|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 301 to 380 out of 380 for Map3k14

<< First    < Previous  |  Next >    Last >>
0.021s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
27068467 | J:235180
First Author: Goldfarb Y
Year: 2016
Journal: Cell Rep
Title: HDAC3 Is a Master Regulator of mTEC Development.
Volume: 15
Issue: 3
Pages: 651-665
•
•
•
•
•
Publication
21527253 | J:172269
First Author: Ohshima D
Year: 2011
Journal: Biochem Biophys Res Commun
Title: RANK signaling induces interferon-stimulated genes in the fetal thymic stroma.
Volume: 408
Issue: 4
Pages: 530-6
•
•
•
•
•
Publication
15001576 | J:89527
First Author: Xu LG
Year: 2004
Journal: J Biol Chem
Title: TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis.
Volume: 279
Issue: 17
Pages: 17278-82
•
•
•
•
•
Publication
27401343 | J:236470
First Author: Akiyama N
Year: 2016
Journal: J Exp Med
Title: Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator.
Volume: 213
Issue: 8
Pages: 1441-58
•
•
•
•
•
Publication
19303389 | J:147033
First Author: Zindl CL
Year: 2009
Journal: Immunity
Title: The lymphotoxin LTalpha(1)beta(2) controls postnatal and adult spleen marginal sinus vascular structure and function.
Volume: 30
Issue: 3
Pages: 408-20
•
•
•
•
•
Publication
12505990 | J:81255
First Author: Yilmaz ZB
Year: 2003
Journal: EMBO J
Title: RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF.
Volume: 22
Issue: 1
Pages: 121-30
•
•
•
•
•
Publication
21441458 | J:173115
First Author: Mouri Y
Year: 2011
Journal: J Immunol
Title: Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.
Volume: 186
Issue: 9
Pages: 5047-57
•
•
•
•
•
Publication
25240383 | J:260268
First Author: Natsuaki Y
Year: 2014
Journal: Nat Immunol
Title: Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin.
Volume: 15
Issue: 11
Pages: 1064-9
•
•
•
•
•
Publication
23422957 | J:195312
First Author: Mancino A
Year: 2013
Journal: EMBO J
Title: I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection.
Volume: 32
Issue: 6
Pages: 816-28
•
•
•
•
•
Publication
20023630 | J:156764
First Author: Moro K
Year: 2010
Journal: Nature
Title: Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells.
Volume: 463
Issue: 7280
Pages: 540-4
•
•
•
•
•
Publication
18799150 | J:139648
First Author: Hikosaka Y
Year: 2008
Journal: Immunity
Title: The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.
Volume: 29
Issue: 3
Pages: 438-50
•
•
•
•
•
Publication
19822644 | J:154064
First Author: Nagatake T
Year: 2009
Journal: J Exp Med
Title: Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.
Volume: 206
Issue: 11
Pages: 2351-64
•
•
•
•
•
Publication
29849151 | J:263554
First Author: Du X
Year: 2018
Journal: Nature
Title: Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells.
Volume: 558
Issue: 7708
Pages: 141-145
•
•
•
•
•
Publication
33207209 | J:306399
First Author: Guendel F
Year: 2020
Journal: Immunity
Title: Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues.
Volume: 53
Issue: 5
Pages: 1015-1032.e8
•
•
•
•
•
Publication
25376721 | J:228639
First Author: Blackburn J
Year: 2015
Journal: J Dent Res
Title: Excess NF-κB induces ectopic odontogenesis in embryonic incisor epithelium.
Volume: 94
Issue: 1
Pages: 121-8
•
•
•
•
•
Publication
10687308 | J:60454
First Author: Matsumoto M
Year: 1999
Journal: J Med Invest
Title: Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting.
Volume: 46
Issue: 3-4
Pages: 141-50
•
•
•
•
•
Publication
18855897 | J:141097
First Author: Craig EA
Year: 2008
Journal: Dev Dyn
Title: MAP3Ks as central regulators of cell fate during development.
Volume: 237
Issue: 11
Pages: 3102-14
•
•
•
•
•
Publication
23913046 | J:208234
First Author: Satpathy AT
Year: 2013
Journal: Nat Immunol
Title: Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Volume: 14
Issue: 9
Pages: 937-48
•
•
•
•
•
Publication
18799149 | J:139649
First Author: Akiyama T
Year: 2008
Journal: Immunity
Title: The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
Volume: 29
Issue: 3
Pages: 423-37
•
•
•
•
•
Publication
28709801 | J:259045
First Author: Onder L
Year: 2017
Journal: Immunity
Title: Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis.
Volume: 47
Issue: 1
Pages: 80-92.e4
•
•
•
•
•
Publication
22761313 | J:185495
First Author: Arnold CN
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.
Volume: 109
Issue: 31
Pages: 12286-93
•
•
•
•
•
Publication
12648490 | J:82631
First Author: Fukuda K
Year: 2003
Journal: Dev Biol
Title: Mesenchymal expression of Foxl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs.
