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Search results 301 to 400 out of 425 for Mavs

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Type Details Score
Publication
22541070 | J:186198
First Author: Tarallo V
Year: 2012
Journal: Cell
Title: DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.
Volume: 149
Issue: 4
Pages: 847-59
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Publication
32150572 | J:287406
First Author: Place DE
Year: 2020
Journal: PLoS Pathog
Title: Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.
Volume: 16
Issue: 3
Pages: e1008364
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Publication
21820332 | J:175845
First Author: Sharma S
Year: 2011
Journal: Immunity
Title: Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
Volume: 35
Issue: 2
Pages: 194-207
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Publication
26682986 | J:257995
First Author: Xu RH
Year: 2015
Journal: Immunity
Title: Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection.
Volume: 43
Issue: 6
Pages: 1148-59
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Publication
27374884 | J:291655
 
First Author: Hayashi M
Year: 2016
Journal: Sci Rep
Title: RNA is an Adjuvanticity Mediator for the Lipid-Based Mucosal Adjuvant, Endocine.
Volume: 6
Pages: 29165
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Publication
27793594 | J:258326
First Author: Yu X
Year: 2016
Journal: Immunity
Title: Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality.
Volume: 45
Issue: 5
Pages: 1093-1107
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Publication
33165593 | J:300370
     
First Author: Onizawa H
Year: 2020
Journal: Int Immunol
Title: Aicardi-Goutières syndrome-like encephalitis in mutant mice with constitutively active MDA5.
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Publication
34471287 | J:361095
First Author: Lee S
Year: 2021
Journal: Nature
Title: AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.
Volume: 597
Issue: 7876
Pages: 415-419
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Publication
27917412 | J:290369
 
First Author: Kuriakose T
Year: 2016
Journal: Sci Immunol
Title: ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.
Volume: 1
Issue: 2
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Publication
34678150 | J:337628
First Author: Xue G
Year: 2021
Journal: Cancer Cell
Title: Adoptive cell therapy with tumor-specific Th9 cells induces viral mimicry to eliminate antigen-loss-variant tumor cells.
Volume: 39
Issue: 12
Pages: 1610-1622.e9
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Publication
29576451 | J:262477
First Author: Karki R
Year: 2018
Journal: Cell
Title: IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.
Volume: 173
Issue: 4
Pages: 920-933.e13
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Publication
33278357 | J:361144
First Author: Karki R
Year: 2021
Journal: Cell
Title: Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.
Volume: 184
Issue: 1
Pages: 149-168.e17
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Publication
28400473 | J:242009
First Author: Choo MK
Year: 2017
Journal: J Exp Med
Title: TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.
Volume: 214
Issue: 5
Pages: 1297-1311
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Publication
36458554 | J:333559
 
First Author: Rupani DN
Year: 2023
Journal: Development
Title: Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling.
Volume: 150
Issue: 2
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Publication
- | J:165963
     
First Author: Centre for Modeling Human Disease
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
18614015 | J:151002
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
21617692 | J:203095
First Author: Rebsamen M
Year: 2011
Journal: Cell Death Differ
Title: NLRX1/NOD5 deficiency does not affect MAVS signalling.
Volume: 18
Issue: 8
Pages: 1387
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Publication
26348439 | J:227019
 
First Author: Xia P
Year: 2015
Journal: Nat Commun
Title: IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation.
Volume: 6
Pages: 8132
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Publication
32679077 | J:294274
First Author: Zhang Z
Year: 2020
Journal: Mol Cell
Title: Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity.
Volume: 79
Issue: 2
Pages: 304-319.e7
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HT Experiment
E-MTAB-11537 | RNA-sequencing of brain RNA from mice with compound mutations in ADAR1 and MAVS or ZBP1
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
36028484 | J:328263
First Author: Bai X
Year: 2022
Journal: Nat Commun
Title: The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation.
Volume: 13
Issue: 1
Pages: 5016
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Publication
28469175 | J:281202
 
First Author: Shi Y
Year: 2017
Journal: Nat Commun
Title: Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity.
Volume: 8
Pages: 15138
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Publication
33177519 | J:297778
First Author: Hanada Y
Year: 2020
Journal: Nat Commun
Title: MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity.
Volume: 11
Issue: 1
Pages: 5711
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Publication
34239064 | J:310614
First Author: Wang S
Year: 2021
Journal: Nat Cell Biol
Title: Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity.
Volume: 23
Issue: 7
Pages: 718-732
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Publication
39141356 | J:353407
First Author: Liu Y
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: MAVS Cys508 palmitoylation promotes its aggregation on the mitochondrial outer membrane and antiviral innate immunity.
Volume: 121
Issue: 34
Pages: e2403392121
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Publication
27419230 | J:259873
First Author: Xiang W
Year: 2016
Journal: Sci Adv
Title: PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1.
Volume: 2
Issue: 7
Pages: e1501889
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Publication
28099857 | J:254031
First Author: Dutta M
Year: 2017
Journal: Cell Rep
Title: A Systems Approach Reveals MAVS Signaling in Myeloid Cells as Critical for Resistance to Ebola Virus in Murine Models of Infection.
Volume: 18
Issue: 3
Pages: 816-829
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Interaction Experiment
Wang Y (2012)
Description: Ndfip1 Negatively Regulates RIG-I-Dependent Immune Signaling by Enhancing E3 Ligase Smurf1-Mediated MAVS Degradation.
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Interaction Experiment
Liu S (2013)
Description: MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades.
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Interaction Experiment
Guan K (2015)
Description: MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3.
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Allele
Mavs<em2Smoc> | MGI:7264801
Name: mitochondrial antiviral signaling protein; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6770929 | C57BL/6JSmoc-Mavs<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Nod1<em1Smoc> | MGI:7291344
Name: nucleotide-binding oligomerization domain containing 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6355068 | C57BL/6JSmoc-Nod1<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Protein
Q8VCF0
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Interaction Experiment
Liu B (2017)
Description: The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination.
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Allele
Mavs<tm1Smoc> | MGI:7786904
Name: mitochondrial antiviral signaling protein; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
23087404 | -
First Author: Wang Y
Year: 2012
Journal: J Immunol
Title: Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation.
Volume: 189
Issue: 11
Pages: 5304-13
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Publication
34845370 | -
First Author: Li X
Year: 2022
Journal: Cell Mol Immunol
Title: SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy.
Volume: 19
Issue: 1
Pages: 67-78
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Strain
MGI:7788743 | C57BL/6JSmoc-Mavs<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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GO Term
GO:0039532 | negative regulation of cytoplasmic pattern recognition receptor signaling pathway
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Ontology Term
- | Inhibition of host MDA5 by virus
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HT Experiment
E-MTAB-11540 | RNA-sequencing of lung RNA from mice with compound mutations in ADAR1 and MAVS, ZBP1 or RIPK3.
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Ontology Term
- | Inhibition of host IKBKE by virus
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Protein
Q9D3J9
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
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Protein
Q8BHV4
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
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Protein
A2ALN9
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
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Protein
Q08EG0
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
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Publication
31001245 | -
 
