Type |
Details |
Score |
Publication |
First Author: |
El-Saafin F |
Year: |
2022 |
Journal: |
Cell Death Differ |
Title: |
Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. |
Volume: |
29 |
Issue: |
5 |
Pages: |
1013-1027 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hughes CHK |
Year: |
2023 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve. |
Volume: |
120 |
Issue: |
32 |
Pages: |
e2220849120 |
|
•
•
•
•
•
|
Publication |
First Author: |
Soma S |
Year: |
2024 |
Journal: |
Stem Cells |
Title: |
O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation. |
Volume: |
42 |
Issue: |
1 |
Pages: |
55-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lumayag S |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. |
Volume: |
110 |
Issue: |
6 |
Pages: |
E507-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt |
Year: |
2021 |
|
Title: |
Electronic Gene Ontology annotations created by ARBA machine learning models |
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•
•
•
•
•
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Publication |
First Author: |
Freeman TC |
Year: |
1998 |
Journal: |
MGI Direct Data Submission |
Title: |
Expression Mapping of Mouse Genes |
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•
•
•
•
•
|
Publication |
First Author: |
Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom |
Year: |
2023 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
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•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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•
•
•
•
•
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Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
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•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
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•
•
•
•
•
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Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
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•
•
•
•
•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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|
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•
•
•
•
•
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
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•
•
•
•
•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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|
|
|
•
•
•
•
•
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
•
•
•
•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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|
•
•
•
•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Zhou P |
Year: |
2001 |
Journal: |
Blood |
Title: |
MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes. |
Volume: |
97 |
Issue: |
12 |
Pages: |
3902-9 |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Publication |
First Author: |
Wei G |
Year: |
2006 |
Journal: |
Cancer Cell |
Title: |
Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. |
Volume: |
10 |
Issue: |
4 |
Pages: |
331-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Allen TD |
Year: |
2011 |
Journal: |
Cancer Res |
Title: |
Interaction between MYC and MCL1 in the genesis and outcome of non-small-cell lung cancer. |
Volume: |
71 |
Issue: |
6 |
Pages: |
2212-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen L |
Year: |
2015 |
Journal: |
Leukemia |
Title: |
Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition. |
Volume: |
29 |
Issue: |
6 |
Pages: |
1290-300 |
|
•
•
•
•
•
|
Publication |
First Author: |
Caenepeel S |
Year: |
2018 |
Journal: |
Cancer Discov |
Title: |
AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies. |
Volume: |
8 |
Issue: |
12 |
Pages: |
1582-1597 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 8, Ruth W Craig |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, mutant stock |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou P |
Year: |
1998 |
Journal: |
Blood |
Title: |
Mcl-1 in transgenic mice promotes survival in a spectrum of hematopoietic cell types and immortalization in the myeloid lineage. |
Volume: |
92 |
Issue: |
9 |
Pages: |
3226-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marriott HM |
Year: |
2005 |
Journal: |
J Clin Invest |
Title: |
Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance. |
Volume: |
115 |
Issue: |
2 |
Pages: |
359-68 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(MCL1)8Caig/? |
Background: |
involves: C57BL/6 * SJL |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Li W |
Year: |
2013 |
Journal: |
Blood |
Title: |
Apc regulates the function of hematopoietic stem cells largely through β-catenin-dependent mechanisms. |
Volume: |
121 |
Issue: |
20 |
Pages: |
4063-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Annunziato S |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer. |
Volume: |
10 |
Issue: |
1 |
Pages: |
397 |
|
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•
•
•
•
|
Publication |
First Author: |
Ertel F |
Year: |
2013 |
Journal: |
EMBO Rep |
Title: |
Programming cancer cells for high expression levels of Mcl1. |
Volume: |
14 |
Issue: |
4 |
Pages: |
328-36 |
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•
•
•
•
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Publication |
First Author: |
Haschka MD |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest. |
Volume: |
6 |
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Pages: |
6891 |
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•
•
•
•
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Publication |
First Author: |
Miletic AV |
Year: |
2010 |
Journal: |
J Exp Med |
Title: |
Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases. |
Volume: |
207 |
Issue: |
11 |
Pages: |
2407-20 |
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•
