by MAP2K4 |
Type: |
modified residue |
End: |
185 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
180 |
Description: |
Phosphothreonine; by MAP2K3, MAP2K4 and MAP2K6 |
Type: |
modified residue |
End: |
180 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
182 |
Description: |
Phosphotyrosine; by MAP2K3, MAP2K4 and MAP2K6 |
Type: |
modified residue |
End: |
182 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Y |
Year: |
2020 |
Journal: |
Neuroscience |
Title: |
Melatonin Promotes Neuroprotection of H2O2-induced Neural Stem Cells via lncRNA MEG3/miRNA-27a-3p/MAP2K4 axis. |
Volume: |
446 |
|
Pages: |
69-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fei J |
Year: |
2018 |
Journal: |
Genes Dev |
Title: |
NDF, a nucleosome-destabilizing factor that facilitates transcription through nucleosomes. |
Volume: |
32 |
Issue: |
9-10 |
Pages: |
682-694 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fang R |
Year: |
2013 |
Journal: |
Mol Cell |
Title: |
LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation. |
Volume: |
49 |
Issue: |
3 |
Pages: |
558-70 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
The PWWP domain is an essential part of the cytokine-like nuclear factor N-PAC protein, also known as NP60 or GLYR1, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha []. NPAC/GLYR1 is a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation and facilitates Pol II transcription through nucleosomes []. It is a KDM1B demethylase cofactor that stimulates H3K4me1 and H3K4me2 demethylation []. In addition to the PWWP domain, NP60 also contains an AT-hook and a C-terminal NAD-binding domain alpha [].The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding proteins, that function as transcription factors regulating a variety of developmental processes []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Fu J |
Year: |
2006 |
Journal: |
J Cell Sci |
Title: |
Nuclear protein NP60 regulates p38 MAPK activity. |
Volume: |
119 |
Issue: |
Pt 1 |
Pages: |
115-23 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
546
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
552
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Stec I |
Year: |
2000 |
Journal: |
FEBS Lett |
Title: |
The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation? |
Volume: |
473 |
Issue: |
1 |
Pages: |
1-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|