First Author: Harris VM
Year: 2019
Journal: Front Immunol
Title: Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells Expressing CXorf21.
Volume: 10
Pages: 578
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Publication
32433612 | -
First Author: Heinz LX
Year: 2020
Journal: Nature
Title: TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9.
Volume: 581
Issue: 7808
Pages: 316-322
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Protein Domain
IPR027869 | TASL
Type: Family
Description: In humans, TASL (TLR adaptor interacting with SLC15A4 on the lysosome) is encoded by CXorf21 that is associated with systemic lupus erythematosus []. It is an immune adaptor that is required for recruitment and activation of IRF5 by TLR7, TLR8 and TLR9, in mechanistic analogy to IRF3 and its three adaptors STING, MAVS and TRIF. TASL interacts with the endolysosomal transporter SLC15A4; the SLC15A4-TASL complex is required for endolysosomal TLR signalling. TASL contains a pLxIS motif that is important for its function [].
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Ontology Term
- | Inhibition of host RLR pathway by virus
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HT Experiment
E-GEOD-62917 | The RNA editing enzyme ADAR1 is a key regulatory of innate immune responses to RNA
Series Id: GSE62917
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
17468758 | J:122421
First Author: Zhao T
Year: 2007
Journal: Nat Immunol
Title: The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.
Volume: 8
Issue: 6
Pages: 592-600
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Publication
22314235 | J:182522
First Author: Berke IC
Year: 2012
Journal: EMBO J
Title: MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA.
Volume: 31
Issue: 7
Pages: 1714-26
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Publication
31324787 | J:279453
First Author: Li SZ
Year: 2019
Journal: Nat Commun
Title: Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response.
Volume: 10
Issue: 1
Pages: 3233
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Publication
30543776 | J:352725
First Author: Li T
Year: 2018
Journal: Cell Host Microbe
Title: O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity.
Volume: 24
Issue: 6
Pages: 791-803.e6
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Publication
32497523 | J:305837
First Author: Gao Y
Year: 2020
Journal: Immunity
Title: m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development.
Volume: 52
Issue: 6
Pages: 1007-1021.e8
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Publication
22749352 | J:187408
First Author: Lei Y
Year: 2012
Journal: Immunity
Title: The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.
Volume: 36
Issue: 6
Pages: 933-46
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Publication
26947079 | J:234562
First Author: Jiang C
Year: 2016
Journal: Cell Rep
Title: CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection.
Volume: 14
Issue: 10
Pages: 2389-401
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Publication
28542569 | J:245551
First Author: Kim JH
Year: 2017
Journal: PLoS Pathog
Title: FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1.
Volume: 13
Issue: 5
Pages: e1006398
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Publication
29769269 | J:263336
First Author: Xing J
Year: 2018
Journal: J Immunol
Title: TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus.
Volume: 201
Issue: 1
Pages: 183-192
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Publication
21703540 | J:173995
First Author: Allen IC
Year: 2011
Journal: Immunity
Title: NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.
Volume: 34
Issue: 6
Pages: 854-65
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Publication
28967880 | J:258696
First Author: Feng H
Year: 2017
Journal: Nat Immunol
Title: NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR.
Volume: 18
Issue: 12
Pages: 1299-1309
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Publication
27595231 | J:259146
First Author: Lee EY
Year: 2016
Journal: Nat Immunol
Title: Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity.
Volume: 17
Issue: 11
Pages: 1252-1262
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Publication
36384137 | J:350509
First Author: Zhang Q
Year: 2022
Journal: Mol Cell
Title: AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity.
Volume: 82
Issue: 23
Pages: 4519-4536.e7
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Publication
29734366 | J:324167
First Author: Zhang L
Year: 2018
Journal: PLoS Pathog
Title: Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome.
Volume: 14
Issue: 5
Pages: e1007067
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Publication
28273895 | J:336080
First Author: Doiron K
Year: 2017
Journal: Sci Rep
Title: The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity.
Volume: 7
Issue: 1
Pages: 107
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Publication
23090998 | J:191237
First Author: Berke IC
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: MDA5 assembles into a polar helical filament on dsRNA.
Volume: 109
Issue: 45
Pages: 18437-41
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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