•
•
•
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Publication |
First Author: |
Benavente CA |
Year: |
2013 |
Journal: |
Oncotarget |
Title: |
Cross-species genomic and epigenomic landscape of retinoblastoma. |
Volume: |
4 |
Issue: |
6 |
Pages: |
844-59 |
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•
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Publication |
First Author: |
Jacque E |
Year: |
2015 |
Journal: |
J Exp Med |
Title: |
BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival. |
Volume: |
212 |
Issue: |
6 |
Pages: |
883-92 |
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•
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Publication |
First Author: |
Qian Z |
Year: |
2008 |
Journal: |
J Exp Med |
Title: |
A critical role for Apc in hematopoietic stem and progenitor cell survival. |
Volume: |
205 |
Issue: |
9 |
Pages: |
2163-75 |
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Publication |
First Author: |
Ebner F |
Year: |
2017 |
Journal: |
J Clin Invest |
Title: |
The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection. |
Volume: |
127 |
Issue: |
6 |
Pages: |
2051-2065 |
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Publication |
First Author: |
Fedorchenko O |
Year: |
2013 |
Journal: |
Blood |
Title: |
CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia. |
Volume: |
121 |
Issue: |
20 |
Pages: |
4126-36 |
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•
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Publication |
First Author: |
Cantley J |
Year: |
2011 |
Journal: |
Diabetologia |
Title: |
Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo. |
Volume: |
54 |
Issue: |
2 |
Pages: |
380-9 |
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Publication |
First Author: |
Pekarsky Y |
Year: |
2010 |
Journal: |
Semin Cancer Biol |
Title: |
Molecular basis of CLL. |
Volume: |
20 |
Issue: |
6 |
Pages: |
370-6 |
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Publication |
First Author: |
Jones KB |
Year: |
2013 |
Journal: |
Oncogene |
Title: |
SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas. |
Volume: |
32 |
Issue: |
18 |
Pages: |
2365-71, 2375.e1-5 |
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Publication |
First Author: |
Wang Y |
Year: |
2014 |
Journal: |
J Exp Med |
Title: |
Adjuvant-specific regulation of long-term antibody responses by ZBTB20. |
Volume: |
211 |
Issue: |
5 |
Pages: |
841-56 |
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Publication |
First Author: |
Prutsch N |
Year: |
2019 |
Journal: |
Leukemia |
Title: |
Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma. |
Volume: |
33 |
Issue: |
3 |
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696-709 |
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Publication |
First Author: |
Jeyasuria P |
Year: |
2011 |
Journal: |
Biol Reprod |
Title: |
Elevated levels of uterine anti-apoptotic signaling may activate NFKB and potentially confer resistance to caspase 3-mediated apoptotic cell death during pregnancy in mice. |
Volume: |
85 |
Issue: |
2 |
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417-24 |
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Publication |
First Author: |
Merkel O |
Year: |
2012 |
Journal: |
Leukemia |
Title: |
Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia. |
Volume: |
26 |
Issue: |
12 |
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2508-16 |
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Publication |
First Author: |
Li Z |
Year: |
2015 |
Journal: |
J Clin Invest |
Title: |
Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies. |
Volume: |
125 |
Issue: |
3 |
Pages: |
1081-97 |
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Publication |
First Author: |
Heneghan JF |
Year: |
2015 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
BH3 domain-independent apolipoprotein L1 toxicity rescued by BCL2 prosurvival proteins. |
Volume: |
309 |
Issue: |
5 |
Pages: |
C332-47 |
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Publication |
First Author: |
Viant C |
Year: |
2017 |
Journal: |
J Exp Med |
Title: |
Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. |
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214 |
Issue: |
2 |
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491-510 |
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Publication |
First Author: |
Izumi M |
Year: |
2024 |
Journal: |
Cell Death Dis |
Title: |
Integrative single-cell RNA-seq and spatial transcriptomics analyses reveal diverse apoptosis-related gene expression profiles in EGFR-mutated lung cancer. |
Volume: |
15 |
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8 |
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580 |
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Publication |
First Author: |
Frieler RA |
Year: |
2017 |
Journal: |
Exp Neurol |
Title: |
Genetic neutrophil deficiency ameliorates cerebral ischemia-reperfusion injury. |
Volume: |
298 |
Issue: |
Pt A |
Pages: |
104-111 |
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Publication |
First Author: |
Hellmuth S |
Year: |
2020 |
Journal: |
Nature |
Title: |
Separase-triggered apoptosis enforces minimal length of mitosis. |
Volume: |
580 |
Issue: |
7804 |
Pages: |
542-547 |
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First Author: |
Chong Z |
Year: |
2018 |
Journal: |
Cell Mol Immunol |
Title: |
E3 ligase FBXW7 aggravates TMPD-induced systemic lupus erythematosus by promoting cell apoptosis. |
Volume: |
15 |
Issue: |
12 |
Pages: |
1057-1070 |
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Publication |
First Author: |
Jiao Y |
Year: |
2019 |
Journal: |
Cell Death Differ |
Title: |
Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes. |
Volume: |
26 |
Issue: |
8 |
Pages: |
1516-1530 |
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•
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Publication |
First Author: |
Debrincat MA |
Year: |
2015 |
Journal: |
Cell Death Dis |
Title: |
BCL-2 is dispensable for thrombopoiesis and platelet survival. |
Volume: |
6 |
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Pages: |
e1721 |
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Publication |
First Author: |
Evans DL |
Year: |
1995 |
Journal: |
J Mol Evol |
Title: |
Molecular evolution and secondary structural conservation in the B-cell lymphoma leukemia 2 (bcl-2) family of proto-oncogene products. |
Volume: |
41 |
Issue: |
6 |
Pages: |
775-83 |
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Publication |
First Author: |
Wang K |
Year: |
1996 |
Journal: |
Genes Dev |
Title: |
BID: a novel BH3 domain-only death agonist. |
Volume: |
10 |
Issue: |
22 |
Pages: |
2859-69 |
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Protein Domain |
Type: |
Domain |
Description: |
Apoptosis, or programmed cell death (PCD), is a common and evolutionarily conserved property of all metazoans []. In many biological processes, apoptosis is required to eliminate supernumerary or dangerous (such as pre-cancerous) cells and to promote normal development. Dysregulation of apoptosis can, therefore, contribute to the development of many major diseases including cancer, autoimmunity and neurodegenerative disorders. In most cases, proteins of the caspase family execute the genetic programme that leads to cell death.Bcl-2 proteins are central regulators of caspase activation, and play a key role in cell death by regulating the integrity of the mitochondrial and endoplasmic reticulum (ER) membranes []. At least 20 Bcl-2 proteins have been reported in mammals, and several others have been identified in viruses. Bcl-2 family proteins fall roughly into three subtypes, which either promote cell survival (anti-apoptotic) or trigger cell death (pro-apoptotic). All members contain at least one of four conserved motifs, termed Bcl-2 Homology (BH) domains. Bcl-2 subfamily proteins, which contain at least BH1 and BH2, promote cell survival by inhibiting the adapters needed for the activation of caspases.Pro-apoptotic members potentially exert their effects by displacing the adapters from the pro-survival proteins; these proteins belong either to the Bax subfamily, which contain BH1-BH3, or to the BH3 subfamily, which mostly only feature BH3 []. Thus, the balance between antagonistic family members is believed to play a role in determining cell fate. Members of the wider Bcl-2 family, which also includes Bcl-x, Bcl-w and Mcl-1, are described by their similarity to Bcl-2 protein, a member of the pro-survival Bcl-2 subfamily []. Full-length Bcl-2 proteins feature all four BH domains, seven α-helices, and a C-terminal hydrophobic motif that targets the protein to the outer mitochondrial membrane, ER and nuclear envelope. Active cell suicide (apoptosis) is induced by events such as growth factor withdrawal and toxins. It is controlled by regulators, which have either an inhibitory effect on programmed cell death (anti-apoptotic) or block the protective effect of inhibitors (pro-apoptotic) [,]. Many viruses have found a way of countering defensive apoptosis by encoding their own anti-apoptosis genes preventing their target-cells from dying too soon. All proteins belonging to the Bcl-2 family []contain either a BH1, BH2, BH3, or BH4 domain. All anti-apoptoticproteins contain BH1 and BH2 domains, some of them contain an additional N-terminal BH4 domain (Bcl-2, Bcl-x(L), Bcl-w), which is never seen in pro-apoptotic proteins, except for Bcl-x(S). On the other hand, all pro-apoptotic proteins contain a BH3 domain (except for Bad) necessary fordimerisation with other proteins of Bcl-2 family and crucial for their killing activity, some of them also contain BH1 and BH2 domains (Bax, Bak). The BH3 domain is also present in some anti-apoptotic protein, such as Bcl-2 or Bcl-x(L). Proteins that are known to contain these domains include vertebrateBcl-2 (alpha and beta isoforms) and Bcl-x (isoforms (Bcl-x(L) and Bcl-x(S)); mammalian proteins Bax and Bak; mouse protein Bid; Xenopus laevis proteins Xr1 and Xr11; human induced myeloid leukemia celldifferentiation protein MCL1 and Caenorhabditis elegans protein ced-9. |
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Publication |
First Author: |
Reed JC |
Year: |
1996 |
Journal: |
Adv Exp Med Biol |
Title: |
Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death. |
Volume: |
406 |
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Pages: |
99-112 |
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Publication |
First Author: |
Vaux DL |
Year: |
1993 |
Journal: |
Curr Biol |
Title: |
A boom time for necrobiology. |
Volume: |
3 |
Issue: |
12 |
Pages: |
877-8 |
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•
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
78
 |
Fragment?: |
true |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
96
 |
Fragment?: |
true |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
193
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
117
 |
Fragment?: |
true |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
154
 |
Fragment?: |
true |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
235
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
333
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
199
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
188
 |
Fragment?: |
true |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
233
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
236
 |
Fragment?: |
false |
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•
•
•
•
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