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Search results 301 to 316 out of 316 for Map2k6

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Type

Details

Score

Allele

Map2k6<em1Smoc> | MGI:7290954

Name:	mitogen-activated protein kinase kinase 6; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

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Allele

Tg(ACTA1-MAP2K6)#Jmol | MGI:5550391

Name:	transgene insertion, Jeffery Molkentin
Allele Type:	Transgenic
Attribute String:	Humanized sequence, Inserted expressed sequence

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Strain

MGI:6429147 | C57BL/6JSmoc-Map2k6<em1Smoc>/Smoc

Attribute String:

coisogenic, mutant strain, endonuclease-mediated mutation

•

Strain

MGI:5550390 | FVB/N-Tg(ACTA1-MAP2K6)#Jmol/J

Attribute String:

coisogenic, mutant strain, transgenic

•

Allele

Tg(Myh6-GFP,MAP2K6)8Ywa | MGI:3581034

Name:	transgene insertion 8, Yibin Wang
Allele Type:	Transgenic
Attribute String:	Inserted expressed sequence

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Genotype

Symbol:	Tg(Myh6-GFP,MAP2K6)8Ywa/?
Background:	Not Specified
Zygosity:	cn
Has Mutant Allele:	true

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Publication

29759984 | J:281258

First Author:	Fei J
Year:	2018
Journal:	Genes Dev
Title:	NDF, a nucleosome-destabilizing factor that facilitates transcription through nucleosomes.
Volume:	32
Issue:	9-10
Pages:	682-694

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Publication

23260659 | -

First Author:	Fang R
Year:	2013
Journal:	Mol Cell
Title:	LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation.
Volume:	49
Issue:	3
Pages:	558-70

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Protein Domain

IPR035501 | NP60_PWWP

Type:

Domain

Description:

The PWWP domain is an essential part of the cytokine-like nuclear factor N-PAC protein, also known as NP60 or GLYR1, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha []. NPAC/GLYR1 is a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation and facilitates Pol II transcription through nucleosomes []. It is a KDM1B demethylase cofactor that stimulates H3K4me1 and H3K4me2 demethylation []. In addition to the PWWP domain, NP60 also contains an AT-hook and a C-terminal NAD-binding domain alpha [].The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding proteins, that function as transcription factors regulating a variety of developmental processes [].

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Publication

15867183 | J:112249

First Author:	Li M
Year:	2005
Journal:	Circulation
Title:	p38 MAP kinase mediates inflammatory cytokine induction in cardiomyocytes and extracellular matrix remodeling in heart.
Volume:	111
Issue:	19
Pages:	2494-502

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Genotype

Symbol:	Tg(Myh6-GFP,MAP2K6)8Ywa/? Myl2/Myl2<+>
Background:	involves: 129S1/Sv * 129X1/SvJ
Zygosity:	cn
Has Mutant Allele:	true

•

Publication

16352664 | -

First Author:	Fu J
Year:	2006
Journal:	J Cell Sci
Title:	Nuclear protein NP60 regulates p38 MAPK activity.
Volume:	119
Issue:	Pt 1
Pages:	115-23

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Publication

24876160 | J:219250

First Author:	Wissing ER
Year:	2014
Journal:	Hum Mol Genet
Title:	P38α MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism.
Volume:	23
Issue:	20
Pages:	5452-63

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Protein

Q922P9

Organism:	Mus musculus/domesticus
Length:	546
Fragment?:	false

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Protein

D3YYT1

Organism:	Mus musculus/domesticus
Length:	552
Fragment?:	false

•

Publication

10802047 | -

First Author:	Stec I
Year:	2000
Journal:	FEBS Lett
Title:	The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?
Volume:	473
Issue:	1
Pages:	1-5

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