Volume: 255
Issue: 2
Pages: 278-89
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•
Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
•
•
•
•
•
Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
•
•
•
•
•
Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
•
•
•
•
•
Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
•
•
•
•
•
Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
•
•
•
•
•
Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
•
•
•
•
•
Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
•
•
•
•
•
Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
•
•
•
•
•
Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
•
•
•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
•
•
•
•
•
Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 176
Description: Phosphoserine; by MAP3K14
Type: modified residue
End: 176
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 869
Description: Phosphoserine; by MAP3K14
Type: modified residue
End: 869
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 865
Description: Phosphoserine; by MAP3K14
Type: modified residue
End: 865
•
•
•
•
•
Allele
Map3k14<em1Smoc> | MGI:7290958
Name: mitogen-activated protein kinase kinase kinase 14; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Strain
MGI:6429149 | C57BL/6JSmoc-Map3k14<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
•
•
•
•
•
Publication
20184394 | -
First Author: Kanno Y
Year: 2010
Journal: J Recept Signal Transduct Res
Title: TACI induces cIAP1-mediated ubiquitination of NIK by TRAF2 and TANK to limit non-canonical NF-kappaB signaling.
Volume: 30
Issue: 2
Pages: 121-32
•
•
•
•
•
Publication
19909783 | -
First Author: Kim HB
Year: 2010
Journal: Biosystems
Title: NIK and IKKbeta interdependence in NF-kappaB signalling--flux analysis of regulation through metabolites.
Volume: 99
Issue: 2
Pages: 140-9
•
•
•
•
•
Protein Domain
IPR042787 | M3K14_STKc
Type: Domain
Description: STKs catalyse the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K14 (also known as NIK) phosphorylates and activates Inhibitor of NF-KappaB Kinase (IKK) alpha, which is a regulator of NF-kB proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others []. NIK is essential in the IKKalpha-mediated non-canonical NF-kB signaling pathway, in which IKKalpha processes the IkB-like C terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus where it regulates gene transcription [, , ].
•
•
•
•
•
Protein Domain
IPR037306 | TRAF1_MATH
Type: Domain
Description: TNF receptor-associated factor 1 (TRAF1) plays a role in the regulation of cell survival and apoptosis []. TRAF1 is unique among TRAF proteins in that it lacks a RING domain found in the N-terminal regions of other TRAFs []. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14 [, ].TRAF1 is unique among the TRAFs in that it lacks a RING domain, which is critical for the activation of nuclear factor-kappaB and Jun NH2-terminal kinase. Studies on TRAF1-deficient mice suggest that TRAF1 has a negative regulatory role in TNFR-mediated signaling events []. TRAF1 contains one zinc finger and one TRAF domain.The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded β-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors [, ].
•
•
•
•
•
Protein Domain
IPR027136 | TRAF1
Type: Family
Description: TNF receptor-associated factor 1 (TRAF1) plays a role in the regulation of cell survival and apoptosis []. TRAF1 is unique among TRAF proteins in that it lacks a RING domain found in the N-terminal regions of other TRAFs []. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14 [, ].TRAF1 is unique among the TRAFs in that it lacks a RING domain, which is critical for the activation of nuclear factor-kappaB and Jun NH2-terminal kinase. Studies on TRAF1-deficient mice suggest that TRAF1 has a negative regulatory role in TNFR-mediated signaling events []. TRAF1 contains one zinc finger and one TRAF domain.
•
•
•
•
•
Publication
18429822 | J:141705
First Author: Kato T Jr
Year: 2008
Journal: Genes Cells
Title: Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1.
Volume: 13
Issue: 5
Pages: 509-20
•
•
•
•
•
Publication
20385093 | -
First Author: Zheng C
Year: 2010
Journal: Mol Cell
Title: Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.
Volume: 38
Issue: 1
Pages: 101-13
•
•
•
•
•
Publication
10692572 | -
First Author: Irmler M
Year: 2000
Journal: FEBS Lett
Title: Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis.
Volume: 468
Issue: 2-3
Pages: 129-33
•
•
•
•
•
Publication
17633014 | -
 
First Author: Lee SY
Year: 2007
Journal: Adv Exp Med Biol
Title: TRAF1 and its biological functions.
Volume: 597
Pages: 25-31
•
•
•
•
•
Publication
12023442 | -
First Author: Zapata JM
Year: 2002
Journal: Sci STKE
Title: TRAF1: lord without a RING.
Volume: 2002
Issue: 133
Pages: pe27
•
•
•
•
•
Protein
Q8C245
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: false
•
•
•
•
•
Protein
P39428
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
•
•
•
•
•
Protein
Q3UM74
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
•
•
•
•
•
Protein
Q4VA12
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
•
•
•
•
•
Protein
Q9WUL6
Organism: Mus musculus/domesticus
Length: 942  
Fragment?: false
•
•
•
•
•
Protein
Q544K4
Organism: Mus musculus/domesticus
Length: 942  
Fragment?: false
•
•
•
•
•
Publication
10518213 | J:57751
First Author: Ye H
Year: 1999
Journal: Mol Cell
Title: The structural basis for the recognition of diverse receptor sequences by TRAF2.
Volume: 4
Issue: 3
Pages: 321-30
•
•
•
•
•
Publication
10206649 | -
First Author: Park YC
Year: 1999
Journal: Nature
Title: Structural basis for self-association and receptor recognition of human TRAF2.
Volume: 398
Issue: 6727
Pages: 533-8
•
•
•
•
•
Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom