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Search results 301 to 400 out of 406 for Mcl1

0.031s
Type Details Score
Publication
First Author: El-Saafin F
Year: 2022
Journal: Cell Death Differ
Title: Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death.
Volume: 29
Issue: 5
Pages: 1013-1027
Publication
First Author: Hughes CHK
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve.
Volume: 120
Issue: 32
Pages: e2220849120
Publication
First Author: Soma S
Year: 2024
Journal: Stem Cells
Title: O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation.
Volume: 42
Issue: 1
Pages: 55-63
Publication
First Author: Lumayag S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.
Volume: 110
Issue: 6
Pages: E507-16
Publication        
First Author: UniProt
Year: 2021
Title: Electronic Gene Ontology annotations created by ARBA machine learning models
Publication      
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
Publication        
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Zhou P
Year: 2001
Journal: Blood
Title: MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes.
Volume: 97
Issue: 12
Pages: 3902-9
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: zebrafish
Publication
First Author: Wei G
Year: 2006
Journal: Cancer Cell
Title: Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance.
Volume: 10
Issue: 4
Pages: 331-42
Publication
First Author: Allen TD
Year: 2011
Journal: Cancer Res
Title: Interaction between MYC and MCL1 in the genesis and outcome of non-small-cell lung cancer.
Volume: 71
Issue: 6
Pages: 2212-21
Publication
First Author: Chen L
Year: 2015
Journal: Leukemia
Title: Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition.
Volume: 29
Issue: 6
Pages: 1290-300
Publication
First Author: Caenepeel S
Year: 2018
Journal: Cancer Discov
Title: AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Volume: 8
Issue: 12
Pages: 1582-1597
Interaction Experiment
Description: Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.
Allele
Name: transgene insertion 8, Ruth W Craig
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Strain
Attribute String: transgenic, mutant stock
Strain
Attribute String: congenic, mutant strain, transgenic
Publication
First Author: Zhou P
Year: 1998
Journal: Blood
Title: Mcl-1 in transgenic mice promotes survival in a spectrum of hematopoietic cell types and immortalization in the myeloid lineage.
Volume: 92
Issue: 9
Pages: 3226-39
Publication
First Author: Marriott HM
Year: 2005
Journal: J Clin Invest
Title: Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance.
Volume: 115
Issue: 2
Pages: 359-68
Genotype
Symbol: Tg(MCL1)8Caig/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Li W
Year: 2013
Journal: Blood
Title: Apc regulates the function of hematopoietic stem cells largely through β-catenin-dependent mechanisms.
Volume: 121
Issue: 20
Pages: 4063-72
Publication
First Author: Annunziato S
Year: 2019
Journal: Nat Commun
Title: Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer.
Volume: 10
Issue: 1
Pages: 397
Publication
First Author: Ertel F
Year: 2013
Journal: EMBO Rep
Title: Programming cancer cells for high expression levels of Mcl1.
Volume: 14
Issue: 4
Pages: 328-36
Publication  
First Author: Haschka MD
Year: 2015
Journal: Nat Commun
Title: The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest.
Volume: 6
Pages: 6891
Publication
First Author: Miletic AV
Year: 2010
Journal: J Exp Med
Title: Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases.
Volume: 207
Issue: 11
Pages: 2407-20
Publication
First Author: Benavente CA
Year: 2013
Journal: Oncotarget
Title: Cross-species genomic and epigenomic landscape of retinoblastoma.
Volume: 4
Issue: 6
Pages: 844-59
Publication
First Author: Jacque E
Year: 2015
Journal: J Exp Med
Title: BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
Volume: 212
Issue: 6
Pages: 883-92
Publication
First Author: Qian Z
Year: 2008
Journal: J Exp Med
Title: A critical role for Apc in hematopoietic stem and progenitor cell survival.
Volume: 205
Issue: 9
Pages: 2163-75
Publication
First Author: Ebner F
Year: 2017
Journal: J Clin Invest
Title: The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection.
Volume: 127
Issue: 6
Pages: 2051-2065
Publication
First Author: Fedorchenko O
Year: 2013
Journal: Blood
Title: CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia.
Volume: 121
Issue: 20
Pages: 4126-36
Publication
First Author: Cantley J
Year: 2011
Journal: Diabetologia
Title: Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo.
Volume: 54
Issue: 2
Pages: 380-9
Publication
First Author: Pekarsky Y
Year: 2010
Journal: Semin Cancer Biol
Title: Molecular basis of CLL.
Volume: 20
Issue: 6
Pages: 370-6
Publication
First Author: Jones KB
Year: 2013
Journal: Oncogene
Title: SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas.
Volume: 32
Issue: 18
Pages: 2365-71, 2375.e1-5
Publication
First Author: Wang Y
Year: 2014
Journal: J Exp Med
Title: Adjuvant-specific regulation of long-term antibody responses by ZBTB20.
Volume: 211
Issue: 5
Pages: 841-56
Publication
First Author: Prutsch N
Year: 2019
Journal: Leukemia
Title: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma.
Volume: 33
Issue: 3
Pages: 696-709
Publication
First Author: Jeyasuria P
Year: 2011
Journal: Biol Reprod
Title: Elevated levels of uterine anti-apoptotic signaling may activate NFKB and potentially confer resistance to caspase 3-mediated apoptotic cell death during pregnancy in mice.
Volume: 85
Issue: 2
Pages: 417-24
Publication
First Author: Merkel O
Year: 2012
Journal: Leukemia
Title: Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia.
Volume: 26
Issue: 12
Pages: 2508-16
Publication
First Author: Li Z
Year: 2015
Journal: J Clin Invest
Title: Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies.
Volume: 125
Issue: 3
Pages: 1081-97
Publication
First Author: Heneghan JF
Year: 2015
Journal: Am J Physiol Cell Physiol
Title: BH3 domain-independent apolipoprotein L1 toxicity rescued by BCL2 prosurvival proteins.
Volume: 309
Issue: 5
Pages: C332-47
Publication
First Author: Viant C
Year: 2017
Journal: J Exp Med
Title: Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival.
Volume: 214
Issue: 2
Pages: 491-510
Publication
First Author: Izumi M
Year: 2024
Journal: Cell Death Dis
Title: Integrative single-cell RNA-seq and spatial transcriptomics analyses reveal diverse apoptosis-related gene expression profiles in EGFR-mutated lung cancer.
Volume: 15
Issue: 8
Pages: 580
Publication
First Author: Frieler RA
Year: 2017
Journal: Exp Neurol
Title: Genetic neutrophil deficiency ameliorates cerebral ischemia-reperfusion injury.
Volume: 298
Issue: Pt A
Pages: 104-111
Publication
First Author: Hellmuth S
Year: 2020
Journal: Nature
Title: Separase-triggered apoptosis enforces minimal length of mitosis.
Volume: 580
Issue: 7804
Pages: 542-547
Publication
First Author: Chong Z
Year: 2018
Journal: Cell Mol Immunol
Title: E3 ligase FBXW7 aggravates TMPD-induced systemic lupus erythematosus by promoting cell apoptosis.
Volume: 15
Issue: 12
Pages: 1057-1070
Publication
First Author: Jiao Y
Year: 2019
Journal: Cell Death Differ
Title: Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes.
Volume: 26
Issue: 8
Pages: 1516-1530
Publication  
First Author: Debrincat MA
Year: 2015
Journal: Cell Death Dis
Title: BCL-2 is dispensable for thrombopoiesis and platelet survival.
Volume: 6
Pages: e1721
Publication
First Author: Evans DL
Year: 1995
Journal: J Mol Evol
Title: Molecular evolution and secondary structural conservation in the B-cell lymphoma leukemia 2 (bcl-2) family of proto-oncogene products.
Volume: 41
Issue: 6
Pages: 775-83
Publication
First Author: Wang K
Year: 1996
Journal: Genes Dev
Title: BID: a novel BH3 domain-only death agonist.
Volume: 10
Issue: 22
Pages: 2859-69
Protein Domain
Type: Domain
Description: Apoptosis, or programmed cell death (PCD), is a common and evolutionarily conserved property of all metazoans []. In many biological processes, apoptosis is required to eliminate supernumerary or dangerous (such as pre-cancerous) cells and to promote normal development. Dysregulation of apoptosis can, therefore, contribute to the development of many major diseases including cancer, autoimmunity and neurodegenerative disorders. In most cases, proteins of the caspase family execute the genetic programme that leads to cell death.Bcl-2 proteins are central regulators of caspase activation, and play a key role in cell death by regulating the integrity of the mitochondrial and endoplasmic reticulum (ER) membranes []. At least 20 Bcl-2 proteins have been reported in mammals, and several others have been identified in viruses. Bcl-2 family proteins fall roughly into three subtypes, which either promote cell survival (anti-apoptotic) or trigger cell death (pro-apoptotic). All members contain at least one of four conserved motifs, termed Bcl-2 Homology (BH) domains. Bcl-2 subfamily proteins, which contain at least BH1 and BH2, promote cell survival by inhibiting the adapters needed for the activation of caspases.Pro-apoptotic members potentially exert their effects by displacing the adapters from the pro-survival proteins; these proteins belong either to the Bax subfamily, which contain BH1-BH3, or to the BH3 subfamily, which mostly only feature BH3 []. Thus, the balance between antagonistic family members is believed to play a role in determining cell fate. Members of the wider Bcl-2 family, which also includes Bcl-x, Bcl-w and Mcl-1, are described by their similarity to Bcl-2 protein, a member of the pro-survival Bcl-2 subfamily []. Full-length Bcl-2 proteins feature all four BH domains, seven α-helices, and a C-terminal hydrophobic motif that targets the protein to the outer mitochondrial membrane, ER and nuclear envelope. Active cell suicide (apoptosis) is induced by events such as growth factor withdrawal and toxins. It is controlled by regulators, which have either an inhibitory effect on programmed cell death (anti-apoptotic) or block the protective effect of inhibitors (pro-apoptotic) [,]. Many viruses have found a way of countering defensive apoptosis by encoding their own anti-apoptosis genes preventing their target-cells from dying too soon. All proteins belonging to the Bcl-2 family []contain either a BH1, BH2, BH3, or BH4 domain. All anti-apoptoticproteins contain BH1 and BH2 domains, some of them contain an additional N-terminal BH4 domain (Bcl-2, Bcl-x(L), Bcl-w), which is never seen in pro-apoptotic proteins, except for Bcl-x(S). On the other hand, all pro-apoptotic proteins contain a BH3 domain (except for Bad) necessary fordimerisation with other proteins of Bcl-2 family and crucial for their killing activity, some of them also contain BH1 and BH2 domains (Bax, Bak). The BH3 domain is also present in some anti-apoptotic protein, such as Bcl-2 or Bcl-x(L). Proteins that are known to contain these domains include vertebrateBcl-2 (alpha and beta isoforms) and Bcl-x (isoforms (Bcl-x(L) and Bcl-x(S)); mammalian proteins Bax and Bak; mouse protein Bid; Xenopus laevis proteins Xr1 and Xr11; human induced myeloid leukemia celldifferentiation protein MCL1 and Caenorhabditis elegans protein ced-9.
Publication  
First Author: Reed JC
Year: 1996
Journal: Adv Exp Med Biol
Title: Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death.
Volume: 406
Pages: 99-112
Publication
First Author: Vaux DL
Year: 1993
Journal: Curr Biol
Title: A boom time for necrobiology.
Volume: 3
Issue: 12
Pages: 877-8
Protein
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false